Sivelestat (sodium tetrahydrate)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.258806
CD36 CD36 molecule (thrombospondin receptor) 0.235774
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.127989
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.116785
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.105674
RAD51B RAD51 paralog B 0.104707
PTMA prothymosin, alpha 0.0889641
EZR ezrin 0.0828454
IER3 immediate early response 3 0.0724347
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0681505
LDHA lactate dehydrogenase A 0.0644612
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0619155
HILPDA hypoxia inducible lipid droplet-associated 0.058492
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0583317
PARD3 par-3 family cell polarity regulator 0.05778
ESYT2 extended synaptotagmin-like protein 2 0.0549215
FHIT fragile histidine triad 0.0535739
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0529628
PDLIM5 PDZ and LIM domain 5 0.0528724
ANXA2 annexin A2 0.0525623
ACTN4 actinin, alpha 4 0.0518204
EEF2 eukaryotic translation elongation factor 2 0.0517984
OXR1 oxidation resistance 1 0.0510749
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0510338
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0500829
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0499564
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0486315
SERINC5 serine incorporator 5 0.045496
OSBPL3 oxysterol binding protein-like 3 0.0446789
MYO5B myosin VB 0.044304
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0439554
RERE arginine-glutamic acid dipeptide (RE) repeats 0.043403
FNDC3B fibronectin type III domain containing 3B 0.0427173
DENND1A DENN/MADD domain containing 1A 0.0424518
SQSTM1 sequestosome 1 0.0420254
GDF15 growth differentiation factor 15 0.0400116
FTH1 ferritin, heavy polypeptide 1 0.0398044
RCOR1 REST corepressor 1 0.0388816
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0386348
FMNL2 formin-like 2 0.0380115
STRN3 striatin, calmodulin binding protein 3 0.0377468
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0377397
RREB1 ras responsive element binding protein 1 0.037519
WDR43 WD repeat domain 43 0.0374807
CUX1 cut-like homeobox 1 0.0373354
ECT2 epithelial cell transforming 2 0.0373163
USP3 ubiquitin specific peptidase 3 0.0372806
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0372463
GNAT3 guanine nucleotide binding protein, alpha transducing 3 0.0366691
MSI2 musashi RNA-binding protein 2 0.036205
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.0360914
FRAS1 Fraser extracellular matrix complex subunit 1 0.035966
TMSB10 thymosin beta 10 0.0358221
OSBPL10 oxysterol binding protein-like 10 0.0353348
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0350978
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0344846
CTBP2 C-terminal binding protein 2 0.0344788
SBF2 SET binding factor 2 0.0342633
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0341064
AHNAK AHNAK nucleoprotein 0.0336371
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0332807
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0330952
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0326047
NT5DC3 5'-nucleotidase domain containing 3 0.032565
BIRC6 baculoviral IAP repeat containing 6 0.032306
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0317049
CANX calnexin 0.0316805
APP amyloid beta (A4) precursor protein 0.0315084
ENO1 enolase 1, (alpha) 0.0314856
HDAC2 histone deacetylase 2 0.0313691
ANKRD17 ankyrin repeat domain 17 0.0312339
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0311632
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0311518
GLG1 golgi glycoprotein 1 0.0306474
NDRG1 N-myc downstream regulated 1 0.0305808
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0304744
KITLG KIT ligand 0.0303183
PCBP2 poly(rC) binding protein 2 0.030161
RUNX2 runt-related transcription factor 2 0.0301002
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0297993
COG5 component of oligomeric golgi complex 5 0.0297687
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0296937
KPNB1 karyopherin (importin) beta 1 0.0290556
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0290529
ARF1 ADP-ribosylation factor 1 0.028612
WAC WW domain containing adaptor with coiled-coil 0.0283996
IGFBP3 insulin-like growth factor binding protein 3 0.0283452
TRIO trio Rho guanine nucleotide exchange factor 0.027991
LGALS3 lectin, galactoside-binding, soluble, 3 0.0279269
IARS1 isoleucyl-tRNA synthetase 1 0.0278785
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.027751
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0275408
EPHA2 EPH receptor A2 0.0275267
GARS1 glycyl-tRNA synthetase 1 0.0273026
OGA O-GlcNAcase 0.0270152
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0267446
NPR2 natriuretic peptide receptor 2 0.0265423
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.0263885
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) 0.0262827
OXSR1 oxidative stress responsive 1 0.0262168

decreased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.128683
AREG amphiregulin -0.121269
LAMC2 laminin, gamma 2 -0.0950603
RPS12 ribosomal protein S12 -0.0827518
RPS3 ribosomal protein S3 -0.0764857
PLAUR plasminogen activator, urokinase receptor -0.0724463
ITPKC inositol-trisphosphate 3-kinase C -0.0606628
RPS2 ribosomal protein S2 -0.0598043
FLOT1 flotillin 1 -0.0585235
RPL37A ribosomal protein L37a -0.0569708
PDE4B phosphodiesterase 4B, cAMP-specific -0.0552744
FERMT1 fermitin family member 1 -0.0534842
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0514137
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0484113
LOC102724023 ES1 protein homolog, mitochondrial -0.0479027
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0476739
BIRC3 baculoviral IAP repeat containing 3 -0.0463002
RPL26 ribosomal protein L26 -0.0458507
RPLP2 ribosomal protein, large, P2 -0.0421478
EREG epiregulin -0.0411884
HSPA8 heat shock 70kDa protein 8 -0.0398877
RBM25 RNA binding motif protein 25 -0.0397501
NUP50 nucleoporin 50kDa -0.0377817
MKI67 marker of proliferation Ki-67 -0.0375016
RPL12 ribosomal protein L12 -0.0373119
RPS6 ribosomal protein S6 -0.0370966
CPOX coproporphyrinogen oxidase -0.036987
NCEH1 neutral cholesterol ester hydrolase 1 -0.0367649
RPL9 ribosomal protein L9 -0.0366275
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0364722
RPS8 ribosomal protein S8 -0.0362185
MACF1 microtubule-actin crosslinking factor 1 -0.0344992
GOLGA4 golgin A4 -0.0328216
RPS17 ribosomal protein S17 -0.0325754
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0318964
ITPRID2 ITPR interacting domain containing 2 -0.0317618
SET SET nuclear proto-oncogene -0.0314395
PRRC2C proline-rich coiled-coil 2C -0.0308932
ATXN1 ataxin 1 -0.0302619
RPS19 ribosomal protein S19 -0.0283921
KTN1 kinectin 1 (kinesin receptor) -0.0282366
LAMA4 laminin, alpha 4 -0.0277559
RPL21 ribosomal protein L21 -0.0276796
FHL2 four and a half LIM domains 2 -0.0271423
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0263286
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0262537
LMO7 LIM domain 7 -0.0262365
SEPTIN9 septin 9 -0.026177
YAP1 Yes-associated protein 1 -0.0261209
NKTR natural killer cell triggering receptor -0.0259993
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0255804
RPL36A ribosomal protein L36a -0.0253925
RPL7A ribosomal protein L7a -0.0251435
CENPF centromere protein F, 350/400kDa -0.0244746
SNX9 sorting nexin 9 -0.0242499
RPL18 ribosomal protein L18 -0.0238947
PARD6B par-6 family cell polarity regulator beta -0.0237396
EGR1 early growth response 1 -0.0234229
DSCAM Down syndrome cell adhesion molecule -0.0226964
RPL27 ribosomal protein L27 -0.0218686
SETD5 SET domain containing 5 -0.0216604
SRSF11 serine/arginine-rich splicing factor 11 -0.021378
AKAP9 A kinase (PRKA) anchor protein 9 -0.0208204
SGMS2 sphingomyelin synthase 2 -0.0206248
RPL7 ribosomal protein L7 -0.0205744
SLTM SAFB-like, transcription modulator -0.0205667
KLF6 Kruppel-like factor 6 -0.0203292
EIF1 eukaryotic translation initiation factor 1 -0.0202154
MT2A metallothionein 2A -0.0201376
RPL11 ribosomal protein L11 -0.0201219
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0198844
RPL5 ribosomal protein L5 -0.0193138
ZFP36 ZFP36 ring finger protein -0.0192431
CLU clusterin -0.0191985
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0191965
CDCP1 CUB domain containing protein 1 -0.0190463
HMGA1 high mobility group AT-hook 1 -0.0187573
BRD2 bromodomain containing 2 -0.0187073
PNISR PNN-interacting serine/arginine-rich protein -0.0186838
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0185595
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0184287
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0183558
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0183071
KLK10 kallikrein-related peptidase 10 -0.01825
MIDN midnolin -0.0182169
COX5A cytochrome c oxidase subunit Va -0.0179165
MAPK8 mitogen-activated protein kinase 8 -0.0179114
LIMA1 LIM domain and actin binding 1 -0.0178409
DOCK5 dedicator of cytokinesis 5 -0.0177153
POM121C POM121 transmembrane nucleoporin C -0.0170232
ARL15 ADP-ribosylation factor-like 15 -0.0169467
H1-4 H1.4 linker histone, cluster member -0.016888
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0168454
EPCAM epithelial cell adhesion molecule -0.0167872
ACTG1 actin gamma 1 -0.0167351
COX6C cytochrome c oxidase subunit VIc -0.0167042
UBXN4 UBX domain protein 4 -0.0166926
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.016658
RNASEH2A ribonuclease H2, subunit A -0.0166293
NABP1 nucleic acid binding protein 1 -0.016581