Sodium Salicylate_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MTSS1 metastasis suppressor 1 0.116768
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0823515
SLC35F3 solute carrier family 35, member F3 0.0798407
FTH1 ferritin, heavy polypeptide 1 0.0555249
LMO7 LIM domain 7 0.0465951
PLEC plectin 0.0460814
ABI3BP ABI family, member 3 (NESH) binding protein 0.0437932
TGM2 transglutaminase 2 0.0432187
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0419893
RAI14 retinoic acid induced 14 0.0402133
PDE4D phosphodiesterase 4D, cAMP-specific 0.0362978
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0351007
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0336219
MEF2A myocyte enhancer factor 2A 0.0325769
EFHD2 EF-hand domain family, member D2 0.03196
NRIP1 nuclear receptor interacting protein 1 0.030973
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.030031
BHLHE40 basic helix-loop-helix family, member e40 0.029744
AKAP13 A kinase (PRKA) anchor protein 13 0.0297268
PODXL podocalyxin-like 0.0288983
HSPG2 heparan sulfate proteoglycan 2 0.0282578
LAMC2 laminin, gamma 2 0.0271475
VEGFA vascular endothelial growth factor A 0.026504
HLA-E major histocompatibility complex, class I, E 0.0258991
PDLIM5 PDZ and LIM domain 5 0.0258204
CALB1 calbindin 1, 28kDa 0.0256964
PTK2 protein tyrosine kinase 2 0.0248706
NAV2 neuron navigator 2 0.0245541
THSD4 thrombospondin, type I, domain containing 4 0.0239237
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0234837
GRB10 growth factor receptor-bound protein 10 0.0227039
DHFR dihydrofolate reductase 0.0219289
ARHGAP21 Rho GTPase activating protein 21 0.0218287
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0214134
JMJD1C jumonji domain containing 1C 0.021366
PSD3 pleckstrin and Sec7 domain containing 3 0.02098
RABGAP1L RAB GTPase activating protein 1-like 0.0207177
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0200486
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 0.0199981
DENND1A DENN/MADD domain containing 1A 0.0195466
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0192118
SQLE squalene epoxidase 0.0184934
FN1 fibronectin 1 0.0184723
ANXA1 annexin A1 0.0183956
BCAR3 breast cancer anti-estrogen resistance 3 0.0183653
SLK STE20-like kinase 0.0181009
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0180568
PCDH1 protocadherin 1 0.0180111
RNF217 ring finger protein 217 0.0179865
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0178104
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0177944
SIK3 SIK family kinase 3 0.0177789
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0177117
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0174647
SQSTM1 sequestosome 1 0.0174154
SPIRE1 spire-type actin nucleation factor 1 0.0173295
ESYT2 extended synaptotagmin-like protein 2 0.0172918
ZEB1 zinc finger E-box binding homeobox 1 0.0168212
UTRN utrophin 0.0157421
DST dystonin 0.0156483
ABLIM3 actin binding LIM protein family, member 3 0.0155758
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.015562
SOD2 superoxide dismutase 2, mitochondrial 0.0154884
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0153364
FAF1 Fas (TNFRSF6) associated factor 1 0.0153034
RASAL2 RAS protein activator like 2 0.0148127
SULF1 sulfatase 1 0.0147706
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 0.0145943
RLIM ring finger protein, LIM domain interacting 0.0145444
BACE2 beta-site APP-cleaving enzyme 2 0.0140367
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.014009
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0139753
PPARG peroxisome proliferator-activated receptor gamma 0.0139633
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0139591
ATP9A ATPase, class II, type 9A 0.013955
NEBL nebulette 0.0138401
SULF2 sulfatase 2 0.0137985
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.013715
CYSTM1 cysteine-rich transmembrane module containing 1 0.0136364
KLF12 Kruppel-like factor 12 0.0135458
PTPRB protein tyrosine phosphatase, receptor type, B 0.0131576
DOK5 docking protein 5 0.0127946
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0126302
LDLR low density lipoprotein receptor 0.0126237
YOD1 YOD1 deubiquitinase 0.012613
SRSF4 serine/arginine-rich splicing factor 4 0.0125716
MBNL2 muscleblind-like splicing regulator 2 0.0125001
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0124211
HMGA2 high mobility group AT-hook 2 0.0121843
SMC5 structural maintenance of chromosomes 5 0.0118412
RAD51B RAD51 paralog B 0.0117851
MX1 MX dynamin-like GTPase 1 0.0117595
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0116199
GRK5 G protein-coupled receptor kinase 5 0.0113557
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0111986
NUMA1 nuclear mitotic apparatus protein 1 0.0111384
OPTN optineurin 0.0110999
ANO1 anoctamin 1, calcium activated chloride channel 0.0110771
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0109972
GPRC5B G protein-coupled receptor, class C, group 5, member B 0.0109501

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.18638
ENO1 enolase 1, (alpha) -0.141649
TMSB10 thymosin beta 10 -0.109077
UBC ubiquitin C -0.100748
MT2A metallothionein 2A -0.0979839
FLNB filamin B, beta -0.0976228
PTMA prothymosin, alpha -0.0929533
RPS21 ribosomal protein S21 -0.0874419
B2M beta-2-microglobulin -0.0865207
PGK1 phosphoglycerate kinase 1 -0.0822237
KRT17 keratin 17, type I -0.0765282
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0722553
CLU clusterin -0.0716461
LDHA lactate dehydrogenase A -0.0705249
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0690911
MYOF myoferlin -0.0633897
RPS27A ribosomal protein S27a -0.0609888
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0585837
RPLP2 ribosomal protein, large, P2 -0.0563778
POTEF POTE ankyrin domain family, member F -0.0547184
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0527252
PKM pyruvate kinase, muscle -0.0514186
RPL23 ribosomal protein L23 -0.0513933
STC1 stanniocalcin 1 -0.0505156
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0498596
RPS3 ribosomal protein S3 -0.0472086
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0449039
IFITM3 interferon induced transmembrane protein 3 -0.0443534
GNAS GNAS complex locus -0.0441517
CEMIP cell migration inducing protein, hyaluronan binding -0.0435857
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0435352
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0432997
RPS12 ribosomal protein S12 -0.0431261
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0426506
LOC112694756 uncharaterized LOC112694756 -0.0420563
TMSB4X thymosin beta 4, X-linked -0.0418957
TPT1 tumor protein, translationally-controlled 1 -0.0418909
CANX calnexin -0.0417596
S100A6 S100 calcium binding protein A6 -0.0415798
NAMPT nicotinamide phosphoribosyltransferase -0.0414581
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0399837
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0397367
NAP1L1 nucleosome assembly protein 1-like 1 -0.0392838
TXNIP thioredoxin interacting protein -0.0390548
SERINC3 serine incorporator 3 -0.038955
ITGA6 integrin, alpha 6 -0.0389271
RPLP1 ribosomal protein, large, P1 -0.0384755
AHNAK AHNAK nucleoprotein -0.038397
RPL11 ribosomal protein L11 -0.0377546
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0370253
KTN1 kinectin 1 (kinesin receptor) -0.036997
GOLGA4 golgin A4 -0.0366382
RPS13 ribosomal protein S13 -0.0364811
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0361282
RPS24 ribosomal protein S24 -0.0358665
CALU calumenin -0.0350686
RPS19 ribosomal protein S19 -0.0346179
RPS8 ribosomal protein S8 -0.0342173
LMNA lamin A/C -0.0337108
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0334539
CUL4B cullin 4B -0.0331969
ASPH aspartate beta-hydroxylase -0.0331966
RPL8 ribosomal protein L8 -0.0330508
VMP1 vacuole membrane protein 1 -0.0330241
CALR calreticulin -0.0329241
RPL37A ribosomal protein L37a -0.0327024
MBNL1 muscleblind-like splicing regulator 1 -0.0326412
S100A9 S100 calcium binding protein A9 -0.0325075
VCL vinculin -0.0317512
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0316809
PNISR PNN-interacting serine/arginine-rich protein -0.0311538
IFITM1 interferon induced transmembrane protein 1 -0.03102
S100A10 S100 calcium binding protein A10 -0.030714
RBM39 RNA binding motif protein 39 -0.0303489
PCBP2 poly(rC) binding protein 2 -0.0302714
TPX2 TPX2, microtubule-associated -0.0302517
IFI6 interferon, alpha-inducible protein 6 -0.0299967
PLAT plasminogen activator, tissue -0.0298098
TOP1 topoisomerase (DNA) I -0.029748
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0297101
PRELID2 PRELI domain containing 2 -0.0294263
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0288587
TM4SF1 transmembrane 4 L six family member 1 -0.0287997
RPS25 ribosomal protein S25 -0.0285603
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.027975
PDIA3 protein disulfide isomerase family A, member 3 -0.0279233
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0276669
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.027227
RPS23 ribosomal protein S23 -0.0270301
YBX3 Y box binding protein 3 -0.026534
FTL ferritin, light polypeptide -0.0265296
RACK1 receptor for activated C kinase 1 -0.0264325
FNDC3B fibronectin type III domain containing 3B -0.0262534
RPL27A ribosomal protein L27a -0.0261746
HLA-B major histocompatibility complex, class I, B -0.0261604
ANLN anillin, actin binding protein -0.0260643
YBX1 Y box binding protein 1 -0.0255754
RPL12 ribosomal protein L12 -0.0255742
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0255475
RPL31 ribosomal protein L31 -0.0252935