| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sivelestat (sodium tetrahydrate) perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.226658 |
| FAT1 | FAT atypical cadherin 1 | 0.103756 |
| LDHA | lactate dehydrogenase A | 0.0963476 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0808805 |
| CALR | calreticulin | 0.0772163 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0670479 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0579452 |
| NDRG1 | N-myc downstream regulated 1 | 0.0563889 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0560137 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0557404 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0531654 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0525692 |
| FAM13A | family with sequence similarity 13, member A | 0.0501418 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0496668 |
| PKM | pyruvate kinase, muscle | 0.0485737 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.04548 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0448693 |
| CANX | calnexin | 0.0445857 |
| ENO1 | enolase 1, (alpha) | 0.0423685 |
| CCNY | cyclin Y | 0.042219 |
| EZR | ezrin | 0.0408288 |
| PTEN | phosphatase and tensin homolog | 0.0401806 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0396781 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0394759 |
| ASPH | aspartate beta-hydroxylase | 0.0369043 |
| FNDC3B | fibronectin type III domain containing 3B | 0.036618 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0357506 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0353444 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0348896 |
| PRELID2 | PRELI domain containing 2 | 0.0343185 |
| MLEC | malectin | 0.0337042 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0336875 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0330575 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0324595 |
| DSPP | dentin sialophosphoprotein | 0.0319887 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.031118 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | 0.0305592 |
| PCBP2 | poly(rC) binding protein 2 | 0.0304833 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0304401 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0301087 |
| MED13L | mediator complex subunit 13-like | 0.0297795 |
| ATXN1 | ataxin 1 | 0.0292293 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0291239 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.029034 |
| FLNB | filamin B, beta | 0.0283903 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0282681 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.027629 |
| ANXA1 | annexin A1 | 0.0275653 |
| TPM3 | tropomyosin 3 | 0.027319 |
| ITGA6 | integrin, alpha 6 | 0.0272467 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0271497 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.026885 |
| TXNIP | thioredoxin interacting protein | 0.0265983 |
| RPS18 | ribosomal protein S18 | 0.0265921 |
| NEBL | nebulette | 0.0265735 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0263736 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0262898 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0260652 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0259029 |
| GPHN | gephyrin | 0.0258712 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0252648 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0249498 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0245145 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0241403 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0241207 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0239434 |
| VEGFA | vascular endothelial growth factor A | 0.023896 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0237144 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0235572 |
| HYOU1 | hypoxia up-regulated 1 | 0.0233852 |
| NBAS | neuroblastoma amplified sequence | 0.0232685 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0231287 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0223769 |
| CDK19 | cyclin-dependent kinase 19 | 0.022282 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0221688 |
| ANXA11 | annexin A11 | 0.0221586 |
| RPL3 | ribosomal protein L3 | 0.0220799 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | 0.021834 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0217656 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0216491 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0214807 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0214518 |
| MYO5B | myosin VB | 0.021099 |
| SUCO | SUN domain containing ossification factor | 0.0207841 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.020757 |
| TPD52 | tumor protein D52 | 0.0206217 |
| PGK1 | phosphoglycerate kinase 1 | 0.020457 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0200349 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0199289 |
| PLEC | plectin | 0.0199066 |
| NRXN3 | neurexin 3 | 0.0197965 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0197867 |
| FRYL | FRY-like | 0.0197138 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0195912 |
| USP34 | ubiquitin specific peptidase 34 | 0.0194989 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.019493 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0193682 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0193631 |
| TRIM2 | tripartite motif containing 2 | 0.0191957 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0190547 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.259133 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.192803 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.15098 |
| TMSB10 | thymosin beta 10 | -0.148344 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.12841 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.118814 |
| NPSR1 | neuropeptide S receptor 1 | -0.0863942 |
| RPS6 | ribosomal protein S6 | -0.0812652 |
| ACTG1 | actin gamma 1 | -0.0779241 |
| RPL34 | ribosomal protein L34 | -0.0762977 |
| RPL35A | ribosomal protein L35a | -0.0681144 |
| RPS8 | ribosomal protein S8 | -0.0670884 |
| RPLP1 | ribosomal protein, large, P1 | -0.0564517 |
| ONECUT3 | one cut homeobox 3 | -0.0561842 |
| S100A6 | S100 calcium binding protein A6 | -0.0561046 |
| RPS21 | ribosomal protein S21 | -0.0554672 |
| RPL9 | ribosomal protein L9 | -0.0541066 |
| RPS24 | ribosomal protein S24 | -0.0538798 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0521467 |
| IER3 | immediate early response 3 | -0.0509197 |
| MYO1E | myosin IE | -0.049145 |
| S100A10 | S100 calcium binding protein A10 | -0.047116 |
| S100A9 | S100 calcium binding protein A9 | -0.0457783 |
| TFF1 | trefoil factor 1 | -0.0445261 |
| RPS19 | ribosomal protein S19 | -0.0419799 |
| VCL | vinculin | -0.0409962 |
| RPLP0 | ribosomal protein, large, P0 | -0.0406893 |
| EPCAM | epithelial cell adhesion molecule | -0.0396924 |
| RPS27A | ribosomal protein S27a | -0.03899 |
| HMGB1 | high mobility group box 1 | -0.0383988 |
| RPL26 | ribosomal protein L26 | -0.0374092 |
| H1-0 | H1.0 linker histone | -0.0364791 |
| LAMA4 | laminin, alpha 4 | -0.0353505 |
| RPLP2 | ribosomal protein, large, P2 | -0.0351524 |
| RPS23 | ribosomal protein S23 | -0.0347104 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0345639 |
| RPL8 | ribosomal protein L8 | -0.0342518 |
| AREG | amphiregulin | -0.0333887 |
| RPL12 | ribosomal protein L12 | -0.0330598 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0309823 |
| RPL38 | ribosomal protein L38 | -0.0305933 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0304219 |
| ANTXR2 | anthrax toxin receptor 2 | -0.030198 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0298606 |
| RPS13 | ribosomal protein S13 | -0.0297997 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0291122 |
| RPL19 | ribosomal protein L19 | -0.0290126 |
| RPL36A | ribosomal protein L36a | -0.0288594 |
| RPL37A | ribosomal protein L37a | -0.0279784 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0274805 |
| GNAS | GNAS complex locus | -0.0264751 |
| DEK | DEK proto-oncogene | -0.0263376 |
| RPS29 | ribosomal protein S29 | -0.025545 |
| KRT18 | keratin 18, type I | -0.0253945 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0252451 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0252129 |
| RPL23 | ribosomal protein L23 | -0.0250226 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0249423 |
| PRSS3 | protease, serine, 3 | -0.0248396 |
| LMNA | lamin A/C | -0.0245585 |
| B4GALNT3 | beta-1,4-N-acetyl-galactosaminyl transferase 3 | -0.0242881 |
| RPS14 | ribosomal protein S14 | -0.0241125 |
| RPL32 | ribosomal protein L32 | -0.0240555 |
| KLK10 | kallikrein-related peptidase 10 | -0.0239868 |
| RPS15 | ribosomal protein S15 | -0.0239866 |
| RPS11 | ribosomal protein S11 | -0.0238779 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0237807 |
| RPL11 | ribosomal protein L11 | -0.023629 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0233706 |
| ZBTB7A | zinc finger and BTB domain containing 7A | -0.0233316 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0229478 |
| RPL37 | ribosomal protein L37 | -0.0227586 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0225786 |
| RPL7A | ribosomal protein L7a | -0.0223629 |
| H3-3B | H3.3 histone B | -0.0223478 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0219698 |
| ZFP36L2 | ZFP36 ring finger protein-like 2 | -0.021933 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0219152 |
| RAB10 | RAB10, member RAS oncogene family | -0.0218347 |
| CSTB | cystatin B (stefin B) | -0.0215126 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0208883 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0207284 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0204464 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0198462 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0197996 |
| UQCRQ | ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa | -0.0197985 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0194378 |
| CBX3 | chromobox homolog 3 | -0.0193621 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0193378 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0192642 |
| CCNI | cyclin I | -0.0192525 |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | -0.0190946 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0190525 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0186927 |
| RBM25 | RNA binding motif protein 25 | -0.0186453 |
| FTL | ferritin, light polypeptide | -0.018069 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.018051 |
| B2M | beta-2-microglobulin | -0.017957 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.0179487 |
| RPL5 | ribosomal protein L5 | -0.0178377 |
