| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sivelestat (sodium tetrahydrate) perturbation in J82 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TRIO | trio Rho guanine nucleotide exchange factor | 0.206386 |
| FN1 | fibronectin 1 | 0.150879 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.137546 |
| EXT1 | exostosin glycosyltransferase 1 | 0.131179 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.111425 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0982122 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0946885 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0940453 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0893069 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0738167 |
| ATP13A3 | ATPase type 13A3 | 0.0719427 |
| COL5A1 | collagen, type V, alpha 1 | 0.0664515 |
| SLC12A8 | solute carrier family 12, member 8 | 0.0629016 |
| FLNB | filamin B, beta | 0.0625278 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0543075 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0518854 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0516007 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0507781 |
| CCBE1 | collagen and calcium binding EGF domains 1 | 0.05037 |
| GLIS3 | GLIS family zinc finger 3 | 0.048047 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0455831 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.045432 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0438407 |
| LDHA | lactate dehydrogenase A | 0.0436056 |
| VEGFC | vascular endothelial growth factor C | 0.0431217 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0422268 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.040397 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0401966 |
| SMAD3 | SMAD family member 3 | 0.039382 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0393816 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0388086 |
| AHNAK | AHNAK nucleoprotein | 0.038365 |
| ERBIN | erbb2 interacting protein | 0.0382954 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0373685 |
| NDRG1 | N-myc downstream regulated 1 | 0.037097 |
| TMEM178B | transmembrane protein 178B | 0.0361398 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0355698 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0354854 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0351654 |
| TSC22D2 | TSC22 domain family, member 2 | 0.035018 |
| TGFB2 | transforming growth factor, beta 2 | 0.0348866 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0346105 |
| SULF1 | sulfatase 1 | 0.0340959 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0339518 |
| ZNF148 | zinc finger protein 148 | 0.0337685 |
| DST | dystonin | 0.0332076 |
| PHACTR1 | phosphatase and actin regulator 1 | 0.0331377 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.032862 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0325473 |
| PLIN2 | perilipin 2 | 0.0324146 |
| ENO1 | enolase 1, (alpha) | 0.0321817 |
| PKM | pyruvate kinase, muscle | 0.0319169 |
| ANXA2 | annexin A2 | 0.0318579 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0313068 |
| GSK3B | glycogen synthase kinase 3 beta | 0.030423 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0303731 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0303651 |
| ACTN1 | actinin, alpha 1 | 0.0300983 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0297852 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0295085 |
| TNS3 | tensin 3 | 0.0294282 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0291993 |
| DIAPH3 | diaphanous-related formin 3 | 0.0291234 |
| PTK2 | protein tyrosine kinase 2 | 0.0282407 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0277538 |
| PCBP2 | poly(rC) binding protein 2 | 0.027333 |
| ARF4 | ADP-ribosylation factor 4 | 0.0267429 |
| PLCB4 | phospholipase C, beta 4 | 0.0265265 |
| RUNX1 | runt-related transcription factor 1 | 0.0264742 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | 0.0263765 |
| PDE10A | phosphodiesterase 10A | 0.0260711 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0259601 |
| EGFR | epidermal growth factor receptor | 0.0258482 |
| NAV2 | neuron navigator 2 | 0.02583 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.025719 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0256974 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0256461 |
| COL5A2 | collagen, type V, alpha 2 | 0.0255708 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.025515 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0252661 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0252021 |
| TENM3 | teneurin transmembrane protein 3 | 0.0248971 |
| CCNL1 | cyclin L1 | 0.0247343 |
| RBM39 | RNA binding motif protein 39 | 0.0246659 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0245072 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0244322 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0244322 |
| RAD51B | RAD51 paralog B | 0.0241582 |
| ATXN1 | ataxin 1 | 0.0241068 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0240964 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0236189 |
| RAPH1 | Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 | 0.0234434 |
| CANX | calnexin | 0.0229851 |
| CLIC4 | chloride intracellular channel 4 | 0.0225901 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.022305 |
| MMP12 | matrix metallopeptidase 12 | 0.0222968 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0220189 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0219425 |
| RTN4 | reticulon 4 | 0.0218863 |
| LYPD6B | LY6/PLAUR domain containing 6B | 0.0218848 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | -0.293568 |
| FTL | ferritin, light polypeptide | -0.194516 |
| HLA-B | major histocompatibility complex, class I, B | -0.139852 |
| B2M | beta-2-microglobulin | -0.0749468 |
| RPS6 | ribosomal protein S6 | -0.0734488 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0664292 |
| SET | SET nuclear proto-oncogene | -0.0603868 |
| PTMA | prothymosin, alpha | -0.0601034 |
| RPLP2 | ribosomal protein, large, P2 | -0.0570392 |
| TMSB10 | thymosin beta 10 | -0.0563684 |
| RPL12 | ribosomal protein L12 | -0.0520223 |
| RPS3 | ribosomal protein S3 | -0.0517284 |
| RPL35A | ribosomal protein L35a | -0.0509987 |
| RPL26 | ribosomal protein L26 | -0.0459663 |
| RPS8 | ribosomal protein S8 | -0.0411016 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0410853 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0405325 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0395086 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0376533 |
| MT1X | metallothionein 1X | -0.0371097 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0370131 |
| RPL37 | ribosomal protein L37 | -0.0366663 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0363284 |
| RPL11 | ribosomal protein L11 | -0.0360267 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0353796 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.034968 |
| HMGB2 | high mobility group box 2 | -0.0344822 |
| RPL7A | ribosomal protein L7a | -0.0334093 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0329844 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0328119 |
| H1-4 | H1.4 linker histone, cluster member | -0.0326653 |
| RPL37A | ribosomal protein L37a | -0.0324682 |
| RPS12 | ribosomal protein S12 | -0.0323828 |
| RPLP1 | ribosomal protein, large, P1 | -0.03213 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0318102 |
| RPL19 | ribosomal protein L19 | -0.0312643 |
| RPS13 | ribosomal protein S13 | -0.0295156 |
| CENPF | centromere protein F, 350/400kDa | -0.0293014 |
| MKI67 | marker of proliferation Ki-67 | -0.0292593 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0291226 |
| TMSB4X | thymosin beta 4, X-linked | -0.0289712 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0285951 |
| GOLGA4 | golgin A4 | -0.028485 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0284803 |
| RPL30 | ribosomal protein L30 | -0.0279545 |
| GOLGB1 | golgin B1 | -0.0278038 |
| RPL23 | ribosomal protein L23 | -0.0274536 |
| RPL35 | ribosomal protein L35 | -0.0272503 |
| RPS2 | ribosomal protein S2 | -0.0262378 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0259179 |
| RPL18 | ribosomal protein L18 | -0.0257219 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0256459 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0254397 |
| RPS19 | ribosomal protein S19 | -0.0252856 |
| RPL36 | ribosomal protein L36 | -0.0242793 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0242651 |
| RPS17 | ribosomal protein S17 | -0.0234527 |
| RPL5 | ribosomal protein L5 | -0.0233419 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0229721 |
| RPL36A | ribosomal protein L36a | -0.0229645 |
| RPL32 | ribosomal protein L32 | -0.0225059 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.0223367 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0219902 |
| RPL7 | ribosomal protein L7 | -0.021887 |
| RPS27 | ribosomal protein S27 | -0.0215816 |
| RACK1 | receptor for activated C kinase 1 | -0.0215012 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0214442 |
| RPS20 | ribosomal protein S20 | -0.0212967 |
| CAVIN1 | caveolae associated protein 1 | -0.0205454 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0204659 |
| HMGB1 | high mobility group box 1 | -0.0204214 |
| YBX3 | Y box binding protein 3 | -0.0203998 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0201244 |
| TMF1 | TATA element modulatory factor 1 | -0.020114 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0200872 |
| LDHB | lactate dehydrogenase B | -0.0199118 |
| GOLT1B | golgi transport 1B | -0.0196049 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0195788 |
| MTDH | metadherin | -0.0195281 |
| RPL31 | ribosomal protein L31 | -0.0194684 |
| RRBP1 | ribosome binding protein 1 | -0.0194243 |
| KIF5B | kinesin family member 5B | -0.0193028 |
| SCAF11 | SR-related CTD-associated factor 11 | -0.0191835 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.019159 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0190582 |
| DEK | DEK proto-oncogene | -0.0188921 |
| CLTC | clathrin, heavy chain (Hc) | -0.0187699 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0185793 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0183866 |
| RPL9 | ribosomal protein L9 | -0.0183856 |
| RPL15 | ribosomal protein L15 | -0.0183716 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0179755 |
| TPR | translocated promoter region, nuclear basket protein | -0.0179733 |
| VIM | vimentin | -0.0179071 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0178452 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | -0.0178191 |
| SERF2 | small EDRK-rich factor 2 | -0.0176196 |
| LMNA | lamin A/C | -0.0174702 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0174414 |
| RPS16 | ribosomal protein S16 | -0.0173772 |
