Sivelestat (sodium tetrahydrate)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.188822
EGFR epidermal growth factor receptor 0.187612
GRAMD1B GRAM domain containing 1B 0.13147
FAM13A family with sequence similarity 13, member A 0.0747252
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0691649
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0652396
HYOU1 hypoxia up-regulated 1 0.0631459
SMAD3 SMAD family member 3 0.0569544
CES1 carboxylesterase 1 0.0562985
CANX calnexin 0.0548179
GRB10 growth factor receptor-bound protein 10 0.0529733
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0529356
THSD4 thrombospondin, type I, domain containing 4 0.0507211
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0505435
FNDC3B fibronectin type III domain containing 3B 0.0456071
NDRG1 N-myc downstream regulated 1 0.0454312
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0448574
MACF1 microtubule-actin crosslinking factor 1 0.0443211
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0439249
HDLBP high density lipoprotein binding protein 0.0407586
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0402148
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0399512
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0385035
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0380548
MCL1 myeloid cell leukemia 1 0.0380104
LDHA lactate dehydrogenase A 0.038006
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0372954
PYGL phosphorylase, glycogen, liver 0.0352347
CALR calreticulin 0.0347885
CAMTA1 calmodulin binding transcription activator 1 0.0345989
SAMD4A sterile alpha motif domain containing 4A 0.0335686
PDIA6 protein disulfide isomerase family A, member 6 0.0331722
PDIA3 protein disulfide isomerase family A, member 3 0.0327699
GOLGB1 golgin B1 0.0327622
CEMIP cell migration inducing protein, hyaluronan binding 0.0327397
RAD51B RAD51 paralog B 0.0317189
TTC3 tetratricopeptide repeat domain 3 0.0304832
PDE8A phosphodiesterase 8A 0.0303768
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0303089
MYOF myoferlin 0.0302765
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0296265
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0295804
LRP12 low density lipoprotein receptor-related protein 12 0.0295654
SEPTIN2 septin 2 0.028954
MYH9 myosin, heavy chain 9, non-muscle 0.0285125
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0284759
ARRDC3 arrestin domain containing 3 0.0283905
HOOK2 hook microtubule-tethering protein 2 0.0283151
TPM3 tropomyosin 3 0.0272421
NBAS neuroblastoma amplified sequence 0.027153
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.026986
SEC31A SEC31 homolog A (S. cerevisiae) 0.0266547
ATP11A ATPase, class VI, type 11A 0.0265859
FNIP1 folliculin interacting protein 1 0.0259998
NGLY1 N-glycanase 1 0.02573
ZNF638 zinc finger protein 638 0.025489
SEC24D SEC24 family member D 0.0253795
TFG TRK-fused gene 0.0251612
KMT2E lysine (K)-specific methyltransferase 2E 0.024776
SUCO SUN domain containing ossification factor 0.0245919
APLP2 amyloid beta (A4) precursor-like protein 2 0.0245155
PLEC plectin 0.0244912
FRY furry homolog (Drosophila) 0.0236916
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0234762
USP34 ubiquitin specific peptidase 34 0.0233115
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0233076
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0228492
SOD2 superoxide dismutase 2, mitochondrial 0.0227033
SRP54 signal recognition particle 54kDa 0.0225426
UBA6 ubiquitin-like modifier activating enzyme 6 0.0225232
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.022252
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0216955
AHNAK AHNAK nucleoprotein 0.021654
CTBP2 C-terminal binding protein 2 0.0216498
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.0216336
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0210817
RBM39 RNA binding motif protein 39 0.0210643
MSN moesin 0.0210358
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0209943
ERRFI1 ERBB receptor feedback inhibitor 1 0.0209805
TMCO3 transmembrane and coiled-coil domains 3 0.0208655
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0208608
ZNF292 zinc finger protein 292 0.0208381
PCBP2 poly(rC) binding protein 2 0.020836
YAP1 Yes-associated protein 1 0.0207067
PKM pyruvate kinase, muscle 0.0206654
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.020228
BIRC6 baculoviral IAP repeat containing 6 0.0201636
ANKRD11 ankyrin repeat domain 11 0.0200808
COPA coatomer protein complex, subunit alpha 0.020042
GSK3B glycogen synthase kinase 3 beta 0.019945
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0199427
PDIA4 protein disulfide isomerase family A, member 4 0.0198989
ZFAND3 zinc finger, AN1-type domain 3 0.0198535
BACE2 beta-site APP-cleaving enzyme 2 0.0197834
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0195382
TMEM45B transmembrane protein 45B 0.019422
OGA O-GlcNAcase 0.019274
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0191843
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0191012

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.345333
TMSB10 thymosin beta 10 -0.15052
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.108844
CAV1 caveolin 1, caveolae protein, 22kDa -0.103
TPT1 tumor protein, translationally-controlled 1 -0.0962304
AKR1C1 aldo-keto reductase family 1, member C1 -0.0841207
ACTG1 actin gamma 1 -0.0810608
S100A10 S100 calcium binding protein A10 -0.0777069
TXNRD1 thioredoxin reductase 1 -0.0748098
B2M beta-2-microglobulin -0.0679774
FTL ferritin, light polypeptide -0.0651336
MT2A metallothionein 2A -0.056817
RPLP1 ribosomal protein, large, P1 -0.0566588
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0549932
RPL35A ribosomal protein L35a -0.0542309
LAMC2 laminin, gamma 2 -0.0527643
SLC38A1 solute carrier family 38, member 1 -0.0521257
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0506146
CST3 cystatin C -0.0505705
STC1 stanniocalcin 1 -0.0503951
RPS24 ribosomal protein S24 -0.0488602
AREG amphiregulin -0.0472342
RPL34 ribosomal protein L34 -0.0471154
EGR1 early growth response 1 -0.0447942
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0442774
IFI6 interferon, alpha-inducible protein 6 -0.0437255
ANKRD12 ankyrin repeat domain 12 -0.0431651
RPS8 ribosomal protein S8 -0.0417639
RPS6 ribosomal protein S6 -0.0406482
RPL11 ribosomal protein L11 -0.0392513
HLA-B major histocompatibility complex, class I, B -0.0382568
SEC61G Sec61 gamma subunit -0.0381118
PTMA prothymosin, alpha -0.036984
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0365419
LMO7 LIM domain 7 -0.0360903
RPL37A ribosomal protein L37a -0.0359657
RPLP0 ribosomal protein, large, P0 -0.0357458
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0353408
OSMR oncostatin M receptor -0.0350704
S100A9 S100 calcium binding protein A9 -0.0347911
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0345914
NSUN6 NOP2/Sun domain family, member 6 -0.0344109
RPS21 ribosomal protein S21 -0.0333847
VCL vinculin -0.0329537
RPS3 ribosomal protein S3 -0.0327771
RPS23 ribosomal protein S23 -0.0322863
PTPRM protein tyrosine phosphatase, receptor type, M -0.0317748
RPS25 ribosomal protein S25 -0.0317575
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0315727
CCND1 cyclin D1 -0.031113
LAMB3 laminin, beta 3 -0.0301768
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.030101
PRRC2C proline-rich coiled-coil 2C -0.0293044
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0292408
RPS27A ribosomal protein S27a -0.0292154
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0289595
BTG1 B-cell translocation gene 1, anti-proliferative -0.0288252
LOC102724023 ES1 protein homolog, mitochondrial -0.028354
RPL30 ribosomal protein L30 -0.0277739
ANXA2 annexin A2 -0.0276576
EIF1 eukaryotic translation initiation factor 1 -0.0272966
MGST1 microsomal glutathione S-transferase 1 -0.0272282
H1-0 H1.0 linker histone -0.0270777
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0261895
BZW1 basic leucine zipper and W2 domains 1 -0.0261508
MYL12B myosin, light chain 12B, regulatory -0.0258391
CIB1 calcium and integrin binding 1 (calmyrin) -0.0256439
KRT18 keratin 18, type I -0.0254597
CPE carboxypeptidase E -0.0251718
RPL8 ribosomal protein L8 -0.0250436
SP100 SP100 nuclear antigen -0.024857
RPL23 ribosomal protein L23 -0.0248347
RPS14 ribosomal protein S14 -0.0243361
EFNA5 ephrin-A5 -0.0242027
UBC ubiquitin C -0.0241428
MT1X metallothionein 1X -0.0238466
KRT7 keratin 7, type II -0.0235264
RPL12 ribosomal protein L12 -0.0235085
S100A6 S100 calcium binding protein A6 -0.0228201
PRDX1 peroxiredoxin 1 -0.0226513
CCNI cyclin I -0.0225524
RPS19 ribosomal protein S19 -0.0225271
RPS29 ribosomal protein S29 -0.0221994
RPS27 ribosomal protein S27 -0.0221847
S100P S100 calcium binding protein P -0.0220569
TKT transketolase -0.0220223
RPL19 ribosomal protein L19 -0.0219315
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0214632
RPL31 ribosomal protein L31 -0.0213936
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.02131
TRIM56 tripartite motif containing 56 -0.0212286
RPL9 ribosomal protein L9 -0.0212125
NCOA7 nuclear receptor coactivator 7 -0.0211826
SCLT1 sodium channel and clathrin linker 1 -0.0209434
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0208437
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.020674
SLC38A2 solute carrier family 38, member 2 -0.0206429
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0205856
GCLM glutamate-cysteine ligase, modifier subunit -0.0205279
RPL37 ribosomal protein L37 -0.0204839