Sivelestat (sodium tetrahydrate)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.055766
LPP LIM domain containing preferred translocation partner in lipoma 0.0537624
GRB10 growth factor receptor-bound protein 10 0.0520317
SAMD4A sterile alpha motif domain containing 4A 0.045631
TRIO trio Rho guanine nucleotide exchange factor 0.0407307
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0377287
LIMCH1 LIM and calponin homology domains 1 0.0357505
EXT1 exostosin glycosyltransferase 1 0.0305391
MYH9 myosin, heavy chain 9, non-muscle 0.0286676
CANX calnexin 0.0272222
LMO7 LIM domain 7 0.0265372
ASPH aspartate beta-hydroxylase 0.0261114
PDLIM5 PDZ and LIM domain 5 0.0249403
PTK2 protein tyrosine kinase 2 0.0221644
MYO6 myosin VI 0.0218925
AHNAK AHNAK nucleoprotein 0.0214834
ZSWIM6 zinc finger, SWIM-type containing 6 0.0211633
EFNA5 ephrin-A5 0.0198855
MACF1 microtubule-actin crosslinking factor 1 0.0188168
CTBP2 C-terminal binding protein 2 0.0185691
DSPP dentin sialophosphoprotein 0.0185583
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0175675
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0170102
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0165043
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.016483
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.016469
RAI14 retinoic acid induced 14 0.0164347
RNF213 ring finger protein 213 0.0161075
FLNB filamin B, beta 0.0160948
FAM13A family with sequence similarity 13, member A 0.0160288
COPA coatomer protein complex, subunit alpha 0.0157827
ZFAND3 zinc finger, AN1-type domain 3 0.0157695
MSI2 musashi RNA-binding protein 2 0.0156291
NAV2 neuron navigator 2 0.0155956
RCOR1 REST corepressor 1 0.01555
AKAP13 A kinase (PRKA) anchor protein 13 0.0154725
BZW1 basic leucine zipper and W2 domains 1 0.0154471
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0152023
FNIP1 folliculin interacting protein 1 0.0150505
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0150472
VCL vinculin 0.0150163
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0147911
CTNND1 catenin (cadherin-associated protein), delta 1 0.0147169
SEC23A Sec23 homolog A (S. cerevisiae) 0.0145972
APP amyloid beta (A4) precursor protein 0.0145066
PLEC plectin 0.0144644
PGBD5 piggyBac transposable element derived 5 0.0144147
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0143206
PICALM phosphatidylinositol binding clathrin assembly protein 0.0141764
ERBIN erbb2 interacting protein 0.0139037
STRN3 striatin, calmodulin binding protein 3 0.013894
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0134477
FBXO32 F-box protein 32 0.0131628
CDC73 cell division cycle 73 0.0130818
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0129261
KMT2C lysine (K)-specific methyltransferase 2C 0.0129205
USP9X ubiquitin specific peptidase 9, X-linked 0.0127934
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0127897
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0126517
MCU mitochondrial calcium uniporter 0.0126351
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0126203
IQGAP1 IQ motif containing GTPase activating protein 1 0.0124961
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0124667
MAML2 mastermind-like 2 (Drosophila) 0.0120735
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0120412
OGA O-GlcNAcase 0.0120348
ARHGAP20 Rho GTPase activating protein 20 0.0119928
GOLGB1 golgin B1 0.0119733
SEC31A SEC31 homolog A (S. cerevisiae) 0.0119648
RBM39 RNA binding motif protein 39 0.0119303
CD2AP CD2-associated protein 0.0118292
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0117998
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0117769
KDM3A lysine (K)-specific demethylase 3A 0.0117322
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0117111
KDM6A lysine (K)-specific demethylase 6A 0.0116288
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0113973
DST dystonin 0.0113911
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0112752
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0112006
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0111123
ZNF148 zinc finger protein 148 0.0110903
AHNAK2 AHNAK nucleoprotein 2 0.0110674
ANKRD17 ankyrin repeat domain 17 0.0110564
CD109 CD109 molecule 0.010916
FBXO34 F-box protein 34 0.0108634
SPAG9 sperm associated antigen 9 0.0108411
ATP11A ATPase, class VI, type 11A 0.0108133
TSC22D2 TSC22 domain family, member 2 0.0108101
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0107443
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0106719
TPM3 tropomyosin 3 0.0106546
BIRC6 baculoviral IAP repeat containing 6 0.0105712
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0105466
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0105291
RASA2 RAS p21 protein activator 2 0.010499
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0104722
RASAL2 RAS protein activator like 2 0.0104431
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0103916
GPBP1 GC-rich promoter binding protein 1 0.0103875

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.243071
FTL ferritin, light polypeptide -0.178812
NDRG1 N-myc downstream regulated 1 -0.0954465
TMSB10 thymosin beta 10 -0.0917243
POTEF POTE ankyrin domain family, member F -0.0863242
ACTG1 actin gamma 1 -0.083995
MT2A metallothionein 2A -0.0720619
HMGA1 high mobility group AT-hook 1 -0.0677187
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0535666
RPS19 ribosomal protein S19 -0.0513451
RPLP1 ribosomal protein, large, P1 -0.0512826
EIF1 eukaryotic translation initiation factor 1 -0.0511072
PTMA prothymosin, alpha -0.0457614
RPL8 ribosomal protein L8 -0.0449995
RPL35A ribosomal protein L35a -0.0434148
RPLP2 ribosomal protein, large, P2 -0.0424244
S100A6 S100 calcium binding protein A6 -0.0419971
RPS6 ribosomal protein S6 -0.040704
RPL34 ribosomal protein L34 -0.0404086
RPS23 ribosomal protein S23 -0.0401884
IFI27 interferon, alpha-inducible protein 27 -0.0378346
S100A10 S100 calcium binding protein A10 -0.0359018
RPS8 ribosomal protein S8 -0.035478
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0351576
RPS13 ribosomal protein S13 -0.0340038
TPT1 tumor protein, translationally-controlled 1 -0.0330942
RPS29 ribosomal protein S29 -0.0328399
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0314652
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0311117
RPL32 ribosomal protein L32 -0.0307691
UBC ubiquitin C -0.0298334
RPL23 ribosomal protein L23 -0.0290377
RPS3 ribosomal protein S3 -0.027458
RPL9 ribosomal protein L9 -0.0270511
RPL12 ribosomal protein L12 -0.0266212
S100A9 S100 calcium binding protein A9 -0.0261313
IFITM3 interferon induced transmembrane protein 3 -0.0258579
RPL28 ribosomal protein L28 -0.0255274
G0S2 G0/G1 switch 2 -0.0252577
RPS14 ribosomal protein S14 -0.0250246
RPL19 ribosomal protein L19 -0.0247212
ISG15 ISG15 ubiquitin-like modifier -0.0244572
RPS27 ribosomal protein S27 -0.0244366
RPL11 ribosomal protein L11 -0.0234616
SLC38A1 solute carrier family 38, member 1 -0.0233585
RACK1 receptor for activated C kinase 1 -0.0233314
RPL37A ribosomal protein L37a -0.0232025
RPL37 ribosomal protein L37 -0.022543
IFITM1 interferon induced transmembrane protein 1 -0.0225358
RPL30 ribosomal protein L30 -0.0225276
FTH1 ferritin, heavy polypeptide 1 -0.0224045
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0217964
RPLP0 ribosomal protein, large, P0 -0.0217175
LOC112694756 uncharaterized LOC112694756 -0.0216524
TUBB4B tubulin, beta 4B class IVb -0.0213698
RPS25 ribosomal protein S25 -0.0211803
RPL36 ribosomal protein L36 -0.020826
RPL5 ribosomal protein L5 -0.0206811
RPS21 ribosomal protein S21 -0.0204905
RPS5 ribosomal protein S5 -0.0204676
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0203584
RPL31 ribosomal protein L31 -0.0203145
CSTB cystatin B (stefin B) -0.0201227
RPL15 ribosomal protein L15 -0.0200545
RPS15 ribosomal protein S15 -0.0197622
RPS10 ribosomal protein S10 -0.0196444
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0189548
UPP1 uridine phosphorylase 1 -0.0184854
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0182071
LAMB3 laminin, beta 3 -0.0180696
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0179235
RPS11 ribosomal protein S11 -0.0178405
RPS16 ribosomal protein S16 -0.0177014
BHLHE40 basic helix-loop-helix family, member e40 -0.0176418
RBM25 RNA binding motif protein 25 -0.0176256
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0175999
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0174016
B2M beta-2-microglobulin -0.0172393
CCNI cyclin I -0.0171756
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0167204
CLDN4 claudin 4 -0.0165973
FOSL1 FOS-like antigen 1 -0.0165061
RPS12 ribosomal protein S12 -0.016394
S100A11 S100 calcium binding protein A11 -0.0163937
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0163689
RPL35 ribosomal protein L35 -0.016363
TACSTD2 tumor-associated calcium signal transducer 2 -0.0162538
LY6E lymphocyte antigen 6 complex, locus E -0.0162227
ANKRD37 ankyrin repeat domain 37 -0.0159208
RPS27A ribosomal protein S27a -0.015813
RPL7A ribosomal protein L7a -0.0157623
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0155892
HLA-B major histocompatibility complex, class I, B -0.0155532
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0155108
GPX4 glutathione peroxidase 4 -0.0153524
RPS17 ribosomal protein S17 -0.0150004
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0149254
DSTN destrin (actin depolymerizing factor) -0.0148788
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0148652
IFI6 interferon, alpha-inducible protein 6 -0.0147498