Sodium Salicylate_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PODXL podocalyxin-like 0.113507
CDH13 cadherin 13 0.110355
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0909066
IGFBP3 insulin-like growth factor binding protein 3 0.082266
SLC39A11 solute carrier family 39, member 11 0.0777401
COL5A1 collagen, type V, alpha 1 0.0631061
TRIO trio Rho guanine nucleotide exchange factor 0.0551694
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0468022
FN1 fibronectin 1 0.0458226
EGFR epidermal growth factor receptor 0.0449021
MAP1B microtubule-associated protein 1B 0.0445116
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0442285
FLNA filamin A, alpha 0.0365135
BHLHE40 basic helix-loop-helix family, member e40 0.0360268
EFNA5 ephrin-A5 0.034976
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0344967
POTEF POTE ankyrin domain family, member F 0.0314778
PBX3 pre-B-cell leukemia homeobox 3 0.0296171
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0287005
CCND1 cyclin D1 0.0286659
ABI3BP ABI family, member 3 (NESH) binding protein 0.0285929
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0284013
DGKG diacylglycerol kinase, gamma 90kDa 0.0279316
PLEC plectin 0.0278891
FSTL1 follistatin-like 1 0.0278848
MACF1 microtubule-actin crosslinking factor 1 0.0278288
DIRAS3 DIRAS family, GTP-binding RAS-like 3 0.0273876
HDAC9 histone deacetylase 9 0.0271387
NDRG1 N-myc downstream regulated 1 0.0269825
PLAT plasminogen activator, tissue 0.0264501
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0259903
TPM4 tropomyosin 4 0.025118
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.024785
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0246753
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0243945
FLT1 fms-related tyrosine kinase 1 0.0233935
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0228886
SUCNR1 succinate receptor 1 0.0225851
PLXNA2 plexin A2 0.0218681
AKAP12 A kinase (PRKA) anchor protein 12 0.0214612
RND3 Rho family GTPase 3 0.0214334
GOLGB1 golgin B1 0.0210986
SORBS2 sorbin and SH3 domain containing 2 0.0208631
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0203869
VEGFA vascular endothelial growth factor A 0.0202144
ANKRD11 ankyrin repeat domain 11 0.0201563
CENPF centromere protein F, 350/400kDa 0.019975
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0189825
CYTH3 cytohesin 3 0.0188158
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0186242
FOSL1 FOS-like antigen 1 0.0184936
MSN moesin 0.018428
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0183002
IARS1 isoleucyl-tRNA synthetase 1 0.017889
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0178461
LMNA lamin A/C 0.0175021
ADARB1 adenosine deaminase, RNA-specific, B1 0.0171022
ALCAM activated leukocyte cell adhesion molecule 0.0170797
SEPTIN9 septin 9 0.0170526
INTS6 integrator complex subunit 6 0.0165678
ANKRD30B ankyrin repeat domain 30B 0.016547
BCL2L1 BCL2-like 1 0.016448
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 0.0164441
MSI2 musashi RNA-binding protein 2 0.0164073
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0160346
CSTB cystatin B (stefin B) 0.0159522
ASPH aspartate beta-hydroxylase 0.0156605
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0152478
KRT81 keratin 81, type II 0.0152305
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0148642
FMN2 formin 2 0.0147342
RPTOR regulatory associated protein of MTOR, complex 1 0.0145934
TOX thymocyte selection-associated high mobility group box 0.0145473
CUX1 cut-like homeobox 1 0.0144935
RPL35A ribosomal protein L35a 0.0143771
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.014254
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0139184
KIAA1549L KIAA1549-like 0.0138701
FTL ferritin, light polypeptide 0.0136076
SYNE1 spectrin repeat containing, nuclear envelope 1 0.0134862
ULK1 unc-51 like autophagy activating kinase 1 0.0134205
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0133677
CSPG4 chondroitin sulfate proteoglycan 4 0.0133461
ADAM32 ADAM metallopeptidase domain 32 0.0132288
HM13 histocompatibility (minor) 13 0.0130379
CALD1 caldesmon 1 0.0127196
GADD45A growth arrest and DNA-damage-inducible, alpha 0.0127066
IL7R interleukin 7 receptor 0.0124717
TUBB4B tubulin, beta 4B class IVb 0.012453
L1CAM L1 cell adhesion molecule 0.012413
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0122228
VEGFC vascular endothelial growth factor C 0.0122119
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0120674
NCOR2 nuclear receptor corepressor 2 0.011795
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.0117118
ACTG1 actin gamma 1 0.0117069
PEA15 phosphoprotein enriched in astrocytes 15 0.0114884
SPDL1 spindle apparatus coiled-coil protein 1 0.0113591
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0110271
NAV1 neuron navigator 1 0.0109732

decreased expression

Symbol Name Standardized Value
UBC ubiquitin C -0.169025
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.15623
FBN1 fibrillin 1 -0.133753
COL3A1 collagen, type III, alpha 1 -0.121818
TMSB10 thymosin beta 10 -0.106699
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0972654
MT2A metallothionein 2A -0.0958929
COL1A2 collagen, type I, alpha 2 -0.0795347
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0795197
LOX lysyl oxidase -0.0783083
COL5A2 collagen, type V, alpha 2 -0.0717816
FNDC3B fibronectin type III domain containing 3B -0.0671636
CD44 CD44 molecule (Indian blood group) -0.0651082
OGA O-GlcNAcase -0.0580865
SOD2 superoxide dismutase 2, mitochondrial -0.0554281
DPYSL3 dihydropyrimidinase-like 3 -0.0529909
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0522864
VIM vimentin -0.0510239
STC1 stanniocalcin 1 -0.048896
AHNAK AHNAK nucleoprotein -0.0484545
NAP1L1 nucleosome assembly protein 1-like 1 -0.0455084
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0435115
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.041848
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0416668
APP amyloid beta (A4) precursor protein -0.0415758
B2M beta-2-microglobulin -0.0408125
ANXA2 annexin A2 -0.0388695
SBF2 SET binding factor 2 -0.0381054
IQGAP1 IQ motif containing GTPase activating protein 1 -0.03752
GPC6 glypican 6 -0.0369661
COL8A1 collagen, type VIII, alpha 1 -0.036501
DLG1 discs, large homolog 1 (Drosophila) -0.0358518
LOXL2 lysyl oxidase-like 2 -0.0356342
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0350561
PTMA prothymosin, alpha -0.0347889
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0336664
PSD3 pleckstrin and Sec7 domain containing 3 -0.0332915
MT1X metallothionein 1X -0.0332646
ATP13A3 ATPase type 13A3 -0.0330004
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0326862
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0313663
AUTS2 autism susceptibility candidate 2 -0.0305277
LDHA lactate dehydrogenase A -0.0303151
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0293961
FLNB filamin B, beta -0.0290617
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.028625
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0281215
CD99 CD99 molecule -0.0281077
NT5C2 5'-nucleotidase, cytosolic II -0.028027
RSAD2 radical S-adenosyl methionine domain containing 2 -0.027963
THBS2 thrombospondin 2 -0.0276361
KDM3A lysine (K)-specific demethylase 3A -0.0271757
XPO1 exportin 1 -0.0270282
ZBTB20 zinc finger and BTB domain containing 20 -0.0267245
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0266342
RPS27A ribosomal protein S27a -0.0263888
KIFAP3 kinesin-associated protein 3 -0.0263525
TXNIP thioredoxin interacting protein -0.0263333
GLS2 glutaminase 2 (liver, mitochondrial) -0.0260105
ELL2 elongation factor, RNA polymerase II, 2 -0.0260052
RBM25 RNA binding motif protein 25 -0.0256684
ANKRD10 ankyrin repeat domain 10 -0.0252567
ARRDC3 arrestin domain containing 3 -0.0249642
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0248535
PCBP2 poly(rC) binding protein 2 -0.024439
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0242686
DENND5A DENN/MADD domain containing 5A -0.0239392
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.023939
ARL15 ADP-ribosylation factor-like 15 -0.0237865
MARCHF6 membrane associated ring-CH-type finger 6 -0.0236991
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0232676
RHOBTB3 Rho-related BTB domain containing 3 -0.0229533
TNIP1 TNFAIP3 interacting protein 1 -0.0229249
WTAP Wilms tumor 1 associated protein -0.0224853
SDC4 syndecan 4 -0.0223612
ACTN4 actinin, alpha 4 -0.0219934
SLC22A23 solute carrier family 22, member 23 -0.0218553
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.021696
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0215504
WWTR1 WW domain containing transcription regulator 1 -0.021407
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.020832
ENO1 enolase 1, (alpha) -0.0207614
ADAM17 ADAM metallopeptidase domain 17 -0.0202275
TMOD1 tropomodulin 1 -0.0200127
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0198271
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0197973
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0197178
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0197085
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0196108
TRIM56 tripartite motif containing 56 -0.0194248
HMGB2 high mobility group box 2 -0.0192209
IGF2R insulin-like growth factor 2 receptor -0.0191636
PDIA3 protein disulfide isomerase family A, member 3 -0.0189665
NAMPT nicotinamide phosphoribosyltransferase -0.0189527
CANX calnexin -0.0188826
IFI16 interferon, gamma-inducible protein 16 -0.0186522
WDFY1 WD repeat and FYVE domain containing 1 -0.0185008
TAGLN2 transgelin 2 -0.0184477
TMSB4X thymosin beta 4, X-linked -0.0183813
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0181143