| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sivelestat (sodium tetrahydrate) perturbation in HT-29 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.184464 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0894059 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.0824301 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.081052 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0667913 |
| HYOU1 | hypoxia up-regulated 1 | 0.0659857 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0626686 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0553295 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0549738 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0547678 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0538736 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0504608 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0463191 |
| SMAD3 | SMAD family member 3 | 0.0460461 |
| ATXN1 | ataxin 1 | 0.044976 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0396891 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0391941 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0385116 |
| CANX | calnexin | 0.0382336 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0381108 |
| VCL | vinculin | 0.0372464 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0371165 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0368356 |
| PCBP2 | poly(rC) binding protein 2 | 0.03522 |
| VMP1 | vacuole membrane protein 1 | 0.0344537 |
| CALR | calreticulin | 0.034208 |
| HELZ | helicase with zinc finger | 0.0340377 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0336829 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0336286 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0335818 |
| CTBP2 | C-terminal binding protein 2 | 0.0329851 |
| SETX | senataxin | 0.0324737 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0324498 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0322023 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0318856 |
| BTBD9 | BTB (POZ) domain containing 9 | 0.0304963 |
| GOLGA4 | golgin A4 | 0.0302848 |
| TUFT1 | tuftelin 1 | 0.0299774 |
| SUCO | SUN domain containing ossification factor | 0.0292466 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0291779 |
| COG5 | component of oligomeric golgi complex 5 | 0.0289858 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0288118 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0287734 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0286377 |
| TES | testin LIM domain protein | 0.0284366 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0283569 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0283132 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0282388 |
| INTS6 | integrator complex subunit 6 | 0.0278081 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0272878 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0272875 |
| FAM91A1 | family with sequence similarity 91, member A1 | 0.0268776 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.026657 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0265308 |
| PTEN | phosphatase and tensin homolog | 0.0263822 |
| RBM39 | RNA binding motif protein 39 | 0.0260694 |
| TXNRD1 | thioredoxin reductase 1 | 0.0260087 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0257947 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0255216 |
| NUP58 | nucleoporin 58 | 0.0253737 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0252137 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0246894 |
| BCL2L1 | BCL2-like 1 | 0.0244947 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0242784 |
| HM13 | histocompatibility (minor) 13 | 0.0242278 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0242094 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0241023 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0238346 |
| SBF2 | SET binding factor 2 | 0.0238142 |
| UBN2 | ubinuclein 2 | 0.023602 |
| FBXO32 | F-box protein 32 | 0.0232147 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0230963 |
| PLEC | plectin | 0.0230353 |
| PGM3 | phosphoglucomutase 3 | 0.0229519 |
| OGA | O-GlcNAcase | 0.0228638 |
| NBAS | neuroblastoma amplified sequence | 0.0227264 |
| TRAM1 | translocation associated membrane protein 1 | 0.0226749 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0225006 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0224787 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0223518 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0221489 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0221142 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0219834 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0218522 |
| RBM33 | RNA binding motif protein 33 | 0.0218161 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0217242 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.020978 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0209399 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0208691 |
| HERC1 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 | 0.020836 |
| MCL1 | myeloid cell leukemia 1 | 0.0208247 |
| MAGT1 | magnesium transporter 1 | 0.0207496 |
| TFG | TRK-fused gene | 0.0201852 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0200995 |
| COPA | coatomer protein complex, subunit alpha | 0.0200919 |
| RTN3 | reticulon 3 | 0.0200469 |
| JMY | junction mediating and regulatory protein, p53 cofactor | 0.0199619 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0199563 |
| SEC24D | SEC24 family member D | 0.0195248 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0193311 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.249966 |
| PTMA | prothymosin, alpha | -0.166413 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.138681 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.126746 |
| TMSB10 | thymosin beta 10 | -0.102907 |
| KRT20 | keratin 20, type I | -0.0974136 |
| FTL | ferritin, light polypeptide | -0.0944795 |
| RPS6 | ribosomal protein S6 | -0.0942186 |
| MYH14 | myosin, heavy chain 14, non-muscle | -0.0895377 |
| RPLP1 | ribosomal protein, large, P1 | -0.0815266 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.0769262 |
| RPS8 | ribosomal protein S8 | -0.0766256 |
| B2M | beta-2-microglobulin | -0.0711649 |
| ACTG1 | actin gamma 1 | -0.0701158 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0693971 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0678772 |
| RPL35A | ribosomal protein L35a | -0.0621774 |
| RPS3 | ribosomal protein S3 | -0.0620385 |
| S100A6 | S100 calcium binding protein A6 | -0.0617473 |
| RPS19 | ribosomal protein S19 | -0.0601509 |
| KRT18 | keratin 18, type I | -0.0564266 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0550679 |
| KRT19 | keratin 19, type I | -0.0546722 |
| FRY | furry homolog (Drosophila) | -0.0541193 |
| JUN | jun proto-oncogene | -0.0534105 |
| RPS12 | ribosomal protein S12 | -0.0530506 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0524183 |
| NECTIN2 | nectin cell adhesion molecule 2 | -0.0518109 |
| RPLP2 | ribosomal protein, large, P2 | -0.0511697 |
| TMC5 | transmembrane channel-like 5 | -0.0505833 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0505315 |
| RNF213 | ring finger protein 213 | -0.0497354 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0496225 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0456124 |
| LMNA | lamin A/C | -0.0455049 |
| RPL13A | ribosomal protein L13a | -0.0454149 |
| RPS24 | ribosomal protein S24 | -0.0444717 |
| RPL34 | ribosomal protein L34 | -0.0440384 |
| MKI67 | marker of proliferation Ki-67 | -0.0435857 |
| RPL37A | ribosomal protein L37a | -0.0422915 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0422295 |
| RPL23 | ribosomal protein L23 | -0.0414958 |
| MMP7 | matrix metallopeptidase 7 | -0.0410541 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0410202 |
| S100A10 | S100 calcium binding protein A10 | -0.0399765 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0391988 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0391735 |
| RPL26 | ribosomal protein L26 | -0.0388243 |
| RPL9 | ribosomal protein L9 | -0.0377088 |
| RPS27A | ribosomal protein S27a | -0.037586 |
| RRBP1 | ribosome binding protein 1 | -0.0375059 |
| PGK1 | phosphoglycerate kinase 1 | -0.0374859 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -0.0367328 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0367136 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0365735 |
| DIAPH2 | diaphanous-related formin 2 | -0.035963 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0359614 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0348058 |
| RPL12 | ribosomal protein L12 | -0.0344735 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0342801 |
| RPL31 | ribosomal protein L31 | -0.0338927 |
| CD2AP | CD2-associated protein | -0.0337232 |
| ASPH | aspartate beta-hydroxylase | -0.0333731 |
| RPLP0 | ribosomal protein, large, P0 | -0.0333651 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0332717 |
| RPL11 | ribosomal protein L11 | -0.0328652 |
| RPL18 | ribosomal protein L18 | -0.0327083 |
| RPL37 | ribosomal protein L37 | -0.0320131 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0318318 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0317397 |
| SERF2 | small EDRK-rich factor 2 | -0.0313504 |
| EGR1 | early growth response 1 | -0.0312229 |
| MUC13 | mucin 13, cell surface associated | -0.0311963 |
| RPL27A | ribosomal protein L27a | -0.0311953 |
| RPL36A | ribosomal protein L36a | -0.0311575 |
| S100P | S100 calcium binding protein P | -0.0311228 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0310801 |
| RPS13 | ribosomal protein S13 | -0.0307908 |
| RPL7A | ribosomal protein L7a | -0.0305969 |
| TRIM56 | tripartite motif containing 56 | -0.0303722 |
| TMEM45B | transmembrane protein 45B | -0.029951 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.029804 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | -0.0297273 |
| ETV6 | ets variant 6 | -0.0295963 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0293778 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.0288949 |
| RDH13 | retinol dehydrogenase 13 (all-trans/9-cis) | -0.0284307 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0284103 |
| PCED1B | PC-esterase domain containing 1B | -0.0281729 |
| HMGB1 | high mobility group box 1 | -0.028092 |
| CD63 | CD63 molecule | -0.0279656 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0279299 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0276655 |
| RPS25 | ribosomal protein S25 | -0.0272828 |
| RPS17 | ribosomal protein S17 | -0.0272663 |
| RPS16 | ribosomal protein S16 | -0.0269577 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0267686 |
| BCAS1 | breast carcinoma amplified sequence 1 | -0.0266716 |
| TMSB4X | thymosin beta 4, X-linked | -0.0266386 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0262112 |
