Sivelestat (sodium tetrahydrate)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.143893
AKAP12 A kinase (PRKA) anchor protein 12 0.131375
VCL vinculin 0.113488
TRIO trio Rho guanine nucleotide exchange factor 0.0963971
DST dystonin 0.0908247
FNDC3B fibronectin type III domain containing 3B 0.0905668
MACF1 microtubule-actin crosslinking factor 1 0.0855076
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0845626
SDK1 sidekick cell adhesion molecule 1 0.0791106
SEPTIN9 septin 9 0.073309
SMAD3 SMAD family member 3 0.0612828
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0601688
THSD4 thrombospondin, type I, domain containing 4 0.0600728
ACTN4 actinin, alpha 4 0.059935
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0587261
ASPH aspartate beta-hydroxylase 0.0582727
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0575737
ERRFI1 ERBB receptor feedback inhibitor 1 0.057414
SLC35F3 solute carrier family 35, member F3 0.0571375
CD44 CD44 molecule (Indian blood group) 0.0568112
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0520605
JMJD1C jumonji domain containing 1C 0.0520598
AKT2 v-akt murine thymoma viral oncogene homolog 2 0.0517489
WWTR1 WW domain containing transcription regulator 1 0.0509529
AHNAK AHNAK nucleoprotein 0.050303
EGFR epidermal growth factor receptor 0.0498166
PTK2 protein tyrosine kinase 2 0.0489777
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0477364
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0475426
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0466973
RTN4 reticulon 4 0.0464954
AFAP1 actin filament associated protein 1 0.0447673
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 0.0442949
PDE10A phosphodiesterase 10A 0.0437911
MYH9 myosin, heavy chain 9, non-muscle 0.0431292
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0423005
LPP LIM domain containing preferred translocation partner in lipoma 0.0422527
MYOF myoferlin 0.0419773
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0409636
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0392162
MCL1 myeloid cell leukemia 1 0.0388987
ANKRD11 ankyrin repeat domain 11 0.0387748
RAD51B RAD51 paralog B 0.0375842
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0374648
TNS3 tensin 3 0.0371274
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0370277
ITGAV integrin, alpha V 0.0368645
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0368442
LDHA lactate dehydrogenase A 0.0366942
EXT1 exostosin glycosyltransferase 1 0.0366827
ATXN1 ataxin 1 0.0362312
CARD18 caspase recruitment domain family, member 18 0.0360388
CDK19 cyclin-dependent kinase 19 0.0347504
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.034118
MED13L mediator complex subunit 13-like 0.0339849
ANO6 anoctamin 6 0.0338497
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0334432
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0331115
IGF1R insulin-like growth factor 1 receptor 0.0325372
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0322685
TRIP12 thyroid hormone receptor interactor 12 0.0320449
MAP1B microtubule-associated protein 1B 0.0318708
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0315184
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0314045
RNF220 ring finger protein 220 0.0313617
VMP1 vacuole membrane protein 1 0.0313306
EXOC4 exocyst complex component 4 0.0311365
MEF2A myocyte enhancer factor 2A 0.0304103
SMYD3 SET and MYND domain containing 3 0.030353
PRELID2 PRELI domain containing 2 0.030236
UTRN utrophin 0.0301731
RASAL2 RAS protein activator like 2 0.0299435
EFNA5 ephrin-A5 0.0298522
RABGAP1L RAB GTPase activating protein 1-like 0.0296396
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0293193
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0290958
EHBP1 EH domain binding protein 1 0.0286691
APLP2 amyloid beta (A4) precursor-like protein 2 0.0285826
SBF2 SET binding factor 2 0.0283939
MYO10 myosin X 0.0283339
TTC28 tetratricopeptide repeat domain 28 0.0282074
YAP1 Yes-associated protein 1 0.0281139
ADGRG6 adhesion G protein-coupled receptor G6 0.0280763
SLC38A2 solute carrier family 38, member 2 0.0275606
AKAP13 A kinase (PRKA) anchor protein 13 0.0272377
APP amyloid beta (A4) precursor protein 0.0270266
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0267804
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0267563
ARHGAP32 Rho GTPase activating protein 32 0.0265143
NHSL1 NHS-like 1 0.0262753
NF1 neurofibromin 1 0.0262456
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0255415
ZNF644 zinc finger protein 644 0.025343
SPRED2 sprouty-related, EVH1 domain containing 2 0.025338
MSN moesin 0.0251774
NAV2 neuron navigator 2 0.0248858
IL6ST interleukin 6 signal transducer 0.0247269
DOCK1 dedicator of cytokinesis 1 0.0246832
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0243307
CD109 CD109 molecule 0.024173

decreased expression

Symbol Name Standardized Value
RPS16 ribosomal protein S16 -0.269771
VIM vimentin -0.206344
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.159523
PTMA prothymosin, alpha -0.0938868
FBL fibrillarin -0.0883546
S100A6 S100 calcium binding protein A6 -0.0612487
RPL35A ribosomal protein L35a -0.0504452
RPLP1 ribosomal protein, large, P1 -0.0470002
FTL ferritin, light polypeptide -0.0454562
ACTG1 actin gamma 1 -0.0454175
RPLP0 ribosomal protein, large, P0 -0.0448669
TMSB10 thymosin beta 10 -0.0431492
RPLP2 ribosomal protein, large, P2 -0.0378388
RPS8 ribosomal protein S8 -0.0365952
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0337729
EIF1 eukaryotic translation initiation factor 1 -0.0329008
RPS5 ribosomal protein S5 -0.0287617
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0263588
YBX1 Y box binding protein 1 -0.026214
MT2A metallothionein 2A -0.0260363
RPL12 ribosomal protein L12 -0.0260184
RPS25 ribosomal protein S25 -0.0259293
RPS12 ribosomal protein S12 -0.0254913
TPT1 tumor protein, translationally-controlled 1 -0.0254586
RPL26 ribosomal protein L26 -0.0244685
RPL28 ribosomal protein L28 -0.0239142
RPS24 ribosomal protein S24 -0.0236185
RPS3 ribosomal protein S3 -0.0232846
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0228018
RPL37A ribosomal protein L37a -0.0225711
S100A10 S100 calcium binding protein A10 -0.0224596
RACK1 receptor for activated C kinase 1 -0.0223447
RPL11 ribosomal protein L11 -0.021973
RPL8 ribosomal protein L8 -0.021682
RPS6 ribosomal protein S6 -0.0213789
WDR45B WD repeat domain 45B -0.0210574
RPS14 ribosomal protein S14 -0.0207281
RPS27A ribosomal protein S27a -0.0203071
NAP1L1 nucleosome assembly protein 1-like 1 -0.0202432
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0199924
RPL27A ribosomal protein L27a -0.0197661
RPL34 ribosomal protein L34 -0.0188114
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -0.018706
RPS2 ribosomal protein S2 -0.0182798
DDIT4 DNA-damage-inducible transcript 4 -0.0181782
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0181389
GOLGA4 golgin A4 -0.0180052
RPS21 ribosomal protein S21 -0.0179218
RPL39 ribosomal protein L39 -0.0176852
RPL36A ribosomal protein L36a -0.0176088
RPS13 ribosomal protein S13 -0.0175507
ADM adrenomedullin -0.017548
RPS19 ribosomal protein S19 -0.0171807
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0169529
NOP58 NOP58 ribonucleoprotein -0.0168422
RPL37 ribosomal protein L37 -0.0160717
RSL1D1 ribosomal L1 domain containing 1 -0.01606
RPL30 ribosomal protein L30 -0.0157804
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0157688
CAVIN1 caveolae associated protein 1 -0.0157088
GNAS GNAS complex locus -0.0154154
SEPTIN7 septin 7 -0.0153775
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0152111
RPS17 ribosomal protein S17 -0.0144102
LOC102724023 ES1 protein homolog, mitochondrial -0.0142034
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.0141886
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0141742
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) -0.0140239
RPL36 ribosomal protein L36 -0.0139875
RPL7 ribosomal protein L7 -0.0139506
IFITM3 interferon induced transmembrane protein 3 -0.0138418
RPL35 ribosomal protein L35 -0.0138326
NACA nascent polypeptide-associated complex alpha subunit -0.0137159
FTH1 ferritin, heavy polypeptide 1 -0.0137072
EIF3K eukaryotic translation initiation factor 3, subunit K -0.0135248
RPL9 ribosomal protein L9 -0.0133711
RLF rearranged L-myc fusion -0.0132018
ASTN2 astrotactin 2 -0.0131151
RPS28 ribosomal protein S28 -0.0130343
RPS20 ribosomal protein S20 -0.0130119
RPL23 ribosomal protein L23 -0.0129999
KPNB1 karyopherin (importin) beta 1 -0.0127629
HMGA1 high mobility group AT-hook 1 -0.0127488
S100A9 S100 calcium binding protein A9 -0.0126521
SUCO SUN domain containing ossification factor -0.0125773
RPL32 ribosomal protein L32 -0.0125083
SRP54 signal recognition particle 54kDa -0.012487
NPR2 natriuretic peptide receptor 2 -0.0124575
SERF2 small EDRK-rich factor 2 -0.0123149
MATR3 matrin 3 -0.0122909
RPS27 ribosomal protein S27 -0.0119332
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0118495
MLF1 myeloid leukemia factor 1 -0.0118335
RPS23 ribosomal protein S23 -0.0117793
UBE2B ubiquitin-conjugating enzyme E2B -0.0117594
RPL38 ribosomal protein L38 -0.0116807
CRABP2 cellular retinoic acid binding protein 2 -0.011429
C15ORF48 chromosome 15 open reading frame 48 -0.0113143
RPS4X ribosomal protein S4, X-linked -0.0112589
B2M beta-2-microglobulin -0.0107828