Sodium Salicylate_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.292607
IGFBP3 insulin-like growth factor binding protein 3 0.22767
COL6A3 collagen, type VI, alpha 3 0.154709
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.126638
FTH1 ferritin, heavy polypeptide 1 0.0882664
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0821988
COL1A2 collagen, type I, alpha 2 0.0642103
TPM4 tropomyosin 4 0.0581539
VEGFA vascular endothelial growth factor A 0.0580297
VIM vimentin 0.0568939
VCAN versican 0.0565277
TGFBI transforming growth factor, beta-induced, 68kDa 0.0508315
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0477902
STC1 stanniocalcin 1 0.0442791
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.041588
TIMP3 TIMP metallopeptidase inhibitor 3 0.038666
LOXL2 lysyl oxidase-like 2 0.0382581
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0376049
CD44 CD44 molecule (Indian blood group) 0.0366748
PLEC plectin 0.035423
ZBTB38 zinc finger and BTB domain containing 38 0.0347936
ECE1 endothelin converting enzyme 1 0.0322795
BHLHE40 basic helix-loop-helix family, member e40 0.0320998
FBN1 fibrillin 1 0.0313409
IER3 immediate early response 3 0.0292228
COL6A1 collagen, type VI, alpha 1 0.0274201
SFTPA2 surfactant protein A2 0.0253967
LIMS1 LIM and senescent cell antigen-like domains 1 0.0253053
CLMP CXADR-like membrane protein 0.0240495
HLA-B major histocompatibility complex, class I, B 0.0237992
MAP1B microtubule-associated protein 1B 0.0237081
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0235257
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0232368
EEF2 eukaryotic translation elongation factor 2 0.0225573
ASPH aspartate beta-hydroxylase 0.0225417
COL1A1 collagen, type I, alpha 1 0.0224896
ATP13A3 ATPase type 13A3 0.0224529
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0218685
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0213691
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0212269
NKAIN3 Na+/K+ transporting ATPase interacting 3 0.0211532
CCND1 cyclin D1 0.0208629
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0208054
F3 coagulation factor III (thromboplastin, tissue factor) 0.0202603
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0199901
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0197321
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0194367
MACF1 microtubule-actin crosslinking factor 1 0.019228
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0190392
FLNA filamin A, alpha 0.0189938
WWTR1 WW domain containing transcription regulator 1 0.0188933
RND3 Rho family GTPase 3 0.018675
LOX lysyl oxidase 0.0186701
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0184083
B2M beta-2-microglobulin 0.0183881
INHBA inhibin, beta A 0.0182983
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0178251
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.017486
P4HB prolyl 4-hydroxylase, beta polypeptide 0.017398
CTSB cathepsin B 0.0172576
HLA-A major histocompatibility complex, class I, A 0.0172511
SQLE squalene epoxidase 0.0171686
ACTG1 actin gamma 1 0.0171034
COL6A2 collagen, type VI, alpha 2 0.0170629
IGFBP7 insulin-like growth factor binding protein 7 0.0170174
TM4SF1 transmembrane 4 L six family member 1 0.0169879
LMAN1 lectin, mannose-binding, 1 0.0166615
ADM adrenomedullin 0.0166249
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.0158783
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0157708
NRP1 neuropilin 1 0.0157003
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0156709
RPS6 ribosomal protein S6 0.0151998
TNIP1 TNFAIP3 interacting protein 1 0.0151566
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0150364
CAVIN1 caveolae associated protein 1 0.0149772
RPLP0 ribosomal protein, large, P0 0.0146357
ERRFI1 ERBB receptor feedback inhibitor 1 0.0144649
FSTL1 follistatin-like 1 0.0142136
LDHA lactate dehydrogenase A 0.0141574
LTBP1 latent transforming growth factor beta binding protein 1 0.0140841
ANXA2 annexin A2 0.0139921
SDC2 syndecan 2 0.0139641
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0138361
CA12 carbonic anhydrase XII 0.0134951
FTL ferritin, light polypeptide 0.0134565
S100A10 S100 calcium binding protein A10 0.0133151
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0132057
DSTN destrin (actin depolymerizing factor) 0.0131655
RPL35A ribosomal protein L35a 0.013103
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0129981
RNF145 ring finger protein 145 0.0129533
CSDE1 cold shock domain containing E1, RNA-binding 0.012766
CKAP4 cytoskeleton-associated protein 4 0.0126877
CALU calumenin 0.0126133
LIMA1 LIM domain and actin binding 1 0.0125452
MYH9 myosin, heavy chain 9, non-muscle 0.0125138
BZW1 basic leucine zipper and W2 domains 1 0.0124904
POSTN periostin, osteoblast specific factor 0.012369
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0123024

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0674511
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0529813
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0490022
UBC ubiquitin C -0.0444894
CADM1 cell adhesion molecule 1 -0.0330267
TRIO trio Rho guanine nucleotide exchange factor -0.0302926
FNDC3B fibronectin type III domain containing 3B -0.0296159
NDRG1 N-myc downstream regulated 1 -0.0279441
PRELID2 PRELI domain containing 2 -0.0267981
CAMTA1 calmodulin binding transcription activator 1 -0.0259357
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0255207
SMYD3 SET and MYND domain containing 3 -0.024939
PSD3 pleckstrin and Sec7 domain containing 3 -0.0246682
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0225759
RPS27A ribosomal protein S27a -0.0206226
ENO1 enolase 1, (alpha) -0.0194718
IARS1 isoleucyl-tRNA synthetase 1 -0.0193055
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0188564
AHNAK AHNAK nucleoprotein -0.0169295
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme -0.0161983
RNF220 ring finger protein 220 -0.0159647
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0152425
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0152315
KDM4B lysine (K)-specific demethylase 4B -0.0149219
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0145366
COL7A1 collagen, type VII, alpha 1 -0.0145244
ABI3BP ABI family, member 3 (NESH) binding protein -0.0143989
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0140729
CDK13 cyclin-dependent kinase 13 -0.014061
JARID2 jumonji, AT rich interactive domain 2 -0.0137802
RBM39 RNA binding motif protein 39 -0.0136338
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0135256
SPDYA speedy/RINGO cell cycle regulator family member A -0.0134167
TBC1D22A TBC1 domain family, member 22A -0.0133906
FNIP1 folliculin interacting protein 1 -0.0133631
LCOR ligand dependent nuclear receptor corepressor -0.0133144
CMIP c-Maf inducing protein -0.0128558
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0125371
GOLGA4 golgin A4 -0.0124694
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0123316
COG5 component of oligomeric golgi complex 5 -0.0120087
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0119961
PDIA5 protein disulfide isomerase family A, member 5 -0.0119948
CLIC4 chloride intracellular channel 4 -0.0118707
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0117865
SENP5 SUMO1/sentrin specific peptidase 5 -0.0115995
PDE10A phosphodiesterase 10A -0.0115121
DGKI diacylglycerol kinase, iota -0.0115091
TBC1D23 TBC1 domain family, member 23 -0.0114415
EGFR epidermal growth factor receptor -0.0112624
USP34 ubiquitin specific peptidase 34 -0.0111375
RSRC1 arginine/serine-rich coiled-coil 1 -0.0111212
MAML2 mastermind-like 2 (Drosophila) -0.0109848
TMED7 transmembrane emp24 protein transport domain containing 7 -0.0109635
KCTD16 potassium channel tetramerization domain containing 16 -0.0108416
RBPMS RNA binding protein with multiple splicing -0.0108293
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0107267
PCBP2 poly(rC) binding protein 2 -0.010717
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 -0.0107064
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) -0.01056
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0104563
NDEL1 nudE neurodevelopment protein 1-like 1 -0.0102039
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0101578
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0100767
BCAS3 breast carcinoma amplified sequence 3 -0.0100564
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0100346
XYLT1 xylosyltransferase I -0.00996964
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.00980687
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -0.00970333
BIRC6 baculoviral IAP repeat containing 6 -0.00966351
FBXO32 F-box protein 32 -0.00965576
TRPS1 trichorhinophalangeal syndrome I -0.00961389
TENM1 teneurin transmembrane protein 1 -0.00954154
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.00946712
ANKHD1 ankyrin repeat and KH domain containing 1 -0.00944405
ZNF207 zinc finger protein 207 -0.00944298
SCFD2 sec1 family domain containing 2 -0.00941692
LARP1B La ribonucleoprotein domain family, member 1B -0.00933327
NABP1 nucleic acid binding protein 1 -0.0092889
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.00918944
MON2 MON2 homolog (S. cerevisiae) -0.00917076
COL5A1 collagen, type V, alpha 1 -0.00915518
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.00905269
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0090278
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.00902117
SLC30A7 solute carrier family 30 (zinc transporter), member 7 -0.00896513
TMSB10 thymosin beta 10 -0.00892816
KDM3A lysine (K)-specific demethylase 3A -0.0089122
SETX senataxin -0.00887219
BBS9 Bardet-Biedl syndrome 9 -0.00880999
RPL23 ribosomal protein L23 -0.00877514
CSNK1A1 casein kinase 1, alpha 1 -0.00875916
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.00870599
AAK1 AP2 associated kinase 1 -0.00865943
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.00863212
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.00862725
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.008572
ZBTB20 zinc finger and BTB domain containing 20 -0.00855909
TTC28 tetratricopeptide repeat domain 28 -0.00836409
SOD2 superoxide dismutase 2, mitochondrial -0.00835149