Sodium Salicylate_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.107696
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0970033
NEBL nebulette 0.0915724
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0884452
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0752486
NPAS3 neuronal PAS domain protein 3 0.0683011
EEF2 eukaryotic translation elongation factor 2 0.0641848
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0640158
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0507039
ZFP36L1 ZFP36 ring finger protein-like 1 0.0479252
ZNF292 zinc finger protein 292 0.0474137
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0459453
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.045166
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0450903
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0450727
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0449095
FMNL2 formin-like 2 0.0429034
PIAS2 protein inhibitor of activated STAT, 2 0.0417473
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.04012
HELZ helicase with zinc finger 0.0395974
MACF1 microtubule-actin crosslinking factor 1 0.038736
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0382028
TTC28 tetratricopeptide repeat domain 28 0.0369055
CABIN1 calcineurin binding protein 1 0.0363676
ZNF638 zinc finger protein 638 0.0363467
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0331583
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0329524
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0325062
KMT2C lysine (K)-specific methyltransferase 2C 0.0317399
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0315531
APLP2 amyloid beta (A4) precursor-like protein 2 0.0313188
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0299978
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0295641
SBF2 SET binding factor 2 0.0293495
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0292866
SLF1 SMC5-SMC6 complex localization factor 1 0.0288815
NUP58 nucleoporin 58 0.028677
TENM2 teneurin transmembrane protein 2 0.0285882
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0285477
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0284645
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0283027
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0282357
ARFGEF3 ARFGEF family member 3 0.0282255
CKAP5 cytoskeleton associated protein 5 0.0281998
ASPH aspartate beta-hydroxylase 0.0281707
ZMYM2 zinc finger, MYM-type 2 0.0281162
INSIG2 insulin induced gene 2 0.0266487
REST RE1-silencing transcription factor 0.0261138
PTK2 protein tyrosine kinase 2 0.0257235
AKAP9 A kinase (PRKA) anchor protein 9 0.0248417
EFNA5 ephrin-A5 0.0248119
ATRN attractin 0.0247553
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0245391
ZNF609 zinc finger protein 609 0.0242809
LMNB1 lamin B1 0.0242041
NGLY1 N-glycanase 1 0.0240818
MSN moesin 0.0238494
PHF21A PHD finger protein 21A 0.0234641
XPO1 exportin 1 0.0234638
AKAP13 A kinase (PRKA) anchor protein 13 0.0233483
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0233056
CENPE centromere protein E, 312kDa 0.0229082
CSDE1 cold shock domain containing E1, RNA-binding 0.0228902
GYS1 glycogen synthase 1 (muscle) 0.0226026
TXNRD1 thioredoxin reductase 1 0.0225634
DARS1 aspartyl-tRNA synthetase 1 0.0225184
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0223929
PHIP pleckstrin homology domain interacting protein 0.0221472
BPTF bromodomain PHD finger transcription factor 0.0220001
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0219867
WDPCP WD repeat containing planar cell polarity effector 0.0218647
DST dystonin 0.0211447
CHD7 chromodomain helicase DNA binding protein 7 0.0210823
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0209556
SPATS2 spermatogenesis associated, serine-rich 2 0.0209066
RNMT RNA (guanine-7-) methyltransferase 0.0208916
SRRM1 serine/arginine repetitive matrix 1 0.0207879
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0207379
SUN1 Sad1 and UNC84 domain containing 1 0.0200513
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0199613
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.019919
PTCH1 patched 1 0.0198001
FLNA filamin A, alpha 0.0197702
HILPDA hypoxia inducible lipid droplet-associated 0.0197288
NUMA1 nuclear mitotic apparatus protein 1 0.0197192
SRRM2 serine/arginine repetitive matrix 2 0.0194916
BRWD1 bromodomain and WD repeat domain containing 1 0.019467
WSB1 WD repeat and SOCS box containing 1 0.0194173
DIXDC1 DIX domain containing 1 0.0193915
PTEN phosphatase and tensin homolog 0.019364
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0192732
TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 0.0190951
TBCD tubulin folding cofactor D 0.0190313
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0189753
FNBP4 formin binding protein 4 0.0189752
TBC1D32 TBC1 domain family, member 32 0.0187538
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0187047
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0186213
EIF4B eukaryotic translation initiation factor 4B 0.0186018
CENPF centromere protein F, 350/400kDa 0.0185215

decreased expression

Symbol Name Standardized Value
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.157978
STAT1 signal transducer and activator of transcription 1, 91kDa -0.147293
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.137399
ACTG1 actin gamma 1 -0.0836965
RPLP1 ribosomal protein, large, P1 -0.076545
RIGI RNA sensor RIG-I -0.0760779
CADM2 cell adhesion molecule 2 -0.0747348
RPS8 ribosomal protein S8 -0.0741076
SLIT2 slit homolog 2 (Drosophila) -0.0667036
PDE4D phosphodiesterase 4D, cAMP-specific -0.0666337
JMJD1C jumonji domain containing 1C -0.0651625
IFI6 interferon, alpha-inducible protein 6 -0.0646358
RAD51B RAD51 paralog B -0.0623512
ZFAND3 zinc finger, AN1-type domain 3 -0.0548056
VCL vinculin -0.0511439
COL5A2 collagen, type V, alpha 2 -0.0505807
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0466331
SHROOM3 shroom family member 3 -0.0451278
RPL35A ribosomal protein L35a -0.0447897
ZNF608 zinc finger protein 608 -0.0445318
NALF1 NALCN channel auxiliary factor 1 -0.0444953
CELF2 CUGBP, Elav-like family member 2 -0.0443645
PTMA prothymosin, alpha -0.0438813
RPL37A ribosomal protein L37a -0.0428158
RPS13 ribosomal protein S13 -0.0427656
RPL31 ribosomal protein L31 -0.0419727
HMGB1 high mobility group box 1 -0.0419692
TOX thymocyte selection-associated high mobility group box -0.0401887
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0401526
RPLP2 ribosomal protein, large, P2 -0.0395753
RPS5 ribosomal protein S5 -0.0392372
RPS25 ribosomal protein S25 -0.038775
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0382815
RPL38 ribosomal protein L38 -0.0374993
EIF1 eukaryotic translation initiation factor 1 -0.0373328
RPL23 ribosomal protein L23 -0.0369729
RPL27A ribosomal protein L27a -0.0367953
MCTP1 multiple C2 domains, transmembrane 1 -0.0367531
RPL34 ribosomal protein L34 -0.0362986
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0362759
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0358261
RPS29 ribosomal protein S29 -0.0352939
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0343977
RPS19 ribosomal protein S19 -0.0338379
RPS23 ribosomal protein S23 -0.0332152
DNAH14 dynein, axonemal, heavy chain 14 -0.033194
RPS24 ribosomal protein S24 -0.033062
TENM3 teneurin transmembrane protein 3 -0.0330369
ADGRG6 adhesion G protein-coupled receptor G6 -0.0323792
TMSB10 thymosin beta 10 -0.0321669
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0317436
RPL5 ribosomal protein L5 -0.0315334
RPL9 ribosomal protein L9 -0.0314382
RPL26 ribosomal protein L26 -0.0310962
RPL37 ribosomal protein L37 -0.0305327
RPS6 ribosomal protein S6 -0.0305139
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0303027
RPS14 ribosomal protein S14 -0.0296513
MAPK8 mitogen-activated protein kinase 8 -0.0294405
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0291871
RPS16 ribosomal protein S16 -0.0281647
GNAS GNAS complex locus -0.0273935
RACK1 receptor for activated C kinase 1 -0.0268716
WAC WW domain containing adaptor with coiled-coil -0.0268285
TPT1 tumor protein, translationally-controlled 1 -0.026566
RPL4 ribosomal protein L4 -0.0262014
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0261284
RHEB Ras homolog enriched in brain -0.0259718
ISG15 ISG15 ubiquitin-like modifier -0.0259468
PUM2 pumilio RNA-binding family member 2 -0.0259382
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0259093
RPL12 ribosomal protein L12 -0.0257499
RAN RAN, member RAS oncogene family -0.0255962
RPL8 ribosomal protein L8 -0.0255214
RPS3 ribosomal protein S3 -0.0253291
ZNFX1 zinc finger, NFX1-type containing 1 -0.0251585
RPS20 ribosomal protein S20 -0.0249725
ZNF33A zinc finger protein 33A -0.0249679
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0249098
NID1 nidogen 1 -0.0247864
TMEM41B transmembrane protein 41B -0.0245419
RPL28 ribosomal protein L28 -0.0243896
SOX5 SRY (sex determining region Y)-box 5 -0.0243725
TNPO1 transportin 1 -0.0243393
RPS27 ribosomal protein S27 -0.024172
RBBP6 retinoblastoma binding protein 6 -0.0239991
TJP1 tight junction protein 1 -0.0236122
RPL19 ribosomal protein L19 -0.0234315
MED13 mediator complex subunit 13 -0.0233422
ATP11A ATPase, class VI, type 11A -0.0232496
RAP1B RAP1B, member of RAS oncogene family -0.0231816
PMP22 peripheral myelin protein 22 -0.0229703
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0227753
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0227615
RPL27 ribosomal protein L27 -0.0224395
SETX senataxin -0.0223959
ATP5F1B ATP synthase F1 subunit beta -0.0223948
RPL36A ribosomal protein L36a -0.0222528
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0221912
RPS21 ribosomal protein S21 -0.0220118