Sodium Salicylate_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.117979
RPLP1 ribosomal protein, large, P1 0.097029
EZR ezrin 0.0776088
PABPC1 poly(A) binding protein, cytoplasmic 1 0.075628
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0746885
LMO7 LIM domain 7 0.0744145
EEF2 eukaryotic translation elongation factor 2 0.0709785
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0626811
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0608134
ERRFI1 ERBB receptor feedback inhibitor 1 0.0561583
RPL35A ribosomal protein L35a 0.0560469
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0524547
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0513164
VEGFA vascular endothelial growth factor A 0.0511541
PELI1 pellino E3 ubiquitin protein ligase 1 0.047065
KMT2E lysine (K)-specific methyltransferase 2E 0.04462
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0444428
NTN4 netrin 4 0.0441974
WNK1 WNK lysine deficient protein kinase 1 0.0432649
ITPKC inositol-trisphosphate 3-kinase C 0.0422035
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0419106
LYZ lysozyme 0.0410627
MBNL2 muscleblind-like splicing regulator 2 0.0410327
RPS19 ribosomal protein S19 0.0407909
ADARB1 adenosine deaminase, RNA-specific, B1 0.0403715
NCEH1 neutral cholesterol ester hydrolase 1 0.0393031
APLP2 amyloid beta (A4) precursor-like protein 2 0.039143
RPS16 ribosomal protein S16 0.0389478
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0388439
RB1CC1 RB1-inducible coiled-coil 1 0.0382275
BRD2 bromodomain containing 2 0.0377809
LOC112694756 uncharaterized LOC112694756 0.0365381
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0363112
FBXO32 F-box protein 32 0.0349185
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.034875
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0347764
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0347457
INTS6 integrator complex subunit 6 0.0335328
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0331893
EXT1 exostosin glycosyltransferase 1 0.0327757
KTN1 kinectin 1 (kinesin receptor) 0.0323617
RPL23 ribosomal protein L23 0.0323161
MYOF myoferlin 0.0316378
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.031563
POTEF POTE ankyrin domain family, member F 0.0315582
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0315484
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0314915
PDZD8 PDZ domain containing 8 0.0314662
KRT20 keratin 20, type I 0.0309148
ARHGAP29 Rho GTPase activating protein 29 0.0306456
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0305752
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0305541
PLEC plectin 0.0305459
AFF1 AF4/FMR2 family, member 1 0.0303274
EEF1G eukaryotic translation elongation factor 1 gamma 0.0302534
SEPTIN7 septin 7 0.0301228
CENPF centromere protein F, 350/400kDa 0.0300876
MBNL1 muscleblind-like splicing regulator 1 0.0300374
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0300273
RPS25 ribosomal protein S25 0.0298186
FAM13A family with sequence similarity 13, member A 0.0297012
MKI67 marker of proliferation Ki-67 0.0292871
PCBP2 poly(rC) binding protein 2 0.029272
ZNF292 zinc finger protein 292 0.0279752
RIOK3 RIO kinase 3 0.0279554
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0278631
GOLGA4 golgin A4 0.0278366
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0277796
LCOR ligand dependent nuclear receptor corepressor 0.0277402
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.02772
DIAPH1 diaphanous-related formin 1 0.0274918
BPTF bromodomain PHD finger transcription factor 0.0273867
RPS14 ribosomal protein S14 0.0272912
CKAP2 cytoskeleton associated protein 2 0.0272795
XPO1 exportin 1 0.0272383
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0270381
RHEB Ras homolog enriched in brain 0.0270356
RPLP2 ribosomal protein, large, P2 0.0269595
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0269034
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0263748
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0261708
TSC22D2 TSC22 domain family, member 2 0.0261053
ZNF638 zinc finger protein 638 0.0259769
RPL21 ribosomal protein L21 0.0259202
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.025816
TJP1 tight junction protein 1 0.0258152
DSCAM Down syndrome cell adhesion molecule 0.025812
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0257782
PRRC2C proline-rich coiled-coil 2C 0.0257189
SETD5 SET domain containing 5 0.0256861
TRA2A transformer 2 alpha homolog (Drosophila) 0.0256171
KDM2A lysine (K)-specific demethylase 2A 0.0255429
CDK8 cyclin-dependent kinase 8 0.0254762
JMY junction mediating and regulatory protein, p53 cofactor 0.0254235
KIF5B kinesin family member 5B 0.0252931
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0252333
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.025199
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0251945
TUFT1 tuftelin 1 0.0251416
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.025056

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.125019
SLC45A4 solute carrier family 45, member 4 -0.109128
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.108886
LAMA4 laminin, alpha 4 -0.0907444
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0903359
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.081913
FTH1 ferritin, heavy polypeptide 1 -0.0753465
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0722308
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0721596
NECTIN2 nectin cell adhesion molecule 2 -0.065249
KRT18 keratin 18, type I -0.0648787
PLAUR plasminogen activator, urokinase receptor -0.0601665
GMDS GDP-mannose 4,6-dehydratase -0.0598996
DIAPH2 diaphanous-related formin 2 -0.0580592
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0579566
PTMA prothymosin, alpha -0.0538984
ACTN4 actinin, alpha 4 -0.051924
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0506257
TRIB1 tribbles pseudokinase 1 -0.0481014
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0474772
SEPTIN9 septin 9 -0.0454503
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0447784
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0442956
TRPS1 trichorhinophalangeal syndrome I -0.0419266
CCSER1 coiled-coil serine-rich protein 1 -0.041628
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0413099
TMSB10 thymosin beta 10 -0.0399076
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0386317
DGKH diacylglycerol kinase, eta -0.0384851
KLK10 kallikrein-related peptidase 10 -0.0349547
MYH14 myosin, heavy chain 14, non-muscle -0.0345855
KRT8 keratin 8, type II -0.0340184
KIAA0232 KIAA0232 -0.0330754
RAB7A RAB7A, member RAS oncogene family -0.0330171
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0314443
PTPRH protein tyrosine phosphatase, receptor type, H -0.0310915
ANXA2 annexin A2 -0.0306531
EXOC4 exocyst complex component 4 -0.0304827
PATJ PATJ crumbs cell polarity complex component -0.0298826
LOC102724023 ES1 protein homolog, mitochondrial -0.0290616
SULF2 sulfatase 2 -0.0284829
CAPN8 calpain 8 -0.0284714
THSD4 thrombospondin, type I, domain containing 4 -0.0282833
WNT2B wingless-type MMTV integration site family, member 2B -0.0274869
MAML3 mastermind-like 3 (Drosophila) -0.0273868
NF1 neurofibromin 1 -0.0271335
NPC1 Niemann-Pick disease, type C1 -0.0271323
USP54 ubiquitin specific peptidase 54 -0.0263943
SDC4 syndecan 4 -0.0262243
RNF213 ring finger protein 213 -0.0260674
TRAPPC9 trafficking protein particle complex 9 -0.0259825
LAMB3 laminin, beta 3 -0.0255139
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0253038
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0251647
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0251071
NPSR1 neuropeptide S receptor 1 -0.0249335
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0248181
PTPRK protein tyrosine phosphatase, receptor type, K -0.0238681
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.023679
CD2AP CD2-associated protein -0.023557
PYGB phosphorylase, glycogen; brain -0.0235125
PAQR5 progestin and adipoQ receptor family member V -0.0232047
WWC1 WW and C2 domain containing 1 -0.0231911
TMC5 transmembrane channel-like 5 -0.0228644
SH3BP2 SH3-domain binding protein 2 -0.0227773
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.022762
PCED1B PC-esterase domain containing 1B -0.022724
NTSR1 neurotensin receptor 1 (high affinity) -0.0226043
PRELID2 PRELI domain containing 2 -0.0225205
S100P S100 calcium binding protein P -0.022403
SDCBP syndecan binding protein (syntenin) -0.0222564
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 -0.0222495
SLC38A1 solute carrier family 38, member 1 -0.0221986
CD59 CD59 molecule, complement regulatory protein -0.0221899
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) -0.0221695
RAB10 RAB10, member RAS oncogene family -0.0218931
PTPRF protein tyrosine phosphatase, receptor type, F -0.0217578
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0217498
MACC1 metastasis associated in colon cancer 1 -0.0212949
ITGA6 integrin, alpha 6 -0.0212433
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.021161
MMP7 matrix metallopeptidase 7 -0.0211169
ITGB5 integrin, beta 5 -0.0210324
LPP LIM domain containing preferred translocation partner in lipoma -0.0204559
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0201291
FA2H fatty acid 2-hydroxylase -0.0201238
CTTNBP2NL CTTNBP2 N-terminal like -0.0200972
MYO1E myosin IE -0.0196257
EPB41 erythrocyte membrane protein band 4.1 -0.0195853
TM4SF4 transmembrane 4 L six family member 4 -0.0194794
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0194141
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.019314
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -0.019295
MTAP methylthioadenosine phosphorylase -0.0192554
ETV6 ets variant 6 -0.0190507
ANKRD10 ankyrin repeat domain 10 -0.0190089
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 -0.0189677
CAMKMT calmodulin-lysine N-methyltransferase -0.018898
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) -0.0184764
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 -0.0182424