| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Sivelestat (sodium tetrahydrate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Sivelestat (sodium tetrahydrate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FNDC3B | fibronectin type III domain containing 3B | 0.0867142 |
| COL1A1 | collagen, type I, alpha 1 | 0.0780051 |
| NDRG1 | N-myc downstream regulated 1 | 0.0658093 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0636887 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0604534 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0502051 |
| RUNX1 | runt-related transcription factor 1 | 0.0474729 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0467496 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.045883 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0430481 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0427605 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0426625 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0414277 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0378911 |
| ACTG1 | actin gamma 1 | 0.0367326 |
| SMAD3 | SMAD family member 3 | 0.0366873 |
| GOLGA4 | golgin A4 | 0.0362438 |
| SETD5 | SET domain containing 5 | 0.0361365 |
| PKM | pyruvate kinase, muscle | 0.035559 |
| LDHA | lactate dehydrogenase A | 0.0348091 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0338438 |
| RTN4 | reticulon 4 | 0.0333055 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0326796 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0326111 |
| HLA-B | major histocompatibility complex, class I, B | 0.0313314 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0312954 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0302254 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0286441 |
| FAM13A | family with sequence similarity 13, member A | 0.0283534 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0282784 |
| PCBP2 | poly(rC) binding protein 2 | 0.0281125 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0280638 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0279738 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0278259 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0277102 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0276583 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0272188 |
| VEGFA | vascular endothelial growth factor A | 0.0268539 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0265977 |
| RPL31 | ribosomal protein L31 | 0.0262189 |
| LOXL2 | lysyl oxidase-like 2 | 0.0261613 |
| JMJD1C | jumonji domain containing 1C | 0.0256974 |
| HELZ | helicase with zinc finger | 0.025587 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0254461 |
| RBM39 | RNA binding motif protein 39 | 0.0248654 |
| RPL35A | ribosomal protein L35a | 0.0247756 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0241596 |
| ZNF292 | zinc finger protein 292 | 0.0241109 |
| RPS23 | ribosomal protein S23 | 0.0237158 |
| RPS13 | ribosomal protein S13 | 0.0235342 |
| MYOF | myoferlin | 0.0232314 |
| PTK2 | protein tyrosine kinase 2 | 0.023183 |
| RPS6 | ribosomal protein S6 | 0.0229126 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0227789 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0226476 |
| PDE8A | phosphodiesterase 8A | 0.0225171 |
| PGK1 | phosphoglycerate kinase 1 | 0.0224073 |
| MSI2 | musashi RNA-binding protein 2 | 0.0222649 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0221934 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.021932 |
| MCL1 | myeloid cell leukemia 1 | 0.0218868 |
| ACTN4 | actinin, alpha 4 | 0.0217218 |
| UBC | ubiquitin C | 0.0214812 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | 0.0214445 |
| EFNA5 | ephrin-A5 | 0.0213838 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0213682 |
| ERBIN | erbb2 interacting protein | 0.0211491 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0209957 |
| TXNRD1 | thioredoxin reductase 1 | 0.0209523 |
| MSN | moesin | 0.0209284 |
| COL1A2 | collagen, type I, alpha 2 | 0.0207105 |
| PTMA | prothymosin, alpha | 0.0206412 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0205957 |
| PTEN | phosphatase and tensin homolog | 0.0202132 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0201413 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0200827 |
| WAC | WW domain containing adaptor with coiled-coil | 0.020004 |
| LMO7 | LIM domain 7 | 0.0194771 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0194421 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0193571 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0192664 |
| POTEF | POTE ankyrin domain family, member F | 0.0189603 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0188024 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0187664 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0186675 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0185824 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0185371 |
| SP3 | Sp3 transcription factor | 0.0184994 |
| CALD1 | caldesmon 1 | 0.0184643 |
| USP34 | ubiquitin specific peptidase 34 | 0.018357 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0180344 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0179293 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0178275 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0178258 |
| RPS16 | ribosomal protein S16 | 0.0177226 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0176303 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0175394 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0174971 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0173562 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0172494 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.236752 |
| INHBA | inhibin, beta A | -0.172418 |
| STC1 | stanniocalcin 1 | -0.172288 |
| HMGA2 | high mobility group AT-hook 2 | -0.155383 |
| MMP1 | matrix metallopeptidase 1 | -0.154597 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.108678 |
| PRKG1 | protein kinase, cGMP-dependent, type I | -0.0979277 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0803187 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0802305 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0736579 |
| FN1 | fibronectin 1 | -0.0671272 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0603434 |
| OXR1 | oxidation resistance 1 | -0.0579907 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | -0.0544698 |
| MYO10 | myosin X | -0.051707 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0507164 |
| GLIS3 | GLIS family zinc finger 3 | -0.0499143 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0466314 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0453983 |
| MT2A | metallothionein 2A | -0.0411063 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0400384 |
| CDH13 | cadherin 13 | -0.0385746 |
| SAMD3 | sterile alpha motif domain containing 3 | -0.0384612 |
| CAVIN1 | caveolae associated protein 1 | -0.0375147 |
| TMSB10 | thymosin beta 10 | -0.0338771 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0330485 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0319055 |
| RAI14 | retinoic acid induced 14 | -0.0297817 |
| NCKAP5 | NCK-associated protein 5 | -0.0293101 |
| EMP1 | epithelial membrane protein 1 | -0.0288143 |
| TMSB4X | thymosin beta 4, X-linked | -0.028553 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.028187 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0279878 |
| FBN1 | fibrillin 1 | -0.0279519 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0278032 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.0269152 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0255135 |
| DNER | delta/notch-like EGF repeat containing | -0.0235136 |
| EFCAB13 | EF-hand calcium binding domain 13 | -0.022813 |
| PRRX1 | paired related homeobox 1 | -0.02208 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.021102 |
| ITGA1 | integrin, alpha 1 | -0.0207501 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0204122 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0190609 |
| HLA-E | major histocompatibility complex, class I, E | -0.0189743 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0187506 |
| ANTXR2 | anthrax toxin receptor 2 | -0.018736 |
| RPS12 | ribosomal protein S12 | -0.0185959 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.0180933 |
| NPTX1 | neuronal pentraxin I | -0.0174059 |
| FRMD4A | FERM domain containing 4A | -0.0171078 |
| ASPH | aspartate beta-hydroxylase | -0.016772 |
| HMGB2 | high mobility group box 2 | -0.0165914 |
| ARHGAP24 | Rho GTPase activating protein 24 | -0.0157991 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0157113 |
| ARHGAP22 | Rho GTPase activating protein 22 | -0.0156897 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0156212 |
| CD59 | CD59 molecule, complement regulatory protein | -0.01562 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0154495 |
| KIAA1549L | KIAA1549-like | -0.015391 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0152984 |
| LAMA4 | laminin, alpha 4 | -0.0150737 |
| RPS3 | ribosomal protein S3 | -0.0149956 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0148934 |
| IGFBP7 | insulin-like growth factor binding protein 7 | -0.0144491 |
| INTS6 | integrator complex subunit 6 | -0.0141592 |
| TCEAL9 | transcription elongation factor A like 9 | -0.0139352 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0138051 |
| RPL18 | ribosomal protein L18 | -0.0137795 |
| PRSS23 | protease, serine, 23 | -0.0136506 |
| COL3A1 | collagen, type III, alpha 1 | -0.0136211 |
| IPO5 | importin 5 | -0.0135515 |
| TMEM165 | transmembrane protein 165 | -0.0135509 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.013545 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0132681 |
| AHNAK | AHNAK nucleoprotein | -0.0131831 |
| PRR16 | proline rich 16 | -0.013163 |
| CCDC47 | coiled-coil domain containing 47 | -0.0128966 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | -0.0128354 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0127062 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0126226 |
| NPAS2 | neuronal PAS domain protein 2 | -0.012614 |
| DCN | decorin | -0.0125911 |
| RPL27 | ribosomal protein L27 | -0.0125143 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.01249 |
| OSMR | oncostatin M receptor | -0.0124841 |
| DIAPH2 | diaphanous-related formin 2 | -0.0124403 |
| PCNX4 | pecanex 4 | -0.0124019 |
| CRADD | CASP2 and RIPK1 domain containing adaptor with death domain | -0.0123663 |
| WNT5A | wingless-type MMTV integration site family, member 5A | -0.0123053 |
| MMP14 | matrix metallopeptidase 14 (membrane-inserted) | -0.0122463 |
| CALR | calreticulin | -0.0121284 |
| TPM4 | tropomyosin 4 | -0.0120645 |
| ETV3 | ets variant 3 | -0.0119991 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0117191 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0116241 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0115506 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0114991 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.0114084 |
| IL6 | interleukin 6 | -0.0112826 |
