Smooth Muscle Contraction Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
Description A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. (Gene Ontology, GO_0006939)
External Link https://reactome.org/PathwayBrowser/#/R-HSA-445355
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Genes

43 proteins participating in the Smooth Muscle Contraction pathway from the Reactome Pathways 2024 dataset.

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTG2 actin, gamma 2, smooth muscle, enteric
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANXA1 annexin A1
ANXA2 annexin A2
ANXA6 annexin A6
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CALD1 caldesmon 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAV3 caveolin 3
DYSF dysferlin
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1
GUCY1A2 guanylate cyclase 1, soluble, alpha 2
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1
ITGA1 integrin, alpha 1
ITGB5 integrin, beta 5
LMOD1 leiomodin 1 (smooth muscle)
MYH11 myosin, heavy chain 11, smooth muscle
MYL10 myosin, light chain 10, regulatory
MYL11 myosin light chain 11
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYL12B myosin, light chain 12B, regulatory
MYL5 myosin, light chain 5, regulatory
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
MYL7 myosin, light chain 7, regulatory
MYL9 myosin, light chain 9, regulatory
MYLK myosin light chain kinase
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PDE5A phosphodiesterase 5A, cGMP-specific
PXN paxillin
SORBS1 sorbin and SH3 domain containing 1
SORBS3 sorbin and SH3 domain containing 3
TLN1 talin 1
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TPM3 tropomyosin 3
TPM4 tropomyosin 4
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase
VCL vinculin