| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sivelestat (sodium tetrahydrate) perturbation in RPMI-7951 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | 0.122113 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.114216 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0722792 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0710855 |
| COL5A1 | collagen, type V, alpha 1 | 0.0661271 |
| TMEM178B | transmembrane protein 178B | 0.0631622 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0567146 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0518121 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0502541 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0502126 |
| CDH13 | cadherin 13 | 0.042638 |
| ASPH | aspartate beta-hydroxylase | 0.04069 |
| NAV1 | neuron navigator 1 | 0.0382228 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0375336 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0366969 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0360572 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0347195 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0343069 |
| LOXL2 | lysyl oxidase-like 2 | 0.0341787 |
| FAM20C | family with sequence similarity 20, member C | 0.0335492 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0328301 |
| CD109 | CD109 molecule | 0.032559 |
| ENO1 | enolase 1, (alpha) | 0.031738 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0307395 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0303832 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0298824 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0290945 |
| PCBP3 | poly(rC) binding protein 3 | 0.0287383 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0284699 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0279962 |
| ATXN1 | ataxin 1 | 0.027598 |
| RAD51B | RAD51 paralog B | 0.0274551 |
| FHIT | fragile histidine triad | 0.0272712 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0272137 |
| DST | dystonin | 0.0268403 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0264805 |
| FNIP1 | folliculin interacting protein 1 | 0.0259572 |
| FRMD4A | FERM domain containing 4A | 0.0258347 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0256656 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0255527 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0251727 |
| COL1A2 | collagen, type I, alpha 2 | 0.0251303 |
| CADM1 | cell adhesion molecule 1 | 0.0249877 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0247638 |
| TNS3 | tensin 3 | 0.0240763 |
| MMP12 | matrix metallopeptidase 12 | 0.0238927 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0238509 |
| HDAC9 | histone deacetylase 9 | 0.023727 |
| VEGFA | vascular endothelial growth factor A | 0.0234474 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0233742 |
| NRP1 | neuropilin 1 | 0.0233162 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0229692 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0228921 |
| MEF2A | myocyte enhancer factor 2A | 0.0228653 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0224218 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.0224196 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0221603 |
| EGFR | epidermal growth factor receptor | 0.0219413 |
| COL6A1 | collagen, type VI, alpha 1 | 0.0212843 |
| TPM1 | tropomyosin 1 (alpha) | 0.021268 |
| MLPH | melanophilin | 0.0209142 |
| IFI44L | interferon-induced protein 44-like | 0.0208657 |
| NDRG1 | N-myc downstream regulated 1 | 0.0206949 |
| CLIC4 | chloride intracellular channel 4 | 0.0203276 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0202343 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0201236 |
| MCL1 | myeloid cell leukemia 1 | 0.0200422 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0199466 |
| SP100 | SP100 nuclear antigen | 0.0195128 |
| EXOC4 | exocyst complex component 4 | 0.019511 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0194774 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0194452 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0192356 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0191616 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0188305 |
| RUNX1 | runt-related transcription factor 1 | 0.0187699 |
| USP34 | ubiquitin specific peptidase 34 | 0.0187173 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0178194 |
| COL5A2 | collagen, type V, alpha 2 | 0.0177423 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0174942 |
| ANO6 | anoctamin 6 | 0.0173034 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0171684 |
| FBN1 | fibrillin 1 | 0.0171475 |
| SH3RF3 | SH3 domain containing ring finger 3 | 0.0169912 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.016799 |
| RNF213 | ring finger protein 213 | 0.0167723 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0167723 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0166659 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0166654 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0165478 |
| CLIP4 | CAP-GLY domain containing linker protein family, member 4 | 0.0162114 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0161718 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0158518 |
| COL1A1 | collagen, type I, alpha 1 | 0.0158472 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0157516 |
| PTK2 | protein tyrosine kinase 2 | 0.0157427 |
| ARHGAP35 | Rho GTPase activating protein 35 | 0.0156443 |
| SMYD3 | SET and MYND domain containing 3 | 0.0155299 |
| EXT1 | exostosin glycosyltransferase 1 | 0.015522 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0154844 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.277049 |
| STC1 | stanniocalcin 1 | -0.151354 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.114102 |
| MT2A | metallothionein 2A | -0.0958593 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0464333 |
| FTL | ferritin, light polypeptide | -0.0454514 |
| CD44 | CD44 molecule (Indian blood group) | -0.0441835 |
| PTMA | prothymosin, alpha | -0.0432524 |
| TMSB10 | thymosin beta 10 | -0.0402762 |
| RPLP1 | ribosomal protein, large, P1 | -0.0345541 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0345535 |
| B2M | beta-2-microglobulin | -0.0310195 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0304414 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0300709 |
| RPS6 | ribosomal protein S6 | -0.0276013 |
| CENPF | centromere protein F, 350/400kDa | -0.0260072 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0257644 |
| RPS8 | ribosomal protein S8 | -0.025376 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0252635 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0251179 |
| RPL35A | ribosomal protein L35a | -0.0248961 |
| SEPTIN7 | septin 7 | -0.0247568 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0246732 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0241465 |
| RPS19 | ribosomal protein S19 | -0.0240014 |
| HMGB2 | high mobility group box 2 | -0.0229704 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0229438 |
| S100A6 | S100 calcium binding protein A6 | -0.0229253 |
| GOLGA4 | golgin A4 | -0.0223235 |
| RPS21 | ribosomal protein S21 | -0.0219767 |
| GNAS | GNAS complex locus | -0.0218212 |
| TPX2 | TPX2, microtubule-associated | -0.0211844 |
| MKI67 | marker of proliferation Ki-67 | -0.0209696 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0209541 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0196788 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0187222 |
| POTEF | POTE ankyrin domain family, member F | -0.0181158 |
| RPL34 | ribosomal protein L34 | -0.0179707 |
| RPS27A | ribosomal protein S27a | -0.0179699 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0179585 |
| TPM4 | tropomyosin 4 | -0.0178278 |
| H1-0 | H1.0 linker histone | -0.0176556 |
| FAM162A | family with sequence similarity 162, member A | -0.0174112 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0171393 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0170476 |
| HLA-B | major histocompatibility complex, class I, B | -0.0167432 |
| IER3 | immediate early response 3 | -0.016583 |
| RPLP2 | ribosomal protein, large, P2 | -0.0164234 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.016399 |
| ACTG1 | actin gamma 1 | -0.0163666 |
| RPL37A | ribosomal protein L37a | -0.0163174 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0161414 |
| CENPE | centromere protein E, 312kDa | -0.0161206 |
| RPL32 | ribosomal protein L32 | -0.0160922 |
| DIAPH3 | diaphanous-related formin 3 | -0.0157894 |
| KIF5B | kinesin family member 5B | -0.0155896 |
| CBX3 | chromobox homolog 3 | -0.0155827 |
| ZNF292 | zinc finger protein 292 | -0.0155525 |
| RPS12 | ribosomal protein S12 | -0.015191 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0151549 |
| RPL12 | ribosomal protein L12 | -0.0150306 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.014978 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0149522 |
| LMNA | lamin A/C | -0.0148283 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.01468 |
| HMGB1 | high mobility group box 1 | -0.0146728 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0146505 |
| S100A9 | S100 calcium binding protein A9 | -0.014511 |
| RPL11 | ribosomal protein L11 | -0.0144729 |
| RPS16 | ribosomal protein S16 | -0.0144521 |
| RRBP1 | ribosome binding protein 1 | -0.0141847 |
| HMGA1 | high mobility group AT-hook 1 | -0.0140454 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0137866 |
| SERF2 | small EDRK-rich factor 2 | -0.0136582 |
| RPS3 | ribosomal protein S3 | -0.0135758 |
| RPL19 | ribosomal protein L19 | -0.0135577 |
| RPS13 | ribosomal protein S13 | -0.0135357 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0134371 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0133938 |
| RPL26 | ribosomal protein L26 | -0.0133526 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0127518 |
| SEC61G | Sec61 gamma subunit | -0.0125129 |
| ANLN | anillin, actin binding protein | -0.0124782 |
| DSTN | destrin (actin depolymerizing factor) | -0.0124509 |
| RPL36 | ribosomal protein L36 | -0.01239 |
| RPL28 | ribosomal protein L28 | -0.0123582 |
| RPL23 | ribosomal protein L23 | -0.0121688 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.012162 |
| MIS18BP1 | MIS18 binding protein 1 | -0.012141 |
| VDAC1 | voltage-dependent anion channel 1 | -0.012041 |
| RPL18 | ribosomal protein L18 | -0.0120274 |
| YBX1 | Y box binding protein 1 | -0.0119677 |
| RPS17 | ribosomal protein S17 | -0.011967 |
| RLF | rearranged L-myc fusion | -0.0119631 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0118511 |
| RBM25 | RNA binding motif protein 25 | -0.0117702 |
| RPL7A | ribosomal protein L7a | -0.0116742 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0116541 |
| SGO2 | shugoshin 2 | -0.0116467 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0116465 |
