| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sivelestat (sodium tetrahydrate) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ASPH | aspartate beta-hydroxylase | 0.124602 |
| EFNA5 | ephrin-A5 | 0.11491 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.100776 |
| MCL1 | myeloid cell leukemia 1 | 0.0965783 |
| DST | dystonin | 0.0948382 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0883707 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0824524 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0744503 |
| PDE10A | phosphodiesterase 10A | 0.0711654 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0692015 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0653247 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0594736 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0593658 |
| VCL | vinculin | 0.0591939 |
| PCBP2 | poly(rC) binding protein 2 | 0.0581543 |
| COL5A2 | collagen, type V, alpha 2 | 0.0579758 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0567901 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0560589 |
| INTS6 | integrator complex subunit 6 | 0.0534032 |
| PKM | pyruvate kinase, muscle | 0.0525145 |
| GRAMD1B | GRAM domain containing 1B | 0.0512003 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0476965 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0464465 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0454153 |
| PTEN | phosphatase and tensin homolog | 0.0452668 |
| GPC6 | glypican 6 | 0.0440893 |
| NRCAM | neuronal cell adhesion molecule | 0.0440338 |
| KYNU | kynureninase | 0.0439372 |
| RPS23 | ribosomal protein S23 | 0.0430054 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0428565 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0417018 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0414324 |
| RPL31 | ribosomal protein L31 | 0.0413734 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0410393 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0397826 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0394522 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0389542 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.038038 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0372666 |
| TXNRD1 | thioredoxin reductase 1 | 0.0364999 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0361137 |
| LDHA | lactate dehydrogenase A | 0.0360377 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0357313 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0352006 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0345263 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0344302 |
| NEK7 | NIMA-related kinase 7 | 0.0343251 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0338113 |
| MYOF | myoferlin | 0.033786 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | 0.0336201 |
| SETX | senataxin | 0.0332918 |
| RBM39 | RNA binding motif protein 39 | 0.0331448 |
| CTSC | cathepsin C | 0.033134 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0322865 |
| RAD51B | RAD51 paralog B | 0.0315125 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0314402 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0313812 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0308565 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0308455 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0293421 |
| ATXN1 | ataxin 1 | 0.0292458 |
| RCOR1 | REST corepressor 1 | 0.0290332 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0289313 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0288714 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0287246 |
| SCFD1 | sec1 family domain containing 1 | 0.0287129 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0286507 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0283612 |
| ANKRD11 | ankyrin repeat domain 11 | 0.028278 |
| EXT1 | exostosin glycosyltransferase 1 | 0.028031 |
| MSN | moesin | 0.0280206 |
| MED13L | mediator complex subunit 13-like | 0.0279472 |
| RPS13 | ribosomal protein S13 | 0.027718 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0275642 |
| PTK2 | protein tyrosine kinase 2 | 0.0275372 |
| USP34 | ubiquitin specific peptidase 34 | 0.0274807 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0274461 |
| COL4A6 | collagen, type IV, alpha 6 | 0.0272133 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.02718 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0270988 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0270236 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0267646 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0267417 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0266033 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0263723 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0262083 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0261881 |
| VMP1 | vacuole membrane protein 1 | 0.0260139 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0258115 |
| ENO1 | enolase 1, (alpha) | 0.0255688 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0255442 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0253695 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0253495 |
| HERPUD1 | homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 | 0.0253348 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0250509 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0250186 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.02501 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0249303 |
| NBAS | neuroblastoma amplified sequence | 0.0247993 |
| RTN4 | reticulon 4 | 0.0246068 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.298377 |
| FN1 | fibronectin 1 | -0.173628 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.123486 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0950198 |
| VIM | vimentin | -0.0695603 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.066784 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.066359 |
| TMSB10 | thymosin beta 10 | -0.0556265 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0528311 |
| RPL12 | ribosomal protein L12 | -0.0506001 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0479552 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0479257 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0468951 |
| STC1 | stanniocalcin 1 | -0.0458402 |
| INHBA | inhibin, beta A | -0.0453532 |
| RPL26 | ribosomal protein L26 | -0.041288 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0379943 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0376088 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0374273 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0361235 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.035355 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0353248 |
| RPLP1 | ribosomal protein, large, P1 | -0.0352876 |
| RPLP0 | ribosomal protein, large, P0 | -0.034545 |
| S100A6 | S100 calcium binding protein A6 | -0.0344264 |
| TMSB4X | thymosin beta 4, X-linked | -0.0335136 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0334861 |
| SLC16A6 | solute carrier family 16, member 6 | -0.0331183 |
| CCDC68 | coiled-coil domain containing 68 | -0.0322631 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0317029 |
| IL6 | interleukin 6 | -0.031361 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0311098 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0301182 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0286367 |
| CTSL | cathepsin L | -0.0280519 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0270174 |
| RPS3 | ribosomal protein S3 | -0.0265508 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.026507 |
| IER3 | immediate early response 3 | -0.0259288 |
| ESM1 | endothelial cell-specific molecule 1 | -0.0252571 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0249761 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0248772 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0242498 |
| PRSS23 | protease, serine, 23 | -0.0241492 |
| FOXC1 | forkhead box C1 | -0.0233267 |
| ZBTB38 | zinc finger and BTB domain containing 38 | -0.0230763 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0230677 |
| NTN4 | netrin 4 | -0.0229613 |
| PCDH9 | protocadherin 9 | -0.0226549 |
| MT2A | metallothionein 2A | -0.0225711 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0224513 |
| RPL18 | ribosomal protein L18 | -0.021334 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0210938 |
| CLMP | CXADR-like membrane protein | -0.0210718 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0209698 |
| RGS2 | regulator of G-protein signaling 2 | -0.020612 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0201332 |
| B2M | beta-2-microglobulin | -0.019997 |
| YBX3 | Y box binding protein 3 | -0.0199346 |
| RPS12 | ribosomal protein S12 | -0.0199114 |
| PTMA | prothymosin, alpha | -0.0198577 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0197722 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0192756 |
| SET | SET nuclear proto-oncogene | -0.0187131 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0186622 |
| CBX3 | chromobox homolog 3 | -0.0184573 |
| RAB31 | RAB31, member RAS oncogene family | -0.0183858 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0183808 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0183341 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0182619 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.0179586 |
| HLA-B | major histocompatibility complex, class I, B | -0.0177756 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0175477 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0170574 |
| CRLF2 | cytokine receptor-like factor 2 | -0.0169494 |
| CHL1 | cell adhesion molecule L1-like | -0.0165922 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0162288 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0161928 |
| ABLIM1 | actin binding LIM protein 1 | -0.0160693 |
| RPL36A | ribosomal protein L36a | -0.0158347 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0158161 |
| RPL32 | ribosomal protein L32 | -0.0156803 |
| OSMR | oncostatin M receptor | -0.0153749 |
| OXSR1 | oxidative stress responsive 1 | -0.0153221 |
| RACK1 | receptor for activated C kinase 1 | -0.0152682 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.0150959 |
| RAI14 | retinoic acid induced 14 | -0.0150676 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0149674 |
| LSAMP | limbic system-associated membrane protein | -0.0146742 |
| BMERB1 | bMERB domain containing 1 | -0.0145882 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0145683 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0144809 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0144286 |
| RPL30 | ribosomal protein L30 | -0.0143978 |
| DUSP4 | dual specificity phosphatase 4 | -0.0143395 |
| CXCL1 | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | -0.0142977 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0142045 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0141704 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0141645 |
| QPCT | glutaminyl-peptide cyclotransferase | -0.0141092 |
