Sivelestat (sodium tetrahydrate)_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 0.265232
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.144354
GMDS GDP-mannose 4,6-dehydratase 0.118602
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.093377
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0905913
CEMIP cell migration inducing protein, hyaluronan binding 0.0887247
HYOU1 hypoxia up-regulated 1 0.0793827
SPTBN1 spectrin, beta, non-erythrocytic 1 0.073421
FNDC3B fibronectin type III domain containing 3B 0.0662089
PDIA3 protein disulfide isomerase family A, member 3 0.0632207
MAML2 mastermind-like 2 (Drosophila) 0.058218
PDIA4 protein disulfide isomerase family A, member 4 0.0550527
ATXN1 ataxin 1 0.050427
FAT1 FAT atypical cadherin 1 0.0489045
CANX calnexin 0.0469421
AHNAK AHNAK nucleoprotein 0.046088
EZR ezrin 0.0446479
ARHGAP32 Rho GTPase activating protein 32 0.0444836
ITGA6 integrin, alpha 6 0.043309
LMO7 LIM domain 7 0.0424138
MBNL2 muscleblind-like splicing regulator 2 0.04158
CEMIP2 cell migration inducing hyaluronidase 2 0.0409061
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.040659
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0398276
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0398144
PLEC plectin 0.0384038
PDIA6 protein disulfide isomerase family A, member 6 0.0383879
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0359353
ZFAND3 zinc finger, AN1-type domain 3 0.0355812
BCL2L1 BCL2-like 1 0.0346216
MACF1 microtubule-actin crosslinking factor 1 0.0340301
MYOF myoferlin 0.03367
ASPH aspartate beta-hydroxylase 0.0335852
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0334271
PRKCA protein kinase C, alpha 0.0332765
SAMD12 sterile alpha motif domain containing 12 0.033207
ANXA2 annexin A2 0.0328871
CTNND1 catenin (cadherin-associated protein), delta 1 0.0328676
MYH9 myosin, heavy chain 9, non-muscle 0.03285
SH3RF1 SH3 domain containing ring finger 1 0.0326354
ACTN4 actinin, alpha 4 0.0326256
LPP LIM domain containing preferred translocation partner in lipoma 0.0324903
FLNB filamin B, beta 0.0322176
ANXA11 annexin A11 0.0317292
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0316797
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0312079
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0301494
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0301325
CALR calreticulin 0.0299539
PTPRK protein tyrosine phosphatase, receptor type, K 0.0297748
BIRC6 baculoviral IAP repeat containing 6 0.0292762
CAPN8 calpain 8 0.0292232
ANKRD11 ankyrin repeat domain 11 0.028991
KLHL29 kelch-like family member 29 0.0288319
MSI2 musashi RNA-binding protein 2 0.0288091
STK24 serine/threonine kinase 24 0.0287625
AKAP13 A kinase (PRKA) anchor protein 13 0.028216
AHR aryl hydrocarbon receptor 0.0278979
ARHGAP26 Rho GTPase activating protein 26 0.0273823
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0271562
MECOM MDS1 and EVI1 complex locus 0.0270137
RBM39 RNA binding motif protein 39 0.0266559
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0265574
MTUS1 microtubule associated tumor suppressor 1 0.0265369
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0265335
YAP1 Yes-associated protein 1 0.0264317
RNF213 ring finger protein 213 0.0261389
SETX senataxin 0.026083
EXOC4 exocyst complex component 4 0.0258851
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0255668
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0255327
KDM4C lysine (K)-specific demethylase 4C 0.0254268
WWC1 WW and C2 domain containing 1 0.0253682
EHBP1 EH domain binding protein 1 0.0249418
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0249002
CLTC clathrin, heavy chain (Hc) 0.0247769
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0247269
USP9X ubiquitin specific peptidase 9, X-linked 0.0246232
TES testin LIM domain protein 0.0240977
KMT2C lysine (K)-specific methyltransferase 2C 0.0240871
PGK1 phosphoglycerate kinase 1 0.0238116
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0236389
CTBP2 C-terminal binding protein 2 0.0236301
TNRC18 trinucleotide repeat containing 18 0.0235868
EXOC6B exocyst complex component 6B 0.023344
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0230112
ETV6 ets variant 6 0.0229499
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0227608
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.022705
PRELID2 PRELI domain containing 2 0.0226709
SEPTIN9 septin 9 0.022457
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0223299
COBL cordon-bleu WH2 repeat protein 0.0223203
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0221057
ARHGAP42 Rho GTPase activating protein 42 0.0220883
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0219989
MYO5B myosin VB 0.0217099
UBE2H ubiquitin-conjugating enzyme E2H 0.0215945
RAD51B RAD51 paralog B 0.0215738
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0214842

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.11064
TPT1 tumor protein, translationally-controlled 1 -0.0963888
RPL35A ribosomal protein L35a -0.0843247
PTMA prothymosin, alpha -0.0802344
RPS6 ribosomal protein S6 -0.0719283
FTL ferritin, light polypeptide -0.0650358
RPL23 ribosomal protein L23 -0.0574929
RPS3 ribosomal protein S3 -0.0566618
RPS25 ribosomal protein S25 -0.0530408
RPS19 ribosomal protein S19 -0.0511809
RPS8 ribosomal protein S8 -0.0509769
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0487263
RPLP1 ribosomal protein, large, P1 -0.0482951
RPL26 ribosomal protein L26 -0.0479173
B2M beta-2-microglobulin -0.0474916
RPL37A ribosomal protein L37a -0.0445252
RPL19 ribosomal protein L19 -0.0393482
LOC102724023 ES1 protein homolog, mitochondrial -0.0390038
RPS12 ribosomal protein S12 -0.0389521
S100A9 S100 calcium binding protein A9 -0.0369171
EIF1 eukaryotic translation initiation factor 1 -0.0360458
RPL12 ribosomal protein L12 -0.035199
RPL34 ribosomal protein L34 -0.0343941
RPS21 ribosomal protein S21 -0.0339584
RPL9 ribosomal protein L9 -0.033054
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0327601
RPS29 ribosomal protein S29 -0.0316993
S100A6 S100 calcium binding protein A6 -0.0314833
AREG amphiregulin -0.031379
RPS27A ribosomal protein S27a -0.0313703
RPS24 ribosomal protein S24 -0.0309283
RPL36A ribosomal protein L36a -0.0300862
RPL11 ribosomal protein L11 -0.0300581
S100P S100 calcium binding protein P -0.0298818
IFI27 interferon, alpha-inducible protein 27 -0.0291388
RPS16 ribosomal protein S16 -0.0290225
RPS17 ribosomal protein S17 -0.0280989
RPS27 ribosomal protein S27 -0.0278402
RPLP2 ribosomal protein, large, P2 -0.0278295
RPL28 ribosomal protein L28 -0.02751
HLA-A major histocompatibility complex, class I, A -0.0266595
S100A10 S100 calcium binding protein A10 -0.0261281
RPL7A ribosomal protein L7a -0.0259838
RPL38 ribosomal protein L38 -0.0251858
RPL8 ribosomal protein L8 -0.0249495
RPS14 ribosomal protein S14 -0.0245614
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0242797
ACTG1 actin gamma 1 -0.0240207
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0238003
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0236361
RPL31 ribosomal protein L31 -0.0235926
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0234263
RPL30 ribosomal protein L30 -0.0230429
RPL18 ribosomal protein L18 -0.0227516
HLA-B major histocompatibility complex, class I, B -0.0227103
RPS11 ribosomal protein S11 -0.0226155
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0219429
RPL36 ribosomal protein L36 -0.0211634
NDUFA4 NDUFA4, mitochondrial complex associated -0.021097
RPS13 ribosomal protein S13 -0.0210479
SERF2 small EDRK-rich factor 2 -0.0210003
RPL5 ribosomal protein L5 -0.0208159
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0204888
RPS20 ribosomal protein S20 -0.0204762
RPL7 ribosomal protein L7 -0.0202939
SEC61G Sec61 gamma subunit -0.0197794
GNAS GNAS complex locus -0.0197543
RPL13A ribosomal protein L13a -0.0193723
RPS5 ribosomal protein S5 -0.0192704
RPL27 ribosomal protein L27 -0.0191632
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0190938
RPL35 ribosomal protein L35 -0.019069
RPL32 ribosomal protein L32 -0.018718
HMGA1 high mobility group AT-hook 1 -0.018099
IER3 immediate early response 3 -0.0175713
RPS10 ribosomal protein S10 -0.0174315
RPS23 ribosomal protein S23 -0.0167795
MYL12B myosin, light chain 12B, regulatory -0.0166134
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0164303
RPLP0 ribosomal protein, large, P0 -0.0163946
TMSB4X thymosin beta 4, X-linked -0.0162584
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0161459
ATF5 activating transcription factor 5 -0.0158055
RPL39 ribosomal protein L39 -0.0156996
RACK1 receptor for activated C kinase 1 -0.0156568
LCN2 lipocalin 2 -0.0156419
RPL10A ribosomal protein L10a -0.0156404
RPL37 ribosomal protein L37 -0.0153333
COX5A cytochrome c oxidase subunit Va -0.015316
LMNA lamin A/C -0.0151481
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed -0.0151207
IFITM3 interferon induced transmembrane protein 3 -0.0147782
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.014764
ATP5F1E ATP synthase F1 subunit epsilon -0.0147514
COX7B cytochrome c oxidase subunit VIIb -0.0145461
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.014517
TFF2 trefoil factor 2 -0.0144755
DSTN destrin (actin depolymerizing factor) -0.0144662
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0142153
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0139713