Sivelestat (sodium tetrahydrate)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.236024
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.205628
NLGN1 neuroligin 1 0.160556
NRG3 neuregulin 3 0.154071
FMN1 formin 1 0.12854
LSAMP limbic system-associated membrane protein 0.114084
FRMD4A FERM domain containing 4A 0.0889513
FNDC3B fibronectin type III domain containing 3B 0.0796256
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0782508
RAD51B RAD51 paralog B 0.0771437
FHIT fragile histidine triad 0.067244
LINGO2 leucine rich repeat and Ig domain containing 2 0.0605551
DST dystonin 0.0566881
LRMDA leucine rich melanocyte differentiation associated 0.0527138
MAML3 mastermind-like 3 (Drosophila) 0.0507155
IGF1R insulin-like growth factor 1 receptor 0.0463531
CADM1 cell adhesion molecule 1 0.0443598
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0439712
MSI2 musashi RNA-binding protein 2 0.0371949
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0365829
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0365351
EXOC4 exocyst complex component 4 0.0361907
MACROD2 MACRO domain containing 2 0.0345916
PRELID2 PRELI domain containing 2 0.0339332
ZBTB20 zinc finger and BTB domain containing 20 0.0317236
LPP LIM domain containing preferred translocation partner in lipoma 0.0313146
RNF213 ring finger protein 213 0.0312118
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0307535
SOX6 SRY (sex determining region Y)-box 6 0.0293616
KAZN kazrin, periplakin interacting protein 0.0293284
FMNL2 formin-like 2 0.0289305
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0276475
SLC39A11 solute carrier family 39, member 11 0.0274319
JMJD1C jumonji domain containing 1C 0.0273846
CNKSR3 CNKSR family member 3 0.0272889
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0271961
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0269936
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.026677
CFAP20DC CFAP20 domain containing 0.0265332
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0264786
FRMD5 FERM domain containing 5 0.0263374
PTK2 protein tyrosine kinase 2 0.0262517
EHBP1 EH domain binding protein 1 0.026008
CDK6 cyclin-dependent kinase 6 0.0254611
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0252104
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.024962
HDAC9 histone deacetylase 9 0.0246567
ASPH aspartate beta-hydroxylase 0.024611
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0244762
AUTS2 autism susceptibility candidate 2 0.0243913
BACE2 beta-site APP-cleaving enzyme 2 0.0242672
CDH13 cadherin 13 0.0239765
MAML2 mastermind-like 2 (Drosophila) 0.0239711
SOX5 SRY (sex determining region Y)-box 5 0.0237713
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0237608
WWOX WW domain containing oxidoreductase 0.02368
SEPTIN9 septin 9 0.0234785
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0233963
INPP5F inositol polyphosphate-5-phosphatase F 0.0232017
LEF1 lymphoid enhancer-binding factor 1 0.0231017
SFTPA2 surfactant protein A2 0.0224951
SMYD3 SET and MYND domain containing 3 0.0223382
TNNC1 troponin C type 1 (slow) 0.0222719
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.0221192
HDAC4 histone deacetylase 4 0.0217177
YEATS2 YEATS domain containing 2 0.0216952
TBC1D5 TBC1 domain family, member 5 0.0215499
JARID2 jumonji, AT rich interactive domain 2 0.0207811
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0206993
PTPRG protein tyrosine phosphatase, receptor type, G 0.0204523
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0204286
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.0201764
FNIP1 folliculin interacting protein 1 0.0199604
BIRC6 baculoviral IAP repeat containing 6 0.0198988
IL1RAP interleukin 1 receptor accessory protein 0.019746
FOXP1 forkhead box P1 0.0197244
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.019388
BCAS3 breast carcinoma amplified sequence 3 0.0190915
CCDC91 coiled-coil domain containing 91 0.0189538
NHSL1 NHS-like 1 0.0186346
FGGY FGGY carbohydrate kinase domain containing 0.0186089
MBNL1 muscleblind-like splicing regulator 1 0.0182553
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0181703
KDM4C lysine (K)-specific demethylase 4C 0.0180385
DENND1A DENN/MADD domain containing 1A 0.017937
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0179118
PTPRM protein tyrosine phosphatase, receptor type, M 0.0177278
SBF2 SET binding factor 2 0.0175623
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0174498
MEF2A myocyte enhancer factor 2A 0.0174454
GRIK5 glutamate receptor, ionotropic, kainate 5 0.0173248
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0172555
ARB2A ARB2 cotranscriptional regulator A 0.0172312
DPP6 dipeptidyl-peptidase 6 0.0172064
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0170892
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.017053
PLCB4 phospholipase C, beta 4 0.0170419
ZNF827 zinc finger protein 827 0.0170365
SUMF1 sulfatase modifying factor 1 0.0168298
FAF1 Fas (TNFRSF6) associated factor 1 0.0167938

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.284217
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.121395
MT2A metallothionein 2A -0.104911
UBC ubiquitin C -0.104039
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.092391
RPS3 ribosomal protein S3 -0.089822
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0743092
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0712781
TMSB10 thymosin beta 10 -0.0590749
TM4SF1 transmembrane 4 L six family member 1 -0.056273
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0560547
RPS27A ribosomal protein S27a -0.0547001
EEF2 eukaryotic translation elongation factor 2 -0.0493693
EIF1 eukaryotic translation initiation factor 1 -0.048596
RPL23 ribosomal protein L23 -0.0464715
CD44 CD44 molecule (Indian blood group) -0.045963
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0415571
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0412676
FTL ferritin, light polypeptide -0.0388506
RPLP1 ribosomal protein, large, P1 -0.0378936
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0369031
TXNRD1 thioredoxin reductase 1 -0.0343076
ICAM1 intercellular adhesion molecule 1 -0.0335999
ACTG1 actin gamma 1 -0.0335275
RPS8 ribosomal protein S8 -0.0327068
RPS12 ribosomal protein S12 -0.0307066
ENO1 enolase 1, (alpha) -0.0306326
EMP1 epithelial membrane protein 1 -0.030361
RACK1 receptor for activated C kinase 1 -0.0297268
RPL12 ribosomal protein L12 -0.0289719
NAP1L1 nucleosome assembly protein 1-like 1 -0.0280691
SQSTM1 sequestosome 1 -0.0277916
ELL2 elongation factor, RNA polymerase II, 2 -0.0272769
PRRC2C proline-rich coiled-coil 2C -0.026615
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0263173
SLC38A1 solute carrier family 38, member 1 -0.0259456
GOLGA4 golgin A4 -0.0257832
RPS6 ribosomal protein S6 -0.0254687
MT1X metallothionein 1X -0.025106
KLF6 Kruppel-like factor 6 -0.0240373
LOC112694756 uncharaterized LOC112694756 -0.0239546
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0227361
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0226492
TPT1 tumor protein, translationally-controlled 1 -0.0220706
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0215822
RPL37A ribosomal protein L37a -0.0214297
ANXA2 annexin A2 -0.0212869
RPLP2 ribosomal protein, large, P2 -0.0211896
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0209747
RPS13 ribosomal protein S13 -0.020875
SET SET nuclear proto-oncogene -0.0204219
RPL19 ribosomal protein L19 -0.0201831
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0200107
PTMA prothymosin, alpha -0.0199545
TFPI2 tissue factor pathway inhibitor 2 -0.0198009
NDRG1 N-myc downstream regulated 1 -0.0197979
TPM3 tropomyosin 3 -0.0197971
RPL15 ribosomal protein L15 -0.0197054
PCBP2 poly(rC) binding protein 2 -0.0192189
HMGB2 high mobility group box 2 -0.0191925
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0190149
RHOA ras homolog family member A -0.018479
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.018442
RPL34 ribosomal protein L34 -0.0181696
VMP1 vacuole membrane protein 1 -0.0180024
RPL5 ribosomal protein L5 -0.0178599
RPL32 ribosomal protein L32 -0.0177906
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0174808
CENPF centromere protein F, 350/400kDa -0.0174076
RTN4 reticulon 4 -0.0172182
RPL36A ribosomal protein L36a -0.0170929
RPL9 ribosomal protein L9 -0.0168788
RPL31 ribosomal protein L31 -0.0168457
MYH9 myosin, heavy chain 9, non-muscle -0.0167147
NAMPT nicotinamide phosphoribosyltransferase -0.0166444
LMNA lamin A/C -0.0165867
SOD2 superoxide dismutase 2, mitochondrial -0.0163045
NAV2 neuron navigator 2 -0.0160982
KTN1 kinectin 1 (kinesin receptor) -0.0160915
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0159496
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0157503
GARS1 glycyl-tRNA synthetase 1 -0.0155078
RPS5 ribosomal protein S5 -0.0155007
JUN jun proto-oncogene -0.0154884
RPS4X ribosomal protein S4, X-linked -0.015425
IER3 immediate early response 3 -0.0154219
HLA-E major histocompatibility complex, class I, E -0.0153521
RPL4 ribosomal protein L4 -0.0153306
RPL8 ribosomal protein L8 -0.0153016
RPS23 ribosomal protein S23 -0.015173
RPL36 ribosomal protein L36 -0.0151448
CCNI cyclin I -0.015085
RPL28 ribosomal protein L28 -0.0150682
MTPN myotrophin -0.0147138
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0146916
FLNA filamin A, alpha -0.0146516
YBX3 Y box binding protein 3 -0.0146493
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0145956
S100A9 S100 calcium binding protein A9 -0.0145415
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0144791