Sivelestat (sodium tetrahydrate)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sivelestat (sodium tetrahydrate) perturbation in SW480 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) 0.320329
MAML2 mastermind-like 2 (Drosophila) 0.0829916
CDH13 cadherin 13 0.0829201
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0761134
AKAP12 A kinase (PRKA) anchor protein 12 0.0748943
DST dystonin 0.0716753
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.070019
CANX calnexin 0.0697794
ETNK1 ethanolamine kinase 1 0.0670655
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0668408
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0651749
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0645064
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0633112
PDE4D phosphodiesterase 4D, cAMP-specific 0.0611418
CDK6 cyclin-dependent kinase 6 0.0610702
KRT18 keratin 18, type I 0.0590862
RUNX1 runt-related transcription factor 1 0.0590327
BIRC6 baculoviral IAP repeat containing 6 0.0549251
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.054262
PROX1 prospero homeobox 1 0.0533052
PGK1 phosphoglycerate kinase 1 0.0530298
ITGA6 integrin, alpha 6 0.052906
ZBTB20 zinc finger and BTB domain containing 20 0.0525423
SPATA13 spermatogenesis associated 13 0.0520423
ENO1 enolase 1, (alpha) 0.0519121
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0505285
TMEM123 transmembrane protein 123 0.0476366
SYT1 synaptotagmin I 0.047048
KIZ kizuna centrosomal protein 0.0456029
OXR1 oxidation resistance 1 0.0446137
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0442811
JMJD1C jumonji domain containing 1C 0.0437885
IARS1 isoleucyl-tRNA synthetase 1 0.0419043
PABPC1 poly(A) binding protein, cytoplasmic 1 0.040846
NF1 neurofibromin 1 0.0398607
APP amyloid beta (A4) precursor protein 0.0396246
LDHA lactate dehydrogenase A 0.0393668
MACC1 metastasis associated in colon cancer 1 0.0390094
FNDC3A fibronectin type III domain containing 3A 0.0388353
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0387036
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0385159
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0382269
MACF1 microtubule-actin crosslinking factor 1 0.0379481
ZFAND3 zinc finger, AN1-type domain 3 0.0372561
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0366093
ITPRID2 ITPR interacting domain containing 2 0.0365206
USP34 ubiquitin specific peptidase 34 0.0364033
ATXN1 ataxin 1 0.0354137
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0350695
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0349609
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0349388
THOC2 THO complex 2 0.0347739
TCF12 transcription factor 12 0.0344846
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0343616
LMO7 LIM domain 7 0.0343457
DSPP dentin sialophosphoprotein 0.0341832
GLG1 golgi glycoprotein 1 0.0337603
ANKRD17 ankyrin repeat domain 17 0.0336968
RBM39 RNA binding motif protein 39 0.0335696
MED13 mediator complex subunit 13 0.0335487
ZMYND8 zinc finger, MYND-type containing 8 0.0334027
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0329938
GMDS GDP-mannose 4,6-dehydratase 0.032965
BCL2L1 BCL2-like 1 0.0329184
KMT2C lysine (K)-specific methyltransferase 2C 0.0327356
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0317801
EIF4B eukaryotic translation initiation factor 4B 0.0317138
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0316284
AOPEP aminopeptidase O (putative) 0.0314233
SEC31A SEC31 homolog A (S. cerevisiae) 0.0311744
EPB41 erythrocyte membrane protein band 4.1 0.0310251
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0305939
BRWD3 bromodomain and WD repeat domain containing 3 0.0304828
SKAP1 src kinase associated phosphoprotein 1 0.0304097
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.030402
GOLGA4 golgin A4 0.0303181
CEP95 centrosomal protein 95kDa 0.0303065
SNX9 sorting nexin 9 0.0301092
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0299619
ANKRD10 ankyrin repeat domain 10 0.0298909
DLG1 discs, large homolog 1 (Drosophila) 0.0298372
MYH9 myosin, heavy chain 9, non-muscle 0.0297145
ARHGAP12 Rho GTPase activating protein 12 0.029138
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.029092
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0290196
ARHGAP9 Rho GTPase activating protein 9 0.0288327
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0288261
USP9X ubiquitin specific peptidase 9, X-linked 0.0285172
TMCC1 transmembrane and coiled-coil domain family 1 0.0284287
ERRFI1 ERBB receptor feedback inhibitor 1 0.0279762
OSBPL3 oxysterol binding protein-like 3 0.0278998
FRMD5 FERM domain containing 5 0.0278009
PIBF1 progesterone immunomodulatory binding factor 1 0.0277288
TMSB4X thymosin beta 4, X-linked 0.0277239
OGA O-GlcNAcase 0.0275282
NCOR1 nuclear receptor corepressor 1 0.0274547
MORF4L2 mortality factor 4 like 2 0.0273949
TPM4 tropomyosin 4 0.0273853
RBM26 RNA binding motif protein 26 0.027252
WDFY2 WD repeat and FYVE domain containing 2 0.0272496

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.132757
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.103038
RPL35A ribosomal protein L35a -0.0774779
TMSB10 thymosin beta 10 -0.0673768
RPS6 ribosomal protein S6 -0.0629368
RPS19 ribosomal protein S19 -0.0627
MT2A metallothionein 2A -0.0609718
RPLP1 ribosomal protein, large, P1 -0.0552186
INTS6 integrator complex subunit 6 -0.0507095
RPL37A ribosomal protein L37a -0.0471517
RPS12 ribosomal protein S12 -0.045808
RPLP2 ribosomal protein, large, P2 -0.0456579
RPL23 ribosomal protein L23 -0.0443559
RPS8 ribosomal protein S8 -0.0397914
TPT1 tumor protein, translationally-controlled 1 -0.0385789
RPL26 ribosomal protein L26 -0.0368223
EGR1 early growth response 1 -0.0355601
RPL9 ribosomal protein L9 -0.0332151
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0316009
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0315912
FTL ferritin, light polypeptide -0.0309453
RPS3 ribosomal protein S3 -0.0307515
RPL28 ribosomal protein L28 -0.0295712
RPL35 ribosomal protein L35 -0.0291901
RPL36 ribosomal protein L36 -0.0289136
SDK1 sidekick cell adhesion molecule 1 -0.0279475
RPS23 ribosomal protein S23 -0.0271442
RPL12 ribosomal protein L12 -0.0265924
RPS17 ribosomal protein S17 -0.0262909
RPL31 ribosomal protein L31 -0.0262557
RPS25 ribosomal protein S25 -0.0248266
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor -0.0219945
RPS13 ribosomal protein S13 -0.0219569
RPL32 ribosomal protein L32 -0.0215064
RPS29 ribosomal protein S29 -0.021429
RPL19 ribosomal protein L19 -0.0213292
ACTG1 actin gamma 1 -0.0207519
RPL5 ribosomal protein L5 -0.0205703
RPS14 ribosomal protein S14 -0.0202953
RPL11 ribosomal protein L11 -0.0201892
LOC102724023 ES1 protein homolog, mitochondrial -0.0201878
RPS21 ribosomal protein S21 -0.0200972
RPS20 ribosomal protein S20 -0.0185466
ZSWIM6 zinc finger, SWIM-type containing 6 -0.018324
RPL27 ribosomal protein L27 -0.0180426
RPS11 ribosomal protein S11 -0.0178316
EMP1 epithelial membrane protein 1 -0.0177815
RPL36A ribosomal protein L36a -0.0176862
CD44 CD44 molecule (Indian blood group) -0.0175823
ACTN4 actinin, alpha 4 -0.0175696
RPL34 ribosomal protein L34 -0.0175478
RPL18 ribosomal protein L18 -0.017398
RPS5 ribosomal protein S5 -0.0169485
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0167713
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0166458
TUBB4B tubulin, beta 4B class IVb -0.0166002
RBP1 retinol binding protein 1, cellular -0.0164571
RPL21 ribosomal protein L21 -0.0162316
ATP5F1E ATP synthase F1 subunit epsilon -0.0161287
RPS15 ribosomal protein S15 -0.0161115
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0159692
EGFR epidermal growth factor receptor -0.0159375
HMGA1 high mobility group AT-hook 1 -0.0158411
LMNA lamin A/C -0.0157313
RPL30 ribosomal protein L30 -0.0155241
RPS10 ribosomal protein S10 -0.0152195
RPS16 ribosomal protein S16 -0.0150986
WWOX WW domain containing oxidoreductase -0.014958
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0148086
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0147696
RPS27 ribosomal protein S27 -0.0147225
RCC1 regulator of chromosome condensation 1 -0.0145858
RPL7A ribosomal protein L7a -0.0145486
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0143969
PTMA prothymosin, alpha -0.0143655
YBX1 Y box binding protein 1 -0.0142619
SMC4 structural maintenance of chromosomes 4 -0.014153
SEC61G Sec61 gamma subunit -0.0140242
NDRG1 N-myc downstream regulated 1 -0.0140202
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0139616
RPS27A ribosomal protein S27a -0.0138481
NTSR1 neurotensin receptor 1 (high affinity) -0.0134334
HMGB1 high mobility group box 1 -0.0134123
NABP1 nucleic acid binding protein 1 -0.0130497
PFN1 profilin 1 -0.0129676
TNS4 tensin 4 -0.0128906
RPS2 ribosomal protein S2 -0.0128216
PABPN1 poly(A) binding protein, nuclear 1 -0.0127623
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0124016
RPL38 ribosomal protein L38 -0.0123157
S100A9 S100 calcium binding protein A9 -0.0121674
RPS4X ribosomal protein S4, X-linked -0.0120802
SQSTM1 sequestosome 1 -0.0120407
RPS24 ribosomal protein S24 -0.0118162
RPL8 ribosomal protein L8 -0.0117094
RPL7 ribosomal protein L7 -0.0114718
NDUFA4 NDUFA4, mitochondrial complex associated -0.0114001
VIM vimentin -0.0113479
S100A10 S100 calcium binding protein A10 -0.0112148
NACA nascent polypeptide-associated complex alpha subunit -0.0111626