| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sivelestat (sodium tetrahydrate) perturbation in HOP62 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.161936 |
| FN1 | fibronectin 1 | 0.158895 |
| FAM13A | family with sequence similarity 13, member A | 0.138221 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.128171 |
| FNDC3B | fibronectin type III domain containing 3B | 0.117529 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.109007 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.101968 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0978127 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0886567 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.086775 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0832072 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0731885 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0701197 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0678092 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0677321 |
| CANX | calnexin | 0.063806 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0609709 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0601265 |
| HELZ | helicase with zinc finger | 0.0594963 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0591152 |
| ZNF292 | zinc finger protein 292 | 0.059084 |
| PGK1 | phosphoglycerate kinase 1 | 0.056963 |
| CDH13 | cadherin 13 | 0.0552629 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0540806 |
| PDE10A | phosphodiesterase 10A | 0.0535591 |
| SPAG9 | sperm associated antigen 9 | 0.0525238 |
| USP3 | ubiquitin specific peptidase 3 | 0.0519203 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0518462 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0516189 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0513582 |
| LDHA | lactate dehydrogenase A | 0.0509231 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0507614 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.0506911 |
| PTK2 | protein tyrosine kinase 2 | 0.0506103 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0504647 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0496712 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.049592 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.048486 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0476857 |
| DTNA | dystrobrevin, alpha | 0.0468309 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0465782 |
| ASPH | aspartate beta-hydroxylase | 0.0460472 |
| RUNX1 | runt-related transcription factor 1 | 0.0458637 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | 0.0449392 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0448484 |
| COL5A1 | collagen, type V, alpha 1 | 0.0419444 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0416431 |
| RLF | rearranged L-myc fusion | 0.0405018 |
| QKI | QKI, KH domain containing, RNA binding | 0.0398298 |
| ATP13A3 | ATPase type 13A3 | 0.0397541 |
| NUP58 | nucleoporin 58 | 0.0396699 |
| ADM | adrenomedullin | 0.0390659 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0390034 |
| MYO1B | myosin IB | 0.0387533 |
| DST | dystonin | 0.0383569 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0378217 |
| SEC24A | SEC24 family member A | 0.0374969 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0365528 |
| INSIG2 | insulin induced gene 2 | 0.0356638 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0350663 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0350018 |
| CD109 | CD109 molecule | 0.0348547 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0345771 |
| PCBP2 | poly(rC) binding protein 2 | 0.0341515 |
| RNF24 | ring finger protein 24 | 0.0336958 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0331956 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.032794 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0327453 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0324776 |
| RNF145 | ring finger protein 145 | 0.0324688 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0324577 |
| FLNB | filamin B, beta | 0.0324277 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0323316 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0320897 |
| MYO10 | myosin X | 0.0319794 |
| ANXA2 | annexin A2 | 0.0318099 |
| WDR45B | WD repeat domain 45B | 0.0317662 |
| COPA | coatomer protein complex, subunit alpha | 0.0315632 |
| CALR | calreticulin | 0.031521 |
| RYBP | RING1 and YY1 binding protein | 0.0313087 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0311879 |
| NGLY1 | N-glycanase 1 | 0.0310247 |
| ENO1 | enolase 1, (alpha) | 0.030778 |
| CADM1 | cell adhesion molecule 1 | 0.0307159 |
| TFRC | transferrin receptor | 0.0305693 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0304833 |
| SETD5 | SET domain containing 5 | 0.0304325 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0303933 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0302335 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0299285 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0299156 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.029851 |
| COL6A2 | collagen, type VI, alpha 2 | 0.029762 |
| JUN | jun proto-oncogene | 0.0297399 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0297306 |
| PKM | pyruvate kinase, muscle | 0.0294367 |
| TAC4 | tachykinin 4 (hemokinin) | 0.0293713 |
| OGA | O-GlcNAcase | 0.0287634 |
| RNMT | RNA (guanine-7-) methyltransferase | 0.0287409 |
| TFG | TRK-fused gene | 0.028708 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.24605 |
| MT2A | metallothionein 2A | -0.214707 |
| TMSB10 | thymosin beta 10 | -0.153662 |
| CD44 | CD44 molecule (Indian blood group) | -0.0933675 |
| HMGA2 | high mobility group AT-hook 2 | -0.0785053 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0575164 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0558306 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0501825 |
| VIM | vimentin | -0.0466905 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0452836 |
| RPLP1 | ribosomal protein, large, P1 | -0.037234 |
| RPS19 | ribosomal protein S19 | -0.033316 |
| EGR1 | early growth response 1 | -0.031467 |
| RPL35A | ribosomal protein L35a | -0.0309027 |
| RPL23 | ribosomal protein L23 | -0.0308333 |
| RPLP2 | ribosomal protein, large, P2 | -0.0298375 |
| ACTG1 | actin gamma 1 | -0.0291144 |
| RPS8 | ribosomal protein S8 | -0.0282908 |
| RPL19 | ribosomal protein L19 | -0.0270349 |
| FTL | ferritin, light polypeptide | -0.0263313 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.02619 |
| RPL9 | ribosomal protein L9 | -0.0260384 |
| MT1X | metallothionein 1X | -0.0253816 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.024651 |
| RPL32 | ribosomal protein L32 | -0.0242188 |
| RPL12 | ribosomal protein L12 | -0.0240268 |
| DUSP6 | dual specificity phosphatase 6 | -0.0237651 |
| CAVIN1 | caveolae associated protein 1 | -0.0230244 |
| NECTIN2 | nectin cell adhesion molecule 2 | -0.0222728 |
| RPS16 | ribosomal protein S16 | -0.021441 |
| RPL34 | ribosomal protein L34 | -0.021366 |
| RPS24 | ribosomal protein S24 | -0.0206294 |
| RPS21 | ribosomal protein S21 | -0.020617 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.020593 |
| OSMR | oncostatin M receptor | -0.0201759 |
| EGFR | epidermal growth factor receptor | -0.0193674 |
| RPL37A | ribosomal protein L37a | -0.019317 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0192498 |
| GLIS3 | GLIS family zinc finger 3 | -0.0182774 |
| PTMA | prothymosin, alpha | -0.018119 |
| RPS29 | ribosomal protein S29 | -0.0178094 |
| RPL30 | ribosomal protein L30 | -0.0172962 |
| RRBP1 | ribosome binding protein 1 | -0.017174 |
| RPL38 | ribosomal protein L38 | -0.0171432 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.017029 |
| RPL37 | ribosomal protein L37 | -0.0167371 |
| RPS13 | ribosomal protein S13 | -0.016501 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0162539 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0162183 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0158811 |
| RPL7A | ribosomal protein L7a | -0.0158296 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0154218 |
| S100A9 | S100 calcium binding protein A9 | -0.0154128 |
| MT1E | metallothionein 1E | -0.0154085 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0153821 |
| VCL | vinculin | -0.0153661 |
| RPL11 | ribosomal protein L11 | -0.0151894 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0151456 |
| RPL36 | ribosomal protein L36 | -0.0146773 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0145599 |
| H3-3B | H3.3 histone B | -0.0144608 |
| RPL28 | ribosomal protein L28 | -0.0142797 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0140598 |
| RPL36A | ribosomal protein L36a | -0.0139865 |
| TBCA | tubulin folding cofactor A | -0.0139348 |
| RPL35 | ribosomal protein L35 | -0.0139031 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0136048 |
| RPL27 | ribosomal protein L27 | -0.0135754 |
| RPS27A | ribosomal protein S27a | -0.0132561 |
| RPS3 | ribosomal protein S3 | -0.0131943 |
| TUBB6 | tubulin, beta 6 class V | -0.0131761 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.012939 |
| ACTN4 | actinin, alpha 4 | -0.0128901 |
| GNAI2 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | -0.0128469 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | -0.0128068 |
| RPS10 | ribosomal protein S10 | -0.0126887 |
| RPL8 | ribosomal protein L8 | -0.0124856 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0122538 |
| TUBB | tubulin, beta class I | -0.0121551 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0121218 |
| KLF6 | Kruppel-like factor 6 | -0.0121211 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.0120884 |
| RPS6 | ribosomal protein S6 | -0.0120481 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0116403 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0115932 |
| SGO2 | shugoshin 2 | -0.0115548 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.011507 |
| UBB | ubiquitin B | -0.0112412 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0112112 |
| ANGPTL4 | angiopoietin-like 4 | -0.0109615 |
| NAV1 | neuron navigator 1 | -0.0108714 |
| RPL31 | ribosomal protein L31 | -0.0108499 |
| EEF1D | eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) | -0.010809 |
| SLF2 | SMC5-SMC6 complex localization factor 2 | -0.0105084 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.0104943 |
| RPS27 | ribosomal protein S27 | -0.0103672 |
| SERF2 | small EDRK-rich factor 2 | -0.0101817 |
| RPS15 | ribosomal protein S15 | -0.0100993 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -0.010041 |
| ZC3H12B | zinc finger CCCH-type containing 12B | -0.00980289 |
