Sodium Salicylate_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.143753
FLNA filamin A, alpha 0.121703
EEF2 eukaryotic translation elongation factor 2 0.108504
PSD3 pleckstrin and Sec7 domain containing 3 0.0762562
LAMA4 laminin, alpha 4 0.064544
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0623528
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0604146
RAD51B RAD51 paralog B 0.0539666
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0521512
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0456266
NDRG1 N-myc downstream regulated 1 0.0448535
INTS6 integrator complex subunit 6 0.0442436
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0440529
ANKRD11 ankyrin repeat domain 11 0.0413015
ANXA1 annexin A1 0.0411915
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0406249
FNDC3B fibronectin type III domain containing 3B 0.0398797
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0388274
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0374093
RUNX1 runt-related transcription factor 1 0.0371118
CYSTM1 cysteine-rich transmembrane module containing 1 0.0369045
HMGA2 high mobility group AT-hook 2 0.0365456
MYO1E myosin IE 0.0355288
CREB5 cAMP responsive element binding protein 5 0.0348175
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0312353
VMP1 vacuole membrane protein 1 0.0306417
ZFP36L1 ZFP36 ring finger protein-like 1 0.0299376
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0289292
RPS4X ribosomal protein S4, X-linked 0.0284794
ZSWIM6 zinc finger, SWIM-type containing 6 0.0280126
CMIP c-Maf inducing protein 0.0274864
SGMS2 sphingomyelin synthase 2 0.0274633
CCDC138 coiled-coil domain containing 138 0.0273953
OSBPL10 oxysterol binding protein-like 10 0.0271456
SHB Src homology 2 domain containing adaptor protein B 0.027048
CEMIP2 cell migration inducing hyaluronidase 2 0.0265752
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0265217
KRT86 keratin 86, type II 0.0264268
GOLGB1 golgin B1 0.0263397
SPATA13 spermatogenesis associated 13 0.0258925
IARS1 isoleucyl-tRNA synthetase 1 0.0252928
WWOX WW domain containing oxidoreductase 0.0252568
FLNB filamin B, beta 0.0246526
MBNL2 muscleblind-like splicing regulator 2 0.0244359
LRRC23 leucine rich repeat containing 23 0.0243278
STC2 stanniocalcin 2 0.0241102
MAML2 mastermind-like 2 (Drosophila) 0.0240977
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.024068
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0239325
DHFR dihydrofolate reductase 0.0236338
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0235365
EMP1 epithelial membrane protein 1 0.023226
EZR ezrin 0.0230756
KRT18 keratin 18, type I 0.0229764
EGR1 early growth response 1 0.0229668
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0228555
EXT1 exostosin glycosyltransferase 1 0.0226911
NABP1 nucleic acid binding protein 1 0.0223302
SEC31A SEC31 homolog A (S. cerevisiae) 0.0222436
N4BP2L2 NEDD4 binding protein 2-like 2 0.0221665
AGRN agrin 0.0219348
CFAP44 cilia and flagella associated protein 44 0.0214792
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0212473
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0212222
FAM120A family with sequence similarity 120A 0.0211909
HMGA1 high mobility group AT-hook 1 0.0211231
SHISA5 shisa family member 5 0.0208449
TIMP2 TIMP metallopeptidase inhibitor 2 0.020724
ADAM32 ADAM metallopeptidase domain 32 0.0206303
SLC38A2 solute carrier family 38, member 2 0.0205505
WWTR1 WW domain containing transcription regulator 1 0.0203816
STAC SH3 and cysteine rich domain 0.020369
PSEN1 presenilin 1 0.0203138
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0201964
EGFR epidermal growth factor receptor 0.0201524
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0201456
FHIT fragile histidine triad 0.0200716
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0200684
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0198741
FRAS1 Fraser extracellular matrix complex subunit 1 0.0196215
CD44 CD44 molecule (Indian blood group) 0.0194563
ZRANB3 zinc finger, RAN-binding domain containing 3 0.0187585
BIRC3 baculoviral IAP repeat containing 3 0.0183743
BBS9 Bardet-Biedl syndrome 9 0.0183548
ATXN1 ataxin 1 0.0182299
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0180903
UBASH3B ubiquitin associated and SH3 domain containing B 0.0179379
AFF1 AF4/FMR2 family, member 1 0.0179375
CLDN4 claudin 4 0.0178726
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0178063
ANK2 ankyrin 2, neuronal 0.0177507
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.017597
ENO2 enolase 2 (gamma, neuronal) 0.0175872
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0175235
HM13 histocompatibility (minor) 13 0.017357
UBAP2 ubiquitin associated protein 2 0.0173445
PTPRD protein tyrosine phosphatase, receptor type, D 0.0171306
NCEH1 neutral cholesterol ester hydrolase 1 0.017115
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0171033
HKDC1 hexokinase domain containing 1 0.0170073

decreased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.155423
MKI67 marker of proliferation Ki-67 -0.0901773
MYH9 myosin, heavy chain 9, non-muscle -0.084696
B2M beta-2-microglobulin -0.0840362
APP amyloid beta (A4) precursor protein -0.0806773
ACTG1 actin gamma 1 -0.0761948
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.072585
MATR3 matrin 3 -0.0716012
PTMA prothymosin, alpha -0.0708227
GOLGA4 golgin A4 -0.0701254
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0693911
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0663665
TMSB4X thymosin beta 4, X-linked -0.0657335
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0633406
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.063266
ENO1 enolase 1, (alpha) -0.0598936
NPEPPS aminopeptidase puromycin sensitive -0.0582508
ANLN anillin, actin binding protein -0.0575381
RPL32 ribosomal protein L32 -0.056007
RPS6 ribosomal protein S6 -0.0556468
OGA O-GlcNAcase -0.0549873
ZNF292 zinc finger protein 292 -0.0546139
TOP2B topoisomerase (DNA) II beta 180kDa -0.0540074
RBM39 RNA binding motif protein 39 -0.0534942
FTL ferritin, light polypeptide -0.0524745
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.052334
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0514395
FXR1 fragile X mental retardation, autosomal homolog 1 -0.050858
SEPTIN7 septin 7 -0.050526
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0496516
KDM3A lysine (K)-specific demethylase 3A -0.0489373
MAP4 microtubule-associated protein 4 -0.0486667
RPS19 ribosomal protein S19 -0.0484418
ANKRD10 ankyrin repeat domain 10 -0.0471901
H1-0 H1.0 linker histone -0.0466522
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0452804
RPL19 ribosomal protein L19 -0.0449658
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0448482
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.044009
NRIP1 nuclear receptor interacting protein 1 -0.0438032
XPO1 exportin 1 -0.0432221
PGK1 phosphoglycerate kinase 1 -0.0428353
DSG2 desmoglein 2 -0.0426306
NIPBL Nipped-B homolog (Drosophila) -0.0425934
RPS12 ribosomal protein S12 -0.0425828
AHNAK AHNAK nucleoprotein -0.0417528
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0417141
APOL1 apolipoprotein L, 1 -0.0416641
NCOR1 nuclear receptor corepressor 1 -0.0415594
CBX3 chromobox homolog 3 -0.0411711
KIF5B kinesin family member 5B -0.0407351
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0405903
TPT1 tumor protein, translationally-controlled 1 -0.0405127
KRT7 keratin 7, type II -0.0397963
UBQLN1 ubiquilin 1 -0.039393
CLTC clathrin, heavy chain (Hc) -0.0392712
USP9X ubiquitin specific peptidase 9, X-linked -0.0391802
NCKAP1 NCK-associated protein 1 -0.0389831
RPL12 ribosomal protein L12 -0.038847
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0387324
CLINT1 clathrin interactor 1 -0.0386971
KMT2E lysine (K)-specific methyltransferase 2E -0.0386232
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0385771
CANX calnexin -0.0383881
RPL26 ribosomal protein L26 -0.038119
MACF1 microtubule-actin crosslinking factor 1 -0.0378579
SNX9 sorting nexin 9 -0.037294
MT2A metallothionein 2A -0.0372045
RPL35A ribosomal protein L35a -0.0370709
SET SET nuclear proto-oncogene -0.0369174
RLF rearranged L-myc fusion -0.0368686
RPL34 ribosomal protein L34 -0.0363267
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0360615
SETD2 SET domain containing 2 -0.0360444
SMC4 structural maintenance of chromosomes 4 -0.0358025
RPLP2 ribosomal protein, large, P2 -0.0357632
PRRC2C proline-rich coiled-coil 2C -0.0356049
RPL14 ribosomal protein L14 -0.0355031
VEZT vezatin, adherens junctions transmembrane protein -0.0353703
SCAF11 SR-related CTD-associated factor 11 -0.0352981
TXNRD1 thioredoxin reductase 1 -0.0350545
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0349977
PDIA3 protein disulfide isomerase family A, member 3 -0.0349736
RPL28 ribosomal protein L28 -0.0343109
RPS5 ribosomal protein S5 -0.0342435
PUM2 pumilio RNA-binding family member 2 -0.0341591
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0339502
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0339179
UGCG UDP-glucose ceramide glucosyltransferase -0.0339133
SETD5 SET domain containing 5 -0.0333034
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0331414
LDHA lactate dehydrogenase A -0.0328472
PHIP pleckstrin homology domain interacting protein -0.0326728
RPLP1 ribosomal protein, large, P1 -0.0325906
AFDN afadin, adherens junction formation factor -0.0323921
PDS5B PDS5 cohesin associated factor B -0.0322825
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0320774
HMGB2 high mobility group box 2 -0.0320135
GMPS guanine monphosphate synthase -0.0318463
CAMTA1 calmodulin binding transcription activator 1 -0.0318244