| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sivelestat (sodium tetrahydrate) perturbation in SHP-77 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NALF1 | NALCN channel auxiliary factor 1 | 0.193203 |
| PDE10A | phosphodiesterase 10A | 0.133522 |
| GPC6 | glypican 6 | 0.129664 |
| NRG1 | neuregulin 1 | 0.108729 |
| SMYD3 | SET and MYND domain containing 3 | 0.0996168 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0930928 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.083334 |
| NKAIN2 | Na+/K+ transporting ATPase interacting 2 | 0.0733631 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0715775 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0711602 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0709996 |
| KCND2 | potassium channel, voltage gated Shal related subfamily D, member 2 | 0.0684159 |
| ENO1 | enolase 1, (alpha) | 0.0666719 |
| CNKSR3 | CNKSR family member 3 | 0.0666704 |
| SNTG1 | syntrophin, gamma 1 | 0.066659 |
| NCKAP5 | NCK-associated protein 5 | 0.0659377 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0640101 |
| ESRRG | estrogen-related receptor gamma | 0.0639079 |
| KCNB2 | potassium channel, voltage gated Shab related subfamily B, member 2 | 0.0623224 |
| RORA | RAR-related orphan receptor A | 0.0612763 |
| NDRG1 | N-myc downstream regulated 1 | 0.0554091 |
| GRIK1 | glutamate receptor, ionotropic, kainate 1 | 0.0542128 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0538866 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.05379 |
| RAD51B | RAD51 paralog B | 0.0520427 |
| KIF26B | kinesin family member 26B | 0.0514614 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | 0.0508898 |
| CACNA1D | calcium channel, voltage-dependent, L type, alpha 1D subunit | 0.0508473 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0503309 |
| FGF14 | fibroblast growth factor 14 | 0.0488476 |
| GPC5 | glypican 5 | 0.0483095 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.048115 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0475811 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0467687 |
| RIT2 | Ras-like without CAAX 2 | 0.0450952 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.0429606 |
| CACNA1A | calcium channel, voltage-dependent, P/Q type, alpha 1A subunit | 0.0422411 |
| AUTS2 | autism susceptibility candidate 2 | 0.0422003 |
| CADM1 | cell adhesion molecule 1 | 0.041404 |
| NBEA | neurobeachin | 0.0404278 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0400801 |
| MSI2 | musashi RNA-binding protein 2 | 0.0389182 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | 0.0386533 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0386225 |
| EPHA6 | EPH receptor A6 | 0.038245 |
| SYT1 | synaptotagmin I | 0.0381123 |
| TSHZ2 | teashirt zinc finger homeobox 2 | 0.0379566 |
| EFNA5 | ephrin-A5 | 0.037934 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0373866 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0371343 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0367892 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0362441 |
| COL22A1 | collagen, type XXII, alpha 1 | 0.0361866 |
| CHD7 | chromodomain helicase DNA binding protein 7 | 0.0361262 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0355497 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0354292 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0354067 |
| NELL1 | NEL-like 1 (chicken) | 0.0353776 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0349854 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0348511 |
| DENND1A | DENN/MADD domain containing 1A | 0.0347143 |
| ASIC2 | acid sensing (proton gated) ion channel 2 | 0.0345875 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | 0.0345801 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0342663 |
| NAV2 | neuron navigator 2 | 0.0341395 |
| PGK1 | phosphoglycerate kinase 1 | 0.0339081 |
| RNF213 | ring finger protein 213 | 0.0336967 |
| TOX | thymocyte selection-associated high mobility group box | 0.0334241 |
| CHGB | chromogranin B | 0.0331962 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0330439 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0326729 |
| DTNA | dystrobrevin, alpha | 0.0326559 |
| KLHL29 | kelch-like family member 29 | 0.0326223 |
| MAP1B | microtubule-associated protein 1B | 0.0325832 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0323701 |
| PCBP3 | poly(rC) binding protein 3 | 0.0323475 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | 0.0319123 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0313835 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0312146 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0310374 |
| CA8 | carbonic anhydrase VIII | 0.0307537 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | 0.0306841 |
| PEG10 | paternally expressed 10 | 0.0303886 |
| MCL1 | myeloid cell leukemia 1 | 0.0298523 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 0.0297772 |
| ARFGEF3 | ARFGEF family member 3 | 0.0296545 |
| SASH1 | SAM and SH3 domain containing 1 | 0.0295223 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0294415 |
| LSAMP | limbic system-associated membrane protein | 0.0292171 |
| WWOX | WW domain containing oxidoreductase | 0.029213 |
| KCTD8 | potassium channel tetramerization domain containing 8 | 0.0290086 |
| FKBP9 | FK506 binding protein 9, 63 kDa | 0.0289636 |
| DGKB | diacylglycerol kinase, beta 90kDa | 0.0289334 |
| ST18 | suppression of tumorigenicity 18, zinc finger | 0.0286492 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0285463 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0279828 |
| PITPNM2 | phosphatidylinositol transfer protein, membrane-associated 2 | 0.0279287 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.027823 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | 0.0275882 |
| FAM13A | family with sequence similarity 13, member A | 0.0275345 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.12461 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0992113 |
| FTL | ferritin, light polypeptide | -0.0751377 |
| RPS3 | ribosomal protein S3 | -0.0674154 |
| RPL37A | ribosomal protein L37a | -0.0618393 |
| RPL26 | ribosomal protein L26 | -0.0461932 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0448304 |
| RPS6 | ribosomal protein S6 | -0.0432463 |
| RPS8 | ribosomal protein S8 | -0.0422053 |
| RPL7 | ribosomal protein L7 | -0.0416143 |
| RPS12 | ribosomal protein S12 | -0.0398892 |
| SET | SET nuclear proto-oncogene | -0.0396079 |
| MT2A | metallothionein 2A | -0.035463 |
| RPLP1 | ribosomal protein, large, P1 | -0.0349056 |
| RPS19 | ribosomal protein S19 | -0.0329467 |
| RPL37 | ribosomal protein L37 | -0.0315047 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0313494 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0296287 |
| RPL5 | ribosomal protein L5 | -0.0294504 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0290418 |
| RPS27 | ribosomal protein S27 | -0.0285081 |
| RPS17 | ribosomal protein S17 | -0.0282165 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0278233 |
| RPS16 | ribosomal protein S16 | -0.0275619 |
| RPL12 | ribosomal protein L12 | -0.0274307 |
| RPL35 | ribosomal protein L35 | -0.0261635 |
| HMGB2 | high mobility group box 2 | -0.0255962 |
| RPS2 | ribosomal protein S2 | -0.0255459 |
| RPS25 | ribosomal protein S25 | -0.0249153 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | -0.0246383 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0246248 |
| RPL36 | ribosomal protein L36 | -0.0245172 |
| RPS27A | ribosomal protein S27a | -0.0245054 |
| RPL19 | ribosomal protein L19 | -0.0236891 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0236633 |
| RPL11 | ribosomal protein L11 | -0.0234335 |
| RPL23 | ribosomal protein L23 | -0.0231962 |
| TMSB10 | thymosin beta 10 | -0.0229309 |
| RPL18 | ribosomal protein L18 | -0.0222696 |
| RPL30 | ribosomal protein L30 | -0.0213357 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | -0.0211122 |
| RPL7A | ribosomal protein L7a | -0.0209438 |
| RPS20 | ribosomal protein S20 | -0.0209076 |
| RPLP2 | ribosomal protein, large, P2 | -0.0206393 |
| RPS5 | ribosomal protein S5 | -0.0199654 |
| B2M | beta-2-microglobulin | -0.0197043 |
| RACK1 | receptor for activated C kinase 1 | -0.0188213 |
| UBA52 | ubiquitin A-52 residue ribosomal protein fusion product 1 | -0.0186363 |
| RPS29 | ribosomal protein S29 | -0.0185457 |
| RPL8 | ribosomal protein L8 | -0.0185183 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0184996 |
| RPL32 | ribosomal protein L32 | -0.0182854 |
| UBB | ubiquitin B | -0.0181408 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0181376 |
| CENPF | centromere protein F, 350/400kDa | -0.0176436 |
| RPL31 | ribosomal protein L31 | -0.01751 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0173711 |
| PNN | pinin, desmosome associated protein | -0.0168741 |
| COX6C | cytochrome c oxidase subunit VIc | -0.016751 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0167243 |
| YBX1 | Y box binding protein 1 | -0.0166272 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0164966 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0164809 |
| PDK4 | pyruvate dehydrogenase kinase, isozyme 4 | -0.0161424 |
| GSTP1 | glutathione S-transferase pi 1 | -0.015861 |
| COX6A1 | cytochrome c oxidase subunit VIa polypeptide 1 | -0.0154048 |
| RPS14 | ribosomal protein S14 | -0.0152676 |
| PABPN1 | poly(A) binding protein, nuclear 1 | -0.015089 |
| COX4I1 | cytochrome c oxidase subunit IV isoform 1 | -0.0150645 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | -0.0149875 |
| RPL35A | ribosomal protein L35a | -0.0149299 |
| RPL9 | ribosomal protein L9 | -0.0148686 |
| ZC3H15 | zinc finger CCCH-type containing 15 | -0.0147304 |
| RPL36A | ribosomal protein L36a | -0.0146711 |
| PA2G4 | proliferation-associated 2G4, 38kDa | -0.0145542 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0144529 |
| RPL10A | ribosomal protein L10a | -0.014404 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0143622 |
| STMN1 | stathmin 1 | -0.0143534 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | -0.0142892 |
| SEPTIN7 | septin 7 | -0.0141614 |
| RPL38 | ribosomal protein L38 | -0.0139219 |
| CBX3 | chromobox homolog 3 | -0.0138235 |
| UQCRQ | ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa | -0.0136903 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0133527 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0131405 |
| RPL36AL | ribosomal protein L36a-like | -0.0131252 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0130751 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.013059 |
| RPL15 | ribosomal protein L15 | -0.0129048 |
| RPLP0 | ribosomal protein, large, P0 | -0.012837 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0127157 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -0.0127154 |
| DSTN | destrin (actin depolymerizing factor) | -0.0126752 |
| SERF2 | small EDRK-rich factor 2 | -0.0126413 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0126338 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0126283 |
| HMGB1 | high mobility group box 1 | -0.0126262 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0124204 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0122965 |
