| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sivelestat (sodium tetrahydrate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | 0.130228 |
| FTL | ferritin, light polypeptide | 0.10246 |
| TXNRD1 | thioredoxin reductase 1 | 0.100459 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0921235 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0839518 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0828154 |
| RBM39 | RNA binding motif protein 39 | 0.0803212 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0723752 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0688584 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0685906 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0633223 |
| GRAMD1B | GRAM domain containing 1B | 0.0627479 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0613289 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0571851 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0561625 |
| MCL1 | myeloid cell leukemia 1 | 0.0546798 |
| TPD52 | tumor protein D52 | 0.0541239 |
| PARD3 | par-3 family cell polarity regulator | 0.0537548 |
| PCBP2 | poly(rC) binding protein 2 | 0.0535073 |
| WDR43 | WD repeat domain 43 | 0.0533263 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0525103 |
| RTN4 | reticulon 4 | 0.0522514 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | 0.0520377 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0517907 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0510574 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0510106 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0503633 |
| WWOX | WW domain containing oxidoreductase | 0.0488041 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0474317 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0444747 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0437245 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0433384 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0432777 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0431505 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0429215 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0423615 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0421163 |
| CCNL1 | cyclin L1 | 0.0408146 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0407449 |
| PTK2 | protein tyrosine kinase 2 | 0.039848 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.039489 |
| FUS | FUS RNA binding protein | 0.0393382 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0386783 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0385554 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.037691 |
| UBAP2L | ubiquitin associated protein 2-like | 0.0376005 |
| AHR | aryl hydrocarbon receptor | 0.0375355 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0373538 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0372248 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0371644 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0370858 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.0368791 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0364024 |
| CALR | calreticulin | 0.0360189 |
| MATR3 | matrin 3 | 0.036016 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0350872 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0348913 |
| SIK3 | SIK family kinase 3 | 0.034625 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0338876 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0336805 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0330641 |
| TPM3 | tropomyosin 3 | 0.0330355 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0328549 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0328441 |
| CYRIB | CYFIP related Rac1 interactor B | 0.0325599 |
| PDE8A | phosphodiesterase 8A | 0.0323557 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0323 |
| ZNF292 | zinc finger protein 292 | 0.0322789 |
| YAP1 | Yes-associated protein 1 | 0.0322765 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0322009 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0319464 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0317328 |
| ENAH | enabled homolog (Drosophila) | 0.0313346 |
| USP3 | ubiquitin specific peptidase 3 | 0.0312768 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0312619 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0312095 |
| FGB | fibrinogen beta chain | 0.0311064 |
| ERBIN | erbb2 interacting protein | 0.030399 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0303423 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0303343 |
| TNPO1 | transportin 1 | 0.0299701 |
| PKM | pyruvate kinase, muscle | 0.0298936 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0297298 |
| RNF145 | ring finger protein 145 | 0.0297207 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0296323 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | 0.0296098 |
| YBX1 | Y box binding protein 1 | 0.0293571 |
| ECT2 | epithelial cell transforming 2 | 0.0293076 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0293041 |
| CUL3 | cullin 3 | 0.0291725 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.028743 |
| FGG | fibrinogen gamma chain | 0.0286694 |
| YBX3 | Y box binding protein 3 | 0.0285985 |
| WTAP | Wilms tumor 1 associated protein | 0.0285921 |
| PRR16 | proline rich 16 | 0.0285834 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0285221 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0281158 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0279748 |
| COG5 | component of oligomeric golgi complex 5 | 0.0279322 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0277195 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.156368 |
| MT2A | metallothionein 2A | -0.132136 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0904947 |
| PYGL | phosphorylase, glycogen, liver | -0.0643903 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0620014 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0551335 |
| STC1 | stanniocalcin 1 | -0.0526681 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0506609 |
| IER3 | immediate early response 3 | -0.0469279 |
| S100A6 | S100 calcium binding protein A6 | -0.0467181 |
| ACTG1 | actin gamma 1 | -0.0427569 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0391926 |
| HDAC9 | histone deacetylase 9 | -0.0378794 |
| TPM4 | tropomyosin 4 | -0.0378144 |
| CAVIN1 | caveolae associated protein 1 | -0.0366732 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0340807 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0340236 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0332611 |
| IGF2 | insulin-like growth factor 2 | -0.0314962 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0294524 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0291295 |
| EGFR | epidermal growth factor receptor | -0.0284942 |
| RPS8 | ribosomal protein S8 | -0.025155 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0249752 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0235827 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0233671 |
| HLA-E | major histocompatibility complex, class I, E | -0.023344 |
| ANGPTL4 | angiopoietin-like 4 | -0.0232804 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0229756 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0224298 |
| FLNB | filamin B, beta | -0.0222034 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0211154 |
| RPL37A | ribosomal protein L37a | -0.0209069 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0202622 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.020003 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0199733 |
| INHBA | inhibin, beta A | -0.0195883 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0194767 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0193335 |
| LAMC2 | laminin, gamma 2 | -0.019222 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0178366 |
| IL6 | interleukin 6 | -0.017709 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0174453 |
| RPS27A | ribosomal protein S27a | -0.0174171 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0171247 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0162358 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | -0.0162125 |
| OSMR | oncostatin M receptor | -0.0161827 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0160475 |
| RAI14 | retinoic acid induced 14 | -0.0155219 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | -0.0153557 |
| HMOX1 | heme oxygenase 1 | -0.0153413 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0152702 |
| RPS6 | ribosomal protein S6 | -0.015029 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0146256 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0145926 |
| BPTF | bromodomain PHD finger transcription factor | -0.0145263 |
| PCNX4 | pecanex 4 | -0.0143845 |
| CD44 | CD44 molecule (Indian blood group) | -0.0143721 |
| ZNF33A | zinc finger protein 33A | -0.0143104 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0142009 |
| LMNA | lamin A/C | -0.0141688 |
| NDRG1 | N-myc downstream regulated 1 | -0.0139548 |
| CUX1 | cut-like homeobox 1 | -0.0136603 |
| TPM1 | tropomyosin 1 (alpha) | -0.0134286 |
| RRBP1 | ribosome binding protein 1 | -0.0132694 |
| RPL35A | ribosomal protein L35a | -0.013091 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0128651 |
| SRGN | serglycin | -0.0127974 |
| TRIP11 | thyroid hormone receptor interactor 11 | -0.012756 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0127502 |
| HMGA2 | high mobility group AT-hook 2 | -0.0127489 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0127012 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0125856 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0124422 |
| PTMA | prothymosin, alpha | -0.0123891 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.0123552 |
| FBXO27 | F-box protein 27 | -0.0122695 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0122479 |
| S100A10 | S100 calcium binding protein A10 | -0.0119506 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0118336 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0114983 |
| MYO9A | myosin IXA | -0.0113265 |
| CDCP1 | CUB domain containing protein 1 | -0.0111962 |
| EHBP1 | EH domain binding protein 1 | -0.0111555 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | -0.0111485 |
| NAV3 | neuron navigator 3 | -0.0111034 |
| KYNU | kynureninase | -0.0110775 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0110553 |
| HLA-B | major histocompatibility complex, class I, B | -0.0109758 |
| TBCA | tubulin folding cofactor A | -0.0109747 |
| RPL26 | ribosomal protein L26 | -0.0107884 |
| HLA-A | major histocompatibility complex, class I, A | -0.010759 |
| GOLGB1 | golgin B1 | -0.0107465 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0107315 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0106574 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.010654 |
| PRSS23 | protease, serine, 23 | -0.0106296 |
| CDK13 | cyclin-dependent kinase 13 | -0.0106217 |
| CTSL | cathepsin L | -0.0103232 |
