Sodium Salicylate_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.0856645
MACC1 metastasis associated in colon cancer 1 0.0709166
SPATA13 spermatogenesis associated 13 0.0547176
FTH1 ferritin, heavy polypeptide 1 0.0492988
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0426732
LYZ lysozyme 0.0416229
EPS8 epidermal growth factor receptor pathway substrate 8 0.0351751
MYO1E myosin IE 0.0290162
GCLC glutamate-cysteine ligase, catalytic subunit 0.0280983
ERBIN erbb2 interacting protein 0.0279377
FOS FBJ murine osteosarcoma viral oncogene homolog 0.026829
TMC5 transmembrane channel-like 5 0.025896
BAIAP2L1 BAI1-associated protein 2-like 1 0.0249694
MCU mitochondrial calcium uniporter 0.0247245
EPSTI1 epithelial stromal interaction 1 (breast) 0.0230905
KIAA1217 KIAA1217 0.0222177
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.021961
VCL vinculin 0.0218748
PHF3 PHD finger protein 3 0.0217556
SEC31A SEC31 homolog A (S. cerevisiae) 0.0216052
IGFBP3 insulin-like growth factor binding protein 3 0.0208663
DUSP10 dual specificity phosphatase 10 0.0199518
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.0196177
EPHB2 EPH receptor B2 0.0194719
TJP1 tight junction protein 1 0.0184837
JAK1 Janus kinase 1 0.0179768
EZR ezrin 0.0175343
CXCL8 chemokine (C-X-C motif) ligand 8 0.0174664
XDH xanthine dehydrogenase 0.0172748
NAMPT nicotinamide phosphoribosyltransferase 0.0172525
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0169804
ITGA6 integrin, alpha 6 0.0167705
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0167522
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0167039
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0166157
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0160692
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0160312
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0158373
AOPEP aminopeptidase O (putative) 0.0158357
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0156456
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0156017
CCNL1 cyclin L1 0.0155712
SAMD4A sterile alpha motif domain containing 4A 0.0155278
RABGAP1L RAB GTPase activating protein 1-like 0.0155198
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0151989
RAB7A RAB7A, member RAS oncogene family 0.0150955
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0144854
MON2 MON2 homolog (S. cerevisiae) 0.0140204
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0136871
MYO5B myosin VB 0.0136362
XAF1 XIAP associated factor 1 0.0135694
ZNF165 zinc finger protein 165 0.0131261
RBM47 RNA binding motif protein 47 0.0130528
AKAP13 A kinase (PRKA) anchor protein 13 0.0130265
HM13 histocompatibility (minor) 13 0.0128138
LYN LYN proto-oncogene, Src family tyrosine kinase 0.0126858
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0126746
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.0125018
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0121289
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0120298
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0119556
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0118408
MAP7 microtubule-associated protein 7 0.011637
PPARG peroxisome proliferator-activated receptor gamma 0.0115393
ABHD2 abhydrolase domain containing 2 0.0115373
FHIT fragile histidine triad 0.0114372
NCEH1 neutral cholesterol ester hydrolase 1 0.0113839
CRY1 cryptochrome circadian clock 1 0.0113527
ZBTB20 zinc finger and BTB domain containing 20 0.0111904
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0111567
AFF1 AF4/FMR2 family, member 1 0.0111407
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0111209
NEBL nebulette 0.0110651
ANKRD10 ankyrin repeat domain 10 0.0110238
DHFR dihydrofolate reductase 0.010987
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0109582
GRK3 G protein-coupled receptor kinase 3 0.0107448
SLK STE20-like kinase 0.0107155
PSEN1 presenilin 1 0.0106656
HKDC1 hexokinase domain containing 1 0.0106203
FA2H fatty acid 2-hydroxylase 0.0105244
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0103652
OCLN occludin 0.0103282
SPATA6L spermatogenesis associated 6-like 0.0102828
EGR1 early growth response 1 0.010242
CD68 CD68 molecule 0.0101492
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 0.0101379
BACE2 beta-site APP-cleaving enzyme 2 0.010126
RDH10 retinol dehydrogenase 10 (all-trans) 0.0100989
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0100779
SREBF2 sterol regulatory element binding transcription factor 2 0.0100124
DDIT3 DNA-damage-inducible transcript 3 0.00997405
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.00993686
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.00991583
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.00984966
SEC24A SEC24 family member A 0.0098394
IGF1R insulin-like growth factor 1 receptor 0.00976565
EPB41L5 erythrocyte membrane protein band 4.1 like 5 0.00966612
FNIP1 folliculin interacting protein 1 0.0096056
ARL5B ADP-ribosylation factor-like 5B 0.00946527

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.153294
UBC ubiquitin C -0.149483
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.129992
TPT1 tumor protein, translationally-controlled 1 -0.124149
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.117226
B2M beta-2-microglobulin -0.112185
TXNIP thioredoxin interacting protein -0.0807076
ENO1 enolase 1, (alpha) -0.0769567
PKM pyruvate kinase, muscle -0.0733842
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0675431
PTMA prothymosin, alpha -0.0642388
LCN2 lipocalin 2 -0.0616494
AHNAK AHNAK nucleoprotein -0.061555
IFI6 interferon, alpha-inducible protein 6 -0.057258
RPL23 ribosomal protein L23 -0.054342
INTS6 integrator complex subunit 6 -0.0478507
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0477509
TMSB10 thymosin beta 10 -0.0477029
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0475853
BTBD9 BTB (POZ) domain containing 9 -0.0465977
EPCAM epithelial cell adhesion molecule -0.0459873
RPS27A ribosomal protein S27a -0.0450897
PDIA4 protein disulfide isomerase family A, member 4 -0.0446555
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0445759
PGK1 phosphoglycerate kinase 1 -0.0432622
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0416682
PERP PERP, TP53 apoptosis effector -0.0412276
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0411511
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0399527
C6ORF132 chromosome 6 open reading frame 132 -0.039278
RPS8 ribosomal protein S8 -0.0390476
FTL ferritin, light polypeptide -0.0390314
RNF43 ring finger protein 43 -0.0383611
PDIA3 protein disulfide isomerase family A, member 3 -0.0375561
PCBP2 poly(rC) binding protein 2 -0.0372655
NDRG1 N-myc downstream regulated 1 -0.036737
RPS6 ribosomal protein S6 -0.0363595
CALR calreticulin -0.0362229
PRRC2C proline-rich coiled-coil 2C -0.0349317
RPS3 ribosomal protein S3 -0.0345362
LDHA lactate dehydrogenase A -0.0342063
CANX calnexin -0.0324195
RPLP1 ribosomal protein, large, P1 -0.0323091
PTBP3 polypyrimidine tract binding protein 3 -0.0322097
ARGLU1 arginine and glutamate rich 1 -0.032159
MT2A metallothionein 2A -0.0319598
RPL12 ribosomal protein L12 -0.030225
WSB1 WD repeat and SOCS box containing 1 -0.0301702
RPL37A ribosomal protein L37a -0.0298562
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0293813
ARHGAP26 Rho GTPase activating protein 26 -0.0293471
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0293138
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0292486
RPL26 ribosomal protein L26 -0.0291657
RUNX1 runt-related transcription factor 1 -0.0290803
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0288263
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0283821
TSC22D1 TSC22 domain family, member 1 -0.0282567
ASPH aspartate beta-hydroxylase -0.0282403
EIF1 eukaryotic translation initiation factor 1 -0.0281264
S100A10 S100 calcium binding protein A10 -0.028059
RPL31 ribosomal protein L31 -0.028012
RPL11 ribosomal protein L11 -0.0278038
LIMA1 LIM domain and actin binding 1 -0.0277141
RNF213 ring finger protein 213 -0.0274905
RPL35A ribosomal protein L35a -0.0273272
EFNB2 ephrin-B2 -0.0272605
ADAM10 ADAM metallopeptidase domain 10 -0.0268409
IFNGR1 interferon gamma receptor 1 -0.0268258
EHF ets homologous factor -0.0266798
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.026239
RPL19 ribosomal protein L19 -0.0262379
RPS12 ribosomal protein S12 -0.0259577
ZNF207 zinc finger protein 207 -0.025832
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0257658
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0255571
RPS19 ribosomal protein S19 -0.0254932
NAP1L1 nucleosome assembly protein 1-like 1 -0.0249426
RPL18 ribosomal protein L18 -0.0246117
RPL34 ribosomal protein L34 -0.0245921
PLSCR2 phospholipid scramblase 2 -0.024474
PTPRF protein tyrosine phosphatase, receptor type, F -0.0243735
NCKAP5 NCK-associated protein 5 -0.0243341
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0238374
IFI27 interferon, alpha-inducible protein 27 -0.0234281
SORBS1 sorbin and SH3 domain containing 1 -0.0234091
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0233137
RPL37 ribosomal protein L37 -0.0231317
RPL9 ribosomal protein L9 -0.0230979
JUN jun proto-oncogene -0.0230605
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0229832
NRIP1 nuclear receptor interacting protein 1 -0.0228275
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0227937
IRS2 insulin receptor substrate 2 -0.022498
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0224926
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0223442
MEIS2 Meis homeobox 2 -0.0222849
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0218506
RPS23 ribosomal protein S23 -0.0218445
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0217416