Sivelestat (sodium tetrahydrate)_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in NCI-H661 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZFAND3 zinc finger, AN1-type domain 3 0.150593
PEG10 paternally expressed 10 0.12926
TSC22D2 TSC22 domain family, member 2 0.114532
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.101853
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0779252
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0777838
PLPP1 phospholipid phosphatase 1 0.0741872
PDE4D phosphodiesterase 4D, cAMP-specific 0.0663852
RLF rearranged L-myc fusion 0.0634995
RBM39 RNA binding motif protein 39 0.062959
MRPS30 mitochondrial ribosomal protein S30 0.0625881
KDM3A lysine (K)-specific demethylase 3A 0.06197
PTK2 protein tyrosine kinase 2 0.0584792
IGF1R insulin-like growth factor 1 receptor 0.0565352
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0560533
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.0557465
FAM171B family with sequence similarity 171, member B 0.0557414
ADAM9 ADAM metallopeptidase domain 9 0.0545628
RAD21 RAD21 homolog (S. pombe) 0.0545467
COL5A2 collagen, type V, alpha 2 0.0545191
MTF2 metal response element binding transcription factor 2 0.0541066
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0539488
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0531736
ZEB2 zinc finger E-box binding homeobox 2 0.0531081
ANK2 ankyrin 2, neuronal 0.0529795
DSCAM Down syndrome cell adhesion molecule 0.0526988
FNDC3B fibronectin type III domain containing 3B 0.0523622
ZNF292 zinc finger protein 292 0.0522966
OLA1 Obg-like ATPase 1 0.0514282
PUM1 pumilio RNA-binding family member 1 0.0505834
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0500441
PGK1 phosphoglycerate kinase 1 0.0499019
KMT2C lysine (K)-specific methyltransferase 2C 0.0495321
RTN4 reticulon 4 0.0488838
CXADR coxsackie virus and adenovirus receptor 0.0486121
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0485474
JMJD1C jumonji domain containing 1C 0.0482369
THBS1 thrombospondin 1 0.0481233
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0481065
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0454067
EVI5 ecotropic viral integration site 5 0.045103
COL3A1 collagen, type III, alpha 1 0.0446233
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0442095
ACTN4 actinin, alpha 4 0.0441578
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0441243
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0430537
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0428739
FOXP2 forkhead box P2 0.0427238
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0423111
SRPK2 SRSF protein kinase 2 0.0421879
SRP72 signal recognition particle 72kDa 0.0420917
STAG2 stromal antigen 2 0.041984
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0412878
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0412477
ANKRD11 ankyrin repeat domain 11 0.0410599
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0405451
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0403148
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0401887
MATR3 matrin 3 0.0401181
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 0.0394669
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0393975
ANKRD33B ankyrin repeat domain 33B 0.0375305
TENM3 teneurin transmembrane protein 3 0.0374777
ACBD3 acyl-CoA binding domain containing 3 0.0373772
TRPS1 trichorhinophalangeal syndrome I 0.0373029
SETD5 SET domain containing 5 0.0366494
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0365608
HMGB2 high mobility group box 2 0.0365591
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0364321
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.03628
BTBD3 BTB (POZ) domain containing 3 0.0362591
KAT6A K(lysine) acetyltransferase 6A 0.0360963
RYBP RING1 and YY1 binding protein 0.035951
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.035843
PDGFC platelet derived growth factor C 0.0357973
USP9X ubiquitin specific peptidase 9, X-linked 0.0356895
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0355658
CSDE1 cold shock domain containing E1, RNA-binding 0.0353786
WSB1 WD repeat and SOCS box containing 1 0.0352147
GOLGA4 golgin A4 0.0351504
NIPBL Nipped-B homolog (Drosophila) 0.0350418
MAP4 microtubule-associated protein 4 0.0350311
NAMPT nicotinamide phosphoribosyltransferase 0.0349709
UBE2G1 ubiquitin-conjugating enzyme E2G 1 0.0348446
USP3 ubiquitin specific peptidase 3 0.0346694
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0341193
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0337551
ENAH enabled homolog (Drosophila) 0.0332754
PDIA3 protein disulfide isomerase family A, member 3 0.0332172
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0330353
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0329958
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0327959
PARD3 par-3 family cell polarity regulator 0.0327096
STRN3 striatin, calmodulin binding protein 3 0.0326857
POU2F1 POU class 2 homeobox 1 0.0323716
RBM27 RNA binding motif protein 27 0.0323386
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4 0.0323154
ZMYM2 zinc finger, MYM-type 2 0.0321574
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0321555
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0321452

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.077946
CADM2 cell adhesion molecule 2 -0.0756244
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0695588
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0589167
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0553649
PTMA prothymosin, alpha -0.0546367
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0468431
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0451093
RPS12 ribosomal protein S12 -0.0430133
SET SET nuclear proto-oncogene -0.0424138
H1-4 H1.4 linker histone, cluster member -0.0423494
CFL2 cofilin 2 (muscle) -0.0399775
ZC3H12B zinc finger CCCH-type containing 12B -0.039697
PDCD5 programmed cell death 5 -0.0387246
RPS2 ribosomal protein S2 -0.0385657
RPL37A ribosomal protein L37a -0.0352914
SNX6 sorting nexin 6 -0.0348324
DOCK5 dedicator of cytokinesis 5 -0.0330038
RPL37 ribosomal protein L37 -0.0325817
NTM neurotrimin -0.0320955
RPL7 ribosomal protein L7 -0.0309216
ADGRV1 adhesion G protein-coupled receptor V1 -0.0308551
RPL26 ribosomal protein L26 -0.0308376
AKAP12 A kinase (PRKA) anchor protein 12 -0.0299981
CCDC88A coiled-coil domain containing 88A -0.0290469
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0286163
RPLP2 ribosomal protein, large, P2 -0.0268708
RPL5 ribosomal protein L5 -0.0262533
TEX11 testis expressed 11 -0.025759
PCLO piccolo presynaptic cytomatrix protein -0.0255929
TARS1 threonyl-tRNA synthetase 1 -0.0254727
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0250897
CCDC102B coiled-coil domain containing 102B -0.025061
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit -0.0250308
H1-5 H1.5 linker histone, cluster member -0.0242254
NDUFA4 NDUFA4, mitochondrial complex associated -0.0238889
SERBP1 SERPINE1 mRNA binding protein 1 -0.0233811
CSMD3 CUB and Sushi multiple domains 3 -0.0230066
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0226272
FAM177A1 family with sequence similarity 177, member A1 -0.0225561
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0224875
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0224331
NCOR2 nuclear receptor corepressor 2 -0.0222573
CENPF centromere protein F, 350/400kDa -0.0222412
TBCA tubulin folding cofactor A -0.0220066
ARHGAP15 Rho GTPase activating protein 15 -0.0216375
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0216035
SAMD4A sterile alpha motif domain containing 4A -0.0213648
NHSL1 NHS-like 1 -0.0212152
RPS6 ribosomal protein S6 -0.0211584
SSRP1 structure specific recognition protein 1 -0.0209037
HSPA8 heat shock 70kDa protein 8 -0.0206684
GPX4 glutathione peroxidase 4 -0.020579
FOXP1 forkhead box P1 -0.0205694
TPTE transmembrane phosphatase with tensin homology -0.0205441
FTL ferritin, light polypeptide -0.0204317
NLGN1 neuroligin 1 -0.0203675
PCDH11Y protocadherin 11 Y-linked -0.0203603
MT2A metallothionein 2A -0.0202261
GPC3 glypican 3 -0.0201114
EIF5B eukaryotic translation initiation factor 5B -0.0200342
BCCIP BRCA2 and CDKN1A interacting protein -0.0198799
TMSB10 thymosin beta 10 -0.0197551
RIMS2 regulating synaptic membrane exocytosis 2 -0.0196495
DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 -0.0194674
LDHB lactate dehydrogenase B -0.0194049
FNIP1 folliculin interacting protein 1 -0.0193539
KTN1 kinectin 1 (kinesin receptor) -0.0193136
EPS15 epidermal growth factor receptor pathway substrate 15 -0.0192555
NRDC nardilysin convertase -0.0191723
RPL12 ribosomal protein L12 -0.0191503
PA2G4 proliferation-associated 2G4, 38kDa -0.0189934
RFC3 replication factor C (activator 1) 3, 38kDa -0.0189927
EEF1G eukaryotic translation elongation factor 1 gamma -0.0188878
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0188604
HSPE1 heat shock 10kDa protein 1 -0.0188364
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -0.0187744
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) -0.0187373
KMT5B lysine methyltransferase 5B -0.0186873
PUS7 pseudouridylate synthase 7 (putative) -0.0183273
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit -0.0182078
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0180915
ADGRL2 adhesion G protein-coupled receptor L2 -0.0179197
SOAT2 sterol O-acyltransferase 2 -0.0179103
FKBP1A FK506 binding protein 1A, 12kDa -0.0177967
YBX1 Y box binding protein 1 -0.0177885
RPS29 ribosomal protein S29 -0.0176904
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0176841
FER fer (fps/fes related) tyrosine kinase -0.0176807
CKAP5 cytoskeleton associated protein 5 -0.0175266
NUP85 nucleoporin 85kDa -0.0173058
ZRANB3 zinc finger, RAN-binding domain containing 3 -0.017286
TAGLN2 transgelin 2 -0.01722
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -0.0171578
PABPN1 poly(A) binding protein, nuclear 1 -0.0171373
RRM2 ribonucleotide reductase M2 -0.0171082
MAP2K5 mitogen-activated protein kinase kinase 5 -0.0169367
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0168881
SLC38A9 solute carrier family 38, member 9 -0.0168442
KLF10 Kruppel-like factor 10 -0.0167544