Sivelestat (sodium tetrahydrate)_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in HS-578T cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.232361
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.114672
TRIO trio Rho guanine nucleotide exchange factor 0.0947058
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0591368
FNDC3B fibronectin type III domain containing 3B 0.0586832
COL6A3 collagen, type VI, alpha 3 0.057197
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0418121
CANX calnexin 0.039532
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0370134
MYH9 myosin, heavy chain 9, non-muscle 0.0339817
LDHA lactate dehydrogenase A 0.0328036
SPAG9 sperm associated antigen 9 0.0320834
ARRDC3 arrestin domain containing 3 0.0313301
ELL2 elongation factor, RNA polymerase II, 2 0.0310358
CAMTA1 calmodulin binding transcription activator 1 0.0309252
PLEC plectin 0.0306506
CADM1 cell adhesion molecule 1 0.0305194
ATP13A3 ATPase type 13A3 0.0305117
ZNF292 zinc finger protein 292 0.0289435
NAMPT nicotinamide phosphoribosyltransferase 0.0281435
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0279732
ESYT2 extended synaptotagmin-like protein 2 0.0277376
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0276642
HYOU1 hypoxia up-regulated 1 0.0261799
PDE10A phosphodiesterase 10A 0.0255903
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0241056
SMAD3 SMAD family member 3 0.0236387
PRELID2 PRELI domain containing 2 0.0235894
OGA O-GlcNAcase 0.023559
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0231349
SOD2 superoxide dismutase 2, mitochondrial 0.0230979
GRB10 growth factor receptor-bound protein 10 0.0218604
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.02128
LOXL2 lysyl oxidase-like 2 0.0211466
HOOK2 hook microtubule-tethering protein 2 0.0198508
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0198083
TNS1 tensin 1 0.0186685
TFG TRK-fused gene 0.0185043
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0182953
APP amyloid beta (A4) precursor protein 0.0178303
YEATS2 YEATS domain containing 2 0.0176232
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0175419
HELZ helicase with zinc finger 0.0174599
PTK2 protein tyrosine kinase 2 0.0174036
FMNL2 formin-like 2 0.0174013
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.017053
DLG1 discs, large homolog 1 (Drosophila) 0.0168135
TENT4A terminal nucleotidyltransferase 4A 0.0168092
TRAM2 translocation associated membrane protein 2 0.0166549
EEF2 eukaryotic translation elongation factor 2 0.016479
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0163016
COL4A1 collagen, type IV, alpha 1 0.0160204
MARCHF6 membrane associated ring-CH-type finger 6 0.0160041
CALR calreticulin 0.0157177
PDIA6 protein disulfide isomerase family A, member 6 0.015582
NAV2 neuron navigator 2 0.0155814
ADAM17 ADAM metallopeptidase domain 17 0.0153863
MRTFA myocardin related transcription factor A 0.0153175
CD109 CD109 molecule 0.0152771
UBA6 ubiquitin-like modifier activating enzyme 6 0.0152
SHB Src homology 2 domain containing adaptor protein B 0.0151763
KDM3A lysine (K)-specific demethylase 3A 0.0150408
CABIN1 calcineurin binding protein 1 0.0148667
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0148241
DOCK7 dedicator of cytokinesis 7 0.014688
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0146283
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0145481
COL7A1 collagen, type VII, alpha 1 0.0145236
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0144423
FAM13A family with sequence similarity 13, member A 0.0143807
KMT2C lysine (K)-specific methyltransferase 2C 0.0143346
RARB retinoic acid receptor, beta 0.0142335
MED13L mediator complex subunit 13-like 0.014159
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0140799
FLNB filamin B, beta 0.0140152
SUCO SUN domain containing ossification factor 0.0138071
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0137992
USP3 ubiquitin specific peptidase 3 0.0136718
WSB1 WD repeat and SOCS box containing 1 0.0136353
TNIP1 TNFAIP3 interacting protein 1 0.0133497
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0133144
DPYSL3 dihydropyrimidinase-like 3 0.013292
ARHGAP35 Rho GTPase activating protein 35 0.0132368
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0132319
RBM39 RNA binding motif protein 39 0.0130416
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0129334
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0128994
QKI QKI, KH domain containing, RNA binding 0.012826
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0127332
AHNAK AHNAK nucleoprotein 0.0125948
ICAM1 intercellular adhesion molecule 1 0.0125303
CLIC4 chloride intracellular channel 4 0.0124645
ARHGAP29 Rho GTPase activating protein 29 0.0124378
CCNY cyclin Y 0.0123462
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0123163
RLF rearranged L-myc fusion 0.0122643
TSC22D2 TSC22 domain family, member 2 0.0122378
XPO1 exportin 1 0.0120773
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0119582
SKIC3 SKI3 subunit of superkiller complex 0.0119452

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.226994
COL1A1 collagen, type I, alpha 1 -0.206946
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.155058
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.130215
COL1A2 collagen, type I, alpha 2 -0.112371
TIMP3 TIMP metallopeptidase inhibitor 3 -0.103214
TMSB10 thymosin beta 10 -0.102617
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0919331
MT2A metallothionein 2A -0.089647
STC1 stanniocalcin 1 -0.0794356
ACTG1 actin gamma 1 -0.0672035
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0632231
IGFBP3 insulin-like growth factor binding protein 3 -0.0582752
INHBA inhibin, beta A -0.0553291
RPS8 ribosomal protein S8 -0.0526237
S100A9 S100 calcium binding protein A9 -0.0509689
TPM4 tropomyosin 4 -0.0509522
RPL35A ribosomal protein L35a -0.0493198
FTL ferritin, light polypeptide -0.0445306
CALD1 caldesmon 1 -0.0435679
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0429245
TGFBI transforming growth factor, beta-induced, 68kDa -0.0416289
IER3 immediate early response 3 -0.0414993
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0410998
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0405414
CD44 CD44 molecule (Indian blood group) -0.0397675
F3 coagulation factor III (thromboplastin, tissue factor) -0.0392605
TM4SF1 transmembrane 4 L six family member 1 -0.0392053
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0390096
S100A6 S100 calcium binding protein A6 -0.0366812
LGALS1 lectin, galactoside-binding, soluble, 1 -0.036532
TPT1 tumor protein, translationally-controlled 1 -0.0364406
CLMP CXADR-like membrane protein -0.0304838
TMSB4X thymosin beta 4, X-linked -0.0295582
GLIS3 GLIS family zinc finger 3 -0.0292811
CDH13 cadherin 13 -0.0289312
HLA-B major histocompatibility complex, class I, B -0.0280486
IGFBP7 insulin-like growth factor binding protein 7 -0.027908
FBN1 fibrillin 1 -0.0278027
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0275336
EIF1 eukaryotic translation initiation factor 1 -0.0272915
ASPH aspartate beta-hydroxylase -0.0272201
S100A10 S100 calcium binding protein A10 -0.0271334
LOX lysyl oxidase -0.0267324
PTMA prothymosin, alpha -0.025973
ARL4C ADP-ribosylation factor-like 4C -0.025884
RPS6 ribosomal protein S6 -0.0253189
RPL28 ribosomal protein L28 -0.0249783
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0246683
VCAN versican -0.0242556
RPL11 ribosomal protein L11 -0.0242126
RPS13 ribosomal protein S13 -0.024091
RPL26 ribosomal protein L26 -0.0240324
IL6 interleukin 6 -0.0237418
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0234601
CAVIN1 caveolae associated protein 1 -0.0231283
EGR1 early growth response 1 -0.0223456
VCL vinculin -0.0222395
RPS21 ribosomal protein S21 -0.0221446
POTEF POTE ankyrin domain family, member F -0.0220279
RPL8 ribosomal protein L8 -0.0219705
LMO4 LIM domain only 4 -0.0216084
HMGA2 high mobility group AT-hook 2 -0.0212012
UQCRB ubiquinol-cytochrome c reductase binding protein -0.021072
RPL30 ribosomal protein L30 -0.0210154
RRBP1 ribosome binding protein 1 -0.0209127
B2M beta-2-microglobulin -0.0206734
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0200713
SDC2 syndecan 2 -0.0199455
RPS24 ribosomal protein S24 -0.0197953
RPL23 ribosomal protein L23 -0.0196871
RPS19 ribosomal protein S19 -0.0196671
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0193457
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0191157
RACK1 receptor for activated C kinase 1 -0.0189249
RPL34 ribosomal protein L34 -0.0188197
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0187909
RPLP1 ribosomal protein, large, P1 -0.0184841
PFN1 profilin 1 -0.0183532
NAV1 neuron navigator 1 -0.0179253
PRSS23 protease, serine, 23 -0.0176465
RPL12 ribosomal protein L12 -0.017601
RPLP2 ribosomal protein, large, P2 -0.0174856
CTSB cathepsin B -0.0173351
LMNA lamin A/C -0.0172522
SOX4 SRY (sex determining region Y)-box 4 -0.0172521
GOLGB1 golgin B1 -0.017095
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0170296
RAB2A RAB2A, member RAS oncogene family -0.0166555
KPNB1 karyopherin (importin) beta 1 -0.0166501
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.016643
TMED9 transmembrane emp24 protein transport domain containing 9 -0.0166188
OXR1 oxidation resistance 1 -0.0165957
EXT1 exostosin glycosyltransferase 1 -0.0165728
COL6A2 collagen, type VI, alpha 2 -0.016492
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0163639
RPS27A ribosomal protein S27a -0.0162902
OSMR oncostatin M receptor -0.0162321
PRRC2C proline-rich coiled-coil 2C -0.016227
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0160867