Sodium Salicylate_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.143967
AKAP12 A kinase (PRKA) anchor protein 12 0.0724006
EEF2 eukaryotic translation elongation factor 2 0.0643328
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0556628
MAP1B microtubule-associated protein 1B 0.0533063
SOS1 son of sevenless homolog 1 (Drosophila) 0.0527051
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0516455
GOLGA4 golgin A4 0.0460351
BIRC6 baculoviral IAP repeat containing 6 0.0453681
TENT5A terminal nucleotidyltransferase 5A 0.0443483
DST dystonin 0.0440418
APP amyloid beta (A4) precursor protein 0.043316
PRRC2B proline-rich coiled-coil 2B 0.0431712
ZNF292 zinc finger protein 292 0.0424147
FMN1 formin 1 0.0423062
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0406455
TIMP3 TIMP metallopeptidase inhibitor 3 0.0397148
LPIN1 lipin 1 0.0389634
FHIT fragile histidine triad 0.0382027
JMJD1C jumonji domain containing 1C 0.0367612
ARB2A ARB2 cotranscriptional regulator A 0.0366058
ATXN1 ataxin 1 0.0346134
UBE2H ubiquitin-conjugating enzyme E2H 0.0345892
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0345805
PARP14 poly (ADP-ribose) polymerase family, member 14 0.034461
KPNB1 karyopherin (importin) beta 1 0.0340589
VEGFA vascular endothelial growth factor A 0.0335698
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0333038
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.03328
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0331152
CDK19 cyclin-dependent kinase 19 0.0329577
NRIP1 nuclear receptor interacting protein 1 0.0329008
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0326974
IFI16 interferon, gamma-inducible protein 16 0.0326878
MINDY2 MINDY lysine 48 deubiquitinase 2 0.032105
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0320752
EIF4A2 eukaryotic translation initiation factor 4A2 0.0314649
TENT2 terminal nucleotidyltransferase 2 0.0312287
MYO6 myosin VI 0.0311817
VCL vinculin 0.0311753
CD36 CD36 molecule (thrombospondin receptor) 0.0309532
PGK1 phosphoglycerate kinase 1 0.0304492
RTN4 reticulon 4 0.0298208
H3-3B H3.3 histone B 0.0297354
TRA2A transformer 2 alpha homolog (Drosophila) 0.0296075
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.0292094
PRRC2C proline-rich coiled-coil 2C 0.0289884
CEP350 centrosomal protein 350kDa 0.0286843
FAM13A family with sequence similarity 13, member A 0.0286077
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0282145
CREBBP CREB binding protein 0.0281527
NDRG1 N-myc downstream regulated 1 0.0281412
PLAT plasminogen activator, tissue 0.0281281
RLF rearranged L-myc fusion 0.0278611
DKK2 dickkopf WNT signaling pathway inhibitor 2 0.0276147
RET ret proto-oncogene 0.0275766
AUTS2 autism susceptibility candidate 2 0.0274308
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.0264207
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0264052
ANGPT1 angiopoietin 1 0.0261501
SYNPO2 synaptopodin 2 0.0260778
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0260009
DUSP16 dual specificity phosphatase 16 0.0258232
FOXP1 forkhead box P1 0.0258223
TPR translocated promoter region, nuclear basket protein 0.0257933
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0257771
TCF12 transcription factor 12 0.0256369
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0255638
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0255146
KTN1 kinectin 1 (kinesin receptor) 0.0254336
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0252599
RSRC2 arginine/serine-rich coiled-coil 2 0.0252178
SLMAP sarcolemma associated protein 0.0251004
SET SET nuclear proto-oncogene 0.0250868
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.024892
PTPRE protein tyrosine phosphatase, receptor type, E 0.024857
PACS1 phosphofurin acidic cluster sorting protein 1 0.0247828
TNRC6A trinucleotide repeat containing 6A 0.0244516
USP8 ubiquitin specific peptidase 8 0.0244123
CEMIP2 cell migration inducing hyaluronidase 2 0.0243008
ANO6 anoctamin 6 0.0242082
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.024069
CHD4 chromodomain helicase DNA binding protein 4 0.0240324
GSK3B glycogen synthase kinase 3 beta 0.0238979
VIM vimentin 0.0238769
DUSP10 dual specificity phosphatase 10 0.0236219
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0234887
PALLD palladin, cytoskeletal associated protein 0.0234711
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0233991
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0232685
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.0230691
VWA8 von Willebrand factor A domain containing 8 0.0230137
CARD16 caspase recruitment domain family, member 16 0.0229534
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0227487
CSDE1 cold shock domain containing E1, RNA-binding 0.0226301
AOPEP aminopeptidase O (putative) 0.0223864
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.02234
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0223198
TPM3 tropomyosin 3 0.0222405
ADAM9 ADAM metallopeptidase domain 9 0.0221245

decreased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 -0.109153
NALF1 NALCN channel auxiliary factor 1 -0.106971
LSAMP limbic system-associated membrane protein -0.0900335
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0829173
RPL19 ribosomal protein L19 -0.0772443
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0701834
PTPRD protein tyrosine phosphatase, receptor type, D -0.0691894
MAPK10 mitogen-activated protein kinase 10 -0.0662006
RPTOR regulatory associated protein of MTOR, complex 1 -0.0643182
RPL23 ribosomal protein L23 -0.0572667
NREP neuronal regeneration related protein -0.0507352
PRKCA protein kinase C, alpha -0.0492242
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0475621
FRMD4A FERM domain containing 4A -0.0466584
DIAPH2 diaphanous-related formin 2 -0.0450567
PTPRM protein tyrosine phosphatase, receptor type, M -0.0448552
ZNF804A zinc finger protein 804A -0.0445528
GMDS GDP-mannose 4,6-dehydratase -0.0445518
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0445115
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0444022
ANTXR1 anthrax toxin receptor 1 -0.0440544
MAML2 mastermind-like 2 (Drosophila) -0.0438702
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0433492
ATRNL1 attractin-like 1 -0.0424355
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0416582
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0402488
FNDC3B fibronectin type III domain containing 3B -0.0399516
CADM1 cell adhesion molecule 1 -0.0395782
RPL34 ribosomal protein L34 -0.0393034
NRG1 neuregulin 1 -0.0378138
THSD4 thrombospondin, type I, domain containing 4 -0.0359104
NPAS2 neuronal PAS domain protein 2 -0.0358755
GSE1 Gse1 coiled-coil protein -0.0353998
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog -0.0348453
COL4A6 collagen, type IV, alpha 6 -0.0347151
AFF3 AF4/FMR2 family, member 3 -0.0346021
SMYD3 SET and MYND domain containing 3 -0.0345528
ACTN1 actinin, alpha 1 -0.0340277
PTMA prothymosin, alpha -0.0337518
RNF150 ring finger protein 150 -0.0334063
IGFBP3 insulin-like growth factor binding protein 3 -0.0331796
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0330408
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0322997
FAM107B family with sequence similarity 107, member B -0.0321479
DACH2 dachshund family transcription factor 2 -0.031899
RPL26 ribosomal protein L26 -0.0309825
CDK14 cyclin-dependent kinase 14 -0.0298736
DNAH14 dynein, axonemal, heavy chain 14 -0.0298562
EGR1 early growth response 1 -0.029793
FNDC3A fibronectin type III domain containing 3A -0.0297109
RAP1B RAP1B, member of RAS oncogene family -0.0290204
CORIN corin, serine peptidase -0.0286203
PRKG1 protein kinase, cGMP-dependent, type I -0.0285041
CNTN4 contactin 4 -0.0284877
LRP1B low density lipoprotein receptor-related protein 1B -0.0281532
ARHGAP32 Rho GTPase activating protein 32 -0.0280621
RPS12 ribosomal protein S12 -0.0276652
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0274124
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0271127
RPS17 ribosomal protein S17 -0.0270563
TMSB10 thymosin beta 10 -0.0262941
RABGAP1L RAB GTPase activating protein 1-like -0.0262726
RPL31 ribosomal protein L31 -0.0261992
COL1A1 collagen, type I, alpha 1 -0.0261242
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0259967
SYT1 synaptotagmin I -0.025947
ENSA endosulfine alpha -0.0256444
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0256343
PTPRG protein tyrosine phosphatase, receptor type, G -0.0246776
RACK1 receptor for activated C kinase 1 -0.0245875
TRRAP transformation/transcription domain-associated protein -0.0244644
ENO1 enolase 1, (alpha) -0.0244247
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0244138
UNC5C unc-5 homolog C (C. elegans) -0.0243182
CALD1 caldesmon 1 -0.0242998
USP15 ubiquitin specific peptidase 15 -0.0241542
RANBP17 RAN binding protein 17 -0.0238188
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0230732
KIAA1217 KIAA1217 -0.0230535
NBAS neuroblastoma amplified sequence -0.0228971
SOD2 superoxide dismutase 2, mitochondrial -0.0226212
CANX calnexin -0.0223173
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.022313
RPS21 ribosomal protein S21 -0.0222387
TFRC transferrin receptor -0.0221358
SCG2 secretogranin II -0.0220379
AEBP2 AE binding protein 2 -0.0220165
COMMD10 COMM domain containing 10 -0.0220163
TBC1D22A TBC1 domain family, member 22A -0.0219186
MT2A metallothionein 2A -0.0219108
ARF1 ADP-ribosylation factor 1 -0.0217927
PHF14 PHD finger protein 14 -0.0217765
SECISBP2 SECIS binding protein 2 -0.0217439
TPM1 tropomyosin 1 (alpha) -0.0216672
MSI2 musashi RNA-binding protein 2 -0.0214925
HDLBP high density lipoprotein binding protein -0.0213893
IGFBP5 insulin-like growth factor binding protein 5 -0.0213358
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0213238
RPL13A ribosomal protein L13a -0.0212412
VAV2 vav 2 guanine nucleotide exchange factor -0.0212287