Sivelestat (sodium tetrahydrate)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RBM39 RNA binding motif protein 39 0.0667167
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0575371
EZR ezrin 0.0452385
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0414345
FNDC3B fibronectin type III domain containing 3B 0.0402681
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.038515
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0376203
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0344913
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0330434
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0318802
GOLGA4 golgin A4 0.0302732
NDRG1 N-myc downstream regulated 1 0.0302422
KDM3A lysine (K)-specific demethylase 3A 0.0301664
KMT2C lysine (K)-specific methyltransferase 2C 0.0301251
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0283446
ZNF292 zinc finger protein 292 0.0280666
PLEC plectin 0.0274946
NBAS neuroblastoma amplified sequence 0.0271778
CTNND1 catenin (cadherin-associated protein), delta 1 0.0267452
FAT1 FAT atypical cadherin 1 0.0265433
TUFT1 tuftelin 1 0.0260275
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0259796
ESYT2 extended synaptotagmin-like protein 2 0.0257642
ANKRD11 ankyrin repeat domain 11 0.025584
MYH9 myosin, heavy chain 9, non-muscle 0.0251144
CEMIP cell migration inducing protein, hyaluronan binding 0.0251032
COG5 component of oligomeric golgi complex 5 0.0250042
KDM6A lysine (K)-specific demethylase 6A 0.0246763
TSC22D2 TSC22 domain family, member 2 0.0245558
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0241248
DSPP dentin sialophosphoprotein 0.0240548
TFG TRK-fused gene 0.023805
ZFAND3 zinc finger, AN1-type domain 3 0.0233053
TXNRD1 thioredoxin reductase 1 0.0231903
ADAM17 ADAM metallopeptidase domain 17 0.0231716
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0231438
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0229146
XPO1 exportin 1 0.0227513
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0225181
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0219222
CANX calnexin 0.0211969
AHNAK AHNAK nucleoprotein 0.0210882
SRP54 signal recognition particle 54kDa 0.0209538
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0208649
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0204142
OGA O-GlcNAcase 0.0203702
PCBP2 poly(rC) binding protein 2 0.0203474
LMTK2 lemur tyrosine kinase 2 0.0200008
HYOU1 hypoxia up-regulated 1 0.0199284
KDM7A lysine (K)-specific demethylase 7A 0.0198544
CLIP2 CAP-GLY domain containing linker protein 2 0.01982
FXR1 fragile X mental retardation, autosomal homolog 1 0.0196368
PDIA3 protein disulfide isomerase family A, member 3 0.0196332
SPAG9 sperm associated antigen 9 0.0194902
DSCAM Down syndrome cell adhesion molecule 0.0194865
RAB6A RAB6A, member RAS oncogene family 0.0194337
USP3 ubiquitin specific peptidase 3 0.0193522
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0192771
YAP1 Yes-associated protein 1 0.0192192
CCNL1 cyclin L1 0.0190593
CALU calumenin 0.0189244
HBP1 HMG-box transcription factor 1 0.0188917
NCOA3 nuclear receptor coactivator 3 0.0182416
USP9X ubiquitin specific peptidase 9, X-linked 0.0181747
NPTN neuroplastin 0.0181372
AFDN afadin, adherens junction formation factor 0.0180228
ANXA11 annexin A11 0.018015
TMEM39A transmembrane protein 39A 0.0179977
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0177685
NCKAP1 NCK-associated protein 1 0.0177374
MTMR3 myotubularin related protein 3 0.0177225
RBM33 RNA binding motif protein 33 0.017393
NAMPT nicotinamide phosphoribosyltransferase 0.0173731
SND1 staphylococcal nuclease and tudor domain containing 1 0.0173313
TM9SF3 transmembrane 9 superfamily member 3 0.0172715
BIRC6 baculoviral IAP repeat containing 6 0.017144
TMF1 TATA element modulatory factor 1 0.0171183
RAB1A RAB1A, member RAS oncogene family 0.0170981
KDM5B lysine (K)-specific demethylase 5B 0.0170935
GCLC glutamate-cysteine ligase, catalytic subunit 0.0170848
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0169868
RNF43 ring finger protein 43 0.016815
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0167511
WAC WW domain containing adaptor with coiled-coil 0.0167081
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0164991
STAG2 stromal antigen 2 0.0161938
ARF4 ADP-ribosylation factor 4 0.016168
MATR3 matrin 3 0.0160899
SUCO SUN domain containing ossification factor 0.0160083
KMT2E lysine (K)-specific methyltransferase 2E 0.0160074
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0159679
CKAP5 cytoskeleton associated protein 5 0.0157891
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.015771
SHB Src homology 2 domain containing adaptor protein B 0.0157162
ORC4 origin recognition complex, subunit 4 0.0156536
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0154849
TRA2A transformer 2 alpha homolog (Drosophila) 0.0153883
CEMIP2 cell migration inducing hyaluronidase 2 0.0152842
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0151755
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0151302

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.253901
PTMA prothymosin, alpha -0.21213
TMSB10 thymosin beta 10 -0.195991
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.123981
RPS21 ribosomal protein S21 -0.0954545
RPL35A ribosomal protein L35a -0.0922358
TPT1 tumor protein, translationally-controlled 1 -0.0868503
RPL12 ribosomal protein L12 -0.0866759
RPS6 ribosomal protein S6 -0.0767905
MAML2 mastermind-like 2 (Drosophila) -0.0767557
KRT18 keratin 18, type I -0.0758965
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0743944
RPLP2 ribosomal protein, large, P2 -0.0724985
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0717817
RPLP1 ribosomal protein, large, P1 -0.0703753
KRT8 keratin 8, type II -0.0694457
RPS3 ribosomal protein S3 -0.0674098
RPL23 ribosomal protein L23 -0.0670422
BCL2L1 BCL2-like 1 -0.0650869
RPS13 ribosomal protein S13 -0.0638517
B2M beta-2-microglobulin -0.0634524
RPL37A ribosomal protein L37a -0.0632156
RPL18 ribosomal protein L18 -0.0624642
RPS19 ribosomal protein S19 -0.0577798
EGR1 early growth response 1 -0.0572217
EIF1 eukaryotic translation initiation factor 1 -0.0554676
RPL31 ribosomal protein L31 -0.0539715
LOC102724023 ES1 protein homolog, mitochondrial -0.0528376
RPS5 ribosomal protein S5 -0.0507127
PERP PERP, TP53 apoptosis effector -0.050014
RPS27A ribosomal protein S27a -0.0499812
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0496082
RPS25 ribosomal protein S25 -0.0481959
CCND1 cyclin D1 -0.0475106
RPL28 ribosomal protein L28 -0.0471587
RPS8 ribosomal protein S8 -0.0468464
ACTG1 actin gamma 1 -0.046234
RPS12 ribosomal protein S12 -0.046151
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0460681
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0456371
RPL8 ribosomal protein L8 -0.0456294
RPL32 ribosomal protein L32 -0.0455853
RPL19 ribosomal protein L19 -0.0454282
ZBTB20 zinc finger and BTB domain containing 20 -0.045065
EPCAM epithelial cell adhesion molecule -0.0441666
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0441052
NCEH1 neutral cholesterol ester hydrolase 1 -0.0440949
RPS24 ribosomal protein S24 -0.0440469
IFITM1 interferon induced transmembrane protein 1 -0.0438861
RPS14 ribosomal protein S14 -0.0438735
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0436444
CST3 cystatin C -0.0435756
CBX3 chromobox homolog 3 -0.0433908
RPS11 ribosomal protein S11 -0.04168
RPL36A ribosomal protein L36a -0.0415384
RPL26 ribosomal protein L26 -0.0411173
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0398176
RPLP0 ribosomal protein, large, P0 -0.0395534
EHBP1 EH domain binding protein 1 -0.0392678
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0390221
IFITM3 interferon induced transmembrane protein 3 -0.0389518
TMSB4X thymosin beta 4, X-linked -0.0387479
S100A6 S100 calcium binding protein A6 -0.0387131
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0386329
RPL27A ribosomal protein L27a -0.0386037
DLG1 discs, large homolog 1 (Drosophila) -0.0384672
EDN1 endothelin 1 -0.0382935
GSTP1 glutathione S-transferase pi 1 -0.0382481
RPL15 ribosomal protein L15 -0.0381575
ATP5F1E ATP synthase F1 subunit epsilon -0.0380439
RPL11 ribosomal protein L11 -0.0373045
RPS17 ribosomal protein S17 -0.0370663
PATJ PATJ crumbs cell polarity complex component -0.0368566
RPL34 ribosomal protein L34 -0.0367129
GNAS GNAS complex locus -0.0362048
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0358027
RACK1 receptor for activated C kinase 1 -0.035771
SOX4 SRY (sex determining region Y)-box 4 -0.0357134
PLSCR1 phospholipid scramblase 1 -0.0355731
RPL37 ribosomal protein L37 -0.0354069
RPL35 ribosomal protein L35 -0.0352951
IFI27 interferon, alpha-inducible protein 27 -0.0347928
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0346516
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0344374
SLC38A1 solute carrier family 38, member 1 -0.0342259
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0339671
RPS15 ribosomal protein S15 -0.0334134
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0333162
MACC1 metastasis associated in colon cancer 1 -0.0331943
IFI6 interferon, alpha-inducible protein 6 -0.0329219
RPL36 ribosomal protein L36 -0.0323826
RPL7A ribosomal protein L7a -0.0321943
HLA-A major histocompatibility complex, class I, A -0.0316969
IER3 immediate early response 3 -0.031583
RPL9 ribosomal protein L9 -0.0311882
HDAC9 histone deacetylase 9 -0.0307502
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0302224
ANXA2 annexin A2 -0.0296716
S100A10 S100 calcium binding protein A10 -0.0293838
EIF5B eukaryotic translation initiation factor 5B -0.0290684