Sodium Salicylate_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KRT18 keratin 18, type I 0.230023
FTH1 ferritin, heavy polypeptide 1 0.161885
FGFR2 fibroblast growth factor receptor 2 0.0739046
TPT1 tumor protein, translationally-controlled 1 0.0652773
GOLGA4 golgin A4 0.0629546
AGR3 anterior gradient 3 0.0594797
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0555014
EMP1 epithelial membrane protein 1 0.0513305
PTMA prothymosin, alpha 0.0437776
AHNAK AHNAK nucleoprotein 0.0403197
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0400889
HLA-B major histocompatibility complex, class I, B 0.0396494
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0394916
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0393425
AGR2 anterior gradient 2 0.0376125
MBNL2 muscleblind-like splicing regulator 2 0.037288
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0370651
MORF4L2 mortality factor 4 like 2 0.0359916
RAB7A RAB7A, member RAS oncogene family 0.0355945
ANXA1 annexin A1 0.0354841
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0344018
EIF1 eukaryotic translation initiation factor 1 0.0314352
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0313041
RPS3 ribosomal protein S3 0.0306632
MYH9 myosin, heavy chain 9, non-muscle 0.0298353
LMO7 LIM domain 7 0.0296845
PMM2 phosphomannomutase 2 0.0294949
SEC31A SEC31 homolog A (S. cerevisiae) 0.0293257
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0290479
ZSWIM6 zinc finger, SWIM-type containing 6 0.0286889
IARS1 isoleucyl-tRNA synthetase 1 0.0280019
AREG amphiregulin 0.0276137
VEGFA vascular endothelial growth factor A 0.0273234
HLA-A major histocompatibility complex, class I, A 0.0265565
S100A6 S100 calcium binding protein A6 0.0262635
HDAC9 histone deacetylase 9 0.0252258
ARHGAP5 Rho GTPase activating protein 5 0.0247887
FAM13A family with sequence similarity 13, member A 0.0246655
B2M beta-2-microglobulin 0.0244099
TPM3 tropomyosin 3 0.0232868
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0230932
LCN2 lipocalin 2 0.022892
CLTC clathrin, heavy chain (Hc) 0.0225766
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0224344
SQSTM1 sequestosome 1 0.0223051
DSG2 desmoglein 2 0.0219397
HLA-C major histocompatibility complex, class I, C 0.0218056
RPL8 ribosomal protein L8 0.0216468
SET SET nuclear proto-oncogene 0.0215042
EIF4A2 eukaryotic translation initiation factor 4A2 0.0212573
HDLBP high density lipoprotein binding protein 0.0209081
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0208757
SCFD1 sec1 family domain containing 1 0.0208427
PCSK5 proprotein convertase subtilisin/kexin type 5 0.0206124
AKAP12 A kinase (PRKA) anchor protein 12 0.0203869
KRT17 keratin 17, type I 0.0203838
RPS17 ribosomal protein S17 0.0202812
TAS2R14 taste receptor, type 2, member 14 0.0202524
PLEC plectin 0.0201792
WSB1 WD repeat and SOCS box containing 1 0.0201214
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0200536
KLHL29 kelch-like family member 29 0.020029
TM9SF3 transmembrane 9 superfamily member 3 0.0199604
MYO5B myosin VB 0.0199398
C6ORF62 chromosome 6 open reading frame 62 0.0198382
GARS1 glycyl-tRNA synthetase 1 0.0197601
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.0196772
RPS6 ribosomal protein S6 0.0194594
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0193928
MAML2 mastermind-like 2 (Drosophila) 0.0191708
HM13 histocompatibility (minor) 13 0.0190766
CENPF centromere protein F, 350/400kDa 0.0188539
GOLGB1 golgin B1 0.0185882
RPS12 ribosomal protein S12 0.018497
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0183216
ESYT2 extended synaptotagmin-like protein 2 0.0180415
RPL37A ribosomal protein L37a 0.0180385
EZR ezrin 0.017925
LAMB3 laminin, beta 3 0.0178114
AKAP9 A kinase (PRKA) anchor protein 9 0.017659
PGM3 phosphoglucomutase 3 0.0174871
RPS2 ribosomal protein S2 0.0173637
ARHGAP32 Rho GTPase activating protein 32 0.0173585
SETD5 SET domain containing 5 0.0172247
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.0169914
SLK STE20-like kinase 0.0169818
DHFR dihydrofolate reductase 0.0169375
SPATA13 spermatogenesis associated 13 0.0168656
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.016804
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.0167459
SRP54 signal recognition particle 54kDa 0.0167385
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0165959
OSBPL10 oxysterol binding protein-like 10 0.0165814
HBP1 HMG-box transcription factor 1 0.0165309
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0162043
CALR calreticulin 0.0158944
IFI6 interferon, alpha-inducible protein 6 0.0157517
TMF1 TATA element modulatory factor 1 0.0156753
ANLN anillin, actin binding protein 0.0156481
HELZ helicase with zinc finger 0.0154933

decreased expression

Symbol Name Standardized Value
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.145239
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.123015
GMDS GDP-mannose 4,6-dehydratase -0.0857199
CEMIP cell migration inducing protein, hyaluronan binding -0.077847
FAT1 FAT atypical cadherin 1 -0.0505801
NPSR1 neuropeptide S receptor 1 -0.0491854
RPL35A ribosomal protein L35a -0.0487362
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0452827
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0442096
AHR aryl hydrocarbon receptor -0.0433564
EPCAM epithelial cell adhesion molecule -0.042681
EXOC4 exocyst complex component 4 -0.0425516
SAMD12 sterile alpha motif domain containing 12 -0.0409147
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0408786
RNF213 ring finger protein 213 -0.0396203
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0391552
GPX2 glutathione peroxidase 2 -0.0372378
CD46 CD46 molecule, complement regulatory protein -0.0369517
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0366381
ADAM9 ADAM metallopeptidase domain 9 -0.0364421
IFI27 interferon, alpha-inducible protein 27 -0.0361292
CDK6 cyclin-dependent kinase 6 -0.036038
LPP LIM domain containing preferred translocation partner in lipoma -0.0346565
RPS19 ribosomal protein S19 -0.0342409
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.03398
RPLP1 ribosomal protein, large, P1 -0.0334046
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0332999
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.033179
ACTN4 actinin, alpha 4 -0.0331521
RTN4 reticulon 4 -0.0325939
FLNB filamin B, beta -0.0316838
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0311331
PCBP2 poly(rC) binding protein 2 -0.0309633
BCAS3 breast carcinoma amplified sequence 3 -0.0309232
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0302378
INSIG1 insulin induced gene 1 -0.0299054
RNF43 ring finger protein 43 -0.0292846
TMSB10 thymosin beta 10 -0.0290052
ACACA acetyl-CoA carboxylase alpha -0.0288488
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0287183
MTUS1 microtubule associated tumor suppressor 1 -0.0282747
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0278117
MECOM MDS1 and EVI1 complex locus -0.027711
PDS5A PDS5 cohesin associated factor A -0.0275104
RAD51B RAD51 paralog B -0.0274994
C6ORF132 chromosome 6 open reading frame 132 -0.0271704
TMEM123 transmembrane protein 123 -0.0263603
STK24 serine/threonine kinase 24 -0.0263383
LOC102724023 ES1 protein homolog, mitochondrial -0.0262967
EGR1 early growth response 1 -0.0259333
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0258615
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0255445
RPL32 ribosomal protein L32 -0.0249364
DLG1 discs, large homolog 1 (Drosophila) -0.0245223
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0244958
SMC4 structural maintenance of chromosomes 4 -0.0244165
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0242192
CLDN4 claudin 4 -0.0240621
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0238688
ACTG1 actin gamma 1 -0.0237707
KPNB1 karyopherin (importin) beta 1 -0.0236562
TXNRD1 thioredoxin reductase 1 -0.0235933
SKAP2 src kinase associated phosphoprotein 2 -0.0234543
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.022879
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 -0.0228786
MDK midkine (neurite growth-promoting factor 2) -0.0226642
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0225722
XPO1 exportin 1 -0.0219463
TAOK1 TAO kinase 1 -0.0217579
PKP4 plakophilin 4 -0.0217139
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0215651
CAMKMT calmodulin-lysine N-methyltransferase -0.0214061
PLSCR1 phospholipid scramblase 1 -0.0212122
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0208822
PGK1 phosphoglycerate kinase 1 -0.0206082
MUC1 mucin 1, cell surface associated -0.0205882
PRELID2 PRELI domain containing 2 -0.0205008
MBNL1 muscleblind-like splicing regulator 1 -0.0204605
TOP2A topoisomerase (DNA) II alpha 170kDa -0.020328
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0201967
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0200266
SPIDR scaffolding protein involved in DNA repair -0.0199072
WWC1 WW and C2 domain containing 1 -0.0198798
ADNP activity-dependent neuroprotector homeobox -0.0198653
SLC38A1 solute carrier family 38, member 1 -0.0192148
PPARG peroxisome proliferator-activated receptor gamma -0.0191777
LPIN1 lipin 1 -0.0190056
YAP1 Yes-associated protein 1 -0.0189073
TRIP12 thyroid hormone receptor interactor 12 -0.0189064
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0187919
PARP9 poly (ADP-ribose) polymerase family, member 9 -0.0185981
MEIS2 Meis homeobox 2 -0.0185944
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0182909
CD2AP CD2-associated protein -0.0181113
VDAC1 voltage-dependent anion channel 1 -0.0180621
KLF3 Kruppel-like factor 3 (basic) -0.0180457
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0179996
SHB Src homology 2 domain containing adaptor protein B -0.0179412
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 -0.0178878
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0178858