Sivelestat (sodium tetrahydrate)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.15394
FN1 fibronectin 1 0.118593
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.110342
NAMPT nicotinamide phosphoribosyltransferase 0.108318
FNDC3B fibronectin type III domain containing 3B 0.0957531
ELL2 elongation factor, RNA polymerase II, 2 0.0653501
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0616232
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0557227
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0546131
EXT1 exostosin glycosyltransferase 1 0.0531245
RTN4 reticulon 4 0.0519844
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0516373
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0510503
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0500938
BICC1 BicC family RNA binding protein 1 0.0449428
MSN moesin 0.0442542
VCL vinculin 0.0419273
MYH9 myosin, heavy chain 9, non-muscle 0.0415533
SMAD3 SMAD family member 3 0.0410579
TENT5A terminal nucleotidyltransferase 5A 0.0315456
MX1 MX dynamin-like GTPase 1 0.0297035
AHR aryl hydrocarbon receptor 0.0295634
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0293138
TNS3 tensin 3 0.0287525
FLNB filamin B, beta 0.0276224
USP9X ubiquitin specific peptidase 9, X-linked 0.0274974
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0269708
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.026873
CCNL1 cyclin L1 0.0268183
JMJD1C jumonji domain containing 1C 0.0265713
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0264083
THBS1 thrombospondin 1 0.0261756
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0261143
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0260371
RIGI RNA sensor RIG-I 0.0260024
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.025968
ARRDC3 arrestin domain containing 3 0.0251031
RBM39 RNA binding motif protein 39 0.0238755
PDE10A phosphodiesterase 10A 0.0235891
RB1CC1 RB1-inducible coiled-coil 1 0.0233199
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0232296
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0231861
TNIP1 TNFAIP3 interacting protein 1 0.0230191
CLIC4 chloride intracellular channel 4 0.0229581
TXNRD1 thioredoxin reductase 1 0.0229556
VMP1 vacuole membrane protein 1 0.0225535
ZNFX1 zinc finger, NFX1-type containing 1 0.0212675
NRIP1 nuclear receptor interacting protein 1 0.02119
TRIP12 thyroid hormone receptor interactor 12 0.0207927
OSMR oncostatin M receptor 0.0207827
SFTPA2 surfactant protein A2 0.0207218
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0204212
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0203574
RNF213 ring finger protein 213 0.0198956
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0197239
CTNND1 catenin (cadherin-associated protein), delta 1 0.0193885
KDM6A lysine (K)-specific demethylase 6A 0.0193473
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.019343
ATP13A3 ATPase type 13A3 0.0192397
ICAM1 intercellular adhesion molecule 1 0.0183428
MCL1 myeloid cell leukemia 1 0.0180368
LDHA lactate dehydrogenase A 0.0179434
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0178072
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0177828
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0177374
IL6ST interleukin 6 signal transducer 0.0176818
ACTN1 actinin, alpha 1 0.0176152
DENND5A DENN/MADD domain containing 5A 0.0175618
PPARD peroxisome proliferator-activated receptor delta 0.0174627
ZNF292 zinc finger protein 292 0.0173559
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0173004
VCAN versican 0.0172302
SBF2 SET binding factor 2 0.0171542
ARF4 ADP-ribosylation factor 4 0.0169927
FOXO3 forkhead box O3 0.0166822
NCOA7 nuclear receptor coactivator 7 0.0165442
DSCAM Down syndrome cell adhesion molecule 0.0163256
VEGFA vascular endothelial growth factor A 0.0162408
C3 complement component 3 0.0162188
CDCP1 CUB domain containing protein 1 0.0161828
MKI67 marker of proliferation Ki-67 0.0160669
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0159139
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0158379
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0157397
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.0157209
LOXL2 lysyl oxidase-like 2 0.015703
TXNIP thioredoxin interacting protein 0.0156737
METTL15 methyltransferase like 15 0.0156607
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0154612
ZFAND3 zinc finger, AN1-type domain 3 0.0153062
FTH1 ferritin, heavy polypeptide 1 0.0150808
CDK17 cyclin-dependent kinase 17 0.015049
PLSCR1 phospholipid scramblase 1 0.0149908
FAM3C family with sequence similarity 3, member C 0.0149535
SDC4 syndecan 4 0.0148366
IL1RAP interleukin 1 receptor accessory protein 0.0148217
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0146254
ARID5B AT rich interactive domain 5B (MRF1-like) 0.014533
UBA6 ubiquitin-like modifier activating enzyme 6 0.0144169
DUSP5 dual specificity phosphatase 5 0.0142024

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.217937
TPT1 tumor protein, translationally-controlled 1 -0.0785898
FTL ferritin, light polypeptide -0.0713437
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0712993
TMSB10 thymosin beta 10 -0.0670732
HMGA2 high mobility group AT-hook 2 -0.0667789
RPS12 ribosomal protein S12 -0.0665816
NAP1L1 nucleosome assembly protein 1-like 1 -0.0647263
RPS6 ribosomal protein S6 -0.0645099
IER3 immediate early response 3 -0.0600871
CDH13 cadherin 13 -0.0548105
RPL37A ribosomal protein L37a -0.0537817
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0536827
RPS8 ribosomal protein S8 -0.0528722
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0524921
MT2A metallothionein 2A -0.048967
FRMD4A FERM domain containing 4A -0.0487906
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0472822
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0465102
RPL26 ribosomal protein L26 -0.0443105
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0438205
RPS3 ribosomal protein S3 -0.0426896
RPL23 ribosomal protein L23 -0.0423445
RPLP1 ribosomal protein, large, P1 -0.0417345
RPLP2 ribosomal protein, large, P2 -0.0406935
HLA-B major histocompatibility complex, class I, B -0.0406534
TMSB4X thymosin beta 4, X-linked -0.0396922
INTS6 integrator complex subunit 6 -0.0387682
RPL35A ribosomal protein L35a -0.0386945
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0365243
RPL12 ribosomal protein L12 -0.0362973
RPS24 ribosomal protein S24 -0.0357918
B2M beta-2-microglobulin -0.0344526
PTMA prothymosin, alpha -0.0336905
RPL9 ribosomal protein L9 -0.0328339
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0314746
RPL5 ribosomal protein L5 -0.0312936
RAB7A RAB7A, member RAS oncogene family -0.0312724
RPL36A ribosomal protein L36a -0.0312475
RPL7A ribosomal protein L7a -0.0292142
RPS4X ribosomal protein S4, X-linked -0.0289538
GLIS3 GLIS family zinc finger 3 -0.0284548
FRMPD4 FERM and PDZ domain containing 4 -0.0283157
RPL11 ribosomal protein L11 -0.0278891
RPS19 ribosomal protein S19 -0.0277299
RACK1 receptor for activated C kinase 1 -0.0272447
TRIO trio Rho guanine nucleotide exchange factor -0.0268708
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0266102
RPL19 ribosomal protein L19 -0.0262221
SLC38A1 solute carrier family 38, member 1 -0.0255033
IGFBP3 insulin-like growth factor binding protein 3 -0.0254042
RPL37 ribosomal protein L37 -0.0248383
RPLP0 ribosomal protein, large, P0 -0.024731
CCBE1 collagen and calcium binding EGF domains 1 -0.0243833
RPS27A ribosomal protein S27a -0.0240188
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0234946
ACTG1 actin gamma 1 -0.0231587
SFRP1 secreted frizzled-related protein 1 -0.022932
RPL27A ribosomal protein L27a -0.0228416
RPL36 ribosomal protein L36 -0.0226101
RPS17 ribosomal protein S17 -0.0222147
CALR calreticulin -0.0220963
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0220554
RPS25 ribosomal protein S25 -0.0217572
RPL7 ribosomal protein L7 -0.0217117
AKAP12 A kinase (PRKA) anchor protein 12 -0.0215337
EIF1 eukaryotic translation initiation factor 1 -0.0206729
CANX calnexin -0.0206601
RPL35 ribosomal protein L35 -0.0202624
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 -0.0202162
ARL4C ADP-ribosylation factor-like 4C -0.019678
SQSTM1 sequestosome 1 -0.0195566
STC1 stanniocalcin 1 -0.0194522
TMEM132D transmembrane protein 132D -0.0194126
AFF3 AF4/FMR2 family, member 3 -0.0193621
EGFR epidermal growth factor receptor -0.0193396
RPL31 ribosomal protein L31 -0.0190955
RPL27 ribosomal protein L27 -0.0190763
GNAS GNAS complex locus -0.018761
RPS13 ribosomal protein S13 -0.018699
IARS1 isoleucyl-tRNA synthetase 1 -0.018666
RPS23 ribosomal protein S23 -0.0184335
RPS10 ribosomal protein S10 -0.0184278
RPS14 ribosomal protein S14 -0.0183294
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0172177
RPL32 ribosomal protein L32 -0.0172152
RPL18 ribosomal protein L18 -0.0170203
GOLGA4 golgin A4 -0.0169038
MACF1 microtubule-actin crosslinking factor 1 -0.0167913
RPS20 ribosomal protein S20 -0.0167576
SLC35F3 solute carrier family 35, member F3 -0.0166456
HMGA1 high mobility group AT-hook 1 -0.016595
DTNA dystrobrevin, alpha -0.0165189
RND3 Rho family GTPase 3 -0.0164585
CD44 CD44 molecule (Indian blood group) -0.0162937
TCEAL9 transcription elongation factor A like 9 -0.0161401
MORF4L2 mortality factor 4 like 2 -0.0159001
HLA-A major histocompatibility complex, class I, A -0.0158823
RPS29 ribosomal protein S29 -0.015842
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0156515