Sodium Salicylate_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TGM2 transglutaminase 2 0.0774689
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0427266
ZSWIM6 zinc finger, SWIM-type containing 6 0.0424636
FNDC3B fibronectin type III domain containing 3B 0.0421356
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0414242
VEGFA vascular endothelial growth factor A 0.0327232
APLP2 amyloid beta (A4) precursor-like protein 2 0.0316663
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0315817
GRB10 growth factor receptor-bound protein 10 0.0304603
NRIP1 nuclear receptor interacting protein 1 0.0289283
INTS6 integrator complex subunit 6 0.0264343
FTH1 ferritin, heavy polypeptide 1 0.0233806
EPAS1 endothelial PAS domain protein 1 0.0233667
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0226228
FAM107B family with sequence similarity 107, member B 0.0213402
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.020614
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0205242
FLNA filamin A, alpha 0.0198218
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.019549
EXT1 exostosin glycosyltransferase 1 0.019183
DOCK5 dedicator of cytokinesis 5 0.0188846
HDAC9 histone deacetylase 9 0.0187335
C3 complement component 3 0.018498
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0183422
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0182331
SGMS2 sphingomyelin synthase 2 0.0180342
ZMIZ1 zinc finger, MIZ-type containing 1 0.0178004
MYO1E myosin IE 0.0171912
ATXN1 ataxin 1 0.0171124
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0167039
TBC1D22A TBC1 domain family, member 22A 0.01627
SMAD3 SMAD family member 3 0.0160707
STC1 stanniocalcin 1 0.0159365
ADAM28 ADAM metallopeptidase domain 28 0.0157833
PPARD peroxisome proliferator-activated receptor delta 0.0156765
LOC102724023 ES1 protein homolog, mitochondrial 0.0152734
KIAA1217 KIAA1217 0.015194
HKDC1 hexokinase domain containing 1 0.0145981
ARHGAP26 Rho GTPase activating protein 26 0.0144074
NTN4 netrin 4 0.0140776
RIMKLB ribosomal modification protein rimK-like family member B 0.0140057
ZFP36L1 ZFP36 ring finger protein-like 1 0.0137985
RAD51B RAD51 paralog B 0.0133674
NABP1 nucleic acid binding protein 1 0.0131894
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0131468
ITGB4 integrin, beta 4 0.0131066
NPAS2 neuronal PAS domain protein 2 0.0130757
MCL1 myeloid cell leukemia 1 0.0130674
TTC3 tetratricopeptide repeat domain 3 0.0130582
NDRG1 N-myc downstream regulated 1 0.013056
SHB Src homology 2 domain containing adaptor protein B 0.0129342
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0124545
MX1 MX dynamin-like GTPase 1 0.012415
NCOR2 nuclear receptor corepressor 2 0.0122963
ANO6 anoctamin 6 0.01229
CMIP c-Maf inducing protein 0.0122659
STC2 stanniocalcin 2 0.0121399
CD44 CD44 molecule (Indian blood group) 0.0120439
ZNF638 zinc finger protein 638 0.012033
KYNU kynureninase 0.0118386
SEC31A SEC31 homolog A (S. cerevisiae) 0.011757
NAV2 neuron navigator 2 0.0117196
FRMD6 FERM domain containing 6 0.0116285
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0114112
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0113814
SOX9 SRY (sex determining region Y)-box 9 0.0113577
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0113525
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0111605
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0110722
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0110371
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0109562
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0109298
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0109071
AREG amphiregulin 0.0107223
BABAM2 BRISC and BRCA1 A complex member 2 0.0106786
MAML3 mastermind-like 3 (Drosophila) 0.0106337
FOSL1 FOS-like antigen 1 0.0105366
PRELID2 PRELI domain containing 2 0.0104447
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0103773
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0103526
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0103481
CEMIP2 cell migration inducing hyaluronidase 2 0.0102664
CATSPERB catsper channel auxiliary subunit beta 0.0102477
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0102428
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0101897
MAML2 mastermind-like 2 (Drosophila) 0.0101695
TMC5 transmembrane channel-like 5 0.0101511
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.0098644
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0098046
PCBP2 poly(rC) binding protein 2 0.00976275
TIMP2 TIMP metallopeptidase inhibitor 2 0.00970662
AADAC arylacetamide deacetylase 0.00969414
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.00955705
UBASH3B ubiquitin associated and SH3 domain containing B 0.00954786
FBXO11 F-box protein 11 0.00954466
DUSP5 dual specificity phosphatase 5 0.00950394
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.00948631
HELZ helicase with zinc finger 0.00945476
WWOX WW domain containing oxidoreductase 0.00941818
CCDC88A coiled-coil domain containing 88A 0.00937526

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.133804
TMSB10 thymosin beta 10 -0.133046
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.116816
PTMA prothymosin, alpha -0.105826
MMP7 matrix metallopeptidase 7 -0.103677
LAMB3 laminin, beta 3 -0.0857515
MT2A metallothionein 2A -0.0851011
EIF1 eukaryotic translation initiation factor 1 -0.067496
ANXA2 annexin A2 -0.0664671
TMSB4X thymosin beta 4, X-linked -0.0663082
RPL19 ribosomal protein L19 -0.0641886
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0630504
B2M beta-2-microglobulin -0.0579265
LAMC2 laminin, gamma 2 -0.0575805
PGK1 phosphoglycerate kinase 1 -0.0575049
S100A6 S100 calcium binding protein A6 -0.0532147
HLA-B major histocompatibility complex, class I, B -0.0508453
RPL23 ribosomal protein L23 -0.0500053
CP ceruloplasmin (ferroxidase) -0.0498127
ENO1 enolase 1, (alpha) -0.0496718
AHNAK AHNAK nucleoprotein -0.0487979
ISG15 ISG15 ubiquitin-like modifier -0.0448195
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0443948
NAMPT nicotinamide phosphoribosyltransferase -0.043109
ACTG1 actin gamma 1 -0.042735
KRT19 keratin 19, type I -0.0424446
RPLP1 ribosomal protein, large, P1 -0.0405695
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0389854
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0386224
RPS8 ribosomal protein S8 -0.0383292
SLC38A1 solute carrier family 38, member 1 -0.0371596
NPEPPS aminopeptidase puromycin sensitive -0.0356256
RPS21 ribosomal protein S21 -0.0350011
KLF6 Kruppel-like factor 6 -0.0348379
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0346164
TM4SF1 transmembrane 4 L six family member 1 -0.0343069
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0338423
APOL1 apolipoprotein L, 1 -0.033755
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0335228
TPT1 tumor protein, translationally-controlled 1 -0.0331382
FTL ferritin, light polypeptide -0.0330476
RPL34 ribosomal protein L34 -0.0327637
UBC ubiquitin C -0.0325075
PLAUR plasminogen activator, urokinase receptor -0.0322928
RPS6 ribosomal protein S6 -0.0306539
VIM vimentin -0.0297403
IFI27 interferon, alpha-inducible protein 27 -0.0296993
CD2AP CD2-associated protein -0.0296919
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.029419
RPL35A ribosomal protein L35a -0.029283
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0291093
HLA-A major histocompatibility complex, class I, A -0.0280037
PATJ PATJ crumbs cell polarity complex component -0.027911
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0277416
HLA-E major histocompatibility complex, class I, E -0.0277135
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0275306
C15ORF48 chromosome 15 open reading frame 48 -0.0273409
IFI6 interferon, alpha-inducible protein 6 -0.0273274
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0271432
H1-0 H1.0 linker histone -0.0270031
RPS27 ribosomal protein S27 -0.0266288
RPS24 ribosomal protein S24 -0.0265165
FAM162A family with sequence similarity 162, member A -0.0265081
RPS25 ribosomal protein S25 -0.0257946
PARD3 par-3 family cell polarity regulator -0.0256529
S100A10 S100 calcium binding protein A10 -0.0253392
STRN3 striatin, calmodulin binding protein 3 -0.025316
RPL11 ribosomal protein L11 -0.0252498
RPS19 ribosomal protein S19 -0.0249995
APP amyloid beta (A4) precursor protein -0.0249237
NT5C2 5'-nucleotidase, cytosolic II -0.0235034
RPS23 ribosomal protein S23 -0.0234627
MT1X metallothionein 1X -0.0234028
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0232703
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0232125
OSMR oncostatin M receptor -0.0231615
RPS3 ribosomal protein S3 -0.023135
RACK1 receptor for activated C kinase 1 -0.0228602
DSG2 desmoglein 2 -0.0225515
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0222187
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.022066
S100A11 S100 calcium binding protein A11 -0.0219185
RPL31 ribosomal protein L31 -0.0217727
RPS29 ribosomal protein S29 -0.0216097
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0215713
HLA-C major histocompatibility complex, class I, C -0.0214329
TPM4 tropomyosin 4 -0.021289
KLF5 Kruppel-like factor 5 (intestinal) -0.0211823
CSTB cystatin B (stefin B) -0.0210507
PKM pyruvate kinase, muscle -0.0210222
KRT8 keratin 8, type II -0.0209146
MACC1 metastasis associated in colon cancer 1 -0.0206069
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0201094
RPS14 ribosomal protein S14 -0.0198514
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0197835
RPLP0 ribosomal protein, large, P0 -0.0195667
YME1L1 YME1-like 1 ATPase -0.0194613
RTN4 reticulon 4 -0.0194566
NEK7 NIMA-related kinase 7 -0.0193241
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0192767