| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sivelestat (sodium tetrahydrate) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.111651 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0687619 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0588408 |
| PGK1 | phosphoglycerate kinase 1 | 0.0580431 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0548318 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0535299 |
| NBAS | neuroblastoma amplified sequence | 0.0534986 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0532897 |
| NDRG1 | N-myc downstream regulated 1 | 0.0505673 |
| LDHA | lactate dehydrogenase A | 0.0502702 |
| CANX | calnexin | 0.0481388 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0480668 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0476485 |
| VIM | vimentin | 0.0453105 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0445164 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0444608 |
| EXOC4 | exocyst complex component 4 | 0.0424649 |
| RBM39 | RNA binding motif protein 39 | 0.042411 |
| SBF2 | SET binding factor 2 | 0.0409741 |
| ENO1 | enolase 1, (alpha) | 0.040757 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0407319 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0407227 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0405429 |
| PTK2 | protein tyrosine kinase 2 | 0.0384858 |
| FMNL2 | formin-like 2 | 0.0381448 |
| NAV2 | neuron navigator 2 | 0.0379983 |
| PDE10A | phosphodiesterase 10A | 0.0373631 |
| PTEN | phosphatase and tensin homolog | 0.0366485 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0366266 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0361559 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.036045 |
| LSAMP | limbic system-associated membrane protein | 0.0359265 |
| COG5 | component of oligomeric golgi complex 5 | 0.035409 |
| PCBP2 | poly(rC) binding protein 2 | 0.0344557 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0344504 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.033708 |
| PTMA | prothymosin, alpha | 0.0325763 |
| COPA | coatomer protein complex, subunit alpha | 0.032315 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0318602 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0316318 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0315441 |
| DST | dystonin | 0.0315422 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0314501 |
| MORF4L2 | mortality factor 4 like 2 | 0.0310919 |
| APP | amyloid beta (A4) precursor protein | 0.0310474 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.030963 |
| TTC17 | tetratricopeptide repeat domain 17 | 0.0307989 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0307817 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0306454 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0303098 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.029915 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.02989 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0295972 |
| CALU | calumenin | 0.0293166 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0290867 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0289608 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0286549 |
| CDC73 | cell division cycle 73 | 0.0279355 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0278546 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0278534 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0274483 |
| ITGA6 | integrin, alpha 6 | 0.0273941 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0272506 |
| ZNF292 | zinc finger protein 292 | 0.0271913 |
| SYT1 | synaptotagmin I | 0.0269759 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0268909 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0267275 |
| RPS6 | ribosomal protein S6 | 0.0267103 |
| FMN1 | formin 1 | 0.0263979 |
| NUP58 | nucleoporin 58 | 0.0261523 |
| MSI2 | musashi RNA-binding protein 2 | 0.0261065 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.025799 |
| SETD5 | SET domain containing 5 | 0.0257637 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.025506 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0254038 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0253806 |
| NFIA | nuclear factor I/A | 0.025341 |
| NLGN1 | neuroligin 1 | 0.0251511 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0248841 |
| RNF43 | ring finger protein 43 | 0.0247876 |
| KIF16B | kinesin family member 16B | 0.024774 |
| ATP11B | ATPase, class VI, type 11B | 0.0245233 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0244337 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0243573 |
| DENND4C | DENN/MADD domain containing 4C | 0.0240861 |
| MED13L | mediator complex subunit 13-like | 0.024079 |
| TPD52 | tumor protein D52 | 0.0240399 |
| UTRN | utrophin | 0.0239333 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0239153 |
| CERS6 | ceramide synthase 6 | 0.0239078 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0238606 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0237946 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0237802 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0237472 |
| CALR | calreticulin | 0.023709 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0236749 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0236342 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0235775 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0235343 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0235277 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.20868 |
| LMO7 | LIM domain 7 | -0.190587 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.143331 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.139735 |
| MYO1E | myosin IE | -0.135846 |
| LAMB3 | laminin, beta 3 | -0.123402 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.118719 |
| ATOSA | atos homolog A | -0.114613 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.105353 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0996712 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0756167 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0709977 |
| SVIL | supervillin | -0.0705461 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0690279 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0683116 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0677287 |
| LAMC2 | laminin, gamma 2 | -0.0675163 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0641809 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0637075 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0620976 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0613416 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0606197 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0602843 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0547523 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0538973 |
| ANXA2 | annexin A2 | -0.0520555 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0512957 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0507296 |
| OSMR | oncostatin M receptor | -0.049645 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0481342 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.04582 |
| KYNU | kynureninase | -0.045753 |
| TJP1 | tight junction protein 1 | -0.0451261 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0451148 |
| RBM47 | RNA binding motif protein 47 | -0.0446078 |
| ABHD17C | abhydrolase domain containing 17C | -0.0445707 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0445225 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0440462 |
| KCNH8 | potassium channel, voltage gated eag related subfamily H, member 8 | -0.0425792 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0420804 |
| MUC16 | mucin 16, cell surface associated | -0.0417749 |
| TMCC3 | transmembrane and coiled-coil domain family 3 | -0.041035 |
| VCAN | versican | -0.0407993 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0405473 |
| GLIS3 | GLIS family zinc finger 3 | -0.0399748 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0399578 |
| CDCP1 | CUB domain containing protein 1 | -0.039897 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0398242 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.039606 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0391041 |
| PRDM1 | PR domain containing 1, with ZNF domain | -0.0389373 |
| TXNIP | thioredoxin interacting protein | -0.0388073 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0381823 |
| JMJD1C | jumonji domain containing 1C | -0.0380995 |
| ZNF217 | zinc finger protein 217 | -0.0371232 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0370951 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0366631 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0365665 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0364984 |
| GRAMD2B | GRAM domain containing 2B | -0.0362456 |
| GRAMD1B | GRAM domain containing 1B | -0.0358785 |
| FOXO3 | forkhead box O3 | -0.0358548 |
| PRSS23 | protease, serine, 23 | -0.0358129 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0354605 |
| MYO5C | myosin VC | -0.0352342 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0350767 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0349162 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0344494 |
| CP | ceruloplasmin (ferroxidase) | -0.033954 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | -0.0333478 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0330194 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0329222 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0329124 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0328753 |
| CLDN4 | claudin 4 | -0.0325871 |
| BPTF | bromodomain PHD finger transcription factor | -0.0322191 |
| ANXA11 | annexin A11 | -0.0321957 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.0314 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.0310626 |
| SLMAP | sarcolemma associated protein | -0.0305298 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0304905 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0299293 |
| DENND2C | DENN/MADD domain containing 2C | -0.0295843 |
| BCL2L1 | BCL2-like 1 | -0.0293472 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0292721 |
| CDK13 | cyclin-dependent kinase 13 | -0.02927 |
| THRB | thyroid hormone receptor, beta | -0.0292324 |
| RAB31 | RAB31, member RAS oncogene family | -0.0290159 |
| STC1 | stanniocalcin 1 | -0.0282348 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | -0.0281883 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0280863 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.02795 |
| PATJ | PATJ crumbs cell polarity complex component | -0.027887 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0271925 |
| H3-3B | H3.3 histone B | -0.027079 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0270395 |
| FOXO1 | forkhead box O1 | -0.0269731 |
| F11R | F11 receptor | -0.0268538 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.0265133 |
| MYO6 | myosin VI | -0.026405 |
