Sivelestat (sodium tetrahydrate)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DLC1 DLC1 Rho GTPase activating protein 0.142302
ZNF438 zinc finger protein 438 0.123321
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0912611
FRMD6 FERM domain containing 6 0.0895528
RAD51B RAD51 paralog B 0.0783358
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0771484
NAV3 neuron navigator 3 0.0685113
FLNB filamin B, beta 0.0673311
PBX3 pre-B-cell leukemia homeobox 3 0.064536
BNC2 basonuclin 2 0.058396
HMGA2 high mobility group AT-hook 2 0.0583849
LPP LIM domain containing preferred translocation partner in lipoma 0.0570098
TTR transthyretin 0.0562881
ARHGAP22 Rho GTPase activating protein 22 0.0545634
NAV2 neuron navigator 2 0.0520849
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0509712
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0505889
FRMD4A FERM domain containing 4A 0.0484003
FHIT fragile histidine triad 0.0479173
SMYD3 SET and MYND domain containing 3 0.0443766
IFI16 interferon, gamma-inducible protein 16 0.0430986
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0429707
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0428399
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0423713
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0416421
ALCAM activated leukocyte cell adhesion molecule 0.0394843
TCF12 transcription factor 12 0.0393938
DGKI diacylglycerol kinase, iota 0.0380669
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.0380451
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.037877
EXOC4 exocyst complex component 4 0.0376637
MTAP methylthioadenosine phosphorylase 0.0376433
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0372472
ASPH aspartate beta-hydroxylase 0.0370023
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0358363
NABP1 nucleic acid binding protein 1 0.0353829
SAMD12 sterile alpha motif domain containing 12 0.0350249
LRMDA leucine rich melanocyte differentiation associated 0.0345414
DENND1A DENN/MADD domain containing 1A 0.0339867
SLC38A2 solute carrier family 38, member 2 0.0339274
SP100 SP100 nuclear antigen 0.0336064
GPHN gephyrin 0.0329053
MACF1 microtubule-actin crosslinking factor 1 0.0319687
ANTXR2 anthrax toxin receptor 2 0.0309054
HDAC9 histone deacetylase 9 0.0307308
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0306368
TBC1D5 TBC1 domain family, member 5 0.0300933
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0298771
EXT1 exostosin glycosyltransferase 1 0.0297865
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0293822
ANK2 ankyrin 2, neuronal 0.028616
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0284831
TAS2R14 taste receptor, type 2, member 14 0.0277141
RAB3IP RAB3A interacting protein 0.0276033
CUX1 cut-like homeobox 1 0.0275447
FNDC3B fibronectin type III domain containing 3B 0.0270987
SPIDR scaffolding protein involved in DNA repair 0.0267117
RIGI RNA sensor RIG-I 0.0265767
AKAP9 A kinase (PRKA) anchor protein 9 0.0260836
PTPRG protein tyrosine phosphatase, receptor type, G 0.0254783
TRIO trio Rho guanine nucleotide exchange factor 0.0245713
FAF1 Fas (TNFRSF6) associated factor 1 0.0245556
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0241035
BABAM2 BRISC and BRCA1 A complex member 2 0.0239978
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 0.0239148
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0239114
WWOX WW domain containing oxidoreductase 0.0235175
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0231057
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.0230078
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0230074
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0229437
AGO2 argonaute RISC catalytic component 2 0.0225518
ZBTB20 zinc finger and BTB domain containing 20 0.0221612
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.021431
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0214177
EFNB2 ephrin-B2 0.0213885
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0213631
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0212003
CRACD capping protein inhibiting regulator of actin dynamics 0.021169
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0209565
PHF14 PHD finger protein 14 0.0208208
DIAPH2 diaphanous-related formin 2 0.0206888
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0205884
CDK6 cyclin-dependent kinase 6 0.0204865
CCDC91 coiled-coil domain containing 91 0.0204724
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0199939
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0198957
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0198064
TRAPPC9 trafficking protein particle complex 9 0.0197348
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0197238
PCNX4 pecanex 4 0.0195933
CAMKMT calmodulin-lysine N-methyltransferase 0.0195258
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.019427
CAST calpastatin 0.0193822
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0190872
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0190726
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0189464
SCMH1 sex comb on midleg homolog 1 (Drosophila) 0.0189072
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0189014
PARP14 poly (ADP-ribose) polymerase family, member 14 0.018568

decreased expression

Symbol Name Standardized Value
ACTG1 actin gamma 1 -0.129365
UBC ubiquitin C -0.102147
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.099449
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0902252
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0790421
RPS27A ribosomal protein S27a -0.068774
EEF2 eukaryotic translation elongation factor 2 -0.066392
JUN jun proto-oncogene -0.0652855
STC1 stanniocalcin 1 -0.0614393
RPL23 ribosomal protein L23 -0.0496204
SET SET nuclear proto-oncogene -0.0493111
RPL8 ribosomal protein L8 -0.0487114
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.045489
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0424431
RAD21 RAD21 homolog (S. pombe) -0.0422268
RPLP1 ribosomal protein, large, P1 -0.0401059
RPL12 ribosomal protein L12 -0.0395685
RPL37A ribosomal protein L37a -0.039521
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0389665
RPS6 ribosomal protein S6 -0.037641
PRRC2C proline-rich coiled-coil 2C -0.0367379
TXNRD1 thioredoxin reductase 1 -0.034562
RPL7A ribosomal protein L7a -0.0341223
RPS8 ribosomal protein S8 -0.0340944
RPL7 ribosomal protein L7 -0.0331185
TMSB10 thymosin beta 10 -0.0331083
RHOA ras homolog family member A -0.0325016
LAMB3 laminin, beta 3 -0.0324198
MT2A metallothionein 2A -0.0322064
OGA O-GlcNAcase -0.0318815
RPS12 ribosomal protein S12 -0.0317409
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0310362
RLF rearranged L-myc fusion -0.030679
RTN4 reticulon 4 -0.0302388
EIF1 eukaryotic translation initiation factor 1 -0.0298285
CREB5 cAMP responsive element binding protein 5 -0.0296471
RPLP2 ribosomal protein, large, P2 -0.0292574
RPS19 ribosomal protein S19 -0.0288206
RPL30 ribosomal protein L30 -0.0286154
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0284889
NIPBL Nipped-B homolog (Drosophila) -0.0284373
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0282045
RBM25 RNA binding motif protein 25 -0.0280143
POTEF POTE ankyrin domain family, member F -0.0278184
RPS21 ribosomal protein S21 -0.0269392
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0262948
LOC112694756 uncharaterized LOC112694756 -0.0257808
RPL28 ribosomal protein L28 -0.0254167
USP3 ubiquitin specific peptidase 3 -0.0253624
S100A6 S100 calcium binding protein A6 -0.0252881
RPS13 ribosomal protein S13 -0.0247081
TPT1 tumor protein, translationally-controlled 1 -0.0243424
BHLHE40 basic helix-loop-helix family, member e40 -0.0242377
GARS1 glycyl-tRNA synthetase 1 -0.0240316
NUP58 nucleoporin 58 -0.0237465
AHNAK AHNAK nucleoprotein -0.0234314
YTHDC1 YTH domain containing 1 -0.0232959
RPL5 ribosomal protein L5 -0.0232695
TOP1 topoisomerase (DNA) I -0.0231486
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0230768
TPD52 tumor protein D52 -0.0230711
SPAG9 sperm associated antigen 9 -0.0229978
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0229834
RPS27 ribosomal protein S27 -0.0223583
WDR45B WD repeat domain 45B -0.0223411
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0222243
RPL9 ribosomal protein L9 -0.0221741
CD44 CD44 molecule (Indian blood group) -0.022065
RPS3 ribosomal protein S3 -0.0218244
RPS29 ribosomal protein S29 -0.0217647
KDM3A lysine (K)-specific demethylase 3A -0.0217491
S100A2 S100 calcium binding protein A2 -0.0217218
RPL32 ribosomal protein L32 -0.0215384
PHIP pleckstrin homology domain interacting protein -0.0212656
PNISR PNN-interacting serine/arginine-rich protein -0.0212393
UPP1 uridine phosphorylase 1 -0.0210695
ZFAND3 zinc finger, AN1-type domain 3 -0.0207633
TPM4 tropomyosin 4 -0.0207153
KDM2A lysine (K)-specific demethylase 2A -0.0205518
RPL26 ribosomal protein L26 -0.0205145
PTMA prothymosin, alpha -0.0204562
FTL ferritin, light polypeptide -0.0201229
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0195462
KMT2C lysine (K)-specific methyltransferase 2C -0.0194993
KIF5B kinesin family member 5B -0.0194286
MYL12B myosin, light chain 12B, regulatory -0.0193617
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0193032
JMJD1C jumonji domain containing 1C -0.0192624
GOLGA4 golgin A4 -0.0191677
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0190923
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0190432
ADAM9 ADAM metallopeptidase domain 9 -0.0190376
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0187248
HMGB2 high mobility group box 2 -0.0187205
S100A9 S100 calcium binding protein A9 -0.01869
SEPTIN7 septin 7 -0.0186188
RNF145 ring finger protein 145 -0.0186054
RNMT RNA (guanine-7-) methyltransferase -0.0185909
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0185726
RPS15 ribosomal protein S15 -0.0185545