Sivelestat (sodium tetrahydrate)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.138664
LRMDA leucine rich melanocyte differentiation associated 0.120652
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0837291
GPC6 glypican 6 0.0819765
SAMD4A sterile alpha motif domain containing 4A 0.0689891
FNDC3B fibronectin type III domain containing 3B 0.0679345
MAML2 mastermind-like 2 (Drosophila) 0.0659588
NPAS2 neuronal PAS domain protein 2 0.0638222
PEG3 paternally expressed 3 0.0621495
IGF2 insulin-like growth factor 2 0.0615278
FN1 fibronectin 1 0.0543373
EHBP1 EH domain binding protein 1 0.0516889
SOX5 SRY (sex determining region Y)-box 5 0.0448712
RBM39 RNA binding motif protein 39 0.0425885
INSIG2 insulin induced gene 2 0.0420563
ATXN1 ataxin 1 0.0419097
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0417951
PTPRM protein tyrosine phosphatase, receptor type, M 0.0393063
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0391203
DSPP dentin sialophosphoprotein 0.0388842
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0369836
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0352053
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0345758
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0338769
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) 0.0327215
PTBP3 polypyrimidine tract binding protein 3 0.0327146
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0325171
EXT1 exostosin glycosyltransferase 1 0.0314182
OSBPL10 oxysterol binding protein-like 10 0.030942
CAMTA1 calmodulin binding transcription activator 1 0.0305758
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.029436
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0291352
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0289319
TTC28 tetratricopeptide repeat domain 28 0.0281532
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0280782
BIRC6 baculoviral IAP repeat containing 6 0.0278476
ATP10A ATPase, class V, type 10A 0.0273389
MSI2 musashi RNA-binding protein 2 0.0272469
KDM7A lysine (K)-specific demethylase 7A 0.0267356
NHSL1 NHS-like 1 0.0255483
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0254756
DTNA dystrobrevin, alpha 0.0251131
TNS1 tensin 1 0.0250793
HOOK2 hook microtubule-tethering protein 2 0.0250026
SESTD1 SEC14 and spectrin domains 1 0.0248471
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0247673
ACSS3 acyl-CoA synthetase short-chain family member 3 0.0245834
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0244768
LCOR ligand dependent nuclear receptor corepressor 0.0244488
DST dystonin 0.0241999
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0240725
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0238088
MTUS1 microtubule associated tumor suppressor 1 0.0236393
TAS2R14 taste receptor, type 2, member 14 0.0234965
ZHX2 zinc fingers and homeoboxes 2 0.023059
ARHGAP9 Rho GTPase activating protein 9 0.0228152
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0227444
DLC1 DLC1 Rho GTPase activating protein 0.0220628
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0214457
VEGFA vascular endothelial growth factor A 0.0213461
AFDN afadin, adherens junction formation factor 0.0208415
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0203584
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0202992
TMEM123 transmembrane protein 123 0.0201377
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.020083
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0195163
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0194937
NBAS neuroblastoma amplified sequence 0.0194912
CCNY cyclin Y 0.019202
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0191601
FHIT fragile histidine triad 0.0188906
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0188075
TBL1X transducin (beta)-like 1X-linked 0.0187194
DOCK4 dedicator of cytokinesis 4 0.0186811
RNF213 ring finger protein 213 0.0186543
RAD51B RAD51 paralog B 0.0185023
ZNF644 zinc finger protein 644 0.0181785
NKD1 naked cuticle homolog 1 (Drosophila) 0.017981
PHF21A PHD finger protein 21A 0.0178714
PLIN2 perilipin 2 0.0177043
ZBTB20 zinc finger and BTB domain containing 20 0.0176042
MYO1B myosin IB 0.0174999
STK39 serine threonine kinase 39 0.0174771
YAP1 Yes-associated protein 1 0.0173879
KIAA1217 KIAA1217 0.0173099
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0170192
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0170073
ZMYM2 zinc finger, MYM-type 2 0.0169612
CHKA choline kinase alpha 0.0167934
PRELID2 PRELI domain containing 2 0.0165711
AMBRA1 autophagy/beclin-1 regulator 1 0.0165073
SETD5 SET domain containing 5 0.0163561
RUNX1 runt-related transcription factor 1 0.0162643
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0161375
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.016066
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 0.0160449
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0158703
KDM4C lysine (K)-specific demethylase 4C 0.0158675
C3 complement component 3 0.0157008
ELL2 elongation factor, RNA polymerase II, 2 0.0156638

decreased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.206383
MT2A metallothionein 2A -0.16124
RPS27A ribosomal protein S27a -0.135703
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.12662
UBC ubiquitin C -0.121463
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.115067
GPC3 glypican 3 -0.112351
TPT1 tumor protein, translationally-controlled 1 -0.0962089
RPS12 ribosomal protein S12 -0.0883511
RPL23 ribosomal protein L23 -0.0855391
RPS8 ribosomal protein S8 -0.0854058
RPS6 ribosomal protein S6 -0.0832424
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0781187
RPL37A ribosomal protein L37a -0.0779361
APOB apolipoprotein B -0.0758836
CCL20 chemokine (C-C motif) ligand 20 -0.0751179
RPLP1 ribosomal protein, large, P1 -0.0744946
ENO1 enolase 1, (alpha) -0.0741997
IGFBP1 insulin-like growth factor binding protein 1 -0.0697603
EEF2 eukaryotic translation elongation factor 2 -0.0665004
RPS24 ribosomal protein S24 -0.060183
FTL ferritin, light polypeptide -0.0593655
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0583615
RPL11 ribosomal protein L11 -0.0575243
APOE apolipoprotein E -0.0574717
RPS19 ribosomal protein S19 -0.055584
TMSB10 thymosin beta 10 -0.0549222
APOA2 apolipoprotein A-II -0.0539299
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0530742
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0523201
TM4SF1 transmembrane 4 L six family member 1 -0.0509757
RPL12 ribosomal protein L12 -0.0507248
NAP1L1 nucleosome assembly protein 1-like 1 -0.0505716
RPS29 ribosomal protein S29 -0.0504543
RPS3 ribosomal protein S3 -0.049907
RPL34 ribosomal protein L34 -0.0497049
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0496228
AKAP12 A kinase (PRKA) anchor protein 12 -0.0477451
JUN jun proto-oncogene -0.0476768
PTMA prothymosin, alpha -0.0474656
RPL5 ribosomal protein L5 -0.0474355
MARCKS myristoylated alanine-rich protein kinase C substrate -0.045645
RPS21 ribosomal protein S21 -0.043653
FBF1 Fas (TNFRSF6) binding factor 1 -0.0429266
RPLP2 ribosomal protein, large, P2 -0.0422182
RPL9 ribosomal protein L9 -0.0416238
RPS13 ribosomal protein S13 -0.0405246
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0400515
RPL26 ribosomal protein L26 -0.0399592
SLC38A2 solute carrier family 38, member 2 -0.0393878
SVIL supervillin -0.0384833
RACK1 receptor for activated C kinase 1 -0.0379288
RPS25 ribosomal protein S25 -0.0370931
RPL36 ribosomal protein L36 -0.0348064
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0343984
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0340254
RRBP1 ribosome binding protein 1 -0.033819
B2M beta-2-microglobulin -0.0325613
RPL38 ribosomal protein L38 -0.0321368
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0305712
SDC4 syndecan 4 -0.0305303
TRIM26 tripartite motif containing 26 -0.030451
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0299443
RPL35A ribosomal protein L35a -0.0298595
RPS14 ribosomal protein S14 -0.0293943
RPL19 ribosomal protein L19 -0.0289767
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0288316
CFB complement factor B -0.0286632
AMBP alpha-1-microglobulin/bikunin precursor -0.0284641
RPS5 ribosomal protein S5 -0.0281719
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0281542
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0280192
RPS17 ribosomal protein S17 -0.0275796
RPL10A ribosomal protein L10a -0.0275732
KRT8 keratin 8, type II -0.027219
KLF6 Kruppel-like factor 6 -0.0272135
RPS10 ribosomal protein S10 -0.0271398
RPL7 ribosomal protein L7 -0.0268234
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0267543
SET SET nuclear proto-oncogene -0.026577
PDGFB platelet-derived growth factor beta polypeptide -0.0264461
EEF1G eukaryotic translation elongation factor 1 gamma -0.0264402
CPE carboxypeptidase E -0.0264336
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0263906
RPL8 ribosomal protein L8 -0.0263321
PERP PERP, TP53 apoptosis effector -0.0262629
RPLP0 ribosomal protein, large, P0 -0.026066
RPL37 ribosomal protein L37 -0.025869
RPL31 ribosomal protein L31 -0.0256247
APOA1 apolipoprotein A-I -0.0255572
RPL36A ribosomal protein L36a -0.025495
RPL28 ribosomal protein L28 -0.0249647
RPS23 ribosomal protein S23 -0.0246959
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0245505
PRRC2C proline-rich coiled-coil 2C -0.0237358
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0236938
RPL18 ribosomal protein L18 -0.0227862
EIF1 eukaryotic translation initiation factor 1 -0.022748
S100A9 S100 calcium binding protein A9 -0.0226027
CELF1 CUGBP, Elav-like family member 1 -0.0224674