Sodium Salicylate_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.144582
KMT2E lysine (K)-specific methyltransferase 2E 0.102176
NDRG1 N-myc downstream regulated 1 0.0876623
VGF VGF nerve growth factor inducible 0.0828879
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0786984
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0771122
APLP2 amyloid beta (A4) precursor-like protein 2 0.0589122
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0555316
RNF145 ring finger protein 145 0.0529577
LEF1 lymphoid enhancer-binding factor 1 0.0518041
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0417369
HILPDA hypoxia inducible lipid droplet-associated 0.0405374
SFTPA2 surfactant protein A2 0.0404904
GLS2 glutaminase 2 (liver, mitochondrial) 0.0393474
FTH1 ferritin, heavy polypeptide 1 0.0388756
FLNA filamin A, alpha 0.0364454
POTEF POTE ankyrin domain family, member F 0.0360862
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0359017
VEGFA vascular endothelial growth factor A 0.0348264
DSCAM Down syndrome cell adhesion molecule 0.034203
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0341779
ZNF292 zinc finger protein 292 0.0337976
BRD2 bromodomain containing 2 0.0336225
KDM5B lysine (K)-specific demethylase 5B 0.0327426
NUP58 nucleoporin 58 0.0324521
FOSL1 FOS-like antigen 1 0.0319707
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0318649
DST dystonin 0.0316648
FNDC3B fibronectin type III domain containing 3B 0.0313018
CABIN1 calcineurin binding protein 1 0.0305796
EEF2 eukaryotic translation elongation factor 2 0.0303575
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0297286
CCNL1 cyclin L1 0.028846
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.027687
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0276513
TMEM178B transmembrane protein 178B 0.0272922
EPS8 epidermal growth factor receptor pathway substrate 8 0.0270689
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0270599
YBX1 Y box binding protein 1 0.0270508
MYH9 myosin, heavy chain 9, non-muscle 0.0270231
KMT2C lysine (K)-specific methyltransferase 2C 0.0268842
UBE2H ubiquitin-conjugating enzyme E2H 0.0265076
ANXA2 annexin A2 0.0264286
MACROD2 MACRO domain containing 2 0.0262579
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0261678
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0257858
FLNB filamin B, beta 0.0254294
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0253804
COPA coatomer protein complex, subunit alpha 0.0253625
CSNK1A1 casein kinase 1, alpha 1 0.0253292
PDLIM5 PDZ and LIM domain 5 0.0252791
RYBP RING1 and YY1 binding protein 0.0250676
SETD5 SET domain containing 5 0.0249912
FMNL2 formin-like 2 0.0244726
RAD23B RAD23 homolog B (S. cerevisiae) 0.023952
IGFBP3 insulin-like growth factor binding protein 3 0.0232791
SFPQ splicing factor proline/glutamine-rich 0.0232182
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0226305
MSN moesin 0.0225607
CD44 CD44 molecule (Indian blood group) 0.0225533
PTMS parathymosin 0.0224691
LOC102724023 ES1 protein homolog, mitochondrial 0.0220793
ZSWIM6 zinc finger, SWIM-type containing 6 0.0216004
KDM6A lysine (K)-specific demethylase 6A 0.0215757
PLEC plectin 0.0213933
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0211958
TXNIP thioredoxin interacting protein 0.0210385
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0208016
RNASEH2A ribonuclease H2, subunit A 0.020794
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0207885
HELZ helicase with zinc finger 0.0207641
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0207367
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0207335
MACF1 microtubule-actin crosslinking factor 1 0.0207319
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0206716
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0205373
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0204296
CEMIP2 cell migration inducing hyaluronidase 2 0.0202416
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0202215
MITF microphthalmia-associated transcription factor 0.0199632
PCBP2 poly(rC) binding protein 2 0.0199593
PUM1 pumilio RNA-binding family member 1 0.0197964
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0196884
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0196515
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0195575
XPO1 exportin 1 0.0190663
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.019062
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0190448
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0190293
UTRN utrophin 0.0190254
AKAP12 A kinase (PRKA) anchor protein 12 0.0190168
RLF rearranged L-myc fusion 0.0190154
EGR1 early growth response 1 0.0189407
RBM39 RNA binding motif protein 39 0.0188569
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0188237
IRS2 insulin receptor substrate 2 0.0187641
ZFP36 ZFP36 ring finger protein 0.0187104
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.018583
RBM33 RNA binding motif protein 33 0.018528
CHPF chondroitin polymerizing factor 0.0185108

decreased expression

Symbol Name Standardized Value
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.224009
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.168485
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.108141
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.107862
IFI16 interferon, gamma-inducible protein 16 -0.105665
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0926652
BACE2 beta-site APP-cleaving enzyme 2 -0.0810722
VIM vimentin -0.0706426
TBC1D22A TBC1 domain family, member 22A -0.0687716
GPC6 glypican 6 -0.0666184
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0655336
PRELID2 PRELI domain containing 2 -0.0627333
NPC1 Niemann-Pick disease, type C1 -0.058696
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0581006
ENO1 enolase 1, (alpha) -0.0566302
MT2A metallothionein 2A -0.0555119
ACTG1 actin gamma 1 -0.0552549
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.054614
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.05113
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0488575
COL19A1 collagen, type XIX, alpha 1 -0.0479204
FMN1 formin 1 -0.0476212
PARVB parvin, beta -0.0472275
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0439716
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0434715
NAV2 neuron navigator 2 -0.0430102
ZMYND8 zinc finger, MYND-type containing 8 -0.0423919
CUX1 cut-like homeobox 1 -0.0402807
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.039835
ZBTB20 zinc finger and BTB domain containing 20 -0.0393813
CDK14 cyclin-dependent kinase 14 -0.0366769
RPLP1 ribosomal protein, large, P1 -0.0363712
IER3 immediate early response 3 -0.0363486
TM4SF1 transmembrane 4 L six family member 1 -0.0363088
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0355211
OXR1 oxidation resistance 1 -0.0345445
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0327904
OSMR oncostatin M receptor -0.0326245
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0323026
CD109 CD109 molecule -0.0314449
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0313148
AHNAK AHNAK nucleoprotein -0.0304973
CALU calumenin -0.0301646
SCFD2 sec1 family domain containing 2 -0.0300878
PGK1 phosphoglycerate kinase 1 -0.0296354
RUNX1 runt-related transcription factor 1 -0.0293037
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0291842
FBXL7 F-box and leucine-rich repeat protein 7 -0.0290953
A2M alpha-2-macroglobulin -0.0283213
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0273978
NLGN1 neuroligin 1 -0.0270461
EHBP1 EH domain binding protein 1 -0.0262961
CANX calnexin -0.0256374
CD63 CD63 molecule -0.0256278
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0255707
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0246869
VDAC1 voltage-dependent anion channel 1 -0.024545
ZSWIM5 zinc finger, SWIM-type containing 5 -0.0244863
FRMD4A FERM domain containing 4A -0.0243775
TMEM123 transmembrane protein 123 -0.0242118
RPL35A ribosomal protein L35a -0.0241722
NAV3 neuron navigator 3 -0.0241199
IL1RAP interleukin 1 receptor accessory protein -0.0240883
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.0240833
HLA-B major histocompatibility complex, class I, B -0.0240541
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0240414
RPS24 ribosomal protein S24 -0.024033
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0238441
ARFGEF3 ARFGEF family member 3 -0.0237273
UBE3C ubiquitin protein ligase E3C -0.0234612
LDHA lactate dehydrogenase A -0.0228401
TAS2R14 taste receptor, type 2, member 14 -0.0228352
PTK2 protein tyrosine kinase 2 -0.022805
GDF15 growth differentiation factor 15 -0.0224024
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0208495
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0208253
ESYT2 extended synaptotagmin-like protein 2 -0.0205063
ATXN1 ataxin 1 -0.0202311
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0201446
TMSB10 thymosin beta 10 -0.0200296
FHIT fragile histidine triad -0.0199041
POM121 POM121 transmembrane nucleoporin -0.0198812
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0198419
ITGB8 integrin, beta 8 -0.0194046
S100A6 S100 calcium binding protein A6 -0.0193986
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0192938
BZW1 basic leucine zipper and W2 domains 1 -0.0191472
STXBP1 syntaxin binding protein 1 -0.0190606
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0190545
PUS7 pseudouridylate synthase 7 (putative) -0.0189933
SBF2 SET binding factor 2 -0.0186201
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0184865
ASPH aspartate beta-hydroxylase -0.0183387
NPAS2 neuronal PAS domain protein 2 -0.0183334
RPL34 ribosomal protein L34 -0.0183117
SNX14 sorting nexin 14 -0.0182841
TULP4 tubby like protein 4 -0.0182765
WDFY1 WD repeat and FYVE domain containing 1 -0.0178331
GHR growth hormone receptor -0.0178302
STAU1 staufen double-stranded RNA binding protein 1 -0.0177428