Sivelestat (sodium tetrahydrate)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RAD51B RAD51 paralog B 0.146171
PDE4D phosphodiesterase 4D, cAMP-specific 0.0930728
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0738912
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0726502
EEF2 eukaryotic translation elongation factor 2 0.0682378
PABPC1 poly(A) binding protein, cytoplasmic 1 0.067554
EXOC4 exocyst complex component 4 0.0669165
GRAMD1B GRAM domain containing 1B 0.0667346
ERRFI1 ERBB receptor feedback inhibitor 1 0.0639519
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0628019
MCL1 myeloid cell leukemia 1 0.0623184
TPM3 tropomyosin 3 0.0620299
THSD4 thrombospondin, type I, domain containing 4 0.0618556
PCBP2 poly(rC) binding protein 2 0.0617256
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0613182
CSDE1 cold shock domain containing E1, RNA-binding 0.0587029
ENO1 enolase 1, (alpha) 0.0586358
LDHA lactate dehydrogenase A 0.0548498
TRIO trio Rho guanine nucleotide exchange factor 0.0547757
ZFAND3 zinc finger, AN1-type domain 3 0.0520105
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0492932
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0490379
WWOX WW domain containing oxidoreductase 0.0484624
PRKCE protein kinase C, epsilon 0.0483769
IGF1R insulin-like growth factor 1 receptor 0.0431167
SMAD3 SMAD family member 3 0.0430321
ADAR adenosine deaminase, RNA-specific 0.0427944
ATXN1 ataxin 1 0.0399986
PRELID2 PRELI domain containing 2 0.0393873
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0372592
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0365373
EXT1 exostosin glycosyltransferase 1 0.0364896
SMYD3 SET and MYND domain containing 3 0.0363303
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0357329
TBC1D5 TBC1 domain family, member 5 0.0355473
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0344563
PDE10A phosphodiesterase 10A 0.0343865
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0342515
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0334281
XPO1 exportin 1 0.0332455
PKM pyruvate kinase, muscle 0.0331773
CANX calnexin 0.0330066
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0329474
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0326841
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0325363
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0324004
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0318631
CMIP c-Maf inducing protein 0.0318508
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0315756
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0311645
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0311197
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0307434
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0304775
WNK1 WNK lysine deficient protein kinase 1 0.03022
YAP1 Yes-associated protein 1 0.0301555
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0298984
DST dystonin 0.0298722
HYOU1 hypoxia up-regulated 1 0.0297877
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0294471
ANKRD36 ankyrin repeat domain 36 0.0293663
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0288924
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0286313
EIF4B eukaryotic translation initiation factor 4B 0.0285568
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0284778
SFPQ splicing factor proline/glutamine-rich 0.0282677
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0281002
RBM39 RNA binding motif protein 39 0.0280512
PHF3 PHD finger protein 3 0.0278847
BCAS3 breast carcinoma amplified sequence 3 0.0277563
RPS18 ribosomal protein S18 0.0275745
WDPCP WD repeat containing planar cell polarity effector 0.0274188
PLEC plectin 0.0272862
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.027141
CD164 CD164 molecule, sialomucin 0.0271062
PDIA6 protein disulfide isomerase family A, member 6 0.0270083
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0269883
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0268901
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0267243
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0266993
DENND1A DENN/MADD domain containing 1A 0.0266348
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0265967
ZYX zyxin 0.0265705
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0264511
BBX bobby sox homolog (Drosophila) 0.0260701
ZNF638 zinc finger protein 638 0.0258203
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0258072
TRIP12 thyroid hormone receptor interactor 12 0.025717
NOTCH2 notch 2 0.0256284
UBAP2L ubiquitin associated protein 2-like 0.0254608
MBNL1 muscleblind-like splicing regulator 1 0.0254316
MYH9 myosin, heavy chain 9, non-muscle 0.0252567
ATP11A ATPase, class VI, type 11A 0.0252519
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0251234
ZCCHC7 zinc finger, CCHC domain containing 7 0.0247107
UBN2 ubinuclein 2 0.0246248
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0244329
WDR43 WD repeat domain 43 0.0243964
ARB2A ARB2 cotranscriptional regulator A 0.024298
MACF1 microtubule-actin crosslinking factor 1 0.0241869
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0239499

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.182774
AKAP12 A kinase (PRKA) anchor protein 12 -0.149507
RPS21 ribosomal protein S21 -0.0943497
TMSB10 thymosin beta 10 -0.0569279
TPT1 tumor protein, translationally-controlled 1 -0.0556795
RPL35A ribosomal protein L35a -0.0547195
MYL12B myosin, light chain 12B, regulatory -0.0481304
HLA-B major histocompatibility complex, class I, B -0.0456555
OSMR oncostatin M receptor -0.0456091
RPL26 ribosomal protein L26 -0.0413694
PTMA prothymosin, alpha -0.040373
RPL8 ribosomal protein L8 -0.0398592
YBX3 Y box binding protein 3 -0.0384011
ACTG1 actin gamma 1 -0.0371454
RPL37 ribosomal protein L37 -0.0346476
RPS27A ribosomal protein S27a -0.0344826
S100A10 S100 calcium binding protein A10 -0.0341438
TM4SF1 transmembrane 4 L six family member 1 -0.0336236
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0335877
RPLP1 ribosomal protein, large, P1 -0.0334811
RPL38 ribosomal protein L38 -0.0328941
RPS15 ribosomal protein S15 -0.0328182
EIF1 eukaryotic translation initiation factor 1 -0.0313926
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0308333
CAVIN1 caveolae associated protein 1 -0.0299268
RPLP0 ribosomal protein, large, P0 -0.0294701
BZW1 basic leucine zipper and W2 domains 1 -0.0286969
LOC102724023 ES1 protein homolog, mitochondrial -0.0286429
RPL34 ribosomal protein L34 -0.0277291
RPS8 ribosomal protein S8 -0.0270118
RPL37A ribosomal protein L37a -0.0268957
WNT2B wingless-type MMTV integration site family, member 2B -0.0268805
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0260441
ANKRD12 ankyrin repeat domain 12 -0.0256537
TPM2 tropomyosin 2 (beta) -0.0249087
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0243312
RPS29 ribosomal protein S29 -0.0234363
SEPTIN7 septin 7 -0.0226801
RPLP2 ribosomal protein, large, P2 -0.0226186
MT2A metallothionein 2A -0.0222644
STC1 stanniocalcin 1 -0.021959
MT1X metallothionein 1X -0.0218592
RPS23 ribosomal protein S23 -0.0210112
RPS10 ribosomal protein S10 -0.0207461
RPL11 ribosomal protein L11 -0.0203879
RPL35 ribosomal protein L35 -0.0202404
RPL36 ribosomal protein L36 -0.0201029
UBC ubiquitin C -0.0200992
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0197262
RPS13 ribosomal protein S13 -0.0196518
RPL30 ribosomal protein L30 -0.0187454
TMEM87A transmembrane protein 87A -0.0186402
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0185612
AHCYL1 adenosylhomocysteinase-like 1 -0.0184544
CBX3 chromobox homolog 3 -0.0184379
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0182383
PPIG peptidylprolyl isomerase G (cyclophilin G) -0.0181574
RTN4 reticulon 4 -0.0179777
KLF6 Kruppel-like factor 6 -0.0179446
H3-3B H3.3 histone B -0.017864
EIF5B eukaryotic translation initiation factor 5B -0.0172708
RPL27A ribosomal protein L27a -0.01724
PFN1 profilin 1 -0.0171979
PABPN1 poly(A) binding protein, nuclear 1 -0.0168678
S100A9 S100 calcium binding protein A9 -0.016755
RPL9 ribosomal protein L9 -0.0166644
IFI6 interferon, alpha-inducible protein 6 -0.0166165
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0165259
RPS4X ribosomal protein S4, X-linked -0.0165211
RBBP6 retinoblastoma binding protein 6 -0.0161607
KHSRP KH-type splicing regulatory protein -0.015979
IGF2 insulin-like growth factor 2 -0.0158092
GOLGA4 golgin A4 -0.0157283
IER3 immediate early response 3 -0.0157116
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0156959
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0155953
SSB Sjogren syndrome antigen B (autoantigen La) -0.0154776
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0154216
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0152669
SRP72 signal recognition particle 72kDa -0.0152438
THOC2 THO complex 2 -0.0151466
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) -0.0149759
RPS24 ribosomal protein S24 -0.0148504
CD2AP CD2-associated protein -0.0148108
RBM25 RNA binding motif protein 25 -0.014806
NACA nascent polypeptide-associated complex alpha subunit -0.0147107
FAM162A family with sequence similarity 162, member A -0.014677
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0146373
CSNK1E casein kinase 1, epsilon -0.0145902
RPL12 ribosomal protein L12 -0.0144934
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0144541
ADRM1 adhesion regulating molecule 1 -0.0144448
VCL vinculin -0.0144336
PRPF38B pre-mRNA processing factor 38B -0.0143052
RPL36A ribosomal protein L36a -0.0142682
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0142376
RAN RAN, member RAS oncogene family -0.0141552
TRIM56 tripartite motif containing 56 -0.0140617
RSL1D1 ribosomal L1 domain containing 1 -0.0140574
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0138081