Sivelestat (sodium tetrahydrate)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.156479
PDE4D phosphodiesterase 4D, cAMP-specific 0.118974
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.118507
NAMPT nicotinamide phosphoribosyltransferase 0.101563
CD44 CD44 molecule (Indian blood group) 0.100656
EFNA5 ephrin-A5 0.0840445
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0811861
USP34 ubiquitin specific peptidase 34 0.0752259
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0700121
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0698676
ARHGAP5 Rho GTPase activating protein 5 0.069404
AKAP13 A kinase (PRKA) anchor protein 13 0.0670492
OSMR oncostatin M receptor 0.0656905
NAV2 neuron navigator 2 0.0615229
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0579858
RBM39 RNA binding motif protein 39 0.0578193
SOD2 superoxide dismutase 2, mitochondrial 0.0563404
DOCK5 dedicator of cytokinesis 5 0.0553519
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0526946
NRG1 neuregulin 1 0.0526464
DSCAM Down syndrome cell adhesion molecule 0.0524651
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0499102
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0495578
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0493627
RAB27B RAB27B, member RAS oncogene family 0.0488462
STC1 stanniocalcin 1 0.048267
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0476387
IGFBP3 insulin-like growth factor binding protein 3 0.0476165
NRP1 neuropilin 1 0.0464229
CXCL8 chemokine (C-X-C motif) ligand 8 0.0452743
BMAL2 basic helix-loop-helix ARNT like 2 0.0438197
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0432584
JMJD1C jumonji domain containing 1C 0.0432175
KDM2A lysine (K)-specific demethylase 2A 0.0428259
ZC3H12C zinc finger CCCH-type containing 12C 0.0426176
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0406138
GRB10 growth factor receptor-bound protein 10 0.0403883
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0401016
GOLGA4 golgin A4 0.0398187
TRIO trio Rho guanine nucleotide exchange factor 0.0397136
PELI1 pellino E3 ubiquitin protein ligase 1 0.0388752
ZEB2 zinc finger E-box binding homeobox 2 0.0387163
MON2 MON2 homolog (S. cerevisiae) 0.0385143
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0383595
ELL2 elongation factor, RNA polymerase II, 2 0.0383188
SEC31A SEC31 homolog A (S. cerevisiae) 0.0376071
ATP13A3 ATPase type 13A3 0.0375942
PID1 phosphotyrosine interaction domain containing 1 0.0369987
NPC1 Niemann-Pick disease, type C1 0.0361707
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0359391
SMAD3 SMAD family member 3 0.035817
RAB1A RAB1A, member RAS oncogene family 0.034905
CDCP1 CUB domain containing protein 1 0.0348215
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0338855
LOX lysyl oxidase 0.033774
AKAP12 A kinase (PRKA) anchor protein 12 0.033648
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0335711
ANKRD28 ankyrin repeat domain 28 0.0335669
PCNX1 pecanex 1 0.0331818
ANKRD17 ankyrin repeat domain 17 0.0331235
FAM20C family with sequence similarity 20, member C 0.0328716
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0327744
ITGAV integrin, alpha V 0.0327063
NGLY1 N-glycanase 1 0.0323387
DLG1 discs, large homolog 1 (Drosophila) 0.0319941
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0317381
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0316887
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0315185
DOCK4 dedicator of cytokinesis 4 0.0314166
AKAP9 A kinase (PRKA) anchor protein 9 0.0312896
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0311466
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0310807
ADD3 adducin 3 (gamma) 0.0310662
SIK3 SIK family kinase 3 0.0310648
RUNX2 runt-related transcription factor 2 0.030955
ANTXR2 anthrax toxin receptor 2 0.0308502
KYNU kynureninase 0.0303925
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0299889
VMP1 vacuole membrane protein 1 0.0296918
GLCCI1 glucocorticoid induced 1 0.0294086
IL6ST interleukin 6 signal transducer 0.0291233
ATXN1 ataxin 1 0.0290853
SEC23A Sec23 homolog A (S. cerevisiae) 0.0287713
COPA coatomer protein complex, subunit alpha 0.028695
TTC28 tetratricopeptide repeat domain 28 0.0286161
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0282993
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.028218
HAS2 hyaluronan synthase 2 0.0280171
SDK1 sidekick cell adhesion molecule 1 0.0279495
FRMD4A FERM domain containing 4A 0.0277608
MEF2A myocyte enhancer factor 2A 0.0277428
EXT1 exostosin glycosyltransferase 1 0.0276279
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0276019
YME1L1 YME1-like 1 ATPase 0.0274681
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.02742
DPYSL3 dihydropyrimidinase-like 3 0.0274086
BIRC6 baculoviral IAP repeat containing 6 0.0272701
NBAS neuroblastoma amplified sequence 0.0271713
TM4SF1 transmembrane 4 L six family member 1 0.0270639
ZFC3H1 zinc finger, C3H1-type containing 0.0269681

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.16007
FTL ferritin, light polypeptide -0.125034
VIM vimentin -0.121853
MT2A metallothionein 2A -0.0843323
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.084315
FN1 fibronectin 1 -0.0652238
RPS19 ribosomal protein S19 -0.0642214
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0638234
PTMA prothymosin, alpha -0.0591648
RPS12 ribosomal protein S12 -0.0553647
RPLP1 ribosomal protein, large, P1 -0.0549841
RPS3 ribosomal protein S3 -0.0451573
NAP1L1 nucleosome assembly protein 1-like 1 -0.0441679
RPL37A ribosomal protein L37a -0.0409515
RPL35A ribosomal protein L35a -0.0406054
IER3 immediate early response 3 -0.0398098
RPLP2 ribosomal protein, large, P2 -0.0380149
RPL36 ribosomal protein L36 -0.0379605
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0362399
RPL12 ribosomal protein L12 -0.0346323
RPS8 ribosomal protein S8 -0.0329752
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0326938
RPS6 ribosomal protein S6 -0.0326373
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0324824
B2M beta-2-microglobulin -0.0315705
RPL9 ribosomal protein L9 -0.0314936
EGR1 early growth response 1 -0.0303974
RPL18 ribosomal protein L18 -0.0298116
RPL7A ribosomal protein L7a -0.029041
C15ORF48 chromosome 15 open reading frame 48 -0.028966
RPL19 ribosomal protein L19 -0.028375
DDIT4 DNA-damage-inducible transcript 4 -0.0277191
DDIT3 DNA-damage-inducible transcript 3 -0.0272538
HMGA1 high mobility group AT-hook 1 -0.0267039
YBX1 Y box binding protein 1 -0.0260512
RPS17 ribosomal protein S17 -0.0259209
RACK1 receptor for activated C kinase 1 -0.025912
RPL23 ribosomal protein L23 -0.02539
TPI1 triosephosphate isomerase 1 -0.0246071
RPS16 ribosomal protein S16 -0.0244999
RPS27 ribosomal protein S27 -0.0241294
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0241119
RPS25 ribosomal protein S25 -0.0239215
COL7A1 collagen, type VII, alpha 1 -0.0238855
SLC38A1 solute carrier family 38, member 1 -0.0233917
RPL11 ribosomal protein L11 -0.023261
ATP5MC2 ATP synthase membrane subunit c locus 2 -0.0232023
RPL32 ribosomal protein L32 -0.0231495
EIF1 eukaryotic translation initiation factor 1 -0.0231112
RPL31 ribosomal protein L31 -0.0229013
RPL7 ribosomal protein L7 -0.022819
KTN1 kinectin 1 (kinesin receptor) -0.0226661
NDRG1 N-myc downstream regulated 1 -0.0222686
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0216833
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0216805
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0212565
GSTP1 glutathione S-transferase pi 1 -0.0211829
IFITM3 interferon induced transmembrane protein 3 -0.0211389
GNAS GNAS complex locus -0.0210333
RPL5 ribosomal protein L5 -0.0210198
ENO1 enolase 1, (alpha) -0.0210174
RPL13A ribosomal protein L13a -0.0208027
SEC61G Sec61 gamma subunit -0.0207186
RPL37 ribosomal protein L37 -0.0206655
ATP5F1E ATP synthase F1 subunit epsilon -0.020583
RPL28 ribosomal protein L28 -0.0198715
RPL34 ribosomal protein L34 -0.0197774
LMNA lamin A/C -0.0196115
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0195694
ACTG1 actin gamma 1 -0.0194753
MAP1B microtubule-associated protein 1B -0.0194378
PFN1 profilin 1 -0.0189434
WLS wntless Wnt ligand secretion mediator -0.0189304
LDHB lactate dehydrogenase B -0.0188825
POTEF POTE ankyrin domain family, member F -0.0188405
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0186701
CFAP20DC CFAP20 domain containing -0.0184401
LRMDA leucine rich melanocyte differentiation associated -0.0183449
NDUFA4 NDUFA4, mitochondrial complex associated -0.0178661
RPL15 ribosomal protein L15 -0.0178506
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0178309
TGFB1 transforming growth factor, beta 1 -0.0173512
SYT1 synaptotagmin I -0.0171164
ANXA1 annexin A1 -0.0171084
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0170882
S100A6 S100 calcium binding protein A6 -0.0169558
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0168528
SUMF1 sulfatase modifying factor 1 -0.0168011
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0167915
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0165447
RPS24 ribosomal protein S24 -0.0165257
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0164981
RAB13 RAB13, member RAS oncogene family -0.0163774
MX2 MX dynamin-like GTPase 2 -0.0156363
PCBP2 poly(rC) binding protein 2 -0.0155882
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0155196
RPS14 ribosomal protein S14 -0.0154882
IFI6 interferon, alpha-inducible protein 6 -0.015333
TPT1 tumor protein, translationally-controlled 1 -0.0151123
HMGA2 high mobility group AT-hook 2 -0.0150098