| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sivelestat (sodium tetrahydrate) perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VMP1 | vacuole membrane protein 1 | 0.0896861 |
| PDE10A | phosphodiesterase 10A | 0.0864931 |
| FN1 | fibronectin 1 | 0.0863848 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0799585 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0797742 |
| SBF2 | SET binding factor 2 | 0.0786517 |
| NAV2 | neuron navigator 2 | 0.0767823 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0665227 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.066384 |
| HELZ | helicase with zinc finger | 0.0637493 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0608543 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0604808 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0592943 |
| SMYD3 | SET and MYND domain containing 3 | 0.0591938 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0587153 |
| MATR3 | matrin 3 | 0.0575536 |
| NCOA3 | nuclear receptor coactivator 3 | 0.0569951 |
| DST | dystonin | 0.0554573 |
| NCOR1 | nuclear receptor corepressor 1 | 0.0553975 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0551978 |
| ENO1 | enolase 1, (alpha) | 0.054727 |
| INHBA | inhibin, beta A | 0.0527774 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0527613 |
| MMP1 | matrix metallopeptidase 1 | 0.0527483 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0524907 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0495286 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0491291 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0481028 |
| MED13L | mediator complex subunit 13-like | 0.0477409 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0474085 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0469753 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0464764 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0454597 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0450162 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.044208 |
| MAP4 | microtubule-associated protein 4 | 0.043758 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0435957 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0432107 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0429539 |
| TXNRD1 | thioredoxin reductase 1 | 0.0428912 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0424762 |
| TNPO1 | transportin 1 | 0.042103 |
| RORA | RAR-related orphan receptor A | 0.041874 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0417432 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0414191 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0409797 |
| RBM39 | RNA binding motif protein 39 | 0.0401421 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0400387 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0396197 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0393316 |
| PKM | pyruvate kinase, muscle | 0.0389558 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0386887 |
| FMNL2 | formin-like 2 | 0.0378993 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0378661 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0373508 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0372901 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0370924 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0361948 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0360908 |
| APP | amyloid beta (A4) precursor protein | 0.03566 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0353908 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.035268 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0352214 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0349615 |
| B2M | beta-2-microglobulin | 0.0347117 |
| BBX | bobby sox homolog (Drosophila) | 0.0345961 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0342836 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0341843 |
| PHF14 | PHD finger protein 14 | 0.0332863 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0329122 |
| EHBP1 | EH domain binding protein 1 | 0.0327429 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0324787 |
| ZNF609 | zinc finger protein 609 | 0.0323133 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0322924 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0314316 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0309898 |
| ASPH | aspartate beta-hydroxylase | 0.0297979 |
| AHNAK | AHNAK nucleoprotein | 0.0293486 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | 0.0289887 |
| RPL13A | ribosomal protein L13a | 0.0287979 |
| ADNP | activity-dependent neuroprotector homeobox | 0.0283633 |
| RASA2 | RAS p21 protein activator 2 | 0.0272901 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0270253 |
| CNKSR3 | CNKSR family member 3 | 0.0260608 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0260249 |
| HLA-A | major histocompatibility complex, class I, A | 0.0259901 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0258538 |
| FAT1 | FAT atypical cadherin 1 | 0.025576 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0254405 |
| HDAC4 | histone deacetylase 4 | 0.0248237 |
| USP34 | ubiquitin specific peptidase 34 | 0.024718 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0246487 |
| GPC6 | glypican 6 | 0.0237723 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.022804 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0227285 |
| ZNF292 | zinc finger protein 292 | 0.0225214 |
| SMC5 | structural maintenance of chromosomes 5 | 0.0217572 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | 0.0211368 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | 0.0210874 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0209493 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.290386 |
| MYO1E | myosin IE | -0.107199 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.103817 |
| TMSB10 | thymosin beta 10 | -0.101794 |
| LAMA4 | laminin, alpha 4 | -0.0848294 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0843655 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0818366 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0725735 |
| RPS13 | ribosomal protein S13 | -0.0723498 |
| RPL15 | ribosomal protein L15 | -0.0701788 |
| HMGA2 | high mobility group AT-hook 2 | -0.0673882 |
| VIM | vimentin | -0.0664945 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0631634 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0627871 |
| RPS19 | ribosomal protein S19 | -0.0605095 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0593637 |
| FHIT | fragile histidine triad | -0.0577014 |
| AREG | amphiregulin | -0.0569996 |
| LMO7 | LIM domain 7 | -0.0538102 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0533725 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0528227 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0523539 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0520459 |
| SLTM | SAFB-like, transcription modulator | -0.0517469 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0486494 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0484654 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0477591 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0473903 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0463572 |
| RPL34 | ribosomal protein L34 | -0.0463512 |
| LAMB3 | laminin, beta 3 | -0.0462335 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0457823 |
| SNX25 | sorting nexin 25 | -0.0454061 |
| HDAC9 | histone deacetylase 9 | -0.0442464 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0437669 |
| CDK13 | cyclin-dependent kinase 13 | -0.0434219 |
| MPRIP | myosin phosphatase Rho interacting protein | -0.0430407 |
| RPL12 | ribosomal protein L12 | -0.0428145 |
| CD44 | CD44 molecule (Indian blood group) | -0.0419547 |
| EGR1 | early growth response 1 | -0.0410589 |
| RPL23 | ribosomal protein L23 | -0.0405767 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0400687 |
| HDLBP | high density lipoprotein binding protein | -0.0391591 |
| VCL | vinculin | -0.0386557 |
| COL5A1 | collagen, type V, alpha 1 | -0.0386305 |
| RPS4X | ribosomal protein S4, X-linked | -0.0378546 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.037272 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0372666 |
| FNIP1 | folliculin interacting protein 1 | -0.0369145 |
| PRKCA | protein kinase C, alpha | -0.0366615 |
| PTMA | prothymosin, alpha | -0.0366117 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0358191 |
| CDH13 | cadherin 13 | -0.0351716 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0351146 |
| RPS3 | ribosomal protein S3 | -0.0349763 |
| PARD3 | par-3 family cell polarity regulator | -0.0343258 |
| RPL30 | ribosomal protein L30 | -0.0339581 |
| RPS25 | ribosomal protein S25 | -0.0323308 |
| RPS8 | ribosomal protein S8 | -0.0323208 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0320635 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0314841 |
| OLA1 | Obg-like ATPase 1 | -0.0306376 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0298454 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0292582 |
| RPS24 | ribosomal protein S24 | -0.0292054 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0290189 |
| GOLGA4 | golgin A4 | -0.0285456 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0279722 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0279349 |
| RCOR1 | REST corepressor 1 | -0.0278846 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0278011 |
| PTEN | phosphatase and tensin homolog | -0.0271489 |
| FRMD5 | FERM domain containing 5 | -0.0271479 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0271438 |
| S100A10 | S100 calcium binding protein A10 | -0.0270194 |
| TPM4 | tropomyosin 4 | -0.0269115 |
| S100A6 | S100 calcium binding protein A6 | -0.0267049 |
| ATXN1 | ataxin 1 | -0.0266376 |
| CANX | calnexin | -0.0263623 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0261838 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.026097 |
| TJP1 | tight junction protein 1 | -0.02569 |
| RPS6 | ribosomal protein S6 | -0.02494 |
| YAP1 | Yes-associated protein 1 | -0.0248323 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0242926 |
| SPAG9 | sperm associated antigen 9 | -0.0236544 |
| RPL32 | ribosomal protein L32 | -0.0233919 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0233471 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0230887 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0230473 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0229822 |
| FLNB | filamin B, beta | -0.0229779 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0226701 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0224056 |
| RRBP1 | ribosome binding protein 1 | -0.0222736 |
| RPL37 | ribosomal protein L37 | -0.0221052 |
| MYOF | myoferlin | -0.0220647 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0218706 |
| NDRG1 | N-myc downstream regulated 1 | -0.02108 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0210058 |
