Sivelestat (sodium tetrahydrate)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4B phosphodiesterase 4B, cAMP-specific 0.100154
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0664156
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0650942
VCL vinculin 0.0617404
CPED1 cadherin-like and PC-esterase domain containing 1 0.0552447
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0458149
HDAC9 histone deacetylase 9 0.043701
SOX6 SRY (sex determining region Y)-box 6 0.0434831
AHNAK AHNAK nucleoprotein 0.0431106
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0414983
FOXP1 forkhead box P1 0.0388001
NBEA neurobeachin 0.0384562
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.03635
TJP1 tight junction protein 1 0.0352819
ZEB1 zinc finger E-box binding homeobox 1 0.0338464
LPP LIM domain containing preferred translocation partner in lipoma 0.0335498
PDGFC platelet derived growth factor C 0.032301
ADAM10 ADAM metallopeptidase domain 10 0.0316071
EGFR epidermal growth factor receptor 0.0307358
DLG1 discs, large homolog 1 (Drosophila) 0.0303103
BMP2K BMP2 inducible kinase 0.0285504
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0279402
SSBP2 single-stranded DNA binding protein 2 0.0276779
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0264436
EFNA5 ephrin-A5 0.0261376
ZFAND3 zinc finger, AN1-type domain 3 0.0257711
EVI5 ecotropic viral integration site 5 0.0242931
TGFBR3 transforming growth factor, beta receptor III 0.0242311
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0240278
NPAS2 neuronal PAS domain protein 2 0.023924
CAMKMT calmodulin-lysine N-methyltransferase 0.0231788
NFIA nuclear factor I/A 0.0224855
GLI3 GLI family zinc finger 3 0.0223823
MSI2 musashi RNA-binding protein 2 0.0221131
DPYD dihydropyrimidine dehydrogenase 0.0220637
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.021837
FNDC3B fibronectin type III domain containing 3B 0.0216791
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0204694
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0203591
SAMD4A sterile alpha motif domain containing 4A 0.0200854
PARD3 par-3 family cell polarity regulator 0.0193539
CAMTA1 calmodulin binding transcription activator 1 0.0191132
TTC28 tetratricopeptide repeat domain 28 0.0184681
RBM39 RNA binding motif protein 39 0.0183137
TCF12 transcription factor 12 0.0173118
ANKRD17 ankyrin repeat domain 17 0.0172512
TAS2R14 taste receptor, type 2, member 14 0.0167539
PRELID2 PRELI domain containing 2 0.0165537
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0165108
PTPRG protein tyrosine phosphatase, receptor type, G 0.0165057
SMYD3 SET and MYND domain containing 3 0.016492
ANKRD11 ankyrin repeat domain 11 0.0164879
NT5C2 5'-nucleotidase, cytosolic II 0.0161066
GLI2 GLI family zinc finger 2 0.0161043
TMEM65 transmembrane protein 65 0.0160144
PICALM phosphatidylinositol binding clathrin assembly protein 0.0159695
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0158512
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0157846
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0155457
WAC WW domain containing adaptor with coiled-coil 0.0155434
PDE4D phosphodiesterase 4D, cAMP-specific 0.0150511
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0149316
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.014521
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0143552
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0143373
MYOF myoferlin 0.0138499
TSC22D1 TSC22 domain family, member 1 0.0138462
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0137005
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0136482
PYGB phosphorylase, glycogen; brain 0.0136427
NBAS neuroblastoma amplified sequence 0.0136099
FNIP1 folliculin interacting protein 1 0.0135328
PUM2 pumilio RNA-binding family member 2 0.0134949
EPS8 epidermal growth factor receptor pathway substrate 8 0.0134028
IGF1R insulin-like growth factor 1 receptor 0.0133204
NF1 neurofibromin 1 0.0133162
BIRC6 baculoviral IAP repeat containing 6 0.0131172
DIAPH3 diaphanous-related formin 3 0.0130957
YAP1 Yes-associated protein 1 0.012989
CYB5B cytochrome b5 type B (outer mitochondrial membrane) 0.0128834
SCAF8 SR-related CTD-associated factor 8 0.012454
GPHN gephyrin 0.0124289
CRPPA CDP-L-ribitol pyrophosphorylase A 0.0124015
ITCH itchy E3 ubiquitin protein ligase 0.0123958
FLNB filamin B, beta 0.0122759
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 0.0121971
EXOC6B exocyst complex component 6B 0.0121276
CTBP2 C-terminal binding protein 2 0.0120327
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0119101
PLXNA1 plexin A1 0.0117274
DENND1A DENN/MADD domain containing 1A 0.0114899
APP amyloid beta (A4) precursor protein 0.0114694
NCEH1 neutral cholesterol ester hydrolase 1 0.0114606
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0113623
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0113434
FAT1 FAT atypical cadherin 1 0.0112703
EIF4B eukaryotic translation initiation factor 4B 0.0112452
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0111642
LOXL3 lysyl oxidase-like 3 0.0111601
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0110931

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.20814
PTMA prothymosin, alpha -0.170159
RPS6 ribosomal protein S6 -0.0919003
RPL35A ribosomal protein L35a -0.0656602
RPS8 ribosomal protein S8 -0.0652537
TPT1 tumor protein, translationally-controlled 1 -0.061255
RPS19 ribosomal protein S19 -0.0601351
PKM pyruvate kinase, muscle -0.055805
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0504945
RPL37A ribosomal protein L37a -0.0496613
RPLP1 ribosomal protein, large, P1 -0.0486439
RPL12 ribosomal protein L12 -0.047646
RPL23 ribosomal protein L23 -0.0455815
ACTG1 actin gamma 1 -0.044955
RPL11 ribosomal protein L11 -0.0440508
TMSB10 thymosin beta 10 -0.0432346
S100A6 S100 calcium binding protein A6 -0.043065
RPL19 ribosomal protein L19 -0.0426444
RPS12 ribosomal protein S12 -0.0425237
EIF1 eukaryotic translation initiation factor 1 -0.0417536
PFN1 profilin 1 -0.0416991
RPL36 ribosomal protein L36 -0.0410413
RPL9 ribosomal protein L9 -0.0398809
RPS3 ribosomal protein S3 -0.0398247
RPS23 ribosomal protein S23 -0.0397213
B2M beta-2-microglobulin -0.0391162
RPS13 ribosomal protein S13 -0.0387185
RPLP2 ribosomal protein, large, P2 -0.0382763
RPL31 ribosomal protein L31 -0.0369525
MT2A metallothionein 2A -0.0367489
RPL34 ribosomal protein L34 -0.0359873
FTL ferritin, light polypeptide -0.034757
RPL13A ribosomal protein L13a -0.0344788
RPL7A ribosomal protein L7a -0.0340462
RPL26 ribosomal protein L26 -0.0324685
RPS25 ribosomal protein S25 -0.0323216
RPLP0 ribosomal protein, large, P0 -0.0318409
ARL4C ADP-ribosylation factor-like 4C -0.0303743
PRDX2 peroxiredoxin 2 -0.0300902
RPL32 ribosomal protein L32 -0.0297755
RACK1 receptor for activated C kinase 1 -0.0291301
S100A9 S100 calcium binding protein A9 -0.0284213
RPS17 ribosomal protein S17 -0.0277289
RPL28 ribosomal protein L28 -0.0275017
RPL5 ribosomal protein L5 -0.0274917
RPS29 ribosomal protein S29 -0.0272828
POTEF POTE ankyrin domain family, member F -0.0272343
RPS16 ribosomal protein S16 -0.0265212
RPS14 ribosomal protein S14 -0.0259754
ENO2 enolase 2 (gamma, neuronal) -0.0258985
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0255523
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0251236
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0245933
RPL8 ribosomal protein L8 -0.024539
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0244915
RPL18 ribosomal protein L18 -0.0239444
RPS11 ribosomal protein S11 -0.0234168
RPS27 ribosomal protein S27 -0.0233827
HSPB1 heat shock 27kDa protein 1 -0.0227599
RPS27A ribosomal protein S27a -0.0225643
RPL7 ribosomal protein L7 -0.0217476
S100A4 S100 calcium binding protein A4 -0.0216303
RPL27A ribosomal protein L27a -0.0209346
S100A10 S100 calcium binding protein A10 -0.0202616
RPS15 ribosomal protein S15 -0.0201216
RPL36A ribosomal protein L36a -0.0198388
RPS5 ribosomal protein S5 -0.0197606
RPS4X ribosomal protein S4, X-linked -0.0195173
IFI16 interferon, gamma-inducible protein 16 -0.0193976
HMGA1 high mobility group AT-hook 1 -0.0193552
RPS10 ribosomal protein S10 -0.0190041
NACA nascent polypeptide-associated complex alpha subunit -0.0187805
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0186427
RPL35 ribosomal protein L35 -0.0185687
IFITM3 interferon induced transmembrane protein 3 -0.0180984
RPL30 ribosomal protein L30 -0.0179718
VIM vimentin -0.0178251
RPS21 ribosomal protein S21 -0.0172772
RPL27 ribosomal protein L27 -0.017166
EEF2 eukaryotic translation elongation factor 2 -0.0171216
S100A11 S100 calcium binding protein A11 -0.0169538
RPL10A ribosomal protein L10a -0.0167258
RPL37 ribosomal protein L37 -0.0162063
RPS24 ribosomal protein S24 -0.0160778
RPS20 ribosomal protein S20 -0.0159954
ATF4 activating transcription factor 4 -0.0158754
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0158067
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0157896
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0157528
RBM25 RNA binding motif protein 25 -0.0156184
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0147744
PRRC2C proline-rich coiled-coil 2C -0.0146061
RPL15 ribosomal protein L15 -0.0143711
PRDX1 peroxiredoxin 1 -0.0143475
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0141186
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0140924
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0139442
ATP5F1E ATP synthase F1 subunit epsilon -0.0138643
NAP1L1 nucleosome assembly protein 1-like 1 -0.0137148
PNISR PNN-interacting serine/arginine-rich protein -0.0134245