Sodium Salicylate_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLEC plectin 0.100701
EFNA5 ephrin-A5 0.0588849
AHNAK AHNAK nucleoprotein 0.0496531
SMAD3 SMAD family member 3 0.0439661
MYH9 myosin, heavy chain 9, non-muscle 0.0393361
HSPA8 heat shock 70kDa protein 8 0.0343755
FLNB filamin B, beta 0.0297418
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.029156
ABTB3 ankyrin repeat and BTB domain containing 3 0.0254015
FMNL2 formin-like 2 0.0253647
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0252507
AKAP12 A kinase (PRKA) anchor protein 12 0.025172
DOCK5 dedicator of cytokinesis 5 0.0246926
TGM2 transglutaminase 2 0.0243623
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0223331
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0220089
PMM2 phosphomannomutase 2 0.0219247
PTK2 protein tyrosine kinase 2 0.020714
FLNA filamin A, alpha 0.0206426
RUNX1 runt-related transcription factor 1 0.0199261
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0194595
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0193886
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0191539
MPRIP myosin phosphatase Rho interacting protein 0.0190819
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0189737
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0185187
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0181906
THSD4 thrombospondin, type I, domain containing 4 0.0181705
BMP6 bone morphogenetic protein 6 0.0181126
TRRAP transformation/transcription domain-associated protein 0.0180836
SAMD4A sterile alpha motif domain containing 4A 0.0174014
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0173397
OGA O-GlcNAcase 0.017005
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0169457
TRIO trio Rho guanine nucleotide exchange factor 0.016749
PPARD peroxisome proliferator-activated receptor delta 0.0166073
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0165847
CTBP2 C-terminal binding protein 2 0.0162895
CAPRIN2 caprin family member 2 0.0151087
SEPTIN9 septin 9 0.0150918
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0144682
NCOR2 nuclear receptor corepressor 2 0.014178
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0140978
RASA3 RAS p21 protein activator 3 0.0140196
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0136184
ATP13A3 ATPase type 13A3 0.0132271
GRB10 growth factor receptor-bound protein 10 0.0131922
ANO6 anoctamin 6 0.0130084
ZMIZ1 zinc finger, MIZ-type containing 1 0.0129429
EXT1 exostosin glycosyltransferase 1 0.0128077
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0127484
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0126869
FTH1 ferritin, heavy polypeptide 1 0.0122533
TLN1 talin 1 0.0122118
DSPP dentin sialophosphoprotein 0.0121266
ZEB1 zinc finger E-box binding homeobox 1 0.0119492
NCKAP1 NCK-associated protein 1 0.0118427
INTS6 integrator complex subunit 6 0.0117498
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0116082
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0112103
MCL1 myeloid cell leukemia 1 0.0111348
NABP1 nucleic acid binding protein 1 0.0108687
MYO5B myosin VB 0.0107158
EHBP1L1 EH domain binding protein 1-like 1 0.0106477
NPAS2 neuronal PAS domain protein 2 0.0105445
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0105376
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 0.010365
KLC1 kinesin light chain 1 0.010352
TBC1D22A TBC1 domain family, member 22A 0.0102068
KIRREL1 kirre like nephrin family adhesion molecule 1 0.010171
PDLIM5 PDZ and LIM domain 5 0.0100395
BCAR3 breast cancer anti-estrogen resistance 3 0.0100333
HAPSTR1 HUWE1 associated protein modifying stress responses 0.00998048
ANKRD11 ankyrin repeat domain 11 0.00991994
BCL2L1 BCL2-like 1 0.00943572
AHNAK2 AHNAK nucleoprotein 2 0.00927449
NRIP1 nuclear receptor interacting protein 1 0.00922398
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.00916788
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.00912051
CANX calnexin 0.00901786
CHD7 chromodomain helicase DNA binding protein 7 0.00893424
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.00888917
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.00878454
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.00875548
NIBAN2 niban apoptosis regulator 2 0.00875186
AFDN afadin, adherens junction formation factor 0.00874865
EIF4B eukaryotic translation initiation factor 4B 0.0087004
PRELID2 PRELI domain containing 2 0.00861995
GOLGA3 golgin A3 0.00861728
ZNF638 zinc finger protein 638 0.00861239
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.00855977
LARP4B La ribonucleoprotein domain family, member 4B 0.00855252
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.008548
RBM19 RNA binding motif protein 19 0.00851217
DOCK1 dedicator of cytokinesis 1 0.00834452
DHFR dihydrofolate reductase 0.00829891
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.008297
EIF4A2 eukaryotic translation initiation factor 4A2 0.00806157
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.00805411
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.00801249

decreased expression

Symbol Name Standardized Value
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.24644
TMSB10 thymosin beta 10 -0.241379
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.140665
VIM vimentin -0.132911
KLK10 kallikrein-related peptidase 10 -0.110515
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.104358
TPT1 tumor protein, translationally-controlled 1 -0.103781
F3 coagulation factor III (thromboplastin, tissue factor) -0.0958033
HMGA1 high mobility group AT-hook 1 -0.092401
POTEF POTE ankyrin domain family, member F -0.089501
PTMA prothymosin, alpha -0.0843512
SACK1A scaffolding CK1 anchoring protein A -0.0814591
B2M beta-2-microglobulin -0.0811601
DHRS9 dehydrogenase/reductase (SDR family) member 9 -0.0798086
S100A10 S100 calcium binding protein A10 -0.0735706
UBC ubiquitin C -0.0693115
FTL ferritin, light polypeptide -0.0684611
TXNIP thioredoxin interacting protein -0.0671513
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0669363
S100A11 S100 calcium binding protein A11 -0.0656078
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0639491
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0620988
MUC17 mucin 17, cell surface associated -0.0597136
LDHA lactate dehydrogenase A -0.0583038
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa -0.0582078
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0573298
S100A6 S100 calcium binding protein A6 -0.0570589
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0505766
LMO7 LIM domain 7 -0.0505665
RPL12 ribosomal protein L12 -0.050556
PERP PERP, TP53 apoptosis effector -0.0501906
RPL35A ribosomal protein L35a -0.0500298
PGK1 phosphoglycerate kinase 1 -0.0499658
MXD1 MAX dimerization protein 1 -0.0494342
RPL37A ribosomal protein L37a -0.0490882
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0490173
LY6E lymphocyte antigen 6 complex, locus E -0.0459635
RIOK3 RIO kinase 3 -0.0450174
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0446431
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.044361
RPS21 ribosomal protein S21 -0.0439251
RPL31 ribosomal protein L31 -0.0438938
EGR1 early growth response 1 -0.0433501
EIF1 eukaryotic translation initiation factor 1 -0.0431053
RPS13 ribosomal protein S13 -0.0428238
RPL23 ribosomal protein L23 -0.0426639
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0423339
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0420526
RPL8 ribosomal protein L8 -0.0407113
TM4SF1 transmembrane 4 L six family member 1 -0.0403319
RPLP2 ribosomal protein, large, P2 -0.0398976
RPS3 ribosomal protein S3 -0.039188
RPS8 ribosomal protein S8 -0.0389898
IFI6 interferon, alpha-inducible protein 6 -0.0388349
SMC3 structural maintenance of chromosomes 3 -0.0382357
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0381348
S100A4 S100 calcium binding protein A4 -0.0380483
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0379216
TPM4 tropomyosin 4 -0.0376124
UBE2B ubiquitin-conjugating enzyme E2B -0.0375009
LAMA4 laminin, alpha 4 -0.0361364
ACTG1 actin gamma 1 -0.035588
RPL30 ribosomal protein L30 -0.0354426
SKAP2 src kinase associated phosphoprotein 2 -0.0353187
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0349073
RPLP1 ribosomal protein, large, P1 -0.0348861
RPL37 ribosomal protein L37 -0.0347001
SLC38A2 solute carrier family 38, member 2 -0.034225
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.033982
RPS25 ribosomal protein S25 -0.0338375
CD59 CD59 molecule, complement regulatory protein -0.0337676
RPL34 ribosomal protein L34 -0.0336756
RPS14 ribosomal protein S14 -0.0335458
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0334817
RPL36A ribosomal protein L36a -0.0324826
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0320806
RPS23 ribosomal protein S23 -0.0312199
AKAP9 A kinase (PRKA) anchor protein 9 -0.031163
LAMB3 laminin, beta 3 -0.0308513
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0307771
LAMC2 laminin, gamma 2 -0.030647
RPS6 ribosomal protein S6 -0.0303235
PFN1 profilin 1 -0.0301664
MYL12B myosin, light chain 12B, regulatory -0.0300385
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0298133
RAB7A RAB7A, member RAS oncogene family -0.0297417
TXNRD1 thioredoxin reductase 1 -0.0297304
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0294302
KLF6 Kruppel-like factor 6 -0.02928
RPS24 ribosomal protein S24 -0.0290216
VCAN versican -0.028775
RPS27A ribosomal protein S27a -0.0286557
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0284992
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0284898
RPL28 ribosomal protein L28 -0.0283036
GNAS GNAS complex locus -0.0282551
RPS19 ribosomal protein S19 -0.0281306
RPL9 ribosomal protein L9 -0.0278342
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.0277154
RPLP0 ribosomal protein, large, P0 -0.0276688