| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sivelestat (sodium tetrahydrate) perturbation in LoVo cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| THSD4 | thrombospondin, type I, domain containing 4 | 0.145297 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.119968 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.116258 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0884011 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0875999 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.0807878 |
| LDHA | lactate dehydrogenase A | 0.0761358 |
| FAT1 | FAT atypical cadherin 1 | 0.0730885 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0727994 |
| ANXA2 | annexin A2 | 0.0657654 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0605509 |
| LMO7 | LIM domain 7 | 0.0580889 |
| MSI2 | musashi RNA-binding protein 2 | 0.0565732 |
| CANX | calnexin | 0.0536977 |
| KRT18 | keratin 18, type I | 0.053661 |
| PGK1 | phosphoglycerate kinase 1 | 0.0531451 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0497904 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0497827 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0478042 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | 0.0453707 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0441398 |
| RAD51B | RAD51 paralog B | 0.0440114 |
| EZR | ezrin | 0.0433171 |
| DSPP | dentin sialophosphoprotein | 0.0428934 |
| CUX1 | cut-like homeobox 1 | 0.0425256 |
| PKM | pyruvate kinase, muscle | 0.0414099 |
| SERINC5 | serine incorporator 5 | 0.0406807 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0396808 |
| DENND1A | DENN/MADD domain containing 1A | 0.0386174 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0385832 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.038367 |
| CTBP2 | C-terminal binding protein 2 | 0.037503 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0372575 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0368664 |
| HDLBP | high density lipoprotein binding protein | 0.0361554 |
| PIK3AP1 | phosphoinositide-3-kinase adaptor protein 1 | 0.0356462 |
| MYOF | myoferlin | 0.0356298 |
| AGR2 | anterior gradient 2 | 0.0347847 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0346327 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 0.0343124 |
| FHIT | fragile histidine triad | 0.0337133 |
| MT2A | metallothionein 2A | 0.0337114 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0330304 |
| PRELID2 | PRELI domain containing 2 | 0.0329699 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0323539 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0319799 |
| ENO1 | enolase 1, (alpha) | 0.0318677 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0316338 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0313135 |
| AOPEP | aminopeptidase O (putative) | 0.0310681 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0307747 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0307137 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0305666 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.030393 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0302417 |
| EXOC4 | exocyst complex component 4 | 0.0299891 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.0297462 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0296263 |
| CALR | calreticulin | 0.0295294 |
| EGFR | epidermal growth factor receptor | 0.0292386 |
| WWOX | WW domain containing oxidoreductase | 0.0286745 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.028404 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0282566 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0278864 |
| SLTM | SAFB-like, transcription modulator | 0.0275404 |
| INTS6 | integrator complex subunit 6 | 0.026842 |
| SEC24D | SEC24 family member D | 0.0268196 |
| MPRIP | myosin phosphatase Rho interacting protein | 0.0265756 |
| MTAP | methylthioadenosine phosphorylase | 0.0264111 |
| MLEC | malectin | 0.0256815 |
| RNF213 | ring finger protein 213 | 0.0254064 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0253545 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0253114 |
| PYGB | phosphorylase, glycogen; brain | 0.0252914 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0250595 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0250023 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0248097 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0243389 |
| RPS18 | ribosomal protein S18 | 0.0240775 |
| NPSR1 | neuropeptide S receptor 1 | 0.0237889 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0237595 |
| ASPH | aspartate beta-hydroxylase | 0.0236329 |
| MYO5B | myosin VB | 0.0234752 |
| DSG2 | desmoglein 2 | 0.0234725 |
| DIAPH2 | diaphanous-related formin 2 | 0.0234341 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0233699 |
| LARP1B | La ribonucleoprotein domain family, member 1B | 0.0232501 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0232173 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.0231617 |
| GOLGB1 | golgin B1 | 0.0228349 |
| NRXN3 | neurexin 3 | 0.0227476 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.022316 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0223105 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | 0.0221466 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | 0.0218728 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0217535 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0213569 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0212833 |
| SPON1 | spondin 1, extracellular matrix protein | 0.0212511 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0212497 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS27A | ribosomal protein S27a | -0.113381 |
| UBC | ubiquitin C | -0.107979 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0919348 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0904094 |
| RPLP1 | ribosomal protein, large, P1 | -0.0846516 |
| AREG | amphiregulin | -0.0667116 |
| RPS21 | ribosomal protein S21 | -0.0581653 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0567429 |
| RPLP2 | ribosomal protein, large, P2 | -0.0520394 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0516656 |
| TMSB10 | thymosin beta 10 | -0.0497091 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0476526 |
| RPS13 | ribosomal protein S13 | -0.0471789 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0446127 |
| RPS6 | ribosomal protein S6 | -0.0438852 |
| RPS23 | ribosomal protein S23 | -0.0388887 |
| RPL23 | ribosomal protein L23 | -0.0382179 |
| TXNRD1 | thioredoxin reductase 1 | -0.036665 |
| RPL34 | ribosomal protein L34 | -0.0355941 |
| RBM25 | RNA binding motif protein 25 | -0.0339538 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0319154 |
| GOLGA4 | golgin A4 | -0.0313765 |
| RPL28 | ribosomal protein L28 | -0.031313 |
| RPL8 | ribosomal protein L8 | -0.0311667 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0306065 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0303037 |
| RPS8 | ribosomal protein S8 | -0.0302788 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0295763 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0294169 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0284127 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.028112 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | -0.0275762 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0270276 |
| CLDN4 | claudin 4 | -0.0270184 |
| CCNI | cyclin I | -0.0269363 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0258339 |
| EREG | epiregulin | -0.0253445 |
| MKI67 | marker of proliferation Ki-67 | -0.0248454 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0235163 |
| ACTG1 | actin gamma 1 | -0.0231551 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0229933 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0228012 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0224003 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0221829 |
| ERBIN | erbb2 interacting protein | -0.0214699 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0212861 |
| OGA | O-GlcNAcase | -0.0212482 |
| RPL5 | ribosomal protein L5 | -0.0212074 |
| XPC | xeroderma pigmentosum, complementation group C | -0.0209347 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0204685 |
| DSG3 | desmoglein 3 | -0.0201083 |
| RPL36A | ribosomal protein L36a | -0.0200703 |
| KLF6 | Kruppel-like factor 6 | -0.019902 |
| HLA-B | major histocompatibility complex, class I, B | -0.01989 |
| SLC6A20 | solute carrier family 6 (proline IMINO transporter), member 20 | -0.0198056 |
| NRDC | nardilysin convertase | -0.0196826 |
| RPS19 | ribosomal protein S19 | -0.0194646 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | -0.019019 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0189299 |
| YTHDC1 | YTH domain containing 1 | -0.0187298 |
| GDF15 | growth differentiation factor 15 | -0.0184791 |
| THOC2 | THO complex 2 | -0.0184674 |
| RPL30 | ribosomal protein L30 | -0.018441 |
| RPS15 | ribosomal protein S15 | -0.0183279 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.018068 |
| RPS20 | ribosomal protein S20 | -0.0179824 |
| RNF145 | ring finger protein 145 | -0.0179669 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0178777 |
| HMGB2 | high mobility group box 2 | -0.0178742 |
| SETD5 | SET domain containing 5 | -0.0174847 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0174047 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0173883 |
| RPS29 | ribosomal protein S29 | -0.0173366 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0172469 |
| DUSP5 | dual specificity phosphatase 5 | -0.0169401 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0169142 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0168521 |
| TBCA | tubulin folding cofactor A | -0.0167908 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0167596 |
| PRSS3 | protease, serine, 3 | -0.0167195 |
| MUC13 | mucin 13, cell surface associated | -0.0167168 |
| ASTN2 | astrotactin 2 | -0.0166647 |
| IER3 | immediate early response 3 | -0.0166636 |
| RPL9 | ribosomal protein L9 | -0.0166374 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0165331 |
| RPS11 | ribosomal protein S11 | -0.0164671 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0162234 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0162113 |
| RPL36 | ribosomal protein L36 | -0.0161431 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0161412 |
| CENPF | centromere protein F, 350/400kDa | -0.016022 |
| CCNG1 | cyclin G1 | -0.0159659 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.0158244 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0158235 |
| PTMA | prothymosin, alpha | -0.0158007 |
| RPS27 | ribosomal protein S27 | -0.0157893 |
| VCL | vinculin | -0.0157892 |
| FHL2 | four and a half LIM domains 2 | -0.0157884 |
| RTN4 | reticulon 4 | -0.015728 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0155549 |
