Small Cell Lung Carcinoma Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)|A highly aggressive subtype of lung carcinoma characterized by the presence of malignant small cells and necrosis. Metastatic disease is usually present at the time of diagnosis.|A highly aggressive subtype of lung carcinoma characterized by the presence of malignant small cells and necrosis. Metastatic disease is usually present at the time of diagnosis. (NCI05) (Experimental Factor Ontology, EFO_0000702)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D055752
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Genes

109 genes/proteins associated with the disease Small Cell Lung Carcinoma from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 2.88009
ZDBF2 zinc finger, DBF-type containing 2 2.88009
TP53 tumor protein p53 2.88009
GRM8 glutamate receptor, metabotropic 8 2.88009
SLIT2 slit homolog 2 (Drosophila) 2.88009
GRIK3 glutamate receptor, ionotropic, kainate 3 2.88009
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog 2.88009
LYRM9 LYR motif containing 9 2.88009
COL22A1 collagen, type XXII, alpha 1 2.88009
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.88009
ELAVL2 ELAV like neuron-specific RNA binding protein 2 2.88009
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 2.88009
AVP arginine vasopressin 2.88009
CNTNAP2 contactin associated protein-like 2 2.88009
COL4A2 collagen, type IV, alpha 2 2.88009
NDRG1 N-myc downstream regulated 1 2.88009
SOX2 SRY (sex determining region Y)-box 2 2.88009
KMT2A lysine (K)-specific methyltransferase 2A 2.88009
EP300 E1A binding protein p300 2.88009
KHSRP KH-type splicing regulatory protein 2.88009
FGFR1 fibroblast growth factor receptor 1 2.88009
PLSCR4 phospholipid scramblase 4 2.88009
PTEN phosphatase and tensin homolog 2.88009
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 2.88009
CKB creatine kinase, brain 2.88009
CDYL chromodomain protein, Y-like 2.88009
EPHA7 EPH receptor A7 2.88009
CSF3 colony stimulating factor 3 (granulocyte) 2.88009
SATB2 SATB homeobox 2 2.88009
BCLAF1 BCL2-associated transcription factor 1 2.88009
CREBBP CREB binding protein 2.88009
ADCY1 adenylate cyclase 1 (brain) 2.88009
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 2.88009
KIF21A kinesin family member 21A 2.88009
RIMS2 regulating synaptic membrane exocytosis 2 2.88009
TMEM132D transmembrane protein 132D 2.88009
RB1 retinoblastoma 1 2.88009
FAS Fas cell surface death receptor 1.74701
BCL2 B-cell CLL/lymphoma 2 1.64506
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.59708
TOP2A topoisomerase (DNA) II alpha 170kDa 1.57546
MGMT O-6-methylguanine-DNA methyltransferase 1.54986
BIRC2 baculoviral IAP repeat containing 2 1.48093
BCL2L1 BCL2-like 1 1.47966
BAX BCL2-associated X protein 1.474
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.4567
MCL1 myeloid cell leukemia 1 1.45537
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.43809
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.42642
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.41613
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.40705
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 1.37103
H2AFX H2A histone family, member X 1.36047
FASLG Fas ligand (TNF superfamily, member 6) 1.34782
BRCA1 breast cancer 1, early onset 1.34314
ERBB2 erb-b2 receptor tyrosine kinase 2 1.32518
ATF3 activating transcription factor 3 1.28333
MPO myeloperoxidase 1.26113
TYMP thymidine phosphorylase 1.25245
BIRC5 baculoviral IAP repeat containing 5 1.23074
FAM171A1 family with sequence similarity 171, member A1 1.21919
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.21791
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 1.21141
RGS1 regulator of G-protein signaling 1 1.20196
VCAM1 vascular cell adhesion molecule 1 1.20064
F3 coagulation factor III (thromboplastin, tissue factor) 1.20031
CCNG2 cyclin G2 1.18915
BID BH3 interacting domain death agonist 1.18751
CCNA2 cyclin A2 1.18159
RAMP1 receptor (G protein-coupled) activity modifying protein 1 1.18159
VEGFA vascular endothelial growth factor A 1.18093
RBM17 RNA binding motif protein 17 1.1786
UBE2C ubiquitin-conjugating enzyme E2C 1.16533
PARP1 poly (ADP-ribose) polymerase 1 1.16401
BUB3 BUB3 mitotic checkpoint protein 1.15022
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.14473
BIRC3 baculoviral IAP repeat containing 3 1.14268
DDIT3 DNA-damage-inducible transcript 3 1.14098
CAT catalase 1.13041
SRI sorcin 1.1136
FGF2 fibroblast growth factor 2 (basic) 1.10353
CXCL8 chemokine (C-X-C motif) ligand 8 1.09716
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.09297
CFLAR CASP8 and FADD-like apoptosis regulator 1.09154
RRM2 ribonucleotide reductase M2 1.08975
IL6 interleukin 6 1.0894
TXNIP thioredoxin interacting protein 1.08797
CCNB1 cyclin B1 1.08726
GPX3 glutathione peroxidase 3 1.07875
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase 1.06917
SGK1 serum/glucocorticoid regulated kinase 1 1.06661
SOD2 superoxide dismutase 2, mitochondrial 1.06588
PCNA proliferating cell nuclear antigen 1.0637
LTF lactotransferrin 1.05349
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.05163
RUNX3 runt-related transcription factor 3 1.04465
E2F3 E2F transcription factor 3 1.04014
BCL2L12 BCL2-like 12 (proline rich) 1.03901
MAPK14 mitogen-activated protein kinase 14 1.03827
ERBB4 erb-b2 receptor tyrosine kinase 4 1.03604
IL1B interleukin 1, beta 1.03567
PRKCD protein kinase C, delta 1.02896
PDE4B phosphodiesterase 4B, cAMP-specific 1.02858
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.02746
BECN1 beclin 1, autophagy related 1.02634
TYMS thymidylate synthetase 1.01814
CDK1 cyclin-dependent kinase 1 1.01701
NRP1 neuropilin 1 1.01512
DPYD dihydropyrimidine dehydrogenase 1.01286