Sodium Salicylate_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MEST mesoderm specific transcript 0.051352
VEGFA vascular endothelial growth factor A 0.0298145
GSE1 Gse1 coiled-coil protein 0.0272048
SFPQ splicing factor proline/glutamine-rich 0.0258453
EEF2 eukaryotic translation elongation factor 2 0.0254143
FLNA filamin A, alpha 0.0249157
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0206982
IGF2 insulin-like growth factor 2 0.0200769
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0192869
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0181493
DST dystonin 0.0168017
ERBIN erbb2 interacting protein 0.0152304
HOXA3 homeobox A3 0.0148586
RAD23B RAD23 homolog B (S. cerevisiae) 0.0148167
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0147578
NCKAP1 NCK-associated protein 1 0.0147509
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0146984
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0145183
DSCAM Down syndrome cell adhesion molecule 0.0144498
NAV2 neuron navigator 2 0.0144009
KDM6A lysine (K)-specific demethylase 6A 0.0142759
BOC BOC cell adhesion associated, oncogene regulated 0.0130927
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0127934
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0121303
USP3 ubiquitin specific peptidase 3 0.0121102
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 0.0120777
FTH1 ferritin, heavy polypeptide 1 0.0119899
CKAP2 cytoskeleton associated protein 2 0.0119569
PPME1 protein phosphatase methylesterase 1 0.0119098
PELI1 pellino E3 ubiquitin protein ligase 1 0.0119017
ZNF516 zinc finger protein 516 0.0115338
DIDO1 death inducer-obliterator 1 0.0114492
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0111554
INTS6 integrator complex subunit 6 0.0111444
BLTP1 bridge-like lipid transfer protein family member 1 0.0111304
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0111203
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0111148
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0110969
RNPS1 RNA binding protein S1, serine-rich domain 0.0110367
SMC1A structural maintenance of chromosomes 1A 0.0109979
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0109521
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.0109122
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0108989
EIF5 eukaryotic translation initiation factor 5 0.0108183
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0107329
CPAP centrosome assembly and centriole elongation protein 0.0106856
PTK2 protein tyrosine kinase 2 0.0106652
SCAF4 SR-related CTD-associated factor 4 0.0105752
GPATCH2L G patch domain containing 2-like 0.0104865
ATF7IP activating transcription factor 7 interacting protein 0.0104755
CKAP5 cytoskeleton associated protein 5 0.0103521
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 0.0103412
RANBP2 RAN binding protein 2 0.0103074
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0102845
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0102558
PLEKHH1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 0.0100861
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.0100473
UGCG UDP-glucose ceramide glucosyltransferase 0.00996471
KDM6B lysine (K)-specific demethylase 6B 0.00996377
LUZP1 leucine zipper protein 1 0.00993605
PARP14 poly (ADP-ribose) polymerase family, member 14 0.00993137
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.00992132
ECT2 epithelial cell transforming 2 0.00984413
SEPTIN2 septin 2 0.00981829
PHF8 PHD finger protein 8 0.00973076
CEP350 centrosomal protein 350kDa 0.00968102
RAD51B RAD51 paralog B 0.00965645
MACF1 microtubule-actin crosslinking factor 1 0.0096427
FANCI Fanconi anemia, complementation group I 0.00964232
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.00956415
SEC24A SEC24 family member A 0.00952764
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.00950065
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.00949846
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.00949797
VIRMA vir like m6A methyltransferase associated 0.00944301
CABIN1 calcineurin binding protein 1 0.00934201
CCDC14 coiled-coil domain containing 14 0.00926767
MYO19 myosin XIX 0.0092249
MB21D2 Mab-21 domain containing 2 0.00921847
AFDN afadin, adherens junction formation factor 0.00919271
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0091748
WDFY3 WD repeat and FYVE domain containing 3 0.00916725
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.00913801
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.00912681
MARCHF7 membrane associated ring-CH-type finger 7 0.0091129
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 0.00903273
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.00902326
STAT1 signal transducer and activator of transcription 1, 91kDa 0.00889872
SPATA6 spermatogenesis associated 6 0.00882227
IRF1 interferon regulatory factor 1 0.00881948
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0088059
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.00877532
LMNB1 lamin B1 0.00877371
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.00875027
DBN1 drebrin 1 0.00868221
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 0.00864735
TM9SF3 transmembrane 9 superfamily member 3 0.00863614
CARMIL1 capping protein regulator and myosin 1 linker 1 0.00863571
KIAA1549 KIAA1549 0.00863352
PAPOLA poly(A) polymerase alpha 0.00862211

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.264113
PRKG1 protein kinase, cGMP-dependent, type I -0.172842
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.155108
CADM2 cell adhesion molecule 2 -0.127733
MGP matrix Gla protein -0.124051
PTMA prothymosin, alpha -0.107363
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0977562
PEG10 paternally expressed 10 -0.0914356
RPS6 ribosomal protein S6 -0.0865996
PDE4D phosphodiesterase 4D, cAMP-specific -0.0817908
RPS8 ribosomal protein S8 -0.0787664
ACTG1 actin gamma 1 -0.0777285
RPLP1 ribosomal protein, large, P1 -0.0713941
RPS24 ribosomal protein S24 -0.069985
TMSB10 thymosin beta 10 -0.0676
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0672246
NFIB nuclear factor I/B -0.0650193
RACK1 receptor for activated C kinase 1 -0.0644593
RPL34 ribosomal protein L34 -0.0631047
SOX4 SRY (sex determining region Y)-box 4 -0.0627976
RPS23 ribosomal protein S23 -0.0614961
COL1A2 collagen, type I, alpha 2 -0.0610042
RPS12 ribosomal protein S12 -0.0595882
RPL23 ribosomal protein L23 -0.058263
RPL26 ribosomal protein L26 -0.0575607
ENO1 enolase 1, (alpha) -0.0573143
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0569287
MT2A metallothionein 2A -0.0546367
RPL35A ribosomal protein L35a -0.0524994
RPS19 ribosomal protein S19 -0.0488885
RPL12 ribosomal protein L12 -0.0474644
CANX calnexin -0.0474059
TPT1 tumor protein, translationally-controlled 1 -0.0470467
HMGA2 high mobility group AT-hook 2 -0.0469295
RPLP2 ribosomal protein, large, P2 -0.0438932
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0438612
WSB1 WD repeat and SOCS box containing 1 -0.0434655
RPS27A ribosomal protein S27a -0.0429348
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0425538
RPL37 ribosomal protein L37 -0.0421374
RPL19 ribosomal protein L19 -0.0420845
RPS13 ribosomal protein S13 -0.0415152
RPL31 ribosomal protein L31 -0.0414492
RPL37A ribosomal protein L37a -0.0409377
RPS3 ribosomal protein S3 -0.0404214
RPS11 ribosomal protein S11 -0.039578
GOLGA4 golgin A4 -0.0393928
TPK1 thiamin pyrophosphokinase 1 -0.0393342
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0385858
LDHA lactate dehydrogenase A -0.0377245
QKI QKI, KH domain containing, RNA binding -0.0373688
RPLP0 ribosomal protein, large, P0 -0.0368971
ZNF292 zinc finger protein 292 -0.0367819
RPS25 ribosomal protein S25 -0.0363922
RPS14 ribosomal protein S14 -0.0361378
IER3 immediate early response 3 -0.0357893
S100A9 S100 calcium binding protein A9 -0.0356629
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0356288
RPL11 ribosomal protein L11 -0.0351338
PDGFC platelet derived growth factor C -0.0347672
RPS21 ribosomal protein S21 -0.0341831
RPL32 ribosomal protein L32 -0.0340271
NAP1L1 nucleosome assembly protein 1-like 1 -0.0331778
RPL30 ribosomal protein L30 -0.0327317
FTL ferritin, light polypeptide -0.0327256
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0320303
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0316157
RPS5 ribosomal protein S5 -0.0315655
IGF2R insulin-like growth factor 2 receptor -0.0314989
RPS16 ribosomal protein S16 -0.0310254
PGK1 phosphoglycerate kinase 1 -0.0308374
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0308164
CALD1 caldesmon 1 -0.0307226
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0306823
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0303474
RPL7A ribosomal protein L7a -0.0301604
RPL8 ribosomal protein L8 -0.0300533
TUBB tubulin, beta class I -0.0297647
JMJD1C jumonji domain containing 1C -0.029725
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0292557
TPI1 triosephosphate isomerase 1 -0.0288944
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.0287328
TBCA tubulin folding cofactor A -0.0286218
RPL36 ribosomal protein L36 -0.0285381
RAB7A RAB7A, member RAS oncogene family -0.0284585
FOXC1 forkhead box C1 -0.0284456
RPL10A ribosomal protein L10a -0.0283839
TSHZ2 teashirt zinc finger homeobox 2 -0.0279923
RPS17 ribosomal protein S17 -0.0279675
TET1 tet methylcytosine dioxygenase 1 -0.0278478
RPL7 ribosomal protein L7 -0.027805
RPS10 ribosomal protein S10 -0.0276934
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0269413
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0261889
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.025945
NIPBL Nipped-B homolog (Drosophila) -0.0256173
NFIA nuclear factor I/A -0.0253642
MEIS2 Meis homeobox 2 -0.0250394
CBX3 chromobox homolog 3 -0.0250385
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0250225