Sivelestat (sodium tetrahydrate)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.166983
ASPH aspartate beta-hydroxylase 0.140914
PRELID2 PRELI domain containing 2 0.134448
RAD51B RAD51 paralog B 0.0879243
FNDC3B fibronectin type III domain containing 3B 0.0873056
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0844626
PAX8 paired box 8 0.0833121
ZBTB20 zinc finger and BTB domain containing 20 0.0795178
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0771797
LPP LIM domain containing preferred translocation partner in lipoma 0.0769461
MYH9 myosin, heavy chain 9, non-muscle 0.0765012
PSD3 pleckstrin and Sec7 domain containing 3 0.0741902
SMYD3 SET and MYND domain containing 3 0.0730037
OSBPL10 oxysterol binding protein-like 10 0.0695063
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.069436
ITGB8 integrin, beta 8 0.0673626
FHIT fragile histidine triad 0.0643976
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.063862
SMAD3 SMAD family member 3 0.0624942
MACROD2 MACRO domain containing 2 0.0621218
TBC1D5 TBC1 domain family, member 5 0.0600214
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0590683
AHNAK AHNAK nucleoprotein 0.0586073
SVIL supervillin 0.0537803
EGFR epidermal growth factor receptor 0.0533781
LIMCH1 LIM and calponin homology domains 1 0.0532083
ANKRD36 ankyrin repeat domain 36 0.0507389
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0504842
BICD1 bicaudal D homolog 1 (Drosophila) 0.0493468
PATJ PATJ crumbs cell polarity complex component 0.0472685
LDHA lactate dehydrogenase A 0.0463852
VCL vinculin 0.0462781
FNIP1 folliculin interacting protein 1 0.0451772
FLNB filamin B, beta 0.0431535
MBD5 methyl-CpG binding domain protein 5 0.0427697
NF1 neurofibromin 1 0.0426615
UTRN utrophin 0.0425424
WWOX WW domain containing oxidoreductase 0.0422374
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0418011
ALCAM activated leukocyte cell adhesion molecule 0.0417812
APP amyloid beta (A4) precursor protein 0.040414
SEPTIN9 septin 9 0.0401774
DOCK1 dedicator of cytokinesis 1 0.0399982
ENO1 enolase 1, (alpha) 0.0399491
EXOC4 exocyst complex component 4 0.0390642
DIAPH3 diaphanous-related formin 3 0.0389957
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0378709
SUMF1 sulfatase modifying factor 1 0.0377787
FLNA filamin A, alpha 0.0368909
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0366371
ATXN1 ataxin 1 0.036153
FER fer (fps/fes related) tyrosine kinase 0.0360771
CANX calnexin 0.035736
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0353519
KAZN kazrin, periplakin interacting protein 0.0353209
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0346151
TTC3 tetratricopeptide repeat domain 3 0.0345373
SBF2 SET binding factor 2 0.0343311
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0340962
RNF213 ring finger protein 213 0.0339422
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0336778
DLC1 DLC1 Rho GTPase activating protein 0.0333283
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0331662
BBX bobby sox homolog (Drosophila) 0.0330482
GSK3B glycogen synthase kinase 3 beta 0.0329137
SSH2 slingshot protein phosphatase 2 0.0328741
MACF1 microtubule-actin crosslinking factor 1 0.0328282
HMGA2 high mobility group AT-hook 2 0.0327636
TBC1D22A TBC1 domain family, member 22A 0.0323649
BPTF bromodomain PHD finger transcription factor 0.0319105
ZNF638 zinc finger protein 638 0.0318407
CDK13 cyclin-dependent kinase 13 0.0318285
CREB5 cAMP responsive element binding protein 5 0.0317595
BIRC6 baculoviral IAP repeat containing 6 0.0317331
BBS9 Bardet-Biedl syndrome 9 0.0314493
ANKRD10 ankyrin repeat domain 10 0.0314264
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0313284
ATG7 autophagy related 7 0.0311746
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0311354
PTPRK protein tyrosine phosphatase, receptor type, K 0.0306263
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0300695
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0299944
ANKRD11 ankyrin repeat domain 11 0.0299393
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0298994
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0298099
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0296526
TNIK TRAF2 and NCK interacting kinase 0.0296095
PLEC plectin 0.0294432
GPR39 G protein-coupled receptor 39 0.0292978
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0291233
ANXA3 annexin A3 0.0290623
MYO1D myosin ID 0.0288527
TAS2R14 taste receptor, type 2, member 14 0.0288202
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0287705
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0285525
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0284924
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0284445
JMJD1C jumonji domain containing 1C 0.0284349
CCND1 cyclin D1 0.0282028
PARD3B par-3 family cell polarity regulator beta 0.0276681

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.116395
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.101654
MT2A metallothionein 2A -0.0861027
RPS6 ribosomal protein S6 -0.0764413
TPT1 tumor protein, translationally-controlled 1 -0.074722
TMSB10 thymosin beta 10 -0.0727854
RPS8 ribosomal protein S8 -0.0724808
RPL35A ribosomal protein L35a -0.0692175
PTMA prothymosin, alpha -0.0625881
RPL12 ribosomal protein L12 -0.0623848
RPS19 ribosomal protein S19 -0.0584192
RPL23 ribosomal protein L23 -0.0546929
B2M beta-2-microglobulin -0.0537557
ACTG1 actin gamma 1 -0.0487185
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0474849
RPLP1 ribosomal protein, large, P1 -0.0461624
RPL19 ribosomal protein L19 -0.0456875
RPL32 ribosomal protein L32 -0.0404186
RPL34 ribosomal protein L34 -0.0397652
RPLP2 ribosomal protein, large, P2 -0.0394372
RPL31 ribosomal protein L31 -0.0383666
RPS12 ribosomal protein S12 -0.0381082
EIF1 eukaryotic translation initiation factor 1 -0.0376385
RPL26 ribosomal protein L26 -0.0368
RPS14 ribosomal protein S14 -0.0356849
RACK1 receptor for activated C kinase 1 -0.0351378
RPL35 ribosomal protein L35 -0.0338385
RPL28 ribosomal protein L28 -0.0334901
RPL37A ribosomal protein L37a -0.0333628
RPL11 ribosomal protein L11 -0.0333151
RPL7A ribosomal protein L7a -0.0328184
S100A9 S100 calcium binding protein A9 -0.0325986
RPL9 ribosomal protein L9 -0.0318218
RPL36 ribosomal protein L36 -0.0308945
RPS27A ribosomal protein S27a -0.0308462
S100A6 S100 calcium binding protein A6 -0.0307558
RPL18 ribosomal protein L18 -0.0301674
RPL5 ribosomal protein L5 -0.0293289
RPS3 ribosomal protein S3 -0.0290998
RPS29 ribosomal protein S29 -0.0286699
RPS16 ribosomal protein S16 -0.0286108
RPLP0 ribosomal protein, large, P0 -0.0284553
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0283761
RPS5 ribosomal protein S5 -0.0268641
S100A10 S100 calcium binding protein A10 -0.02621
RPS24 ribosomal protein S24 -0.0251537
RPS25 ribosomal protein S25 -0.0247925
RPS11 ribosomal protein S11 -0.0246936
RPS27 ribosomal protein S27 -0.0243178
UGCG UDP-glucose ceramide glucosyltransferase -0.0237809
GNAS GNAS complex locus -0.0234876
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0234253
RPL7 ribosomal protein L7 -0.023399
RPS13 ribosomal protein S13 -0.0232008
RPS17 ribosomal protein S17 -0.0228506
YBX1 Y box binding protein 1 -0.0226712
RPS23 ribosomal protein S23 -0.0225509
RPS20 ribosomal protein S20 -0.0221639
SET SET nuclear proto-oncogene -0.0221411
FTH1 ferritin, heavy polypeptide 1 -0.0217949
RPL8 ribosomal protein L8 -0.0208228
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0206242
TMSB4X thymosin beta 4, X-linked -0.0205837
RPL13A ribosomal protein L13a -0.0204931
RPL15 ribosomal protein L15 -0.0202851
NAP1L1 nucleosome assembly protein 1-like 1 -0.0201847
RPL36A ribosomal protein L36a -0.0196956
RPS21 ribosomal protein S21 -0.019638
RPS10 ribosomal protein S10 -0.0190397
RPL30 ribosomal protein L30 -0.0189405
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0188733
HMGA1 high mobility group AT-hook 1 -0.0188571
HMGB1 high mobility group box 1 -0.0185273
RPL38 ribosomal protein L38 -0.0181508
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0180496
KMT2E lysine (K)-specific methyltransferase 2E -0.0178156
SEPTIN7 septin 7 -0.0178088
RPS4X ribosomal protein S4, X-linked -0.017788
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0174657
NPEPPS aminopeptidase puromycin sensitive -0.0172735
VIM vimentin -0.0172142
RPS15 ribosomal protein S15 -0.0171362
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0170278
RPL27 ribosomal protein L27 -0.017024
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0167667
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0164961
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0164788
RPL10A ribosomal protein L10a -0.0163607
FAM162A family with sequence similarity 162, member A -0.0158733
BHLHE40 basic helix-loop-helix family, member e40 -0.015793
RPS2 ribosomal protein S2 -0.0157167
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0156993
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0155245
TUBB4B tubulin, beta 4B class IVb -0.0155185
IER3 immediate early response 3 -0.0155072
DDIT4 DNA-damage-inducible transcript 4 -0.0154118
EIF5B eukaryotic translation initiation factor 5B -0.0153755
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0152553
TPI1 triosephosphate isomerase 1 -0.0152148
RBM27 RNA binding motif protein 27 -0.0151929