Sodium Salicylate_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KRT18 keratin 18, type I 0.0838317
P4HB prolyl 4-hydroxylase, beta polypeptide 0.072011
POTEF POTE ankyrin domain family, member F 0.0482046
FTH1 ferritin, heavy polypeptide 1 0.0479984
EZR ezrin 0.0464503
SETD5 SET domain containing 5 0.0439587
SON SON DNA binding protein 0.0439373
DIAPH3 diaphanous-related formin 3 0.0435818
FLNA filamin A, alpha 0.0435125
GOLGA4 golgin A4 0.0433843
MYH9 myosin, heavy chain 9, non-muscle 0.0420255
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0418792
EEF2 eukaryotic translation elongation factor 2 0.0417999
EXT1 exostosin glycosyltransferase 1 0.0412946
ZFAND3 zinc finger, AN1-type domain 3 0.041029
PLEC plectin 0.0401034
PRELID2 PRELI domain containing 2 0.0391194
APLP2 amyloid beta (A4) precursor-like protein 2 0.0365996
KMT2C lysine (K)-specific methyltransferase 2C 0.0364785
RAD51B RAD51 paralog B 0.0363664
TXNRD1 thioredoxin reductase 1 0.036262
NUP58 nucleoporin 58 0.0357632
BRD2 bromodomain containing 2 0.0335813
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0332379
DST dystonin 0.031715
AKAP9 A kinase (PRKA) anchor protein 9 0.0316419
PDE4D phosphodiesterase 4D, cAMP-specific 0.0315687
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0306422
TMF1 TATA element modulatory factor 1 0.0304992
COPA coatomer protein complex, subunit alpha 0.0296406
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0279745
AKAP12 A kinase (PRKA) anchor protein 12 0.0276187
SMC4 structural maintenance of chromosomes 4 0.0274975
KTN1 kinectin 1 (kinesin receptor) 0.0272319
BRD4 bromodomain containing 4 0.0270891
TPM3 tropomyosin 3 0.0261103
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0256707
EIF5 eukaryotic translation initiation factor 5 0.0252378
PCM1 pericentriolar material 1 0.0251125
CSNK1A1 casein kinase 1, alpha 1 0.0251107
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0249865
RAD23B RAD23 homolog B (S. cerevisiae) 0.0249095
ARL5B ADP-ribosylation factor-like 5B 0.024867
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0247033
HELZ helicase with zinc finger 0.0245716
HMGA1 high mobility group AT-hook 1 0.0244681
PDIA3 protein disulfide isomerase family A, member 3 0.0243002
UBA6 ubiquitin-like modifier activating enzyme 6 0.0242743
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0240458
ERBIN erbb2 interacting protein 0.023802
RIGI RNA sensor RIG-I 0.0237006
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0233048
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0228792
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0228254
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0227932
RRM2 ribonucleotide reductase M2 0.0226902
KDM2A lysine (K)-specific demethylase 2A 0.0225509
KMT2E lysine (K)-specific methyltransferase 2E 0.02255
ITCH itchy E3 ubiquitin protein ligase 0.0224645
SRPK2 SRSF protein kinase 2 0.022227
WNK1 WNK lysine deficient protein kinase 1 0.0220111
RBM25 RNA binding motif protein 25 0.0218177
RNPS1 RNA binding protein S1, serine-rich domain 0.0216927
GSPT1 G1 to S phase transition 1 0.0215973
WDPCP WD repeat containing planar cell polarity effector 0.0212994
RICTOR RPTOR independent companion of MTOR, complex 2 0.0212618
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0210197
NOP58 NOP58 ribonucleoprotein 0.0208369
CENPF centromere protein F, 350/400kDa 0.0207729
BCLAF1 BCL2-associated transcription factor 1 0.0207625
TPR translocated promoter region, nuclear basket protein 0.0207488
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0207334
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0207181
CCNL1 cyclin L1 0.0206938
VEGFA vascular endothelial growth factor A 0.0206907
PABPN1 poly(A) binding protein, nuclear 1 0.0205658
ANKRD12 ankyrin repeat domain 12 0.020379
PTGES2 prostaglandin E synthase 2 0.020361
CKAP5 cytoskeleton associated protein 5 0.0202864
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0200393
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0200224
SRP54 signal recognition particle 54kDa 0.0199103
KDM6A lysine (K)-specific demethylase 6A 0.0199027
TSC22D2 TSC22 domain family, member 2 0.0198812
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0198649
SS18 synovial sarcoma translocation, chromosome 18 0.0197025
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0195759
CEP350 centrosomal protein 350kDa 0.0195409
TOR1AIP2 torsin A interacting protein 2 0.0194142
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.0194131
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0193398
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0192929
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0192904
ATXN7 ataxin 7 0.0190363
LOC102724023 ES1 protein homolog, mitochondrial 0.0190178
TMEM41B transmembrane protein 41B 0.0189723
FOS FBJ murine osteosarcoma viral oncogene homolog 0.018917
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0188446
METTL15 methyltransferase like 15 0.0186903
MIDEAS mitotic deacetylase associated SANT domain protein 0.0186246

decreased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein -0.287957
NDRG1 N-myc downstream regulated 1 -0.156341
FAT1 FAT atypical cadherin 1 -0.136524
PTMA prothymosin, alpha -0.126519
TPT1 tumor protein, translationally-controlled 1 -0.117816
ENO1 enolase 1, (alpha) -0.103115
ERRFI1 ERBB receptor feedback inhibitor 1 -0.100985
PATJ PATJ crumbs cell polarity complex component -0.0915463
UBC ubiquitin C -0.0834666
TMSB10 thymosin beta 10 -0.073113
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0699326
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0655295
SERINC5 serine incorporator 5 -0.0631154
PGK1 phosphoglycerate kinase 1 -0.0590186
RPL35A ribosomal protein L35a -0.0527094
RPS8 ribosomal protein S8 -0.0525143
RPS27A ribosomal protein S27a -0.0522909
CTBP2 C-terminal binding protein 2 -0.0507943
RPS24 ribosomal protein S24 -0.0491924
LDHA lactate dehydrogenase A -0.0485094
RPL4 ribosomal protein L4 -0.048305
CANX calnexin -0.0472543
EPCAM epithelial cell adhesion molecule -0.044784
RACK1 receptor for activated C kinase 1 -0.0440161
RPL34 ribosomal protein L34 -0.0429284
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0421646
S100A10 S100 calcium binding protein A10 -0.0403037
RPL26 ribosomal protein L26 -0.0396171
BACE2 beta-site APP-cleaving enzyme 2 -0.0392939
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0391299
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0387702
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0386418
RPL31 ribosomal protein L31 -0.0381684
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0380792
NF1 neurofibromin 1 -0.0380597
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0371919
RPS25 ribosomal protein S25 -0.0361384
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.035961
MCL1 myeloid cell leukemia 1 -0.0354742
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0341395
SPDYA speedy/RINGO cell cycle regulator family member A -0.034003
MXI1 MAX interactor 1, dimerization protein -0.0331425
RPL5 ribosomal protein L5 -0.0330315
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.0329347
TBC1D22A TBC1 domain family, member 22A -0.0324317
S100A6 S100 calcium binding protein A6 -0.0323534
PKM pyruvate kinase, muscle -0.0323507
RPLP0 ribosomal protein, large, P0 -0.0320671
RSL1D1 ribosomal L1 domain containing 1 -0.0317883
RPL38 ribosomal protein L38 -0.0317153
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0314674
RPL37 ribosomal protein L37 -0.031227
RPL7A ribosomal protein L7a -0.0311648
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) -0.0306776
FDPS farnesyl diphosphate synthase -0.0304683
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0301023
RPS6 ribosomal protein S6 -0.029873
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0298063
TPM4 tropomyosin 4 -0.0294102
FNIP1 folliculin interacting protein 1 -0.0293633
ADD1 adducin 1 (alpha) -0.0291747
MRPS6 mitochondrial ribosomal protein S6 -0.0286241
PDXK pyridoxal (pyridoxine, vitamin B6) kinase -0.0283795
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.028161
EIF1 eukaryotic translation initiation factor 1 -0.0281389
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0281282
EGR1 early growth response 1 -0.027736
SLC38A1 solute carrier family 38, member 1 -0.0269892
RPL37A ribosomal protein L37a -0.026585
RPS12 ribosomal protein S12 -0.0262474
SCARB1 scavenger receptor class B, member 1 -0.0260544
KDM4B lysine (K)-specific demethylase 4B -0.0260017
DENND1A DENN/MADD domain containing 1A -0.0259519
TMEM123 transmembrane protein 123 -0.0257352
APP amyloid beta (A4) precursor protein -0.025588
SDC4 syndecan 4 -0.0254053
RPL23 ribosomal protein L23 -0.025338
EREG epiregulin -0.025041
VCL vinculin -0.02496
RPS3 ribosomal protein S3 -0.0243757
RPS13 ribosomal protein S13 -0.0243016
UBB ubiquitin B -0.0242651
RPL36 ribosomal protein L36 -0.0242414
MEF2A myocyte enhancer factor 2A -0.0240415
RPS15 ribosomal protein S15 -0.0240209
RPL15 ribosomal protein L15 -0.0240073
ARF1 ADP-ribosylation factor 1 -0.0238564
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0237631
SLC38A2 solute carrier family 38, member 2 -0.0235521
LLGL2 lethal giant larvae homolog 2 (Drosophila) -0.0235316
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0234914
ARHGAP32 Rho GTPase activating protein 32 -0.0233994
ARHGAP5 Rho GTPase activating protein 5 -0.023337
RPL30 ribosomal protein L30 -0.023329
CUX1 cut-like homeobox 1 -0.0231045
HLA-E major histocompatibility complex, class I, E -0.02293
FRMD5 FERM domain containing 5 -0.0228502
HOOK2 hook microtubule-tethering protein 2 -0.0228049
GPC5 glypican 5 -0.0227301
SNX14 sorting nexin 14 -0.0227221