Sodium Salicylate_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Sodium Salicylate perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Sodium Salicylate_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.116988
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.108528
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.104391
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0682708
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0594264
FAT1 FAT atypical cadherin 1 0.0530188
LMO7 LIM domain 7 0.0526017
FTH1 ferritin, heavy polypeptide 1 0.0481157
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0478314
ITGA6 integrin, alpha 6 0.0477473
EEF2 eukaryotic translation elongation factor 2 0.0461556
DSPP dentin sialophosphoprotein 0.0398297
CEMIP cell migration inducing protein, hyaluronan binding 0.0395435
TXNIP thioredoxin interacting protein 0.0393944
RNF145 ring finger protein 145 0.0393879
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0382303
GOLGA4 golgin A4 0.0372349
MED13 mediator complex subunit 13 0.0352274
EZR ezrin 0.0343596
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0334119
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0333575
ANKRD11 ankyrin repeat domain 11 0.0326033
EPS8 epidermal growth factor receptor pathway substrate 8 0.0323484
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0312156
ZFAND3 zinc finger, AN1-type domain 3 0.0301449
MED13L mediator complex subunit 13-like 0.0301216
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0287364
RAB1A RAB1A, member RAS oncogene family 0.0283599
H1-0 H1.0 linker histone 0.0278696
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.027535
VEGFA vascular endothelial growth factor A 0.0274468
SERINC5 serine incorporator 5 0.0273819
RBM39 RNA binding motif protein 39 0.0272694
AHNAK AHNAK nucleoprotein 0.0266138
RNF43 ring finger protein 43 0.0264735
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0256794
AFF1 AF4/FMR2 family, member 1 0.0255297
SETD5 SET domain containing 5 0.0253495
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0252035
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0250827
WAC WW domain containing adaptor with coiled-coil 0.0246779
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0243398
PTMA prothymosin, alpha 0.0241032
CALR calreticulin 0.0237445
GPHN gephyrin 0.0237404
FAM13A family with sequence similarity 13, member A 0.0235798
LOC112694756 uncharaterized LOC112694756 0.0233686
GARS1 glycyl-tRNA synthetase 1 0.0222354
SHROOM3 shroom family member 3 0.0219759
PDZD8 PDZ domain containing 8 0.0219497
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0219367
TXNRD1 thioredoxin reductase 1 0.0218584
KMT2E lysine (K)-specific methyltransferase 2E 0.021774
LDHA lactate dehydrogenase A 0.0217339
TRIM2 tripartite motif containing 2 0.0215617
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0215409
DSCAM Down syndrome cell adhesion molecule 0.0214393
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0210132
KRT18 keratin 18, type I 0.0209216
CANX calnexin 0.0207362
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0207087
NCOR1 nuclear receptor corepressor 1 0.0205697
CTBP2 C-terminal binding protein 2 0.0205292
UBE2H ubiquitin-conjugating enzyme E2H 0.0204911
GDF15 growth differentiation factor 15 0.0204057
ERBIN erbb2 interacting protein 0.020159
OGA O-GlcNAcase 0.0201577
PUM2 pumilio RNA-binding family member 2 0.0200224
WDR45B WD repeat domain 45B 0.0198755
USP6NL USP6 N-terminal like 0.019851
KDM3A lysine (K)-specific demethylase 3A 0.0197385
HELZ helicase with zinc finger 0.0197118
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0195679
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0195261
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0194638
IQGAP1 IQ motif containing GTPase activating protein 1 0.0194375
HDLBP high density lipoprotein binding protein 0.019406
EREG epiregulin 0.0193987
CADPS Ca++-dependent secretion activator 0.0193986
FNDC3B fibronectin type III domain containing 3B 0.0193397
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0192599
MLEC malectin 0.019136
ANXA1 annexin A1 0.0187874
ARHGAP12 Rho GTPase activating protein 12 0.0187654
CEMIP2 cell migration inducing hyaluronidase 2 0.0187404
KIF5B kinesin family member 5B 0.0186282
CLCN3 chloride channel, voltage-sensitive 3 0.0185965
STRN3 striatin, calmodulin binding protein 3 0.0184079
CENPF centromere protein F, 350/400kDa 0.0183362
MATR3 matrin 3 0.0182646
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0181758
CD44 CD44 molecule (Indian blood group) 0.0181316
TPD52 tumor protein D52 0.0180434
COPA coatomer protein complex, subunit alpha 0.0180331
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0180246
DDIT4 DNA-damage-inducible transcript 4 0.0178774
RAD21 RAD21 homolog (S. pombe) 0.0177905
GSK3B glycogen synthase kinase 3 beta 0.0176919
ANKRD17 ankyrin repeat domain 17 0.0176678
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0176624

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.0805368
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0744138
TPT1 tumor protein, translationally-controlled 1 -0.0708155
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0553376
TMSB10 thymosin beta 10 -0.0441154
VCL vinculin -0.0410279
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.037833
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0271243
RPS6 ribosomal protein S6 -0.0265442
RPL9 ribosomal protein L9 -0.0255186
SLC35F3 solute carrier family 35, member F3 -0.0251366
TFF1 trefoil factor 1 -0.0249903
NALF1 NALCN channel auxiliary factor 1 -0.024707
TPM4 tropomyosin 4 -0.0242539
ANTXR2 anthrax toxin receptor 2 -0.0238062
RPS12 ribosomal protein S12 -0.0220939
MYO1E myosin IE -0.0208766
ACTG1 actin gamma 1 -0.0204424
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.01953
RPL35A ribosomal protein L35a -0.0193986
MT2A metallothionein 2A -0.0186012
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0171418
RPL37A ribosomal protein L37a -0.0170338
F3 coagulation factor III (thromboplastin, tissue factor) -0.0165412
LAMA4 laminin, alpha 4 -0.0164451
PTPRB protein tyrosine phosphatase, receptor type, B -0.0161363
IER3 immediate early response 3 -0.0160999
PDLIM5 PDZ and LIM domain 5 -0.0159903
S100A6 S100 calcium binding protein A6 -0.0159547
ONECUT3 one cut homeobox 3 -0.0154823
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0153532
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0152845
RPS24 ribosomal protein S24 -0.0152542
PDE4D phosphodiesterase 4D, cAMP-specific -0.0150613
FHIT fragile histidine triad -0.0147867
RPL34 ribosomal protein L34 -0.0142032
CCSER1 coiled-coil serine-rich protein 1 -0.0142015
RPL31 ribosomal protein L31 -0.0138239
PSD3 pleckstrin and Sec7 domain containing 3 -0.0136355
EGR1 early growth response 1 -0.0130154
PLAUR plasminogen activator, urokinase receptor -0.012945
PCDH9 protocadherin 9 -0.0129435
ALCAM activated leukocyte cell adhesion molecule -0.0128392
PALLD palladin, cytoskeletal associated protein -0.0128343
RPL26 ribosomal protein L26 -0.0126928
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0123374
GCC2 GRIP and coiled-coil domain containing 2 -0.0122695
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.011744
FOSL1 FOS-like antigen 1 -0.0115745
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0113428
RAD51B RAD51 paralog B -0.0112938
EGFR epidermal growth factor receptor -0.0109068
ANXA3 annexin A3 -0.0109052
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0108628
FLNB filamin B, beta -0.0107742
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0106645
RPS27A ribosomal protein S27a -0.0106147
KLK10 kallikrein-related peptidase 10 -0.0105608
MUC17 mucin 17, cell surface associated -0.0105433
RPS17 ribosomal protein S17 -0.0103238
MAML3 mastermind-like 3 (Drosophila) -0.0102535
FERMT1 fermitin family member 1 -0.0102259
RPL37 ribosomal protein L37 -0.0102157
CCDC91 coiled-coil domain containing 91 -0.0101442
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0100836
RPS13 ribosomal protein S13 -0.0100414
SOX4 SRY (sex determining region Y)-box 4 -0.010014
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.00979243
TSPAN8 tetraspanin 8 -0.00972544
SAMD5 sterile alpha motif domain containing 5 -0.00960429
TFF3 trefoil factor 3 (intestinal) -0.00956797
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.00935014
EXT1 exostosin glycosyltransferase 1 -0.0089404
RPL27 ribosomal protein L27 -0.00888176
RPL36A ribosomal protein L36a -0.00879522
N4BP2L2 NEDD4 binding protein 2-like 2 -0.00874165
BACE2 beta-site APP-cleaving enzyme 2 -0.00871659
TPM1 tropomyosin 1 (alpha) -0.0086397
RPL30 ribosomal protein L30 -0.00856852
HSPE1 heat shock 10kDa protein 1 -0.0085273
RIGI RNA sensor RIG-I -0.00848052
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.00845627
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.00835876
ARHGAP6 Rho GTPase activating protein 6 -0.00828567
KLF6 Kruppel-like factor 6 -0.0082526
MTAP methylthioadenosine phosphorylase -0.00818198
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.00817657
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.00816972
UQCRB ubiquinol-cytochrome c reductase binding protein -0.00808609
IGFL2 IGF-like family member 2 -0.00798061
SERINC2 serine incorporator 2 -0.00774732
SH3D19 SH3 domain containing 19 -0.00757761
RPL22L1 ribosomal protein L22-like 1 -0.00726027
HLA-B major histocompatibility complex, class I, B -0.00725053
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.00720447
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.00719759
IFI27 interferon, alpha-inducible protein 27 -0.00716144
LAMB3 laminin, beta 3 -0.00710094
CADPS2 Ca++-dependent secretion activator 2 -0.00709232
LUZP1 leucine zipper protein 1 -0.00708668