Sivelestat (sodium tetrahydrate)_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DST dystonin 0.116336
PSD3 pleckstrin and Sec7 domain containing 3 0.115958
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0947898
CD44 CD44 molecule (Indian blood group) 0.0762966
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0714053
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0652363
ERRFI1 ERBB receptor feedback inhibitor 1 0.0629005
DPYD dihydropyrimidine dehydrogenase 0.0621302
WARS1 tryptophanyl-tRNA synthetase 1 0.0582765
APP amyloid beta (A4) precursor protein 0.0582757
ENO1 enolase 1, (alpha) 0.0577806
TSC22D1 TSC22 domain family, member 1 0.0553118
TP63 tumor protein p63 0.0538255
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0538091
RAD51B RAD51 paralog B 0.0521248
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0485707
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0481637
CANX calnexin 0.0481063
FMNL2 formin-like 2 0.0463111
LDHA lactate dehydrogenase A 0.0461006
CADM2 cell adhesion molecule 2 0.045341
RIGI RNA sensor RIG-I 0.0444912
EXOC4 exocyst complex component 4 0.0443745
ZDHHC14 zinc finger, DHHC-type containing 14 0.0440641
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0433625
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0427798
CAPRIN2 caprin family member 2 0.042728
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0420949
MACF1 microtubule-actin crosslinking factor 1 0.0418685
EHBP1 EH domain binding protein 1 0.0404184
RNF213 ring finger protein 213 0.0403123
BCAR3 breast cancer anti-estrogen resistance 3 0.0398931
DLG1 discs, large homolog 1 (Drosophila) 0.0387194
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.038667
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0385494
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0381394
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.037595
TRIP12 thyroid hormone receptor interactor 12 0.0375465
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0374785
ANKRD11 ankyrin repeat domain 11 0.0368314
PTK2 protein tyrosine kinase 2 0.0361916
LPP LIM domain containing preferred translocation partner in lipoma 0.0353404
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.035311
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0350622
RUNX1 runt-related transcription factor 1 0.0333283
AHNAK AHNAK nucleoprotein 0.0333201
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0327703
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.032153
FNDC3B fibronectin type III domain containing 3B 0.0319827
SMYD3 SET and MYND domain containing 3 0.0318071
TNS3 tensin 3 0.0305406
CFAP299 cilia and flagella associated protein 299 0.030474
TRIO trio Rho guanine nucleotide exchange factor 0.030147
YEATS2 YEATS domain containing 2 0.029613
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0294866
SP100 SP100 nuclear antigen 0.0289276
FNIP1 folliculin interacting protein 1 0.0280268
PRELID2 PRELI domain containing 2 0.0280197
HDAC9 histone deacetylase 9 0.0279946
PLK2 polo-like kinase 2 0.0276679
DOCK11 dedicator of cytokinesis 11 0.0276621
CALR calreticulin 0.0274168
TTC28 tetratricopeptide repeat domain 28 0.0270949
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0265529
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0262238
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0260512
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0259191
UBE2E3 ubiquitin-conjugating enzyme E2E 3 0.0258297
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0255468
MBNL2 muscleblind-like splicing regulator 2 0.0254832
COL5A2 collagen, type V, alpha 2 0.0252945
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0252065
VCL vinculin 0.0248891
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0248869
RAB27B RAB27B, member RAS oncogene family 0.0248531
DNER delta/notch-like EGF repeat containing 0.0245779
ADAM10 ADAM metallopeptidase domain 10 0.0245251
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0242858
PGK1 phosphoglycerate kinase 1 0.0241893
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0240951
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0240304
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0237323
ADGRG6 adhesion G protein-coupled receptor G6 0.0236961
IFI6 interferon, alpha-inducible protein 6 0.0233682
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0233232
XPO1 exportin 1 0.0227095
RPS18 ribosomal protein S18 0.0224923
EZR ezrin 0.0220483
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0220441
ESYT2 extended synaptotagmin-like protein 2 0.0219343
PCBP2 poly(rC) binding protein 2 0.0216208
EPHA4 EPH receptor A4 0.0213335
TTC3 tetratricopeptide repeat domain 3 0.0213046
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0211425
PIAS2 protein inhibitor of activated STAT, 2 0.0210469
IFIH1 interferon induced with helicase C domain 1 0.0208432
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0207845
CDK6 cyclin-dependent kinase 6 0.0207469
SETX senataxin 0.0207142
DENND1A DENN/MADD domain containing 1A 0.0204419

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.303891
MT2A metallothionein 2A -0.15807
VIM vimentin -0.108841
TM4SF1 transmembrane 4 L six family member 1 -0.0783781
MT1X metallothionein 1X -0.060143
TMSB10 thymosin beta 10 -0.0597994
TPT1 tumor protein, translationally-controlled 1 -0.0505292
PTMA prothymosin, alpha -0.042467
ACTG1 actin gamma 1 -0.0422555
RPS8 ribosomal protein S8 -0.0416009
RPS6 ribosomal protein S6 -0.0386515
FTL ferritin, light polypeptide -0.037779
MT1E metallothionein 1E -0.0348258
TXNRD1 thioredoxin reductase 1 -0.0318924
RPLP1 ribosomal protein, large, P1 -0.0317618
RPS23 ribosomal protein S23 -0.030999
RPL35A ribosomal protein L35a -0.0291492
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.025164
SRGN serglycin -0.0248287
RPL8 ribosomal protein L8 -0.0247823
RPL5 ribosomal protein L5 -0.0238407
RPS19 ribosomal protein S19 -0.0232721
EIF1 eukaryotic translation initiation factor 1 -0.022463
S100A10 S100 calcium binding protein A10 -0.0222268
RPS29 ribosomal protein S29 -0.021347
RPL28 ribosomal protein L28 -0.0212438
RPL38 ribosomal protein L38 -0.0210935
S100A6 S100 calcium binding protein A6 -0.0210293
RPLP0 ribosomal protein, large, P0 -0.0206717
TMEM41B transmembrane protein 41B -0.0206473
RPS21 ribosomal protein S21 -0.0206207
RPL12 ribosomal protein L12 -0.0198632
RPLP2 ribosomal protein, large, P2 -0.0194008
RPS15 ribosomal protein S15 -0.018847
RPS13 ribosomal protein S13 -0.0179558
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0178657
S100A9 S100 calcium binding protein A9 -0.0176069
RPL9 ribosomal protein L9 -0.0175989
EGR1 early growth response 1 -0.0173889
RPS27A ribosomal protein S27a -0.0172032
HMGA1 high mobility group AT-hook 1 -0.0166438
RPL34 ribosomal protein L34 -0.0165054
AREG amphiregulin -0.0163694
RPL36A ribosomal protein L36a -0.0162615
RPL36 ribosomal protein L36 -0.0157259
RPL26 ribosomal protein L26 -0.0150835
RPL32 ribosomal protein L32 -0.0150583
ANGPTL4 angiopoietin-like 4 -0.0149055
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0148756
UBC ubiquitin C -0.0146773
RPS24 ribosomal protein S24 -0.0143247
RPS27 ribosomal protein S27 -0.0135107
RPL37A ribosomal protein L37a -0.013302
RPL23 ribosomal protein L23 -0.0132845
UPP1 uridine phosphorylase 1 -0.0132291
KLF6 Kruppel-like factor 6 -0.0130759
RPS16 ribosomal protein S16 -0.0128961
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0126105
RPS5 ribosomal protein S5 -0.0122262
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0121889
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0119401
RPL35 ribosomal protein L35 -0.0116508
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0116222
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0115449
LHX1 LIM homeobox 1 -0.011356
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0112457
EREG epiregulin -0.0111647
RPL27 ribosomal protein L27 -0.0110843
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy -0.0110525
TMSB4X thymosin beta 4, X-linked -0.0109095
WDR45B WD repeat domain 45B -0.0107007
RPS11 ribosomal protein S11 -0.0106356
RPL11 ribosomal protein L11 -0.0106159
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0105858
RPL37 ribosomal protein L37 -0.0101379
RPS28 ribosomal protein S28 -0.0100591
RPL13A ribosomal protein L13a -0.00995402
RPL31 ribosomal protein L31 -0.00991673
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.00977662
SEPTIN7 septin 7 -0.00959473
RPS10 ribosomal protein S10 -0.00950347
RPL7A ribosomal protein L7a -0.00923779
LOC112694756 uncharaterized LOC112694756 -0.00913145
PNISR PNN-interacting serine/arginine-rich protein -0.00895977
PRDX1 peroxiredoxin 1 -0.00879987
FOSL1 FOS-like antigen 1 -0.00877822
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.00868823
RPS14 ribosomal protein S14 -0.0086322
TIMP1 TIMP metallopeptidase inhibitor 1 -0.00854531
RPL19 ribosomal protein L19 -0.00849245
RPS4X ribosomal protein S4, X-linked -0.0084512
SEC61G Sec61 gamma subunit -0.0083481
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.00818132
RPL39 ribosomal protein L39 -0.00811685
HMOX1 heme oxygenase 1 -0.00810975
RPS20 ribosomal protein S20 -0.00807702
MIS18BP1 MIS18 binding protein 1 -0.00790629
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.00779672
CCNI cyclin I -0.00776477
MYL12B myosin, light chain 12B, regulatory -0.00776073