Sodium Salicylate_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DTNA dystrobrevin, alpha 0.145795
EEF2 eukaryotic translation elongation factor 2 0.0703089
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.068665
NUP58 nucleoporin 58 0.062114
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0535532
ADAM9 ADAM metallopeptidase domain 9 0.0482512
SPAG9 sperm associated antigen 9 0.0477436
KDM3A lysine (K)-specific demethylase 3A 0.0468787
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0457272
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0447457
WDR45B WD repeat domain 45B 0.0438471
RNF145 ring finger protein 145 0.0408469
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0408039
RUNX1 runt-related transcription factor 1 0.0376971
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0370367
EGLN1 egl-9 family hypoxia-inducible factor 1 0.035391
HOOK2 hook microtubule-tethering protein 2 0.0345586
MCTP1 multiple C2 domains, transmembrane 1 0.0338651
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0327633
TSC22D2 TSC22 domain family, member 2 0.0325653
CXCL8 chemokine (C-X-C motif) ligand 8 0.0307995
KMT2E lysine (K)-specific methyltransferase 2E 0.0307934
ATP13A3 ATPase type 13A3 0.0302871
RLF rearranged L-myc fusion 0.0294521
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0284269
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0282134
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.027874
WDR43 WD repeat domain 43 0.0276225
UBA6 ubiquitin-like modifier activating enzyme 6 0.0267467
MALT1 MALT1 paracaspase 0.0258869
KDM2A lysine (K)-specific demethylase 2A 0.0258478
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0257451
JUN jun proto-oncogene 0.0248055
HELZ helicase with zinc finger 0.0237821
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0237741
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0237192
FLNA filamin A, alpha 0.0236659
QKI QKI, KH domain containing, RNA binding 0.0235759
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0235502
CASC3 cancer susceptibility candidate 3 0.023523
RNMT RNA (guanine-7-) methyltransferase 0.0234286
RAB6A RAB6A, member RAS oncogene family 0.0233883
RND3 Rho family GTPase 3 0.0228919
BRD2 bromodomain containing 2 0.0228317
TXNRD1 thioredoxin reductase 1 0.0228271
NAMPT nicotinamide phosphoribosyltransferase 0.0227594
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0226464
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0225923
UGCG UDP-glucose ceramide glucosyltransferase 0.0223486
NCKAP1 NCK-associated protein 1 0.0222971
HILPDA hypoxia inducible lipid droplet-associated 0.0221646
GOLGA4 golgin A4 0.0221111
KTN1 kinectin 1 (kinesin receptor) 0.0219463
MIMS1 mitochondrial inner membrane scaffold 1 0.0218821
PAWR PRKC, apoptosis, WT1, regulator 0.0216127
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0214515
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0208072
RAB8B RAB8B, member RAS oncogene family 0.0207074
MARCHF6 membrane associated ring-CH-type finger 6 0.0206271
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0205601
KMT2C lysine (K)-specific methyltransferase 2C 0.0203078
MED13 mediator complex subunit 13 0.020269
CHD1 chromodomain helicase DNA binding protein 1 0.020114
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0199493
ZFAND3 zinc finger, AN1-type domain 3 0.0199397
TFRC transferrin receptor 0.0199059
GLS2 glutaminase 2 (liver, mitochondrial) 0.0198353
ESYT2 extended synaptotagmin-like protein 2 0.0198313
CHD7 chromodomain helicase DNA binding protein 7 0.0196494
FAM117B family with sequence similarity 117, member B 0.0193032
USP3 ubiquitin specific peptidase 3 0.0192853
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0192797
VEZT vezatin, adherens junctions transmembrane protein 0.0189794
DENR density-regulated protein 0.0186714
MYO1B myosin IB 0.0185407
ARHGAP21 Rho GTPase activating protein 21 0.0182384
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0181882
TAC4 tachykinin 4 (hemokinin) 0.0181176
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0180511
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0178887
LRRC8C leucine rich repeat containing 8 family, member C 0.0178787
SMAP1 small ArfGAP 1 0.017815
CORO1C coronin, actin binding protein, 1C 0.0178066
MXI1 MAX interactor 1, dimerization protein 0.0174196
SRP54 signal recognition particle 54kDa 0.0173539
WAC WW domain containing adaptor with coiled-coil 0.0173462
USP37 ubiquitin specific peptidase 37 0.0172575
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0168814
ARID1A AT rich interactive domain 1A (SWI-like) 0.0168608
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0168252
SLMAP sarcolemma associated protein 0.0167305
CD109 CD109 molecule 0.0166457
PRKCI protein kinase C, iota 0.0166264
DDIT4 DNA-damage-inducible transcript 4 0.0164731
NGLY1 N-glycanase 1 0.0164612
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0162666
CDC73 cell division cycle 73 0.0162049
RYBP RING1 and YY1 binding protein 0.0161989
POM121 POM121 transmembrane nucleoporin 0.015982
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0157769

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.163068
TMSB10 thymosin beta 10 -0.152641
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.147861
AKAP12 A kinase (PRKA) anchor protein 12 -0.145024
VIM vimentin -0.139018
EFNA5 ephrin-A5 -0.114511
GPC6 glypican 6 -0.110537
PRKG1 protein kinase, cGMP-dependent, type I -0.0980918
ASPH aspartate beta-hydroxylase -0.0910918
RPL23 ribosomal protein L23 -0.0858268
AHNAK AHNAK nucleoprotein -0.0833865
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0799445
TPT1 tumor protein, translationally-controlled 1 -0.0795961
CDH13 cadherin 13 -0.0792634
NALF1 NALCN channel auxiliary factor 1 -0.0789074
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0768465
PDE4D phosphodiesterase 4D, cAMP-specific -0.0754112
SAMD3 sterile alpha motif domain containing 3 -0.0752998
KIAA1549L KIAA1549-like -0.0719238
RPS6 ribosomal protein S6 -0.071547
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0707821
PTCHD4 patched domain containing 4 -0.0655933
PHACTR1 phosphatase and actin regulator 1 -0.0655179
NAV1 neuron navigator 1 -0.0649531
VCL vinculin -0.0641734
MT2A metallothionein 2A -0.0582084
NTM neurotrimin -0.0569054
ACTG1 actin gamma 1 -0.0560509
MBD5 methyl-CpG binding domain protein 5 -0.0556796
ALCAM activated leukocyte cell adhesion molecule -0.0532524
SDCCAG8 serologically defined colon cancer antigen 8 -0.0531737
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0529438
PTPRG protein tyrosine phosphatase, receptor type, G -0.0522947
HMGA2 high mobility group AT-hook 2 -0.0520961
KIAA1217 KIAA1217 -0.0519458
RPL12 ribosomal protein L12 -0.0499661
RPS19 ribosomal protein S19 -0.0474922
RAD51B RAD51 paralog B -0.0466502
RPL35A ribosomal protein L35a -0.0462436
PTMA prothymosin, alpha -0.0460654
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0458961
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0450929
RPS12 ribosomal protein S12 -0.0450395
PTPRD protein tyrosine phosphatase, receptor type, D -0.0449507
ZNF804A zinc finger protein 804A -0.0449217
RPLP1 ribosomal protein, large, P1 -0.0449105
RPS3 ribosomal protein S3 -0.0443851
LSAMP limbic system-associated membrane protein -0.0422257
RPL19 ribosomal protein L19 -0.0416221
INTS6 integrator complex subunit 6 -0.0406548
MMP12 matrix metallopeptidase 12 -0.0406019
LIMCH1 LIM and calponin homology domains 1 -0.0404907
RPS21 ribosomal protein S21 -0.0404197
RPS8 ribosomal protein S8 -0.04
AEBP2 AE binding protein 2 -0.0397698
FOXP1 forkhead box P1 -0.0378643
LPP LIM domain containing preferred translocation partner in lipoma -0.0375436
ADAM19 ADAM metallopeptidase domain 19 -0.0374974
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0365236
RPS23 ribosomal protein S23 -0.0358019
RPS24 ribosomal protein S24 -0.0357474
FTL ferritin, light polypeptide -0.0353571
RPL37A ribosomal protein L37a -0.0345029
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0342497
RPLP2 ribosomal protein, large, P2 -0.0338937
RPS17 ribosomal protein S17 -0.0332787
RPL31 ribosomal protein L31 -0.033238
RPL11 ribosomal protein L11 -0.0330437
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0330272
RPLP0 ribosomal protein, large, P0 -0.0329226
RPL26 ribosomal protein L26 -0.0323913
RPL36 ribosomal protein L36 -0.0320549
NABP1 nucleic acid binding protein 1 -0.0318887
RNF213 ring finger protein 213 -0.0317505
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0315966
TM4SF1 transmembrane 4 L six family member 1 -0.0314119
RPL32 ribosomal protein L32 -0.0312276
RPS27A ribosomal protein S27a -0.0311921
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0311918
RPL9 ribosomal protein L9 -0.0311121
EXT1 exostosin glycosyltransferase 1 -0.0310091
FN1 fibronectin 1 -0.0307666
TPI1 triosephosphate isomerase 1 -0.0307109
EGFR epidermal growth factor receptor -0.0306252
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0302927
FNDC3B fibronectin type III domain containing 3B -0.0296785
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0295206
SASH1 SAM and SH3 domain containing 1 -0.0294005
PRELID2 PRELI domain containing 2 -0.0292529
SBF2 SET binding factor 2 -0.0291978
TRPS1 trichorhinophalangeal syndrome I -0.0291871
TRIO trio Rho guanine nucleotide exchange factor -0.0286295
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.028342
RPL34 ribosomal protein L34 -0.0277579
DIAPH3 diaphanous-related formin 3 -0.0277103
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0276982
TAS2R14 taste receptor, type 2, member 14 -0.0276478
VEPH1 ventricular zone expressed PH domain-containing 1 -0.0275192
RPS13 ribosomal protein S13 -0.0274253
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0272283