Sjogren'S Syndrome Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A hypersensitivity reaction type II disease that involves attack of immune cells which destroy the exocrine glands that produce tears and saliva. (Human Disease Ontology, DOID_12894)
External Link https://www.disgenet.org/browser/0/1/0/C1527336
Similar Terms
Downloads & Tools

Genes

440 genes associated with the disease Sjogren'S Syndrome in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACAD8 acyl-CoA dehydrogenase family, member 8
ACR acrosin
ADA adenosine deaminase
ADAM17 ADAM metallopeptidase domain 17
ADIPOQ adiponectin, C1Q and collagen domain containing
AGER advanced glycosylation end product-specific receptor
AICDA activation-induced cytidine deaminase
AIRE autoimmune regulator
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALB albumin
ALCAM activated leukocyte cell adhesion molecule
ALPP alkaline phosphatase, placental
AMH anti-Mullerian hormone
AMY1A amylase, alpha 1A (salivary)
AMY1B amylase, alpha 1B (salivary)
AMY1C amylase, alpha 1C (salivary)
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
APOH apolipoprotein H (beta-2-glycoprotein I)
AQP1 aquaporin 1 (Colton blood group)
AQP3 aquaporin 3 (Gill blood group)
AQP4 aquaporin 4
AQP5 aquaporin 5
AREG amphiregulin
ARHGAP45 Rho GTPase activating protein 45
ASCL2 achaete-scute family bHLH transcription factor 2
ASRGL1 asparaginase like 1
ATF6 activating transcription factor 6
ATF7IP activating transcription factor 7 interacting protein
ATG5 autophagy related 5
ATN1 atrophin 1
ATRNL1 attractin-like 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL6 B-cell CLL/lymphoma 6
BDNF brain-derived neurotrophic factor
BLK BLK proto-oncogene, Src family tyrosine kinase
BMP6 bone morphogenetic protein 6
BPIFA2 BPI fold containing family A, member 2
BTG3 BTG family, member 3
BTK Bruton agammaglobulinemia tyrosine kinase
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CA6 carbonic anhydrase VI
CALR calreticulin
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CAST calpastatin
CCL17 chemokine (C-C motif) ligand 17
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL21 chemokine (C-C motif) ligand 21
CCL22 chemokine (C-C motif) ligand 22
CCL25 chemokine (C-C motif) ligand 25
CCL27 chemokine (C-C motif) ligand 27
CCL5 chemokine (C-C motif) ligand 5
CCN1 cellular communication network factor 1
CCR7 chemokine (C-C motif) receptor 7
CCR9 chemokine (C-C motif) receptor 9
CD14 CD14 molecule
CD2 CD2 molecule
CD27 CD27 molecule
CD274 CD274 molecule
CD4 CD4 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CD68 CD68 molecule
CD69 CD69 molecule
CD8A CD8a molecule
CD9 CD9 molecule
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CENPB centromere protein B, 80kDa
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CHIA chitinase, acidic
CHP1 calcineurin-like EF-hand protein 1
CHRM3 cholinergic receptor, muscarinic 3
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CKAP4 cytoskeleton-associated protein 4
CLDN5 claudin 5
CLN3 ceroid-lipofuscinosis, neuronal 3
CLOCK clock circadian regulator
CNN3 calponin 3, acidic
CNTN2 contactin 2 (axonal)
CP ceruloplasmin (ferroxidase)
CR2 complement component (3d/Epstein Barr virus) receptor 2
CRISP3 cysteine-rich secretory protein 3
CRP C-reactive protein, pentraxin-related
CST3 cystatin C
CTLA4 cytotoxic T-lymphocyte-associated protein 4
CTSB cathepsin B
CTSD cathepsin D
CTSS cathepsin S
CUL9 cullin 9
CX3CL1 chemokine (C-X3-C motif) ligand 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR3 chemokine (C-X-C motif) receptor 3
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR5 chemokine (C-X-C motif) receptor 5
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DGKQ diacylglycerol kinase, theta 110kDa
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40
DLAT dihydrolipoamide S-acetyltransferase
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
DNASE1 deoxyribonuclease I
DSTN destrin (actin depolymerizing factor)
E2F1 E2F transcription factor 1
EBI3 Epstein-Barr virus induced 3
EDA ectodysplasin A
EDA2R ectodysplasin A2 receptor
EDNRA endothelin receptor type A
EGF epidermal growth factor
EGFR epidermal growth factor receptor
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ELN elastin
EPHB2 EPH receptor B2
ERV3-1 endogenous retrovirus group 3, member 1
ESR1 estrogen receptor 1
F9 coagulation factor IX
FAM167A family with sequence similarity 167, member A
FAS Fas cell surface death receptor
FASLG Fas ligand (TNF superfamily, member 6)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FLNB filamin B, beta
FMR1 fragile X mental retardation 1
FOXP3 forkhead box P3
FPR2 formyl peptide receptor 2
FUCA1 fucosidase, alpha-L- 1, tissue
FUCA2 fucosidase, alpha-L- 2, plasma
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GOLGA1 golgin A1
GOLGA4 golgin A4
GORASP1 golgi reassembly stacking protein 1, 65kDa
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
GPT glutamic-pyruvate transaminase (alanine aminotransferase)
GRAP GRB2-related adaptor protein
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRN granulin
GSN gelsolin
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
GSTT1 glutathione S-transferase theta 1
GTF2I general transcription factor IIi
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HEYL hes-related family bHLH transcription factor with YRPW motif-like
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3
HMCN1 hemicentin 1
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
HSPA4 heat shock 70kDa protein 4
ICA1 islet cell autoantigen 1, 69kDa
ICAM1 intercellular adhesion molecule 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNLR1 interferon, lambda receptor 1
IGH immunoglobulin heavy locus
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IL10 interleukin 10
IL12A interleukin 12A
IL12RB1 interleukin 12 receptor, beta 1
IL13 interleukin 13
IL17A interleukin 17A
IL17D interleukin 17D
IL17F interleukin 17F
IL17RB interleukin 17 receptor B
IL18 interleukin 18
IL18R1 interleukin 18 receptor 1
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IL2 interleukin 2
IL21 interleukin 21
IL22 interleukin 22
IL23A interleukin 23, alpha subunit p19
IL23R interleukin 23 receptor
IL25 interleukin 25
IL27 interleukin 27
IL2RA interleukin 2 receptor, alpha
IL33 interleukin 33
IL4 interleukin 4
IL5 interleukin 5
IL6 interleukin 6
IL6R interleukin 6 receptor
IL7 interleukin 7
IL7R interleukin 7 receptor
ILF2 interleukin enhancer binding factor 2
ILF3 interleukin enhancer binding factor 3, 90kDa
INSRR insulin receptor-related receptor
IRAK1 interleukin-1 receptor-associated kinase 1
IRAK1BP1 interleukin-1 receptor-associated kinase 1 binding protein 1
IRF1 interferon regulatory factor 1
IRF2 interferon regulatory factor 2
IRF5 interferon regulatory factor 5
ISG20 interferon stimulated exonuclease gene 20kDa
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
ITSN2 intersectin 2
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3
KDR kinase insert domain receptor
KLRG1 killer cell lectin-like receptor subfamily G, member 1
KRT6B keratin 6B, type II
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2
LAPTM5 lysosomal protein transmembrane 5
LCN1 lipocalin 1
LEF1 lymphoid enhancer-binding factor 1
LEP leptin
LEPR leptin receptor
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3
LOC102723407 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8
LOC102724971 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8
LOC105371045 uncharacterized LOC105371045
LOC400736 PRAME family member-like
LPL lipoprotein lipase
LTA lymphotoxin alpha
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3)
LTF lactotransferrin
LY9 lymphocyte antigen 9
LYZ lysozyme
MALT1 MALT1 paracaspase
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MAPK1 mitogen-activated protein kinase 1
MAPK8 mitogen-activated protein kinase 8
MBL2 mannose-binding lectin (protein C) 2, soluble
MDK midkine (neurite growth-promoting factor 2)
MFN2 mitofusin 2
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MSC musculin
MSH5 mutS homolog 5
MSMB microseminoprotein, beta-
MSN moesin
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
MUC19 mucin 19, oligomeric
MUC4 mucin 4, cell surface associated
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
MUC5B mucin 5B, oligomeric mucus/gel-forming
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCBP MYC binding protein
MYD88 myeloid differentiation primary response 88
MYDGF myeloid-derived growth factor
NAPB N-ethylmaleimide-sensitive factor attachment protein, beta
NAT10 N-acetyltransferase 10 (GCN5-related)
NCF1 neutrophil cytosolic factor 1
NCR3 natural cytotoxicity triggering receptor 3
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NGF nerve growth factor (beta polypeptide)
NLRP3 NLR family, pyrin domain containing 3
NOD1 nucleotide-binding oligomerization domain containing 1
NR1I3 nuclear receptor subfamily 1, group I, member 3
NR1I4 nuclear receptor subfamily 1, group I, member 4
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRP1 neuropilin 1
NRSN1 neurensin 1
NT5C1A 5'-nucleotidase, cytosolic IA
NUCLEOLIN nucleolin multifunctional protein
NUDT10 nudix (nucleoside diphosphate linked moiety X)-type motif 10
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15
NXF1 nuclear RNA export factor 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OCLN occludin
OXTR oxytocin receptor
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7
PADI4 peptidyl arginine deiminase, type IV
PAEP progestagen-associated endometrial protein
PAX3 paired box 3
PAX6 paired box 6
PDCD1 programmed cell death 1
PDLIM3 PDZ and LIM domain 3
PHIP pleckstrin homology domain interacting protein
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
POU2F1 POU class 2 homeobox 1
PPARA peroxisome proliferator-activated receptor alpha
PPARG peroxisome proliferator-activated receptor gamma
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRDM1 PR domain containing 1, with ZNF domain
PRG4 proteoglycan 4
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PRL prolactin
PRTN3 proteinase 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSPH phosphoserine phosphatase
PSPN persephin
PTEN phosphatase and tensin homolog
PTN pleiotrophin
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTTG1 pituitary tumor-transforming 1
PUF60 poly-U binding splicing factor 60KDa
PYCARD PYD and CARD domain containing
RAB3D RAB3D, member RAS oncogene family
RAB4A RAB4A, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RBBP4 retinoblastoma binding protein 4
RBM45 RNA binding motif protein 45
RBPJ recombination signal binding protein for immunoglobulin kappa J region
REG1A regenerating islet-derived 1 alpha
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RELN reelin
RETN resistin
RIDA reactive intermediate imine deaminase A homolog
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNPC3 RNA-binding region (RNP1, RRM) containing 3
RO60 Ro60, Y RNA binding protein
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RORC RAR-related orphan receptor C
RPE65 retinal pigment epithelium-specific protein 65kDa
RPP14 ribonuclease P/MRP 14kDa subunit
RTEL1 regulator of telomere elongation helicase 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SATB1 SATB homeobox 1
SEC14L2 SEC14-like 2 (S. cerevisiae)
SELE selectin E
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SF3B6 splicing factor 3b, subunit 6, 14kDa
SHISA9 shisa family member 9
SLC17A1 solute carrier family 17 (organic anion transporter), member 1
SLC22A1 solute carrier family 22 (organic cation transporter), member 1
SLC26A9 solute carrier family 26 (anion exchanger), member 9
SLPI secretory leukocyte peptidase inhibitor
SOAT1 sterol O-acyltransferase 1
SPRR1B small proline-rich protein 1B
SPRR2A small proline-rich protein 2A
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SSB Sjogren syndrome antigen B (autoantigen La)
SSRP1 structure specific recognition protein 1
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
STIM1 stromal interaction molecule 1
STS steroid sulfatase (microsomal), isozyme S
STXBP3 syntaxin binding protein 3
SUB1 SUB1 homolog (S. cerevisiae)
SYT1 synaptotagmin I
TAC1 tachykinin, precursor 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
TARBP1 TAR (HIV-1) RNA binding protein 1
TBK1 TANK-binding kinase 1
TET2 tet methylcytosine dioxygenase 2
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TLR7 toll-like receptor 7
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM132D transmembrane protein 132D
TNF tumor necrosis factor
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNFRSF9 tumor necrosis factor receptor superfamily, member 9
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNIP1 TNFAIP3 interacting protein 1
TNPO3 transportin 3
TP53 tumor protein p53
TP63 tumor protein p63
TPMT thiopurine S-methyltransferase
TPPP tubulin polymerization promoting protein
TRAF3IP2 TRAF3 interacting protein 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRAT1 T cell receptor associated transmembrane adaptor 1
TREX1 three prime repair exonuclease 1
TRIM21 tripartite motif containing 21
TRIM22 tripartite motif containing 22
TRIM27 tripartite motif containing 27
TRIM38 tripartite motif containing 38
TRIM68 tripartite motif containing 68
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSPO translocator protein (18kDa)
TTR transthyretin
TXLNA taxilin alpha
TXN thioredoxin
UBTF upstream binding transcription factor, RNA polymerase I
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
USO1 USO1 vesicle transport factor
UVRAG UV radiation resistance associated
VAC14 Vac14 homolog (S. cerevisiae)
VAMP8 vesicle-associated membrane protein 8
VCAM1 vascular cell adhesion molecule 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VIP vasoactive intestinal peptide
VIPR2 vasoactive intestinal peptide receptor 2
WDHD1 WD repeat and HMG-box DNA binding protein 1
WNK1 WNK lysine deficient protein kinase 1
XBP1 X-box binding protein 1
XDH xanthine dehydrogenase