Sivelestat (sodium tetrahydrate)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.039757
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0359778
SMAD3 SMAD family member 3 0.0328512
ELL2 elongation factor, RNA polymerase II, 2 0.0321817
CD109 CD109 molecule 0.0321774
KDM3A lysine (K)-specific demethylase 3A 0.0305981
AHNAK AHNAK nucleoprotein 0.030154
ZNF292 zinc finger protein 292 0.0284567
ATP13A3 ATPase type 13A3 0.0277605
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0276426
TXNRD1 thioredoxin reductase 1 0.0271146
VCL vinculin 0.0270933
FNDC3B fibronectin type III domain containing 3B 0.0270207
RBM39 RNA binding motif protein 39 0.0260881
APP amyloid beta (A4) precursor protein 0.0256843
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0255527
MYH9 myosin, heavy chain 9, non-muscle 0.0252256
PICALM phosphatidylinositol binding clathrin assembly protein 0.025108
ZFAND3 zinc finger, AN1-type domain 3 0.0246186
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.024368
MED13L mediator complex subunit 13-like 0.0238346
RUNX1 runt-related transcription factor 1 0.0236939
EIF4B eukaryotic translation initiation factor 4B 0.0232694
ADAM9 ADAM metallopeptidase domain 9 0.0230616
SPAG9 sperm associated antigen 9 0.0228135
GLS2 glutaminase 2 (liver, mitochondrial) 0.0225643
MCTP1 multiple C2 domains, transmembrane 1 0.0225311
HOOK2 hook microtubule-tethering protein 2 0.0220958
NUP58 nucleoporin 58 0.0218167
FRMD6 FERM domain containing 6 0.0214872
NCKAP1 NCK-associated protein 1 0.0206581
NEK7 NIMA-related kinase 7 0.0206117
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0202988
DST dystonin 0.0198842
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0195652
SPRED1 sprouty-related, EVH1 domain containing 1 0.0195325
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0192139
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0191119
TRIO trio Rho guanine nucleotide exchange factor 0.0190441
WDR26 WD repeat domain 26 0.0189843
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0189329
PSME4 proteasome (prosome, macropain) activator subunit 4 0.018696
TSC22D2 TSC22 domain family, member 2 0.0185312
HELZ helicase with zinc finger 0.0181693
BCAR3 breast cancer anti-estrogen resistance 3 0.0181312
NAMPT nicotinamide phosphoribosyltransferase 0.0175571
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0174007
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0173913
GSK3B glycogen synthase kinase 3 beta 0.016963
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0168726
ERBIN erbb2 interacting protein 0.0168081
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0167958
PUM2 pumilio RNA-binding family member 2 0.0167332
YAP1 Yes-associated protein 1 0.0166947
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.016648
OGA O-GlcNAcase 0.0165153
MARCHF6 membrane associated ring-CH-type finger 6 0.0164328
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0163846
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.01606
KMT2C lysine (K)-specific methyltransferase 2C 0.0159982
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0159561
BDNF brain-derived neurotrophic factor 0.0158861
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.015775
RB1CC1 RB1-inducible coiled-coil 1 0.0157681
BIRC6 baculoviral IAP repeat containing 6 0.0157245
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0156346
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.015628
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0155697
ZFC3H1 zinc finger, C3H1-type containing 0.0155638
ETNK1 ethanolamine kinase 1 0.0154561
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0153297
MALT1 MALT1 paracaspase 0.0151253
PLEC plectin 0.0150339
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.014896
SAMD4A sterile alpha motif domain containing 4A 0.0146662
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0145143
MED13 mediator complex subunit 13 0.0145056
ARID1A AT rich interactive domain 1A (SWI-like) 0.0144721
SMYD3 SET and MYND domain containing 3 0.0141443
LDHA lactate dehydrogenase A 0.0140964
CDC73 cell division cycle 73 0.0137027
TLE4 transducin-like enhancer of split 4 0.0134452
MACF1 microtubule-actin crosslinking factor 1 0.0133925
ERRFI1 ERBB receptor feedback inhibitor 1 0.0133319
ZMYM2 zinc finger, MYM-type 2 0.0132572
BRWD3 bromodomain and WD repeat domain containing 3 0.0132193
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0131958
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0131158
WDR45B WD repeat domain 45B 0.0130982
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0130758
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0129665
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0129579
NBAS neuroblastoma amplified sequence 0.0129464
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0129068
PCBP2 poly(rC) binding protein 2 0.0125709
MYO6 myosin VI 0.0124724
CUL3 cullin 3 0.0124099
USP15 ubiquitin specific peptidase 15 0.0123323
RYBP RING1 and YY1 binding protein 0.0123217
WAC WW domain containing adaptor with coiled-coil 0.0123193

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.389678
TMSB10 thymosin beta 10 -0.190517
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.172914
RPS6 ribosomal protein S6 -0.159996
AKAP12 A kinase (PRKA) anchor protein 12 -0.121924
TPT1 tumor protein, translationally-controlled 1 -0.0914335
MT2A metallothionein 2A -0.0852755
PTMA prothymosin, alpha -0.0851847
RPL35A ribosomal protein L35a -0.0748405
RPL23 ribosomal protein L23 -0.0741874
RPS8 ribosomal protein S8 -0.0713701
FTL ferritin, light polypeptide -0.0710214
LSAMP limbic system-associated membrane protein -0.0689092
RPS19 ribosomal protein S19 -0.0681314
RPS12 ribosomal protein S12 -0.0671813
RPS3 ribosomal protein S3 -0.0671124
RPL37A ribosomal protein L37a -0.0659571
RPLP1 ribosomal protein, large, P1 -0.0651446
RPL12 ribosomal protein L12 -0.0618149
ACTG1 actin gamma 1 -0.0561625
PHACTR1 phosphatase and actin regulator 1 -0.0557399
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0552767
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0549653
RPLP2 ribosomal protein, large, P2 -0.0543404
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0520635
NAP1L1 nucleosome assembly protein 1-like 1 -0.0520031
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.05172
EGR1 early growth response 1 -0.0497115
RPS27A ribosomal protein S27a -0.0450389
SAMD3 sterile alpha motif domain containing 3 -0.0448448
RPS13 ribosomal protein S13 -0.0444834
CDH13 cadherin 13 -0.0429075
RPL26 ribosomal protein L26 -0.0428191
RPLP0 ribosomal protein, large, P0 -0.0423508
RPS25 ribosomal protein S25 -0.0422772
RPL31 ribosomal protein L31 -0.0415162
RPL19 ribosomal protein L19 -0.0407817
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0395924
RPS17 ribosomal protein S17 -0.0393884
RPL5 ribosomal protein L5 -0.039202
PRKG1 protein kinase, cGMP-dependent, type I -0.039101
RPL11 ribosomal protein L11 -0.0390062
RPL36 ribosomal protein L36 -0.0387391
POTEF POTE ankyrin domain family, member F -0.0379651
RPL8 ribosomal protein L8 -0.0376238
HMGA1 high mobility group AT-hook 1 -0.0374019
EIF1 eukaryotic translation initiation factor 1 -0.0364733
RACK1 receptor for activated C kinase 1 -0.0355299
KIAA1549L KIAA1549-like -0.0351553
RPL9 ribosomal protein L9 -0.0349552
RPL7 ribosomal protein L7 -0.0336721
RPL30 ribosomal protein L30 -0.0331641
SDCCAG8 serologically defined colon cancer antigen 8 -0.0327538
CSTB cystatin B (stefin B) -0.0324097
RPL7A ribosomal protein L7a -0.0321615
RPL36A ribosomal protein L36a -0.0321474
RPS23 ribosomal protein S23 -0.0320568
RPL37 ribosomal protein L37 -0.0315205
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0310813
RPS14 ribosomal protein S14 -0.0310188
RPS20 ribosomal protein S20 -0.0309959
RPL34 ribosomal protein L34 -0.0309566
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0307362
KIAA1217 KIAA1217 -0.0300674
NAV1 neuron navigator 1 -0.0296804
RPS29 ribosomal protein S29 -0.0287915
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.028598
RPL32 ribosomal protein L32 -0.0285543
PFN1 profilin 1 -0.028424
TPM4 tropomyosin 4 -0.0279531
RPS21 ribosomal protein S21 -0.027677
RPS24 ribosomal protein S24 -0.0268067
RPL27A ribosomal protein L27a -0.0265245
RPS16 ribosomal protein S16 -0.0262494
RPL28 ribosomal protein L28 -0.0262148
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0260774
RPL35 ribosomal protein L35 -0.0257566
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0253407
RPL18 ribosomal protein L18 -0.0246219
RPS4X ribosomal protein S4, X-linked -0.0244003
RPL13A ribosomal protein L13a -0.0242026
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0238177
RPS27 ribosomal protein S27 -0.0235602
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0234244
HDAC9 histone deacetylase 9 -0.0234006
NACA nascent polypeptide-associated complex alpha subunit -0.0233903
RPS10 ribosomal protein S10 -0.0232998
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0229425
RPL27 ribosomal protein L27 -0.0225702
RPL15 ribosomal protein L15 -0.0223617
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0222583
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0220736
LDHB lactate dehydrogenase B -0.0219018
DTNA dystrobrevin, alpha -0.0214565
TPI1 triosephosphate isomerase 1 -0.0211457
C2CD2 C2 calcium-dependent domain containing 2 -0.0210928
GNAS GNAS complex locus -0.0210087
RPL10A ribosomal protein L10a -0.0209657
NALF1 NALCN channel auxiliary factor 1 -0.0206376
VDAC1 voltage-dependent anion channel 1 -0.0203457